Tomonaga-Luttinger physics in electronic quantum circuits

In one-dimensional conductors, interactions result in correlated electronic systems. At low energy, a hallmark signature of the so-called Tomonaga-Luttinger liquids (TLL) is the universal conductance curve predicted in presence of an impurity. A seemingly different topic is the quantum laws of electricity, when distinct quantum conductors are assembled in a circuit. In particular, the conductances are suppressed at low energy, a phenomenon called dynamical Coulomb blockade (DCB). Here we investigate the conductance of mesoscopic circuits constituted by a short single-channel quantum conductor in series with a resistance, and demonstrate a proposed link to TLL physics. We reformulate and establish experimentally a recently derived phenomenological expression for the conductance using a wide range of circuits, including carbon nanotube data obtained elsewhere. By confronting both conductance data and phenomenological expression with the universal TLL curve, we demonstrate experimentally the predicted mapping between DCB and the transport across a TLL with an impurity.Comment: 9p,6fig+SI; to be published in nature comm; v2: mapping extended to finite range interactions, added discussion and SI material, added reference

Inferring Energy Bounds via Static Program Analysis and Evolutionary Modeling of Basic Blocks

The ever increasing number and complexity of energy-bound devices (such as the ones used in Internet of Things applications, smart phones, and mission critical systems) pose an important challenge on techniques to optimize their energy consumption and to verify that they will perform their function within the available energy budget. In this work we address this challenge from the software point of view and propose a novel parametric approach to estimating tight bounds on the energy consumed by program executions that are practical for their application to energy verification and optimization. Our approach divides a program into basic (branchless) blocks and estimates the maximal and minimal energy consumption for each block using an evolutionary algorithm. Then it combines the obtained values according to the program control flow, using static analysis, to infer functions that give both upper and lower bounds on the energy consumption of the whole program and its procedures as functions on input data sizes. We have tested our approach on (C-like) embedded programs running on the XMOS hardware platform. However, our method is general enough to be applied to other microprocessor architectures and programming languages. The bounds obtained by our prototype implementation can be tight while remaining on the safe side of budgets in practice, as shown by our experimental evaluation.Comment: Pre-proceedings paper presented at the 27th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2017), Namur, Belgium, 10-12 October 2017 (arXiv:1708.07854). Improved version of the one presented at the HIP3ES 2016 workshop (v1): more experimental results (added benchmark to Table 1, added figure for new benchmark, added Table 3), improved Fig. 1, added Fig.

Assessing suicide risk in patients with obsessive-compulsive disorder: a dimensional approach

Objectives: Although an association has been found recently between obsessive-compulsive disorder and an increased risk of suicide, the prevalence of both suicidal ideation and attempts vary considerably and are generally assessed categorically. Our aims were to evaluate the prevalence of suicidal ideation and behaviors using a dimensional approach. Methods: The sample included 129 patients with obsessive-compulsive disorder. Suicidality was assessed by administering the Columbia-Suicide Severity Rating Scale. Logistic and linear regres-sions were used to examine predictors of suicidal ideation, severe suicidal ideation, and suicidal behavior. Results: The lifetime prevalence of suicidal ideation and behaviors were 64.3% and 16.3%, respectively. Lifetime suicidal ideation was associated with the number of stressful life events, duration of illness, Hamilton Rating Scale for Depression scores, and family history of mood disorders. A family history of obsessive-compulsive disorder was associated with a lower probability of lifetime suicidal ideation. Severe suicidal ideation was related to greater severity of the most stressful life event, Hamilton Rating Scale for Depression scores, and longer duration of untreated illness. The probability of lifetime suicidal behavior was related to Hamilton Rating Scale for Anxiety scores, symmetry obsessions, and washing and checking compulsions. The probability of lifetime non-suicidal self-injurious behaviors was related to Hamilton Rating Scale for Anxiety scores. Conclusions: Recognizing predictors of suicidal ideation/behavior is crucial to identifying patients at greater risk

A Study to Analyze the Efficacy of Maitland’s Mobilization Technique and Neuromuscular Electrical Stimulation on Pain and Hand Grip Strength in Patients with Post Colle’s Fracture Stiffness

Abstract- BACKGROUND: Colle’s fracture is a very common extra-articular fracture that occurs as the result of a fall on out stretched hand (FOOSH). Although Colle’s fractures are commonly seen in all age groups and demographics, they are particularly common in osteoporotic individuals and as such are more frequently seen in elderly women. Some complications are associated with injury itself. The complications such as persistent neuropathy of median nerve, ulnar nerve or radial nerve, malunited fracture and post traumatic stiffness have been reported in 1 out of 3 patients. Rehabilitation of fractures is a very important thing because of the limitations produced by improper management can lead to stiffness, deformity and limitation of functions. OBJECTIVE: The purpose of the study was to find out the effects of Maitland’s mobilization with Neuro-Muscular Electrical Stimulation (NMES) on pain and hand grip strength in patients with post Colle’s fracture stiffness. DESIGN: Pre- test and Post- test experimental study desig

Relasi Pembantu Presiden Dalam Kabinet Kerja Jokowi-jk

The conflicts between Minister of Maritime and Natural Resources Rizal Ramli and vice president Jusuf Kalla in electricity projects, Minister of State-Owned Companies and Minister of Transportation regarding fast-train development, Minister of Energy and Mineral Resources and Minister of State-Owned Companies regarding management policy of Masela Block, are conflicts inside the circle of the President\u27s assistants. These conflicts are implications from the obscurity of positions and authorities of said assistants. The author then researched with juridical empiric method. Through this research, it is hoped that the effective formulation of relation between the President\u27s assistants can be found.IntisariPerselisihan antara Menko bidang Kemaritiman dan SDA Rizal Ramli terhadap Wapres Jusuf Kalla dalam proyek listrik, Menteri BUMN dan Menteri Perhubungan dalam pembangunan kereta cepat, Menteri ESDM dan Menteri BUMN dalam kebijakan pengelolaan Blok Masela merupakan perseteruan di lingkaran pembantu presiden. Perseteruan tersebut merupakan implikasi dari ketidakjelasan kedudukan dan wewenang para pembantu presiden. Penulis kemudian meneliti permasalahan ini dengan metode yuridis empiris. Melalui penelitian ini, diharapkan dapat ditemukan formulasi pengaturan dan upaya untuk mewujudkan relasi pembantu presiden dalam Kabinet Jokowi-JK yang efektif dan efisien

Design of 12.5 kA current leads for the Large Hadron Collider using high temperature superconductor material

The Large Hadron Collider will be equipped with about 8000 superconducting magnets. Some 2600 current leads will feed the currents ranging from 25 to 12500 A. CERN aims to reduce the consumption of liquid helium, using high temperature superconductors in these leads. A development of leads for 12.5 kA is being conducted in collaboration with Oxford Instruments. The design options for these leads are described. A test rig and prototype lead have been made according to one of the options. Electrical contact tests are in progress on BSCCO-2212 and YBCO-123 samples. In the first run, the prototype carried 13000 A

Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach

Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 consecutively enrolled adult and pediatric patients with TRK fusion cancer (Drilon et al.,NEJM2018). Here, we report the clinical activity of larotrectinib in an additional 35 TRK fusion cancer patients and provide updated follow-up of the primary analysis set (PAS) of 55 patients as of 19thFeb 2018. Methods: Patients with TRK fusion cancer detected by molecular profiling from 3 larotrectinib clinical trials (NCT02122913, NCT02637687, and NCT02576431) were eligible.Larotrectinib was administered until disease progression, withdrawal, or unacceptable toxicity. Disease status was assessed using RECIST version 1.1. Results: As of Feb 2018, by independent review, 6 PRs in the PAS deepened to CRs. The median duration of response (DoR) and progression-free survival in the PAS had still not been reached, with 12.9 months median follow-up. At 1 year, 69% of responses were ongoing, 58% of patients remained progression-free and 90% of patients were alive. An additional 19 children and 25 adults (age range, 0.1-78 years) with TRK fusion cancer were enrolled after the PAS, and included cancers of the salivary gland, thyroid, lung, colon, melanoma, sarcoma, GIST and congenital mesoblastic nephroma. In 35 evaluable patients, the ORR by investigator assessment was 74% (5 CR, 21 PR, 6 SD, 2 PD, 1 not determined). In these patients, with median follow-up of 5.5 months, median DoR had not yet been reached, and 88% of responses were ongoing at 6 months, consistent with the PAS. Adverse events (AEs) were predominantly grade 1, with dizziness, increased AST/ALT, fatigue, nausea and constipation the most common AEs reported in ≥ 10% of patients. No AE of grade 3 or 4 related to larotrectinib occurred in more than 5% of patients. Conclusions: TRK fusions are detected in a broad range of tumor types. Larotrectinib is an effective age- and tumor-agnostic treatment for TRK fusion cancer with a positive safety profile. Screening patients for NTRK gene fusions in solid- and brain tumors should be actively considered

Correlates of violent suicide attempts in patients with bipolar disorder

Background: Suicide is one of the leading causes of death in bipolar disorder (BD); violent suicide attempts are associated with the highest level of lethality. We aimed to evaluate factors related to the risk of violent suicide in a large naturalistic sample of patients with BD; in addition, we analyzed the rates of lifetime suicide attempts and the variables associated with suicidal behavior. Methods: We recruited 847 patients with BD. Patients were grouped according to whether they had a lifetime history of suicide attempts and, among suicide attempters, subjects who had used a violent suicide method were compared with those who had attempted suicide with a nonviolent method. Comparisons were performed using \u3c72 tests for categorical variables and ANOVA for continuous variables. Logistic regression (LogReg) was used to identify explanatory variables associated with violent suicide attempts (dependent variable). Results: Two hundred and two patients (24%) had a lifetime history of suicide attempts. Subjects with at least one lifetime suicide attempt showed longer duration of illness (22.4 \ub1 14.1 years vs 19.9 \ub1 14.2 years: p 0.028), more lifetime hypomanic episodes (3.3 \ub1 4.3 vs 2.3 \ub1 3.1: p 0.001), more lifetime depressive episodes (6.0 \ub1 4.4 vs 4.7 \ub1 4.1: p < 0.001), higher rates of lifetime psychiatric comorbidities (50.0% vs 41.3%: p 0.029), higher rates of lifetime medical comorbidities (58.0% vs 48.9%: p 0.028) and higher rates of reduced HDL cholesterol (46.2% vs 36.7%: p 0.030). Among suicide attempters, fifty-two patients (30.6%) attempted suicide with a violent method. We found more men in the group of violent suicide attempters than in the group of nonviolent suicide attempters (65% vs 28%; p: <0.001). Moreover subjects with previous violent attempts showed higher mean values of weight (80.5 \ub1 18.3 vs 69.4 \ub1 14.7: p < 0.001), body mass index (27.8 \ub1 5.6 vs 25.2 \ub1 4.7: p < 0.003) and waist circumference (98.7 \ub1 18.5 vs 92.4 \ub1 14.3: p 0.032). The LogReg analysis confirmed the association of violent attempts with male gender (p: <0.001; Phi: 0.35) and higher waist circumference (p: <0.001; Cohen's d: 0.39). Limitations: In our research we analyzed lifetime suicide attempts, but the sample does not include completed suicides, meaning that we are unable to test whether the results are generalizable to suicide deaths. Moreover, some relevant variables, such as medical comorbidities/metabolic parameters at the time of suicide attempts and previous medication, were not collected. Another limitation concerns the heterogeneity of recruited patients in terms of clinical characteristics (e.g.: medical conditions, drug treatments), with potential confounding factors. Conclusions: The present study confirms the association between male gender and violent suicide and suggests a correlation between obesity and the use of violent suicide methods. The relationship between obesity and suicidal behaviour is worthy of interest and deserves to be explored by further studies

Random Geometric Graphs

We analyse graphs in which each vertex is assigned random coordinates in a geometric space of arbitrary dimensionality and only edges between adjacent points are present. The critical connectivity is found numerically by examining the size of the largest cluster. We derive an analytical expression for the cluster coefficient which shows that the graphs are distinctly different from standard random graphs, even for infinite dimensionality. Insights relevant for graph bi-partitioning are included.Comment: 16 pages, 10 figures. Minor changes. Added reference