125 research outputs found
Louis I. Kahn and Richard Kelly: collaborative design in creation of the luminous environment
As one of the most prominent architects of the twentieth century, Louis I. Kahn aspired to use natural light to shape his architecture. The lighting designer Richard Kelly, one of his close collaborators, had significant influence on modern architectural lighting design in the twentieth century. Kahn and Kelly designed the luminous environments in three art-gallery and museum buildings, The Yale University Art Gallery, the Kimbell Art Museum and the Yale Center for British Art. Collaboration between the architect and the lighting designer resulted in well-resolved lighting solutions. This research investigated the collaboration between Louis I. Kahn and Richard Kelly from both theoretical and pragmatic perspectives. In terms of the theoretical perspective, a detailed overview of their collaborative work is provided through literature review. In terms of the pragmatic perspective, the background of their cooperation and the technical details are presented. In addition, daylighting performance analysis of these three buildings through digital modelling was undertaken. This study found that the lighting design solutions produced together by Louis I. Kahn and Richard Kelly, especially the way of using daylight, have had significant impact on architectural space and the luminous environment. More importantly, this kind of collaborative working method could provide a useful reference and guidance for contemporary architecture and lighting design
Электроснабжение установки перекачки нефти п. Пионерный ОАО «Томскнефть»
РЕФЕРАТ
Выпускная квалификационная работа 149 с., 23 рис., 32 табл., 29 источников, 6 прил.
Ключевые слова: нефтепровод, насос, электрооборудование, схема электроснабжения, линия, сеть, электроприемник, нагрузка, оборудование, защита, ток, напряжение, мощность.
Объектом исследования является электрическая часть УПН п. Пионерный ОАО «Томскенефть».
Цель работы – проектирование схемы электроснабжения предприятия, выбор оборудования.
В процессе исследования проводился сбор исходных данных в ходе производственной практики на объекте исследования.
В результате была спроектирована схема электроснабжения от подстанции энергосистемы, до конечного электроприемника. Были выбраны кабели и провода, коммутационное оборудование, были сделаны необходимые проверки. Также результатом работы сталESSAY
Final qualifying work 149 p., 23 fig., 32 tab., 29 sources, 6 adj.
Keywords: oil, pump, electrical equipment, power supply circuit, line, network, power-consuming equipment, load equipment, protection, current, voltage, power.
The object of research is the electrical part of UPN claim. Pionerny of "Tomskeneft".
The purpose of work - designing enterprise power scheme, the choice of equipment.
The study was conducted to collect baseline data in the course of practical training on the subject of the study.
As a result, power supply circuit has been designed from the substation grid, appliance, to the end. Were selected cables and wires, switching equipment, the necessary checks have been made. It is also the result of the work became an economic calculation of capital costs for the con
Collaborative workplaces for innovation in service companies: barriers and enablers for supporting new ways of working
Precision measurement of the index of refraction of deep glacial ice at radio frequencies at Summit Station, Greenland
Glacial ice is used as a target material for the detection of ultra-high
energy neutrinos, by measuring the radio signals that are emitted when those
neutrinos interact in the ice. Thanks to the large attenuation length at radio
frequencies, these signals can be detected over distances of several
kilometers. One experiment taking advantage of this is the Radio Neutrino
Observatory Greenland (RNO-G), currently under construction at Summit Station,
near the apex of the Greenland ice sheet. These experiments require a thorough
understanding of the dielectric properties of ice at radio frequencies. Towards
this goal, calibration campaigns have been undertaken at Summit, during which
we recorded radio reflections off internal layers in the ice sheet. Using data
from the nearby GISP2 and GRIP ice cores, we show that these reflectors can be
associated with features in the ice conductivity profiles; we use this
connection to determine the index of refraction of the bulk ice as n=1.778 +/-
0.006
Ubiquitination of CXCR7 Controls Receptor Trafficking
The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. Despite having all the canonical features of G protein-coupled receptors (GPCRs), the signalling pathways following CXCR7 activation remain controversial, since unlike typical chemokine receptors, CXCR7 fails to activate Gαi-proteins. CXCR7 has recently been shown to interact with β-arrestins and such interaction has been suggested to be responsible for G protein-independent signals through ERK-1/2 phosphorylation. Signal transduction by CXCR7 is controlled at the membrane by the process of GPCR trafficking. In the present study we investigated the regulatory processes triggered by CXCR7 activation as well as the molecular interactions that participate in such processes. We show that, CXCR7 internalizes and recycles back to the cell surface after agonist exposure, and that internalization is not only β-arrestin-mediated but also dependent on the Serine/Threonine residues at the C-terminus of the receptor. Furthermore we describe, for the first time, the constitutive ubiquitination of CXCR7. Such ubiquitination is a key modification responsible for the correct trafficking of CXCR7 from and to the plasma membrane. Moreover, we found that CXCR7 is reversibly de-ubiquitinated upon treatment with CXCL12. Finally, we have also identified the Lysine residues at the C-terminus of CXCR7 to be essential for receptor cell surface delivery. Together these data demonstrate the differential regulation of CXCR7 compared to the related CXCR3 and CXCR4 receptors, and highlight the importance of understanding the molecular determinants responsible for this process
Unconventional applications of wire bonding create opportunities for microsystem integration
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation
Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a wide variety of physiological responses, including apoptosis, cellular proliferation and neuronal differentiation. However, the intracellular mechanisms underlying these effects of AChR signaling are not fully understood. It is known that activation of AChRs increase cellular proliferation and neurogenesis and that regulation of intracellular calcium through AChRs may underlie the many functions of ACh. Intriguingly, activation of diverse signaling molecules such as Ras-mitogen-activated protein kinase, phosphatidylinositol 3-kinase-Akt, protein kinase C and c-Src is modulated by AChRs. Here we discuss the roles of ACh in neuronal differentiation, cell proliferation and apoptosis. We also discuss the pathways involved in these processes, as well as the effects of novel endogenous AChRs agonists and strategies to enhance neuronal-differentiation of stem and neural progenitor cells. Further understanding of the intracellular mechanisms underlying AChR signaling may provide insights for novel therapeutic strategies, as abnormal AChR activity is present in many diseases
The Shear Stress-Induced Transcription Factor KLF2 Affects Dynamics and Angiopoietin-2 Content of Weibel-Palade Bodies
BACKGROUND: The shear-stress induced transcription factor KLF2 has been shown to induce an atheroprotective phenotype in endothelial cells (EC) that are exposed to prolonged laminar shear. In this study we characterized the effect of the shear stress-induced transcription factor KLF2 on regulation and composition of Weibel-Palade bodies (WPBs) using peripheral blood derived ECs. METHODOLOGY AND PRINCIPAL FINDINGS: Lentiviral expression of KLF2 resulted in a 4.5 fold increase in the number of WPBs per cell when compared to mock-transduced endothelial cells. Unexpectedly, the average length of WPBs was significantly reduced: in mock-transduced endothelial cells WPBs had an average length of 1.7 µm versus 1.3 µm in KLF2 expressing cells. Expression of KLF2 abolished the perinuclear clustering of WPBs observed following stimulation with cAMP-raising agonists such as epinephrine. Immunocytochemistry revealed that WPBs of KLF2 expressing ECs were positive for IL-6 and IL-8 (after their upregulation with IL-1β) but lacked angiopoietin-2 (Ang2), a regular component of WPBs. Stimulus-induced secretion of Ang2 in KLF2 expressing ECs was greatly reduced and IL-8 secretion was significantly lower. CONCLUSIONS AND SIGNIFICANCE: These data suggest that KLF2 expression leads to a change in size and composition of the regulated secretory compartment of endothelial cells and alters its response to physiological stimuli
Predicting norm enforcement: the individual and joint predictive power of economic preferences, personality, and self-control
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