Fast and rewritable colloidal assembly via field synchronized particle swapping

We report a technique to realize reconfigurable colloidal crystals by using the controlled motion of particle defects above an externally modulated magnetic substrate. The transport of particles is induced by applying a uniform rotating magnetic field to a ferrite garnet film characterized by a periodic lattice of magnetic bubbles. For filling factor larger than one colloid per bubble domain, the particle current arises from propagating defects where particles synchronously exchange their position when passing from one occupied domain to the next. The amplitude of an applied alternating magnetic field can be used to displace the excess particles via a swapping mechanism, or to mobilize the entire colloidal system at a predefined speed

Magnetostrictive behaviour of thin superconducting disks

Flux-pinning-induced stress and strain distributions in a thin disk superconductor in a perpendicular magnetic field is analyzed. We calculate the body forces, solve the magneto-elastic problem and derive formulas for all stress and strain components, including the magnetostriction $\Delta R/R$. The flux and current density profiles in the disk are assumed to follow the Bean model. During a cycle of the applied field the maximum tensile stress is found to occur approximately midway between the maximum field and the remanent state. An effective relationship between this overall maximum stress and the peak field is found.Comment: 8 pages, 6 figures, submitted to Supercond. Sci. Technol., Proceed. of MEM03 in Kyot

Dramatic role of critical current anisotropy on flux avalanches in MgB2 films

Anisotropic penetration of magnetic flux in MgB2 films grown on vicinal sapphire substrates is investigated using magneto-optical imaging. Regular penetration above 10 K proceeds more easily along the substrate surface steps, anisotropy of the critical current being 6%. At lower temperatures the penetration occurs via abrupt dendritic avalanches that preferentially propagate {\em perpendicular} to the surface steps. This inverse anisotropy in the penetration pattern becomes dramatic very close to 10 K where all flux avalanches propagate in the strongest-pinning direction. The observed behavior is fully explained using a thermomagnetic model of the dendritic instability.Comment: 4 pages, 5 figure

Finger patterns produced by thermomagnetic instability in superconductors

A linear analysis of thermal diffusion and Maxwell equations is applied to study the thermomagnetic instability in a type-II superconducting slab. It is shown that the instability can lead to formation of spatially nonuniform distributions of magnetic field and temperature. The distributions acquire a finger structure with fingers perpendicular to the screening current direction. We derive the criterion for the instability, and estimate its build-up time and characteristic finger width. The fingering instability emerges when the background electric field is larger than a threshold field, $E>E_c$, and the applied magnetic field exceeds a value $H_fing \propto 1/\sqrt{E}$. Numerical simulations support the analytical results, and allow to follow the development of the fingering instability beyond the linear regime. The fingering instability may be responsible for the nucleation of dendritic flux patterns observed in superconducting films using magneto-optical imaging.Comment: 8 pages, 6 figures, accepted to Phys. Rev. B; (new version: minor changes

Local threshold field for dendritic instability in superconducting MgB2 films

Using magneto-optical imaging the phenomenon of dendritic flux penetration in superconducting films was studied. Flux dendrites were abruptly formed in a 300 nm thick film of MgB2 by applying a perpendicular magnetic field. Detailed measurements of flux density distributions show that there exists a local threshold field controlling the nucleation and termination of the dendritic growth. At 4 K the local threshold field is close to 12 mT in this sample, where the critical current density is 10^7 A/cm^2. The dendritic instability in thin films is believed to be of thermo-magnetic origin, but the existence of a local threshold field, and its small value are features that distinctly contrast the thermo-magnetic instability (flux jumps) in bulk superconductors.Comment: 6 pages, 6 figures, submitted to Phys. Rev.

Flaws in design, analysis and interpretation of Pfizer's antifungal trials of voriconazole and uncritical subsequent quotations

We have previously described how a series of trials sponsored by Pfizer of its antifungal drug, fluconazole, in cancer patients with neutropenia handicapped the control drug, amphotericin B, by flaws in design and analysis. We describe similar problems in two pivotal trials of Pfizer's new antifungal agent, voriconazole, published in a prestigious journal. In a non-inferiority trial, voriconazole was significantly inferior to liposomal amphothericin B, but the authors concluded that voriconazole was a suitable alternative. The second trial used amphothericin B deoxycholate as comparator, but handicapped the drug by not requiring pre-medication to reduce infusion-related toxicity or substitution with electrolytes and fluid to reduce nephrotoxicity, although the planned duration of treatment was 84 days. Voriconazole was given for 77 days on average, but the comparator for only 10 days, which precludes a meaningful comparison. In a random sample of 50 references to these trials, we found that the unwarranted conclusions were mostly uncritically propagated. It was particularly surprising that relevant criticism raised by the FDA related to the first trial was only quoted once, and that none of the articles noted the obvious flaws in the design of the second trial. We suggest that editors ensure that the abstract reflects fairly on the remainder of the paper, and that journals do not impose any time limit for accepting letters that point out serious weaknesses in a study that have not been noted before

BioConcens: Biomass and bioenergy production agriculture – consequences for soil fertility, environment, spread of animal parasites and socio-economy

The research programme called “international research cooperation and organic integrity” was commenced for a period 2006-2010. It is coordinated by DARCOF (The Danish Research Centre for Organic Farming). The whole programme, with acronym DARCOF III, consists of 15 projects (http://www.darcof.dk/research/darcofiii/index.html). One of them is BIOCONCENS - Biomass and bioenergy production in organic farming – consequences for soil fertility, environment, spread of animal parasites and socio-economy (http://www.bioconcens.elr.dk/uk/). The production of bioenergy in organic agriculture (OA) can reduce its dependency of fossil fuels and decrease green house gasses emission; consequently it will increase sustainability of organic farms. Biorefinery concept based on co-production of biogas, bioethanol and protein fodder in organic farming will be developed within the BIOCONCENS project and the background for the project and the different work packages will be presented in this paper

A Model for Prejudiced Learning in Noisy Environments

Based on the heuristics that maintaining presumptions can be beneficial in uncertain environments, we propose a set of basic axioms for learning systems to incorporate the concept of prejudice. The simplest, memoryless model of a deterministic learning rule obeying the axioms is constructed, and shown to be equivalent to the logistic map. The system's performance is analysed in an environment in which it is subject to external randomness, weighing learning defectiveness against stability gained. The corresponding random dynamical system with inhomogeneous, additive noise is studied, and shown to exhibit the phenomena of noise induced stability and stochastic bifurcations. The overall results allow for the interpretation that prejudice in uncertain environments entails a considerable portion of stubbornness as a secondary phenomenon.Comment: 21 pages, 11 figures; reduced graphics to slash size, full version on Author's homepage. Minor revisions in text and references, identical to version to be published in Applied Mathematics and Computatio