On the influence of the cosmological constant on gravitational lensing in small systems

The cosmological constant Lambda affects gravitational lensing phenomena. The contribution of Lambda to the observable angular positions of multiple images and to their amplification and time delay is here computed through a study in the weak deflection limit of the equations of motion in the Schwarzschild-de Sitter metric. Due to Lambda the unresolved images are slightly demagnified, the radius of the Einstein ring decreases and the time delay increases. The effect is however negligible for near lenses. In the case of null cosmological constant, we provide some updated results on lensing by a Schwarzschild black hole.Comment: 8 pages, 1 figure; v2: extended discussion on the lens equation, references added, results unchanged, in press on PR

Survival patterns in cystic fibrosis

This paper describes the Data Registry System of the Cystic Fibrosis Foundation. Through this system an annual up-dated and corrected data base has been prepared for cystic fibrosis patients seen at U.S.A. Centers from 1966 through 1972.From the data base, a large number of life table studies are calculated. A study is specified by its data base, the observation period, analysis year (age year or year since diagnosis), the Centers included, and the condition of patients at birth, and possible additional factors such as sex, age at diagnosis, or race. The annual rates of mortality are measured by a force of mortality technique.Two techniques have been used to appraise the mortality of particular groups, graphing the cumulative survival function for the group together with the cumulative survival function for a comparison group, and calculation of mortality ratios of actual to expected deaths (by an applicable standard mortality table). This latter approach lends itself readily to tests of significance.For the purpose of calculating mortality ratios, two standard tables have been prepared on the basis of the 1972 Data Base and the 1966-1972 observations. The first of these standard tables is for use with age year studies, and the second is for years since diagnosis studies.The paper comments on a number of mortality studies by calendar year, by sex, by condition at birth, by age at diagnosis, and of survival from diagnosis of patients diagnosed in 1966-1972. The calendar year studies indicate an improvement trend in the survival experience from 1966 to 1972 but a change may be occurring. The study by sex exhibits a higher female mortality. The 7% of patients who have meconium ileus at birth show a significantly higher first-year mortality, and a somewhat lower survival rate thereafter even if the first year of life experience is excluded. Mortality data for groups specified by age at diagnosis are given. For patients diagnosed during 1966-1972, there is some indication of better survival than for patients diagnosed prior to 1966.The continuation of these mortality studies on an annual basis should further our understanding of survival patterns for cystic fibrosis patients.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21939/1/0000346.pd

First observation of the Charmless Decay B to K pi0pi0 and Study of its Dalitz Plot Structure

Results for the first measurement of the inclusive branching and CP asymmetry of the charmless 3-body decay B{sup +} {yields} K{sup +}{pi}{sup 0}{pi}{sup 0} are presented. The analysis uses a data sample with an integrated luminosity of 429.0 fb{sup -1}, recorded by the BABAR detector at the PEP-II asymmetric B Factory. This sample corresponds to 470.9 {+-} 2.8 million B{bar B} pairs. Measurements of the branching fractions (B) and CP asymmetries (A{sub CP}) of some of the intermediate resonances in the K{sup +}{pi}{sup 0}{pi}{sup 0} Dalitz plot are also presented

Subaru High-Dispersion Spectroscopy of Narrow-Line Region in the Seyfert Galaxy NGC 4151

We report on a study of forbidden emission-line spectrum of nearby Seyfert 1.5 galaxy NGC 4151 based on the high-resolution (R ~ 45,000) optical spectrum obtained by using the High Dispersion Spectrograph boarded on the Subaru Telescope. The profile parameters such as the emission-line widths, the velocity shifts from the recession velocity of the host galaxy, and the asymmetry indices, for emission lines including very faint ones such as [Ar IV]4712,4740 and [Fe VI]5631,5677 are investigated. Statistically significant correlations between the measured profile parameters and the critical densities of transitions are found while there are no meaningful correlations between the profile parameters and the ionization potentials of ions. By comparing the results with photoionization model calculations, we remark that a simple power-law distribution of the gas density which is independent of the radius from the nucleus cannot explain the observed correlation between the emission-line widths and the critical densities of the transitions. Taking the additional dense gas component expected to exist at the innermost of the narrow-line region into account, the observed correlations between the emission-line width and the critical density of the transitions can be understood since high-critical-density emission lines can arise at such relatively inner regions even if their ionization potentials are low. The observed correlation between the blueshift amounts of emission lines and the critical densities of the ions is also explained if such dense gas clouds located closer to the nucleus have larger outflowing velocities.Comment: 19 pages and 1 separate jpeg figure. Accepted for publication in A

Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures

Background: Mental health disorders in the child and adolescent population are a pressing public health concern. Despite the high prevalence of psychopathology in this vulnerable population, the transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) has many obstacles such as deficiencies in planning, organisational readiness and policy gaps. All these factors contribute to an inadequate and suboptimal transition process. A suite of measures is required that would allow young people to be assessed in a structured and standardised way to determine the on-going need for care and to improve communication across clinicians at CAMHS and AMHS. This will have the potential to reduce the overall health economic burden and could also improve the quality of life for patients travelling across the transition boundary. The MILESTONE (Managing the Link and Strengthening Transition from Child to Adult Mental Health Care) project aims to address the significant socioeconomic and societal challenge related to the transition process. This protocol paper describes the development of two MILESTONE transition-related measures: The Transition Readiness and Appropriateness Measure (TRAM), designed to be a decision-making aide for clinicians, and the Transition Related Outcome Measure (TROM), for examining the outcome of transition. Methods: The TRAM and TROM have been developed and were validated following the US FDA Guidance for Patient-reported Outcome Measures which follows an incremental stepwise framework. The study gathers information from service users, parents, families and mental health care professionals who have experience working with young people undergoing the transition process from eight European countries. Discussion: There is an urgent need for comprehensive measures that can assess transition across the CAMHS/AMHS boundary. This study protocol describes the process of development of two new transition measures: the TRAM and TROM. The TRAM has the potential to nurture better transitions as the findings can be summarised and provided to clinicians as a clinician-decision making support tool for identifying cases who need to transition and the TROM can be used to examine the outcomes of the transition process. Trial registration: MILESTONE study registration: ISRCTN83240263 Registered 23-July-2015 - ClinicalTrials.gov NCT03013595 Registered 6 January 2017

Evolving Treatment Patterns and Outcomes of Neovascular Age-Related Macular Degeneration Over a Decade

PURPOSE: Management of neovascular age-related macular degeneration (nAMD) has evolved over the last decade with several treatment regimens and medications. This study describes the treatment patterns and visual outcomes over 10 years in a large cohort of patients. DESIGN: Retrospective analysis of electronic health records from 27 National Health Service secondary care healthcare providers in the UK. PARTICIPANTS: Treatment-naïve patients receiving at least 3 intravitreal anti-vascular endothelial growth factor (VEGF) injections for nAMD in their first 6 months of follow-up were included. Patients with missing data for age or gender and those aged less than 55 years were excluded. METHODS: Eyes with at least 3 years of follow-up were grouped by years of treatment initiation, and 3-year outcomes were compared between the groups. Data were generated during routine clinical care between September 2008 and December 2018. MAIN OUTCOME MEASURES: Visual acuity (VA), number of injections, and number of visits. RESULTS: A total of 15 810 eyes of 13 705 patients receiving 195 104 injections were included. Visual acuity improved from baseline during the first year, but decreased thereafter, resulting in loss of visual gains. This trend remained consistent throughout the past decade. Although an increasing proportion of eyes remained in the driving standard, this was driven by better presenting VA over the decade. The number of injections decreased substantially between the first and subsequent years, from a mean of 6.25 in year 1 to 3 in year 2 and 2.5 in year 3, without improvement over the decade. In a multivariable regression analysis, final VA improved by 0.24 letters for each year since 2008, and younger age and baseline VA were significantly associated with VA at 3 years. CONCLUSIONS: Our findings show that despite improvement in functional VA over the years, primarily driven by improving baseline VA, patients continue to lose vision after the first year of treatment, with only marginal change over the past decade. The data suggest these results may be related to suboptimal treatment patterns, which have not improved over the years. Rethinking treatment strategies may be warranted, possibly on a national level or through the introduction of longer-acting therapies

On the Physics Case of a Super Flavour Factory

We summarize the physics case of a high-luminosity e{sup +}e{sup -} flavor factory collecting an integrated luminosity of 50 - 75 ab{sup -1}. Many New Physics sensitive measurements involving B and D mesons and {tau} leptons, unique to a Super Flavor Factory, can be performed with excellent sensitivity to new particles with masses up to {approx} 100 (or even {approx} 1000) TeV. Flavor- and CP-violating couplings of new particles that may be discovered at the LHC can be measured in most scenarios, even in unfavorable cases assuming minimal flavor violation. Together with the LHC, a Super Flavor Factory, following either the SuperKEKB or the SuperB proposal, could be soon starting the project of reconstructing the New Physics Lagrangian

Managing the link and strengthening transition from child to adult mental health care in Europe (MILESTONE) : background, rationale and methodology

Background Transition from distinct Child and Adolescent Mental Health (CAMHS) to Adult Mental Health Services (AMHS) is beset with multitude of problems affecting continuity of care for young people with mental health needs. Transition-related discontinuity of care is a major health, socioeconomic and societal challenge globally. The overall aim of the Managing the Link and Strengthening Transition from Child to Adult Mental Health Care in Europe (MILESTONE) project (2014-19) is to improve transition from CAMHS to AMHS in diverse healthcare settings across Europe. MILESTONE focuses on current service provision in Europe, new transition-related measures, long term outcomes of young people leaving CAMHS, improving transitional care through 'managed transition', ethics of transitioning and the training of health care professionals. Methods Data will be collected via systematic literature reviews, pan-European surveys, and focus groups with service providers, users and carers, and members of youth advocacy and mental health advocacy groups. A prospective cohort study will be conducted with a nested cluster randomised controlled trial in eight European Union (EU) countries (Belgium, Croatia, France, Germany, Ireland, Italy, Netherlands, UK) involving over 1000 CAMHS users, their carers, and clinicians. Discussion Improving transitional care can facilitate not only recovery but also mental health promotion and mental illness prevention for young people. MILESTONE will provide evidence of the organisational structures and processes influencing transition at the service interface across differing healthcare models in Europe and longitudinal outcomes for young people leaving CAMHS, solutions for improving transitional care in a cost-effective manner, training modules for clinicians, and commissioning and policy guidelines for service providers and policy makers