15 research outputs found
Exploring Predictors of Outcome in the Psychosis Prodrome: Implications for Early Identification and Intervention
Functional disability is a key component of many psychiatric illnesses, particularly schizophrenia. Impairments in social and role functioning are linked to cognitive deficits, a core feature of psychosis. Retrospective analyses demonstrate that substantial functional decline precedes the onset of psychosis. Recent investigations reveal that individuals at clinical-high-risk (CHR) for psychosis show impairments in social relationships, work/school functioning and daily living skills. CHR youth also demonstrate a pattern of impairment across a range of cognitive domains, including social cognition, which is qualitatively similar to that of individuals with schizophrenia. While many studies have sought to elucidate predictors of clinical deterioration, specifically the development of schizophrenia, in such CHR samples, few have investigated factors relevant to psychosocial outcome. This review integrates recent findings regarding cognitive and social-cognitive predictors of outcome in CHR individuals, and proposes potential directions for future research that will contribute to targeted interventions and improved outcome for at-risk youth
Search for Extended Sources of Neutrino Emission in the Galactic Plane with IceCube
The Galactic plane, harboring a diffuse neutrino flux, is a particularly
interesting target to study potential cosmic-ray acceleration sites. Recent
gamma-ray observations by HAWC and LHAASO have presented evidence for multiple
Galactic sources that exhibit a spatially extended morphology and have energy
spectra continuing beyond 100 TeV. A fraction of such emission could be
produced by interactions of accelerated hadronic cosmic rays, resulting in an
excess of high-energy neutrinos clustered near these regions. Using 10 years of
IceCube data comprising track-like events that originate from charged-current
muon neutrino interactions, we perform a dedicated search for extended neutrino
sources in the Galaxy. We find no evidence for time-integrated neutrino
emission from the potential extended sources studied in the Galactic plane. The
most significant location, at 2.6 post-trials, is a 1.7 sized
region coincident with the unidentified TeV gamma-ray source 3HWC J1951+266. We
provide strong constraints on hadronic emission from several regions in the
Galaxy.Comment: 13 pages, 4 figures, 5 tables including an appendix. Accepted for
publication in Astrophysical Journa
Lernen in virtuellen webbasierten Lernumgebungen
Walber M. Lernen in virtuellen webbasierten Lernumgebungen. In: Witthaus U, Wittwer W, Espe C, eds. Selbst gesteuertes Lernen. Theoretische und praktische Zugänge. Wissenschaft - Praxis - Dialog Berufliche Bildung. Vol 10. Bielefed: Betrelsmann; 2003: 209-222
The utility and efficacy of the new insulins in the management of diabetes and pregnancy
Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study
Suid-Afrikaanse “alternatiewe” rolprente en die Suid-Afrikaanse sosio-politieke werklikheid (Deel 2)
Randomized trial of oral teriflunomide for relapsing multiple sclerosis
Teriflunomide is a new oral disease-modifying therapy for relapsing forms of multiple sclerosis