Concept of Sushrutokta Guda Shareera

Swastha Rakshana and Vikara Prashamana are the prime goals of Ayurveda. Knowledge about structural and functional aspect of Shareera is considered as a key to reach these goals. Guda is one such structural entity explained in Ayurveda, which play a role in elimination of Pureesha and Apana Vata. In Basti Chikitsa, one of the prime treatment modality of Vata medicine usually administered through Guda Marga only. Hence knowledge of Guda is helpful in understanding the physiology of Pureesha Bahirgamana and concept of Basti Chikitsa. In this article an attempt is made to understand the concept of Sushrutokta Guda Shareera

A Conceptual Review of Shiras as Pranayatana in Charaka Samhita

Ayurveda is a life science which mainly aims at maintaining the health of an individual and at the same time treating the ailments of a diseased person. “DashaPranayatana” is a unique concept of Ayurveda mentioned in Charaka Samhita. In Sutrasthana, we find a whole chapter dedicated to the study ofDashaPranayatana and highlighted that one who knows these concepts will be known as Pranabhisara Vaidya, i.e., one who is confident and having absolute knowledge of the patient and the disease. In Charaka Samhita, we find references of ten such entities known as DashaPranayatana, which every Ayurvedic physician should be aware of, as they are seats of life or vitality. In such instance, it becomes important to understand the concept of Prana along with their seats in the context of Shareera Rachana. Shiras is one such Pranayatana mentioned in Charaka Samhita. It has been given much importance that it has been mentioned both in the context of DashaPranayatana and Marma. In this article, an attempt is made to understand and review Shiras in the context of DashaPranayatanas

Study on Pramana Shareera in relation to Prakriti

Ayurveda in its principle has given importance to individualistic approach rather than generalize. Application of this examination can be clearly seem like even though two patients suffering from same disease, the treatment modality may change depending upon the results of Dashvidha Pariksha. Prakruti and Pramana both used in Dashvidha Pariksha. Both determine the health of the individual and Bala (strength) of Rogi (Patient). Ayurveda followed Swa-angula Pramana as the unit of measurement for measuring the different parts of the body which is prime step assessing patient before treatment. Sushruta and Charaka had stated different Angula Pramana of each Pratyanga (body parts). Specificity is the characteristic property of Swa-angula Pramana. This can be applicable in present era for example artificial limbs. A scientific research includes collection, compilation, analysis and lastly scrutiny of entire findings to arrive at a conclusion. Study of Pramana and its relation with Prakruti was conducted in 1000 volunteers using Prakruti Parkishan proforma with an objective of evaluation of Anguli Pramana in various Prakriti. It was observed co-relating Pramana in each Prakruti and Granthokta Pramana that there is no vast difference in measurement of head, upper limb and lower limb. The observational study shows closer relation of features with classical texts

Importance of Pramana Pareeksha in Clinical Practice

In Ayurveda the term Pareeksha is used in place of Pramana. The synonyms of Pareeksha are Pramana, Saadana, Jnana, Upalabdhi. Pariksha means through which investigation cognition of valid apprehension of the state of the object arise is called Pariksha. Which is investigated in depth, establishment of reality of an object is Pareeksha. “Rogamadou Pareekshet Tathonantaram Aoushadam” it is very essential that before planning any treatment one should have complete knowledge of Roga and Rogibala. The purpose of examination is to obtain knowledge regarding span of life, strength and intensity of morbidity. Hence patient to be examined in respect of Prakruti (constitution of body), Vikruti (pathological examination), Sara (examination of elemental tissue and mind), Samhana (examination of compactness of body), Pramana (measurement), Satmya (suitability), Satva (examination of mental constitution), Aaharashakti (examination of digestive power), Vyayamashakti (examination of strength by exercise), Vaya (examination of age). Among these Dashavidha Pareeksha except Vikruti Pareeksha is to be done to understand the overview condition of the person. Vikrutipariksha is to be done to elicit the factors which are responsible for the pathogenesis of the diseases

Different factors influencing Deha Prakriti (constitution) and influenced by Prakriti (constitution)

Complete psychosomatic architect of an individual is represented by his Prakriti (constitution) which starts to take shape at the very first step of conception in mother’s womb. Deeds of previous incarnation, physical and psychological state of mother and father during conception, nutrition and regimen of mother, social melue, practice of wholesomeness by mother (during pregnancy) and child in postnatal period and many more factors are attributed in the Prakriti formation. Thus generated Prakriti helps in understanding the health and disease state of an individual and facilitate in promotive and curative aspects. Not only this, inherited psycho constution (Manasik Prakriti) is also very helpful in prediction and deciding the profession, effectiveness and efficiency evaluation too. Management education sector, Life and Health insurance sectors are now showing a keen interest in incorporating concept of Prakriti (constitution) in their business. Genomic relations of Prakriti concept of Ayurveda in the recent researches in India and abroad has established the facts that the difference in genomic make up is responsible for all variations in health and disease state of life which we have analyzed and summarized in this review. In the present literary research paper all the factors which influence the Prakriti are enumerated in classified manner and different types of psychosomatic contributions are detailed along with their effect on health and disease condition of life as well as preventive and promotive aspects

A bird’s eye view on Kesha (hair) in Charaka Samhita

Ayurveda is a Tantra which mainly aims at preserving the health of an individual and to treat the illness of a patient. The structure and function of bodily entities vary in health and disease conditions accordingly. The study of these structures acts as a yardstick to understand the health and illness of a person. One such indicator of health or disease is hair (Kesha). Kesha being one such parameter of health, description about it regarding its formation, characteristics, variation according to different body constitution (Prakruti), beneficial and harmful factors for Kesha, its maintenance, importance in clinical diagnosis and prognosis of a disease etc. is available in Ayurveda. In this article, an attempt is made to understand Kesha Sharira according to Charaka Samhita

Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1H-pyrazolo3,4-bpyridin-6-amines

Meglumine efficiently catalyzes the one-pot, five-component reaction of hydrazine, ethyl acetoacetate, aryl aldehydes, substituted phenylacetonitriles and ammonium acetate in ethanol at room temperature to afford novel 4,7-dihydro-1H-pyrazolo3,4-bpyridin-6-amine derivatives. The present approach offers several advantages such as shorter reaction durations, low cost, excellent yields, milder reaction conditions, simple workup procedure and is environment friendly. All the synthesized derivatives are characterized by IR,1H NMR,13C NMR, HRMS and CHN analysis. � 2016 Mohamed Afzal Pash

Platform Dependent Verification: On Engineering Verification Tools for 21st Century

The paper overviews recent developments in platform-dependent explicit-state LTL model checking.Comment: In Proceedings PDMC 2011, arXiv:1111.006

Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain

The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in detectable metabolite concentrations between DAT KO and wild-type (WT) mice. In contrast, alterations in the circuitry from the prefrontal cortex to the mesocortical limbic system, an important brain component intimately tied to function of mesolimbic/mesocortical dopamine reward pathways, were revealed by manganese-enhanced MRI (MEMRI). Analysis of co-registered MEMRI images taken over the 26 hours after introduction of Mn^(2+) into the prefrontal cortex indicated that DAT KO mice have a truncated Mn^(2+) distribution within this circuitry with little accumulation beyond the thalamus or contralateral to the injection site. By contrast, WT littermates exhibit Mn^(2+) transport into more posterior midbrain nuclei and contralateral mesolimbic structures at 26 hr post-injection. Thus, DAT KO mice appear, at this level of anatomic resolution, to have preserved cortico-striatal-thalamic connectivity but diminished robustness of reward-modulating circuitry distal to the thalamus. This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here