Quantum instability in a dc-SQUID with strongly asymmetric dynamical parameters

A classical system cannot escape out of a metastable state at zero temperature. However, a composite system made from both classical and quantum degrees of freedom may drag itself out of the metastable state by a sequential process. The sequence starts with the tunneling of the quantum component which then triggers a distortion of the trapping potential holding the classical part. Provided this distortion is large enough to turn the metastable state into an unstable one, the classical component can escape. This process reminds of the famous baron Muenchhausen who told the story of rescuing himself from sinking in a swamp by pulling himself up by his own hair--we thus term this decay the `Muenchhausen effect'. We show that such a composite system can be conveniently studied and implemented in a dc-SQUID featuring asymmetric dynamical parameters. We determine the dynamical phase diagram of this system for various choices of junction parameters and system preparations.Comment: 12 pages, 12 figure

Time-Resolved Coherent Photoelectron Spectroscopy of Quantized Electronic States on Metal Surfaces

Time-resolved two-photon photoemission in combination with the coherent excitation of several quantum states was used to study the ultrafast electron dynamics of imagepotential states on metal surfaces. For a (100) surface of copper, the spectroscopy of quantum beats made previously unresolved high-order states (quantum number n Ն 4) experimentally accessible. By exciting electrons close to the vacuum level, electron wave packets could be created and detected that described the quasi-classical periodic motion of weakly bound electrons. They traveled more than 200 Å away from the surface and oscillated back and forth with a period of 800 femtoseconds. Photoelectron spectroscopy has developed into one of the most versatile and successful tools for surface studies. Particularly attractive features of this technique are the high surface sensitivity associated with the low escape depth of the photoelectrons and the capability of angle-resolved photoemission to completely characterize electronic states in energy and momentum space (1). Recently, these features have been combined with ultrafast laser excitation for direct time-domain investigations of electron dynamics at surfaces (2). Here, we demonstrate another facet of this powerful technique, the investigation of coherence phenomena in real time. In contrast to experimental methods that rely merely on intensities, coherent spectroscopies offer the unique capability of accessing not only the amplitudes but also the phases of the wave functions of interest (3). This technique dramatically increases the amount of information that one is able to obtain about the temporal evolution of fast processes. In this report, we discuss the dynamics of image-potential states, that is, the quantized excited states of electrons that exist in front of many metal surfaces (4, 5). Using femtosecond time-resolved two-photon photoemission (2PPE), we observed the interference between the wave functions of neighboring eigenstates and the quasi-classical motion of electron wave packets created by the coherent superposition of several quantum states. Recently, the imaging of the static charge density of related surface electronic (ground) states in real space with the scanning tunneling microscope has attracted considerable interest (6); the present results reveal the dynamical evolution of excited electrons in real time. Image-potential states are conceptually rather simple. An electron at a distance z in front of a conducting metal surface experiences an attractive force F(z) ϭ Ϫe 2 /(2z) 2 identical to that produced by a positive (mirror image) charge at a distance z inside the metal converging toward the vacuum energy, where the influence of the surface potential on the binding energy E B ϭ ϪE n is approximated by a quantum defect 0 Յ a Յ 0.5. Experimentally, image-potential states have been studied with 2PPE on many metal surfaces including surfaces covered with adsorbates and metallic overlayers (5, 7-11). One photon with energy ប a (ប is Planck's constant h divided by 2 and is the photon frequency times 2) excites an electron out of an occupied state below the Fermi energy E F into the image-potential state n. A second photon with energy ប b excites the electron to an energy above E vac The experimental setup consisted of a 80-MHz Ti:sapphire laser system that generated infrared (IR) pulses of 70-fs duration. Frequency-tripled 95-fs ultraviolet (UV) pulses from this laser were used for the excitation step (ប a ϭ 4.7 eV). The photoelectrons were emitted by the fundamental IR pulses (ប b ϭ 1.57 eV) and were detected in a hemispherical analyzer with an energy resolution of 30 meV and an angular acceptance of Ϯ0.6°about the surface normal. The preparation of the Cu(111) and Cu(100) samples and details of the ultrahigh-vacuum chamber have been described elsewhere (5). The samples were kept at room temperature. Typical energy-resolved 2PPE spectra of C

Conversion between the Montreal Cognitive Assessment and the Mini-Mental Status Examination.

BACKGROUND Early and accurate detection of cognitive changes using simple tools is essential for an appropriate referral to a more detailed neurocognitive assessment and for the implementation of therapeutic strategies. The Mini-Mental Status Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are two commonly used psychometric tests for cognitive screening. Both tests have different strengths and weaknesses. Preferences regarding test selection may therefore differ among clinicians. The aim of this retrospective observational cohort study was to define corresponding scores for the MMSE and the MoCA. METHODS We examined the relationship between the cognitive screening tests in 803 German-speaking Memory Clinic outpatients, encompassing a wide range of neurocognitive disorders. We produced a conversion table using the equipercentile equating method with log-linear smoothing. In addition, we conducted a systematic review of existing MMSE-MoCA conversions to create a table allowing for the conversion of MoCA scores into MMSE scores and vice versa using the weighted mean method. RESULTS The Memory Clinic sample showed that the prediction of MMSE to MoCA was overall less accurate compared to the conversion from MoCA to MMSE. The 19 studies included after thorough literature search showed that MoCA scores were consistently lower than MMSE scores. Eleven of 19 conversion studies had addressed the conversion of the MoCA to the MMSE, while two studies converted MMSE to MoCA scores. Another six studies applied bi-directional conversions. We provide an easy-to-use table covering the entire range of scores and taking into account all currently existing conversion formulas. CONCLUSION The comprehensive MMSE-MoCA conversion table enables a direct comparison of cognitive test scores at screening examinations and over the course of disease in patients with neurocognitive disorders

Noise properties of an optical frequency comb from a SESAM-mode-locked 1.5-μm solid-state laser stabilized to the 10−13 level

We present a detailed investigation of the noise properties of an optical frequency comb generated from a femtosecond diode-pumped solid-state laser operating in the 1.5-μm spectral region. The stabilization of the passively mode-locked Er:Yb:glass laser oscillator, referred to as ERGO, is achieved using pump power modulation for the control of the carrier envelope offset (CEO) frequency and by adjusting the laser cavity length for the control of the repetition rate. The stability and the noise of the ERGO comb are characterized in free-running and in phase-locked operation by measuring the noise properties of the CEO, of the repetition rate, and of a comb line at 1558nm. The comb line is analyzed from the heterodyne beat signal with a cavity-stabilized ultra-narrow-linewidth laser using a frequency discriminator. Two different schemes to stabilize the comb to a radio-frequency (RF) reference are compared. The comb properties (phase noise, frequency stability) are limited in both cases by the RF oscillator used to stabilize the repetition rate, while the contribution of the CEO is negligible at all Fourier frequencies, as a consequence of the low-noise characteristics of the CEO-beat. Alinewidth of ≈150kHz and a fractional frequency instability of 4.2×10−13 at 1s are obtained for an optical comb line at 1558nm. Improved performance is obtained by stabilizing the comb to an optical reference, which is a cavity-stabilized ultra-narrow linewidth laser at 1558nm. The fractional frequency stability of 8×10−14 at 1s, measured in preliminary experiments, is limited by the reference oscillator used in the frequency compariso

Pharmacovigilance in pregnancy: adverse drug reactions associated with fetal disorders.

Abstract Objective: To provide the first update on drug safety profiles and adverse drug reactions (ADRs) associated with fetal disorders from the Swiss national ADR database. Methods: We conducted a retrospective study using data from 202 pharmacovigilance reports on drug-associated fetal disorders from the Swiss national ADR database from 1990 to 2009. Evaluated aspects included administrative information on the report, drug exposure, and disorders. Results: The ADR reporting frequency on the topic of fetal disorders has increased during the last 20 years, from only 1 report in 1991 to a maximum of 31 reports in 2008. Nervous system drugs were the most frequently reported drug group (40.2%) above all antidepressants and antiepileptics. The highest level of overall drug intake could be observed for the 1st trimester (85.4%), especially for the first 6 weeks of pregnancy. The most frequently reported types of fetal disorders were malformations (68.8%), especially those of the musculoskeletal and circulatory systems. A positive association was discovered between antiepileptics and malformations in general and in particular of the circulatory system and the eye, ear, face, and neck. Conclusions: The results suggest that the nervous system drug group bears an especially high risk for malformations. The most commonly identified drug exposures can help focus pharmacoepidemiologic efforts in drug-induced birth defects

First results on light readout from the 1-ton ArDM liquid argon detector for dark matter searches

ArDM-1t is the prototype for a next generation WIMP detector measuring both the scintillation light and the ionization charge from nuclear recoils in a 1-ton liquid argon target. The goal is to reach a minimum recoil energy of 30\,keVr to detect recoiling nuclei. In this paper we describe the experimental concept and present results on the light detection system, tested for the first time in ArDM on the surface at CERN. With a preliminary and incomplete set of PMTs, the light yield at zero electric field is found to be between 0.3-0.5 phe/keVee depending on the position within the detector volume, confirming our expectations based on smaller detector setups.Comment: 14 pages, 10 figures, v2 accepted for publication in JINS

Annotated Bibliography "Arabic Papyrology and Documentary Studies on the Mediterranean and the Islamicate World": New Publications 2019 and Addenda 2018

Middle Eastern Studie