11 research outputs found

    NURS 360: Does the administration of CODE ICE to a cardiac arrest patient result in regained brain function when discontinued?

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    The increase in heart disease in this country has created the need for more treatment options for out-of hospital cardiac arrest (OOHCA). Therapeutic hypothermia, also referred to as code ice, involves the cooling of a patient’s body temperature to around thirty-two degrees Celsius, and it has become a standard of care for patients who are resuscitated after a OOHCA. When these patients experience cardiac arrest outside of the hospital there is a risk for decreased brain function. This decrease in brain function can lead to patient being declared brain dead and placed on a ventilator. However, some research indicates that therapeutic hypothermia has resulted in a higher likelihood of survival and hospital discharge

    Lunabotics Mining: Evolution of ARTEMIS PRIME

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    This slide presentation reviews the development of Amassing Regolith with Topper Engineers eMploying Innovative Solutions (ARTEMIS) in a competition to develop robotic lunar mining capabilities. The goal of the competition was to design, build and operate a remotely controlled device that is capable of excavating, transporting and discharging lunar regolith simulant in a lunar environment over a 13 minute period

    Wireless, Battery-Free Implants for Electrochemical Catecholamine Sensing and Optogenetic Stimulation

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    Neurotransmitters and neuromodulators mediate communication between neurons and other cell types; knowledge of release dynamics is critical to understanding their physiological role in normal and pathological brain function. Investigation into transient neurotransmitter dynamics has largely been hindered due to electrical and material requirements for electrochemical stimulation and recording. Current systems require complex electronics for biasing and amplification and rely on materials that offer limited sensor selectivity and sensitivity. These restrictions result in bulky, tethered, or battery-powered systems impacting behavior and that require constant care of subjects. To overcome these challenges, we demonstrate a fully implantable, wireless, and battery-free platform that enables optogenetic stimulation and electrochemical recording of catecholamine dynamics in real time. The device is nearly 1/10th the size of previously reported examples and includes a probe that relies on a multilayer electrode architecture featuring a microscale light emitting diode (μ-LED) and a carbon nanotube (CNT)-based sensor with sensitivities among the highest recorded in the literature (1264.1 nA μM-1 cm-2). High sensitivity of the probe combined with a center tapped antenna design enables the realization of miniaturized, low power circuits suitable for subdermal implantation even in small animal models such as mice. A series of in vitro and in vivo experiments highlight the sensitivity and selectivity of the platform and demonstrate its capabilities in freely moving, untethered subjects. Specifically, a demonstration of changes in dopamine concentration after optogenetic stimulation of the nucleus accumbens and real-time readout of dopamine levels after opioid and naloxone exposure in freely behaving subjects highlight the experimental paradigms enabled by the platform.Fil: Stuart, Tucker. University of Arizona; Estados UnidosFil: Jeang, William J.. Northwestern University; Estados UnidosFil: Slivicki, Richard A.. University of Washington; Estados UnidosFil: Brown, Bobbie J.. University of Washington; Estados UnidosFil: Burton, Alex. University of Arizona; Estados UnidosFil: Brings, Victoria E.. University of Washington; Estados UnidosFil: Agyare, Prophecy. Northwestern University; Estados UnidosFil: Alarcon Segovia, Lilian Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; ArgentinaFil: Ruiz, Savanna. Northwestern University; Estados UnidosFil: Tyree, Amanda. University of Arizona; Estados UnidosFil: Pruitt, Lindsay. University of Arizona; Estados UnidosFil: Madhvapathy, Surabhi. Northwestern University; Estados UnidosFil: Niemiec, Martin. University of Arizona; Estados UnidosFil: Zhuang, James. University of Arizona; Estados UnidosFil: Krishnan, Siddharth. Northwestern University; Estados UnidosFil: Copits, Bryan A.. University of Washington; Estados UnidosFil: Rogers, John A.. Northwestern University; Estados UnidosFil: Gereau, Robert W.. Washington University in St. Louis; Estados UnidosFil: Samineni, Vijay K.. University of Washington; Estados UnidosFil: Bandodkar, Amay J.. No especifíca;Fil: Gutruf, Philipp. University of Arizona; Estados Unido
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