Mobility of liquid molecules within aerosil pores

Self-diffusion coefficients (D), times of longitudinal (T1) and cross (T2) magnetic relaxations of protons of polar (dimethylsulphoxide, dimethylphthalate) and nonpolar (tridecane) liquids within aerosil pores were measured using NMR spectroscopy. Measured T2 values of polar molecules are less by two orders and more than the values of nonpolar molecules. D coefficients of liquids are independent on their polarity. The results obtained can be explained by the orienting action of aerosil particles surface on polar molecules which leads to anisotropy of their rotating ability. Anisotropy parameter and times of isotropic reorientation equal to 1.6×10-7 and 6.8×10-7 s respectively for DMSO and DMP molecules were estimated

A Study on the Economic Effect of Deregulations in Japan : A Temporary Simulation by Macroeconometric Models (2/2)

The anomal temperature dependences of the transverse NMR-relaxation time T2 of solvent molecules water and DMSO in agarose gels have been obtained being qualitatively explained in the framework of the three-phase model with the molecular exchange between phases. Acceleration of the transverse magnetic relaxation of solvent molecules in agarose gels is explained by the presence of few fast-relaxing molecules incorporated into the network points of a gel. The values of the activation energy of molecular exchange and of the content of molecules with short T2 time are numerically evaluated

Business administration as a basis for development of global entrepreneurship

The purpose of the article is to determine the role and meaning of business administration in development of global entrepreneurship. The work uses the proprietary methodology of evaluation of global competitiveness of enterprise and the proprietary methodology of evaluation of efficiency of business administration of enterprise, as well as method of correlation analysis. The authors determine the role of business administration in management of factors of development of global enterprise and offer the proprietary structural and logical model of organization of the process of business administration of global enterprise as a perspective tool for provision of global competitiveness of business and development of global entrepreneurship on the whole. The authors come to the conclusion that business administration is a basis for development of global entrepreneurship and plays an important role in this process, which consists in managing other internal and external factors of functioning of global business.peer-reviewe

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review.publishersversionPeer reviewe

THE THYMIDINE KINASE-1(TK-1) AS A POTENTIAL TUMOR MARKER: SERUM LEVELS IN SERUM OF PATIENTS WITH SOLID AND SYSTEM MALIGNANCE NEOPLASMS

The review summarizes the results of studies of levels and/or activity in the blood serum of a metabolic marker thymidine kinase-1 (TK-1) of proliferating cells in patients with lymphoproliferative diseases (LPD) and malignant neopasms (NM).Comparison of the data in the literature in some cases have been difficult due to the fundamentally different methods of detection the activity or concentration of TK-1, used by authors, even despite the presence of relatively high (but not absolute) correlation between these parameters (maximum 0.8).Many clinical and laboratory studies have shown levels of correlation and/or TK-1 activity with clinical stages and different types of LPD and solid MN and can serve as a prognostic factor for overall and recurrence-free survival of patients. When solid MN shown that the activity of TK-1 accurately reflects the proliferative status of tumor.A comparison of the dynamics of TC-1 in the process of chemotherapy and its clinical efficacy, different authors have received fundamentally different results: in some cases the marker reduction was associated with treatment efficacy, and in part of publications they show that the clinically relevant effects of the treatment observed increase in the marker after the first chemotherapy.The entire set of received data demonstrates the relevance of the further development of the algorithm use of TK-1 in oncology practice