Simulation and Control of One-room Heating, Ventilation and Air-conditioning System

In the present study, a practical model of one-room thermodynamic behavior is proposed handling different dynamic modes of operation of air-conditioner and the corresponding adapted controllers. The developed model is based on the algorithm of Van Schijndel coupling the CFD modelling with SimuLink environment. A S-function block has been programmed which provides 5 input entities and 8 output entities to the Sfunction block thus simulating conditions close to the practice including unavoidable perturbation and constituting a MIMO system. The optimal position of the sensor has been achieved and the corresponding characteristics and optimal performance of standard PID/PI controller have been tuned in attempt to reach maximum comfort and cost effective conditions

Exploring computational power markets with evolutionary algorithms

The recent deregulation of the electric industry in the United States opened some sectors of the power market to competition. This work addresses a computational restructured wholesale electricity market. The goal of the study is to model agent driven bilateral power market auctions where the players are represented by autonomous intelligent agents. Different aspects of the market are considered. Some of them are studies on structural and strategic market power of buyers and sellers varies with changes in relative concentration and relative capacity. Others are cases where players attempt to benefit from causing instabilities like brownouts and blackouts, as well as economic instabilities by applying different gaming strategies. Agents are modeled using various evolutionary programming techniques, such as reinforced learning, genetic algorithms and genetic programming. The results suggest that some of the solutions are suitable for robust industrial applications

Milzruptur: Klinisch-pathologische Zusammenhänge und Diagnostik

Zusammenfassung: Obwohl selten, stellen Milzrupturen die häufigste Splenektomieindikation dar. Bei der überwiegenden Mehrzahl der Fälle (traumatische Rupturen) lässt sich eine klare Kausalität mit Gewalteinwirkung feststellen, bei einem anderen Teil (pathologische Rupturen) liegt eine Vorerkrankung der Milz vor, bei einem kleinen Teil der Patienten (spontane Rupturen) lässt sich kein Zusammenhang mit Traumen oder anderen Grunderkrankungen eruieren. Bei etwa 10% der rupturierten Milzen ist mit Iatrogenie im weitestem Sinne (inklusive Medikamentennebenwirkungen) sowie mit relevanten pathologischen Befunden (die Hälfe davon unerwartet) zu rechnen. Kenntnisse der Pathophysiologie, die Erhebung einfacher makroskopischer Befunde wie Größen- und Gewichtsangaben und Angaben sichtbarer Läsionen sowie die sorgfältige histologische Analyse mit gezielter Suche nach wegweisenden Veränderungen, ggf. unter Anwendung histo- und immunhistochemischer Zusatzuntersuchungen am gut vorbereiteten Material, sind die Schlüssel zur adäquaten Diagnosti

Prognostic Significance of in situ Phenotypic Marker Expression in Diffuse Large B-cell Lymphomas

Diffuse large B-cell lymphomas (DLBCL) are the most common lymphoid malignancies, and encompass all malignant lymphomas characterized by large neoplastic cells and B-cell derivation. In the last decade, DLBCL has been subjected to intense clinical, phenotypic and molecular studies, and were found to represent a heterogeneous group of tumors. These studies suggested new disease subtypes and variants with distinct clinical characteristics, morphologies, immunophenotypes, genotypes or gene expression profiles, associated with distinct prognoses or unique sensitivities to particular therapy regimens. Unfortunately, the reliability and reproducibility of the molecular results remains unclear due to contradictory reports in the literature resulting from small sample sizes, referral and selection biases, and variable methodologies and cut-off levels used to determine positivity. Here, we review phenotypic studies on the prognostic significance of protein expression profiles in DLBCL and reconsider our own retrospective data on 301 primary DLBCL cases obtained on a previously validated tissue microarray in light of powerful statistical methods of determining optimal cut-off values of phenotypic factors for prediction of outcome

Vascular Endothelial Growth Factor-Related Pathways in Hemato-Lymphoid Malignancies

Angiogenesis is essential for malignant tumor growth. This has been documented for solid tumors, and there is an emerging evidence suggesting that tumor progression of hematolymphoid malignancies also depends on the induction of new blood vessel formation. The most important proangiogenic agent is vascular endothelial growth factor (VEGF), activating VEGF receptors 1 and 2. The available data on angiogenesis in hemato-lymphoid malignancies, such as acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, multiple myeloma, and lymphomas, point towards the significance of autocrine and paracrine VEGF-mediated effects for proliferation and survival of leukemia/lymphoma cells in addition to tumor vascularization. Antiangiogenic strategies have become an important therapeutic modality for solid tumors. Several antiangiogenic agents targeting VEGF-related pathways are also being utilized in clinical trials for the treatment of hemato-lymphoid malignancies, and in some instances these pathways have emerged as promising therapeutic targets. This review summarizes recent advances in the basic understanding of the role of angiogenesis in hemato-lymphoid malignancies and the translation of such basic findings into clinical studies

Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3.

Systemic mastocytoses represent neoplastic proliferations of mast cells. In about 20% of cases systemic mastocytoses are accompanied by clonal haematopoietic non-mast cell-lineage disorders, most commonly myeloid neoplasms. A case of systemic mastocytosis carrying the characteristic mutation at codon 816 (D816V) in the KIT gene of mast cells, with two concurrent accompanying clonal haematopoietic non-mast cell-lineage disorders, chronic myeloproliferative disease, unclassifiable and precursor B lymphoblastic leukaemia is documented. Both accompanying clonal haematopoietic non-mast cell-lineage disorders carried the wild-type KIT gene, but had a novel t(13;13)(q12;q22) involving the FLT3 locus at 13q12. The chronic myeloproliferative disease, unclassifiable and the precursor B lymphoblastic leukaemia were cured by syngenous stem cell transplantation, but the systemic mastocytosis persisted for more than 10 years. The additional impact of molecular techniques on the correct diagnosis in haematological malignancies is highlighted, and evidence is provided that, apart from internal tandem duplications and mutations, FLT3 can be activated by translocations

Normales Knochenmark und häufige reaktive Veränderungen

Zusammenfassung: Die histologische Knochenmarkuntersuchung spielt, wegen ihrer großen Aussagekraft bei relativ geringem Aufwand eine bedeutende Rolle in der Diagnostik von hämatologischen und nichthämatologischen Erkrankungen. Dafür ist die Kenntnis des normalen Knochenmarks mit seiner individuellen, insbesondere altersabhängigen, Variabilität, unentbehrlich. Neben entnahmebedingten Artefakten, die falsch interpretiert werden können, oder suboptimal fixierten bzw. verarbeiteten Biopsien, die diagnostisch überbewertet werden, gibt es eine Vielfalt von reaktiven Knochenmarkveränderungen, die einen neoplastischen Prozess vortäuschen und zu schwerwiegenden diagnostischen Fehlern führen können. Bei derartigen nichtneoplastischen Veränderungen können ein oder auch mehrere Kompartimente der Hämatopoiese qualitativ und quantitativ betroffen sein. Es kann zu Verteilungs- bzw. Architekturstörungen und/oder zu Veränderungen des Knochenmarkstromas kommen. Eine optimale Knochenmarkdiagnostik erfordert, neben Spezialfärbungen, zusätzlich oftmals immunhistochemische Untersuchungen und manchmal molekularpathologische Analysen. Mehr als bei anderen Organbiopsien ist die Kenntnis klinischer Befunde, insbesondere vorangegangener Therapien, relevant, um eine korrekte Diagnose zu stellen. In diesem Beitrag sind neben dem normalen Knochenmark die häufigsten reaktiven Veränderungen dargestell

Fractal structure of the positive free-air gravity anomalies within the Balkan Peninsula

The investigations of the fractal structure and properties of the different geophysical elements is new and fast developing area of research among the geophysical society. The fractal properties of the earthquake clusters, faults and folds at different scale, even the plutonic bodies and other elements of the positive landforms are the most exploited areas of research. In our caste the special attention is paid to the gravity field (free-air anomalies) as the most expressive element of the surface elevated structures and their influence to the relief. The Balkan Peninsula is well known as the one of the most variable Earth’s surface elevation area in the world. The fractal properties of gravity field in such area could be useful to try to establish formal relationships to the surface elevation, as well as to prove the possibility to get some information about the self-organization and the origin of the mountain landforms in the same area

Fractal Analysis of The Lunar Bouguer Gravity Field

Recent dedicated lunar gravity measure mission provided high-resolution data for the Moon. The collected data are the starting material for the construction of the latest gravity model.  Like all celestial bodies, our natural satellite, is not a perfectly spherical object and its internal structure is not formed of homogeneous layers of equal thickness and gravity field varies from place to place. By measuring variations in lunar gravity can determine the density variations and deduce its internal structure. Gravity anomalies of the Moon are caused by concentrations of huge masses of material known as "mascons". Mascons are a symbol of the periods of creation and destruction in the course of the turbulent geological history of the Moon. This article present the results of the fractal analysis of the lunar Bouguer gravity field. The results obtained in the course of the study confirm the fractal geometry of the lunar Bouguer gravity field. The resulting fractal dimensions (D) varies from 1,4-1,5 to 2,4-2,5 and indicate a high level of gravity values fragmentation. Also, the spatial relationship between Bouguer gravity anomalies, "free-air" gravity anomalies and lunar digital elevation model (DEM) are considered.&nbsp