Ultrahigh sensitivity of slow-light gyroscope

Slow light generated by Electromagnetically Induced Transparency is extremely susceptible with respect to Doppler detuning. Consequently, slow-light gyroscopes should have ultrahigh sensitivity

Randomised field trial to evaluate serological response after foot-and-mouth disease vaccination in Turkey

AbstractDespite years of biannual mass vaccination of cattle, foot-and-mouth disease (FMD) remains uncontrolled in Anatolian Turkey. To evaluate protection after mass vaccination we measured post-vaccination antibodies in a cohort of cattle (serotypes O, A and Asia-1). To obtain results reflecting typical field protection, participants were randomly sampled from across Central and Western Turkey after routine vaccination. Giving two-doses one month apart is recommended when cattle are first vaccinated against FMD. However, due to cost and logistics, this is not routinely performed in Turkey, and elsewhere. Nested within the cohort, we conducted a randomised trial comparing post-vaccination antibodies after a single-dose versus a two-dose primary vaccination course.Four to five months after vaccination, only a third of single-vaccinated cattle had antibody levels above a threshold associated with protection. A third never reached this threshold, even at peak response one month after vaccination. It was not until animals had received three vaccine doses in their lifetime, vaccinating every six months, that most (64% to 86% depending on serotype) maintained antibody levels above this threshold. By this time cattle would be >20 months old with almost half the population below this age. Consequently, many vaccinated animals will be unprotected for much of the year. Compared to a single-dose, a primary vaccination course of two-doses greatly improved the level and duration of immunity. We concluded that the FMD vaccination programme in Anatolian Turkey did not produce the high levels of immunity required. Higher potency vaccines are now used throughout Turkey, with a two-dose primary course in certain areas.Monitoring post-vaccination serology is an important component of evaluation for FMD vaccination programmes. However, consideration must be given to which antigens are present in the test, the vaccine and the field virus. Differences between these antigens affect the relationship between antibody titre and protection

Light Rays at Optical Black Holes in Moving Media

Light experiences a non-uniformly moving medium as an effective gravitational field, endowed with an effective metric tensor $\tilde{g}^{\mu \nu}=\eta^{\mu \nu}+(n^2-1)u^\mu u^\nu$, $n$ being the refractive index and $u^\mu$ the four-velocity of the medium. Leonhardt and Piwnicki [Phys. Rev. A {\bf 60}, 4301 (1999)] argued that a flowing dielectric fluid of this kind can be used to generate an 'optical black hole'. In the Leonhardt-Piwnicki model, only a vortex flow was considered. It was later pointed out by Visser [Phys. Rev. Lett. {\bf 85}, 5252 (2000)] that in order to form a proper optical black hole containing an event horizon, it becomes necessary to add an inward radial velocity component to the vortex flow. In the present paper we undertake this task: we consider a full spiral flow, consisting of a vortex component plus a radially infalling component. Light propagates in such a dielectric medium in a way similar to that occurring around a rotating black hole. We calculate, and show graphically, the effective potential versus the radial distance from the vortex singularity, and show that the spiral flow can always capture light in both a positive, and a negative, inverse impact parameter interval. The existence of a genuine event horizon is found to depend on the strength of the radial flow, relative to the strength of the azimuthal flow. A limitation of our fluid model is that it is nondispersive.Comment: 30 pages, LaTeX, 4 ps figures. Expanded discussion especially in section 6; 5 new references. Version to appear in Phys. Rev.

756-1 Non Surgical Septum Reduction: A New Treatment for Hypertrophic Obstructive Cardiomyopathy (HOCM)

In patients with HOCM and marked intraventricular gradients resistant to conventional drug treatment with beta blockers and/or Verapamil surgical resection of the muscular septal bulge has been advocated. We have investigated a new catheter treatment in 5 patients with HOCM and significant LV ouflow tract gradients. All patients were in class 3 NYHA with angina and shortness of breath. Intraventricular gradients were measured with transeptally introduced Brockenbrough catheters in the LV inflow tract and arterial catheters in the aortic root. All patients were studied at rest, during the Valsalva manoeuvre, after nitrates and after Isoproterenol infusion. The measurements were repeated during balloon occlusion of the first major septal branch of the left anterior descending coronary artery. — In all patients the resting intraventricular gradient was reduced to less than 20mm/Hg and provocative testing (nitrates and post extrasystolic potentation) failed to create typical increments. The longest inflation time was 30 minutes. Three patients had Verapamil 0.5mg injected through the angioplasty balloon which resulted in a longer lasting gradient/reduction after deflation of the balloon.–After informed consent, 2 patient had 3–5ml of desiccated alcohol infused through the inflated balloon catheter in order to devitalise the offending myocardium. This resulted in a CK elevation up to 2,500 units and permanent abolition of the intraventricular gradient accompanied by marked clinical improvement.From these preliminary observations we conclude that non surgical septum ablation maybe a promising new technique for the treatment of HOCM. Further studies are warranted

Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure in humans. In the PKD/Mhm(cy/+) rat model of ADPKD, the point mutation R823W in the sterile alpha motif (SAM) domain of the protein ANKS6 is responsible for disease. SAM domains are known protein-protein interaction domains, capable of binding each other to form polymers and heterodimers. Despite its physiological importance, little is known about the function of ANKS6 and how the R823W point mutation leads to PKD. Recent work has revealed that ANKS6 interacts with a related protein called ANKS3. Both ANKS6 and ANKS3 have a similar domain structure, with ankyrin repeats at the N-terminus and a SAM domain at the C-terminus. Results: The SAM domain of ANKS3 is identified as a direct binding partner of the ANKS6 SAM domain. We find that ANKS3-SAM polymerizes and ANKS6-SAM can bind to one end of the polymer. We present crystal structures of both the ANKS3-SAM polymer and the ANKS3-SAM/ANKS6-SAM complex, revealing the molecular details of their association. We also learn how the R823W mutation disrupts ANKS6 function by dramatically destabilizing the SAM domain such that the interaction with ANKS3-SAM is lost. Conclusions: ANKS3 is a direct interacting partner of ANKS6. By structurally and biochemically characterizing the interaction between the ANKS3 and ANKS6 SAM domains, our work provides a basis for future investigation of how the interaction between these proteins mediates kidney function

Size Segregation of Granular Matter in Silo Discharges

We present an experimental study of segregation of granular matter in a quasi-two dimensional silo emptying out of an orifice. Size separation is observed when multi-sized particles are used with the larger particles found in the center of the silo in the region of fastest flow. We use imaging to study the flow inside the silo and quantitatively measure the concentration profiles of bi-disperse beads as a function of position and time. The angle of the surface is given by the angle of repose of the particles, and the flow occurs in a few layers only near the top of this inclined surface. The flowing region becomes deeper near the center of the silo and is confined to a parabolic region centered at the orifice which is approximately described by the kinematic model. The experimental evidence suggests that the segregation occurs on the surface and not in the flow deep inside the silo where velocity gradients also are present. We report the time development of the concentrations of the bi-disperse particles as a function of size ratios, flow rate, and the ratio of initial mixture. The qualitative aspects of the observed phenomena may be explained by a void filling model of segregation.Comment: 6 pages, 10 figures (gif format), postscript version at http://physics.clarku.edu/~akudrolli/nls.htm

A matrix-valued point interactions model

We study a matrix-valued Schr\"odinger operator with random point interactions. We prove the absence of absolutely continuous spectrum for this operator by proving that away from a discrete set its Lyapunov exponents do not vanish. For this we use a criterion by Gol'dsheid and Margulis and we prove the Zariski denseness, in the symplectic group, of the group generated by the transfer matrices. Then we prove estimates on the transfer matrices which lead to the H\"older continuity of the Lyapunov exponents. After proving the existence of the integrated density of states of the operator, we also prove its H\"older continuity by proving a Thouless formula which links the integrated density of states to the sum of the positive Lyapunov exponents

Application of the Shiono and Knight Method in asymmetric compound channels with different side slopes of the internal wall

The Shiono and Knight Method (SKM) is widely used to predict the lateral distribution of depth-averaged velocity and boundary shear stress for flows in compound channels. Three calibrating coefficients need to be estimated for applying the SKM, namely eddy viscosity coefficient (λ), friction factor (f) and secondary flow coefficient (k). There are several tested methods which can satisfactorily be used to estimate λ, f. However, the calibration of secondary flow coefficients k to account for secondary flow effects correctly is still problematic. In this paper, the calibration of secondary flow coefficients is established by employing two approaches to estimate correct values of k for simulating asymmetric compound channel with different side slopes of the internal wall. The first approach is based on Abril and Knight (2004) who suggest fixed values for main channel and floodplain regions. In the second approach, the equations developed by Devi and Khatua (2017) that relate the variation of the secondary flow coefficients with the relative depth (β) and width ratio (α) are used. The results indicate that the calibration method developed by Devi and Khatua (2017) is a better choice for calibrating the secondary flow coefficients than using the first approach which assumes a fixed value of k for different flow depths. The results also indicate that the boundary condition based on the shear force continuity can successfully be used for simulating rectangular compound channels, while the continuity of depth-averaged velocity and its gradient is accepted boundary condition in simulations of trapezoidal compound channels. However, the SKM performance for predicting the boundary shear stress over the shear layer region may not be improved by only imposing the suitable calibrated values of secondary flow coefficients. This is because difficulties of modelling the complex interaction that develops between the flows in the main channel and on the floodplain in this region

Modeling software design diversity

Design diversity has been used for many years now as a means of achieving a degree of fault tolerance in software-based systems. Whilst there is clear evidence that the approach can be expected to deliver some increase in reliability compared with a single version, there is not agreement about the extent of this. More importantly, it remains difficult to evaluate exactly how reliable a particular diverse fault-tolerant system is. This difficulty arises because assumptions of independence of failures between different versions have been shown not to be tenable: assessment of the actual level of dependence present is therefore needed, and this is hard. In this tutorial we survey the modelling issues here, with an emphasis upon the impact these have upon the problem of assessing the reliability of fault tolerant systems. The intended audience is one of designers, assessors and project managers with only a basic knowledge of probabilities, as well as reliability experts without detailed knowledge of software, who seek an introduction to the probabilistic issues in decisions about design diversity

The causal effect of testosterone on men’s competitive behavior is moderated by basal cortisol and cues to an opponent’s status: Evidence for a context-dependent dual hormone hypothesis

Testosterone has been theorized to direct status-seeking behaviors, including competitive behavior. However, most human studies to date have adopted correlational designs, and findings across studies are inconsistent. This experiment (n = 115) pharmacologically manipulated men’s testosterone levels prior to a mixed-gender math competition and examined basal cortisol (a hormone implicated in stress and social avoidance) and context cues related to an opponent’s perceived status (an opponent’s gender or a win/loss in a prior competition) as factors that may moderate testosterone’s impact on competitive behavior. We test and find support for the hypothesis that testosterone given to low-cortisol men evokes status-seeking behavior, whereas testosterone given to high-cortisol men evokes status-loss avoidance. In the initial rounds of competition, testosterone’s influence on competitive decisions depended on basal cortisol and opponent gender. After providing opponent-specific win-lose feedback, testosterone’s influence on decisions to re-enter competitions depended on basal cortisol and this objective cue to status, not gender. Compared to placebo, men given exogenous testosterone who were low in basal cortisol showed an increased tendency to compete against male and high-status opponents relative to female and low-status opponents (status-seeking). Men given exogenous testosterone who were high in basal cortisol showed the opposite pattern - an increased tendency to compete against female and low-status opponents relative to male and high-status opponents (status-loss avoidance). These results provide support for a context-dependent dual hormone hypothesis: Testosterone flexibly directs men’s competitive behavior contingent on basal cortisol levels and cues that signal an opponent’s status