The Newton stratification on deformations of local G-shtukas

Bounded local G-shtukas are function field analogs for p-divisible groups with extra structure. We describe their deformations and moduli spaces. The latter are analogous to Rapoport-Zink spaces for p-divisible groups. The underlying schemes of these moduli spaces are affine Deligne-Lusztig varieties. For basic Newton polygons the closed Newton stratum in the universal deformation of a local G-shtuka is isomorphic to the completion of a corresponding affine Deligne-Lusztig variety in that point. This yields bounds on the dimension and proves equidimensionality of the basic affine Deligne-Lusztig varieties.Comment: several improvements, definition of local G-shtuka is change

ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin

A hallmark of Huntington's disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that cultured striatal cells and murine brain striatum have remarkably low levels of phosphorylation of translation initiation factor eIF2 alpha, a stress-induced process that interferes with general protein synthesis and also induces differential translation of pro-apoptotic factors. EIF2 alpha phosphorylation was elevated in a striatal cell line stably expressing pathogenic huntingtin, as well as in brain sections of Huntington's disease model mice. Pathogenic huntingtin caused endoplasmic reticulum (ER) stress and increased eIF2 alpha phosphorylation by increasing the activity of PKR-like ER-localized eIF2 alpha kinase (PERK). Importantly, striatal neurons exhibited special sensitivity to ER stress-inducing agents, which was potentiated by pathogenic huntingtin. We could strongly reduce huntingtin toxicity by inhibiting PERK. Therefore, alteration of protein homeostasis and eIF2 alpha phosphorylation status by pathogenic huntingtin appears to be an important cause of striatal cell death. A dephosphorylated state of eIF2 alpha has been linked to cognition, which suggests that the effect of pathogenic huntingtin might also be a source of the early cognitive impairment seen in patients

The electric two-echelon vehicle routing problem

Two-echelon distribution systems are attractive from an economical standpoint and help to keep large vehicles out of densely populated city centers. Large trucks can be used to deliver goods to intermediate facilities in accessible locations, whereas smaller vehicles allow to reach the final customers. Due to their reduced size, pollution, and noise, multiple companies consider using an electric fleet of terrestrial or aerial vehicles for last-mile deliveries. Route planning in multi-tier logistics leads to notoriously difficult problems. This difficulty is accrued in the presence of an electric fleet since each vehicle operates on a smaller range and may require planned visits to recharging stations. To study these challenges, we introduce the electric two-echelon vehicle routing problem (E2EVRP) as a prototypical problem. We propose a large neighborhood search (LNS) metaheuristic as well as an exact mathematical programming algorithm, which uses decomposition techniques to enumerate promising first-level solutions in conjunction with bounding functions and route enumeration for the second-level routes. These algorithms produce optimal or near-optimal solutions for the problem and allow us to evaluate the impact of several defining features of optimized battery-powered distribution networks. We created representative E2EVRP benchmark instances to simulate realistic metropolitan areas. In particular, we observe that the detour miles due to recharging decrease proportionally to 1/ρx with x ≈ 5/4 as a function of the charging stations density ρ; e.g., in a scenario where the density of charging stations is doubled, recharging detours are reduced by 58%. Finally, we evaluate the trade-off between battery capacity and detour miles. This estimate is critical for strategic fleet-acquisition decisions, in a context where large batteries are generally more costly and less environment-friendly

On a Conjecture of Rapoport and Zink

In their book Rapoport and Zink constructed rigid analytic period spaces $F^{wa}$ for Fontaine's filtered isocrystals, and period morphisms from PEL moduli spaces of $p$-divisible groups to some of these period spaces. They conjectured the existence of an \'etale bijective morphism $F^a \to F^{wa}$ of rigid analytic spaces and of a universal local system of $Q_p$-vector spaces on $F^a$. For Hodge-Tate weights $n-1$ and $n$ we construct in this article an intrinsic Berkovich open subspace $F^0$ of $F^{wa}$ and the universal local system on $F^0$. We conjecture that the rigid-analytic space associated with $F^0$ is the maximal possible $F^a$, and that $F^0$ is connected. We give evidence for these conjectures and we show that for those period spaces possessing PEL period morphisms, $F^0$ equals the image of the period morphism. Then our local system is the rational Tate module of the universal $p$-divisible group and enjoys additional functoriality properties. We show that only in exceptional cases $F^0$ equals all of $F^{wa}$ and when the Shimura group is $GL_n$ we determine all these cases.Comment: v2: 48 pages; many new results added, v3: final version that will appear in Inventiones Mathematica

High-resolution temperature variability reconstructed from black pine tree ring densities in Southern Spain

The presence of an ancient, high-elevation pine forest in the Natural Park of Sierras de Cazorla in southern Spain, including some trees reaching &gt;700 years, stimulated efforts to develop high-resolution temperature reconstructions in an otherwise drought-dominated region. Here, we present a reconstruction of spring and fall temperature variability derived from black pine tree ring maximum densities reaching back to 1350 Coefficient of Efficiency (CE). The reconstruction is accompanied by large uncertainties resulting from low interseries correlations among the single trees and a limited number of reliable instrumental stations in the study region. The reconstructed temperature history reveals warm conditions during the early 16th and 19th centuries that were of similar magnitude to the warm temperatures recorded since the late 20th century. A sharp transition from cold conditions in the late 18th century (t1781–1810 = −1.15 °C ± 0.64 °C) to warm conditions in the early 19th century (t1818–1847 = −0.06 °C ± 0.49 °C) is centered around the 1815 Tambora eruption (t1816 = −2.1 °C ± 0.55 °C). The new reconstruction from southern Spain correlates significantly with high-resolution temperature histories from the Pyrenees located ~600 km north of the Cazorla Natural Park, an association that is temporally stable over the past 650 years (r1350–2005 &gt; 0.3, p &lt; 0.0001) and particularly strong in the high-frequency domain (rHF &gt; 0.4). Yet, only a few of the reconstructed cold extremes (1453, 1601, 1816) coincide with large volcanic eruptions, suggesting that the severe cooling events in southern Spain are controlled by internal dynamics rather than external (volcanic) forcing.</jats:p

Dimer, trimer and FFLO liquids in mass- and spin-imbalanced trapped binary mixtures in one dimension

We present a systematic investigation of attractive binary mixtures in presence of both spin- and mass-imbalance in one dimensional setups described by the Hubbard model. After discussing typical cold atomic experimental realizations and the relation between microscopic and effective parameters, we study several many-body features of trapped Fermi-Fermi and Bose-Bose mixtures such as density profiles, momentum distributions and correlation functions by means of numerical density-matrix-renormalization-group and Quantum Monte Carlo simulations. In particular, we focus on the stability of Fulde-Ferrell-Larkin-Ovchinnikov, dimer and trimer fluids in inhomogeneous situations, as typically realized in cold gas experiments due to the harmonic confinement. We finally consider possible experimental signatures of these phases both in the presence of a finite polarization and of a finite temperature.Comment: 19 pages, 25 figure

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

Protein aggregation is linked with neurodegeneration and numerous other diseases by mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils. Using quantitative proteomics, we found that the toxicity of these proteins in human cells correlates with the capacity of their aggregates to promote aberrant protein interactions and to deregulate the cytosolic stress response. The endogenous proteins that are sequestered by the aggregates share distinct physicochemical properties: They are relatively large in size and significantly enriched in predicted unstructured regions, features that are strongly linked with multifunctionality. Many of the interacting proteins occupy essential hub positions in cellular protein networks, with key roles in chromatin organization, transcription, translation, maintenance of cell architecture and protein quality control. We suggest that amyloidogenic aggregation targets a metastable subproteome, thereby causing multifactorial toxicity and, eventually, the collapse of essential cellular functions. PaperFlick: © 2011 Elsevier Inc

Corporate Governance, Opaque Bank Activities, and Risk/Return Efficiency: Pre- and Post-Crisis Evidence from Turkey

Does better corporate governance unambiguously improve the risk/return efficiency of banks? Or does either a re-orientation of banks' revenue mix towards more opaque products, an economic downturn, or tighter supervision create off-setting or reinforcing effects? The authors relate bank efficiency to shortfalls from a stochastic risk/return frontier. They analyze how internal governance mechanisms (CEO duality, board experience, political connections, and education profile) and external governance mechanisms (discipline exerted by shareholders, depositors, or skilled employees) determine efficiency in a sample of Turkish banks. The 2000 financial crisis was a wakeup call for bank efficiency and corporate governance. As a result, better corporate governance mechanisms have been able to improve risk/return efficiency when the economic, regulatory, and supervisory environments are more stable and bank products are more complex.corporate governance;bank risk;noninterest income;crisis;frontier