Long-Term Efficacy and Safety of Chronic Globus Pallidus Internus Stimulation in Different Types of Primary Dystonia

Background: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) offers a very promising therapy for medically intractable dystonia. However, little is known about the long-term benefit and safety of this procedure. We therefore performed a retrospective long-term analysis of 18 patients (age 12-78 years) suffering from primary generalized (9), segmental (6) or focal (3) dystonia (minimum follow-up: 36 months). Methods: Outcome was assessed using the Burke-Fahn-Marsden (BFM) scores (generalized dystonia) and the Tsui score (focal/segmental dystonia). Follow-up ranged between 37 and 90 months (mean 60 months). Results: Patients with generalized dystonia showed a mean improvement in the BFM movement score of 39.4% (range 0 68.8%), 42.5% (range -16.0 to 81.3%) and 46.8% (range-2.7 to 83.1%) at the 3- and 12-month, and long-term follow-up, respectively. In focal/ segmental dystonia, the mean reduction in the Tsui score was 36.8% (range 0-100%), 65.1% (range 16.7-100%) and 59.8% (range 16.7-100%) at the 3- and 12-month, and long-term follow-up, respectively. Local infections were noted in 2 patients and hardware problems (electrode dislocation and breakage of the extension cable) in 1 patient. Conclusion: Our data showed Gpi-DBS to offer a very effective and safe therapy for different kinds of primary dystonia, with a significant long-term benefit in the majority of cases. Copyright (c) 2008 S. Karger AG, Base

Detection of mutations in the gyrA of clinical Salmonella spp.

The high prevalence of resistance to nalidixic acid and reduced susceptibility to ciprofloxacin of Salmonella spp. obtained from stool samples of neonates presenting with acute diarrhea in 2001 at the King Edward VIII hospital in Durban, South Africa, prompted this study to determine if there were any mutations in the QRDR of these isolates and to search for the qnrA gene. All isolates with nalidixic acid MICs > 48 μg/ml had the single mutation D87N, or D87G in the QRDR of the gyrA gene, and only 2 strains had an additional mutation; S83L and S83F respectively. The mutation S83T was present in only one isolate with the nalidixic acid MIC of 10 μg/ml whilst the 6 other strains with nalidixic acid MICs < 10 μg/ml had no changes in the QRDR of the gyrA gene. The qnrA gene was not found. These findings indicate that there are mutations in the gyrA of Salmonella isolates which could contribute to resistance to nalidixic acid with reduced susceptibility to ciprofloxacin and there is the co-expression of quinolone and extended-spectrum ß-lactam resistance among Salmonella spp

Improved acoustics for semi-enclosed spaces in the proximity of residential buildings

Continuous urban densification exacerbates acoustic challenges for residents of housing complexes. They are confronted with higher noise immission from railway, road traffic, construction, as well as louder neighborhood acoustic environments. Thereby, not only noise immission indoors is associated with stress, annoyance, and sleep disturbance, but also the immediate outdoor living environment (e.g., courtyards, private gardens and playgrounds, etc.) can be acoustically unpleasant and annoying. This non-exhaustive narrative review paper elaborates on the role of a number of design parameters on improving the quality of the outdoor soundscape of housing complexes: architectural and morphological design, facade material characteristics, balconies, greenery, ground, background sounds, and several factors concerning quality of sounds (e.g., multisensory perception, holistic design, the relevance of space, context, social factors, co-creation, etc.). It mainly covers literature including both acoustical (e.g., sound pressure level and room acoustical parameters) and human/perceptual (e.g., comfort and annoyance) factors. A series of recommendations are presented here as to how the semi-enclosed outdoor spaces in the proximity of residential complexes can be acoustically improved

On the Nodal Count Statistics for Separable Systems in any Dimension

We consider the statistics of the number of nodal domains aka nodal counts for eigenfunctions of separable wave equations in arbitrary dimension. We give an explicit expression for the limiting distribution of normalised nodal counts and analyse some of its universal properties. Our results are illustrated by detailed discussion of simple examples and numerical nodal count distributions.Comment: 21 pages, 4 figure

Effects of pallidal deep brain stimulation and levodopa treatment on reaction-time performance in Parkinson's disease

Basal ganglia-thalamocortical circuits play an important role in movement preparation and execution. Tracer, single-cell, and lesion studies in monkeys suggest the existence of topologically segregated motor and nonmotor basal ganglia cortical circuits. In this study we used deep brain stimulation (DBS) of the posteroventrolateral globus pallidus internus (GPi) in patients with Parkinson's disease to elucidate the function of the GPi in human sensorimotor behavior. This question was investigated by comparing the influence of DBS on patients' performance in various reaction-time tasks that differed with respect to cognitive but not motor requirements. As a main result, DBS improved performance on the different tasks independently of the complexity of the involved cognitive processing functions. Furthermore, the observed effects did not depend on the modality of the processed information. These results suggest that the functional state of the posteroventrolateral GPi selectively affects the motor stage in simple sensorimotor acts, because this stage was the only stage involved in all investigated tasks. In addition to DBS, we manipulated the levodopa medication state of the PD patients. In contrast to DBS, levodopa effects on reaction times were less consistent. Levodopa improved reaction times in choice reaction tasks significantly, while affecting reaction times in a simple reaction task to a lesser extent. Error analysis revealed that the medication-dependent reaction-time improvement in the choice reaction tasks was accompanied by an increase in errors, suggesting a shift of the speed-accuracy criteria of the patients. A similar pattern of results was not observed for the DBS effects. Taken together, our data are in agreement with recent findings in monkeys that indicate a topological organization of the GPi in which motor functions are localized in posterolateral regions apart from cognitive regions. Furthermore, our data show a way to uncover the subcortical-cortical circuitry serving human sensorimotor behavior

Spitzer Power-law AGN Candidates in the Chandra Deep Field-North

We define a sample of 62 galaxies in the Chandra Deep Field-North whose Spitzer IRAC SEDs exhibit the characteristic power-law emission expected of luminous AGN. We study the multiwavelength properties of this sample, and compare the AGN selected in this way to those selected via other Spitzer color-color criteria. Only 55% of the power-law galaxies are detected in the X-ray catalog at exposures of >0.5 Ms, although a search for faint emission results in the detection of 85% of the power-law galaxies at the > 2.5 sigma detection level. Most of the remaining galaxies are likely to host AGN that are heavily obscured in the X-ray. Because the power-law selection requires the AGN to be energetically dominant in the near- and mid-infrared, the power-law galaxies comprise a significant fraction of the Spitzer-detected AGN population at high luminosities and redshifts. The high 24 micron detection fraction also points to a luminous population. The power-law galaxies comprise a subset of color-selected AGN candidates. A comparison with various mid-infrared color selection criteria demonstrates that while the color-selected samples contain a larger fraction of the X-ray luminous AGN, there is evidence that these selection techniques also suffer from a higher degree of contamination by star-forming galaxies in the deepest exposures. Considering only those power-law galaxies detected in the X-ray catalog, we derive an obscured fraction of 68% (2:1). Including all of the power-law galaxies suggests an obscured fraction of < 81% (4:1).Comment: Accepted for publication in the Astrophysical Journal, 27 pages, 20 figures, 5 tables, version with high-resolution figures and online-only tables available at: http://frodo.as.arizona.edu/~jdonley/powerlaw

First mid-infrared spectrum of a faint high-z galaxy: Observations of CFRS 14.1157 with the Infrared Spectrograph on the Spitzer Space Telescope

The unprecedented sensitivity of the Infrared Spectrograph on the Spitzer Space Telescope allows for the first time the measurement of mid-infrared spectra from 14 to 38 microns of faint high-z galaxies. This unique capability is demonstrated with observations of sources having 16 micron fluxes of 3.6 mJy (CFRS 14.1157) and 0.35 mJy (CFRS 14.9025). A spectral-fitting technique is illustrated which determines the redshift by fitting emission and absorption features characteristic of nearby galaxies to the spectrum of an unknown source. For CFRS 14.1157, the measured redshift is z = 1.00+/-0.20 in agreement with the published result of z = 1.15. The spectrum is dominated by emission from an AGN, similar to the nucleus of NGC 1068, rather than a typical starburst with strong PAH emission like M82. Such spectra will be crucial in characterizing the nature of newly discovered distant galaxies, which are too faint for optical follow-up.Comment: Accepted in ApJ Sup. Spitzer Special Issue, 4 pages, 5 figure

A Spitzer Infrared Spectrograph Survey of Warm Molecular Hydrogen in Ultra-luminous Infrared Galaxies

We have conducted a survey of Ultra-luminous Infrared Galaxies (ULIRGs) with the Infrared Spectrograph on the Spitzer Space Telescope, obtaining spectra from 5.0-38.5um for 77 sources with 0.02<z <0.93. Observations of the pure rotational H2 lines S(3) 9.67um, S(2) 12.28um, and S(1) 17.04um are used to derive the temperature and mass of the warm molecular gas. We detect H2 in 77% of the sample, and all ULIRGs with F(60um)>2Jy. The average warm molecular gas mass is ~2x10^8solar-masses. High extinction, inferred from the 9.7um silicate absorption depth, is not observed along the line of site to the molecular gas. The derived H2 mass does not depend on F(25um)/F(60um), which has been used to infer either starburst or AGN dominance. Similarly, the molecular mass does not scale with the 25 or 60um luminosities. In general, the H2 emission is consistent with an origin in photo-dissociation regions associated with star formation. We detect the S(0) 28.22um emission line in a few ULIRGs. Including this line in the model fits tends to lower the temperature by ~50-100K, resulting in a significant increase in the gas mass. The presence of a cooler component cannot be ruled out in the remainder of our sample, for which we do not detect the S(0) line. The measured S(7) 5.51um line fluxes in six ULIRGs implies ~3x10^6 solar-masses of hot (~1400K) H2. The warm gas mass is typically less than 1% of the cold gas mass derived from CO observations.Comment: Accepted ApJ 01 September 2006, v648n1 issue. 14 pages 12 figures IRAS 06361-6217 the f25/f60 ratio is 0.10 not 1.0

Monitoring of tritium purity during long-term circulation in the KATRIN test experiment LOOPINO using laser Raman spectroscopy

The gas circulation loop LOOPINO has been set up and commissioned at Tritium Laboratory Karlsruhe (TLK) to perform Raman measurements of circulating tritium mixtures under conditions similar to the inner loop system of the neutrino-mass experiment KATRIN, which is currently under construction. A custom-made interface is used to connect the tritium containing measurement cell, located inside a glove box, with the Raman setup standing on the outside. A tritium sample (purity > 95%, 20 kPa total pressure) was circulated in LOOPINO for more than three weeks with a total throughput of 770 g of tritium. Compositional changes in the sample and the formation of tritiated and deuterated methanes CT_(4-n)X_n (X=H,D; n=0,1) were observed. Both effects are caused by hydrogen isotope exchange reactions and gas-wall interactions, due to tritium {\beta} decay. A precision of 0.1% was achieved for the monitoring of the T_2 Q_1-branch, which fulfills the requirements for the KATRIN experiment and demonstrates the feasibility of high-precision Raman measurements with tritium inside a glove box