The Magnetic Field Induced by a Lightning Strikes Indirect Effect Double Exponential Current Waveform

Problem statement: Develop a new formula which describes the magnetic field induced by a lightning strike\u27s indirect effect double exponential current waveform. Approach: A novel approach for developing a closed-form solution for the magnetic field from the indirect effect double exponential current waveform will be presented. In the literature, models typically employ the pulse waveform to derive the corresponding electromagnetic fields. However, given the Department of Defense (DoD) has incorporated the double exponential current waveform as part of their Electromagnetic Environmental Effects Requirements For Systems , we felt it important to develop a solution for the magnetic field which utilized this waveform. In order to facilitate the integration required for deriving the field, Taylor series expansion was used for all variable dependent exponential terms. In many publications, the dipole and monopole techniques have been used when solving for the magnetic field. However, for this study the dipole technique was deemed the preferred method for evaluating the field. A derivation of the magnetic field will be presented along with a graphical illustration of the field\u27s distribution over time. Results: The equation presented utilized Taylor series to augment the integration required to solve for the magnetic field. Conclusion: A new method for deriving the magnetic field induced by a lightning strike\u27s indirect effect double exponential has been presented. By approximating the variable dependent exponential terms, we were able to minimize the complexity of the mathematics required to solve for the magnetic field in closed-form

Differences in Relationship and Sexual Satisfaction and Social Support Between Only Lesbian, Mostly Lesbian, and Bisexual Women

Research suggests relationship and sexual satisfaction and social support are correlated with components of well-being such as anxiety, depression, and physical health. Differences in relationship and sexual satisfaction and social support have been identified between sexual minority women (SMW; i.e., lesbian and bisexual) and heterosexual women. However, classifying SMW into a single group may mask important differences. Further research is needed to better understand the differences in relationship and sexual satisfaction and social support between subgroups of SMW. Thus, the purpose of the present study was to examine differences in these constructs between women who identify as only lesbian, mostly lesbian, and bisexual. Participants were 427 partnered sexual minority women (Mage = 24.66; 84.8% White; 46.8% only lesbian; 34.2% mostly lesbian; 19% bisexual) recruited from social media to complete an online survey consisting of measures of relationship, health, and related factors as part of a larger study. A one-way ANOVA revealed statistically significant differences between only lesbian, mostly lesbian, and bisexual women in relationship satisfaction (p=.021), sexual satisfaction (p=.049), and social support (p=.034). Post-hoc pairwise comparisons revealed women who identified as only lesbian reported better relationship satisfaction (p=.007), sexual satisfaction (p=.015), and social support (p=.010) than women who identified as mostly lesbian. There were no differences between bisexual women and women who identified as either only lesbian or mostly lesbian. These findings identified important differences between subgroups of SMW, with women who identify as mostly lesbian reporting the lowest relationship and sexual satisfaction and social support. This study provides further evidence that collapsing across identities within the broad category of SMW may mask meaningful subgroup differences. Additional research is needed to further explore disparities in well-being among subsections of SMW. Findings may help identify important protective factors for mental and physical health and well-being specific to SMW of different identities.https://digitalcommons.odu.edu/gradposters2023_sciences/1007/thumbnail.jp

How Lightning Tortuosity Affects the Electromagnetic Fields by Augmenting Their Effective Distance

A novel approach for developing the electromagnetic fields from a lightning return stroke which follows a tortuous path will be presented. The proposed model is unique in that it recognizes that the symmetrical tortuosity of lightning directly impacts the observable distance r, which in turn, alters the resulting electromagnetic fields. In the literature, lightning return stroke models typically employ the assumption that the cloud-to-ground path is straight. Although this assumption yields fairly consistent results across an array of varying approaches, it does not account for lightning\u27s natural physical appearance. Furthermore, straight-line models only account for the cloud-to-ground discharges and do not address branching and/or cloud-to-cloud discharges which are far more common. In reality, the steps which make up the lightning channel\u27s initial descent are staggered or tortuous with respect to each other. Given this fact, the upward traveling current wavefront which follows this prescribed path will exhibit the same characteristics. In doing so, each current segment, which forms along its respective step, induces electromagnetic fields with angular aggregates that propagate outward from their origin. This, in turn, will generate spatial points where there are fields of higher and lower intensities. The results presented in this paper will show how the effective observable distance due to symmetrical tortuosity alters the resulting electromagnetic fields. Furthermore, it will be shown that as the observable distance r is increased, results from the proposed model closely resemble the straight-line model which strongly suggests that symmetrical tortuosity is only influential at relatively close distances

Effect of EMIC waves on relativistic and ultrarelativistic electron populations: Ground-based and Van Allen Probes observations

Abstract We study the effect of electromagnetic ion cyclotron (EMIC) waves on the loss and pitch angle scattering of relativistic and ultrarelativistic electrons during the recovery phase of a moderate geomagnetic storm on 11 October 2012. The EMIC wave activity was observed in situ on the Van Allen Probes and conjugately on the ground across the Canadian Array for Real-time Investigations of Magnetic Activity throughout an extended 18 h interval. However, neither enhanced precipitation of \u3e0.7 MeV electrons nor reductions in Van Allen Probe 90° pitch angle ultrarelativistic electron flux were observed. Computed radiation belt electron pitch angle diffusion rates demonstrate that rapid pitch angle diffusion is confined to low pitch angles and cannot reach 90°. For the first time, from both observational and modeling perspectives, we show evidence of EMIC waves triggering ultrarelativistic (~2-8 MeV) electron loss but which is confined to pitch angles below around 45° and not affecting the core distribution. Key Points EMIC wave activity is not associated with precipitation of MeV electrons EMIC waves do not deplete the ultra-relativistic belt down to 90° EMIC waves cause loss of low pitch angle electrons with energies ~2-8 MeV

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

The response to the coronavirus disease 2019 (COVID-19) pandemic has been hampered by lack of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral therapy. Here we report the use of remdesivir in a patient with COVID-19 and the prototypic genetic antibody deficiency X-linked agammaglobulinaemia (XLA). Despite evidence of complement activation and a robust T cell response, the patient developed persistent SARS-CoV-2 pneumonitis, without progressing to multi-organ involvement. This unusual clinical course is consistent with a contribution of antibodies to both viral clearance and progression to severe disease. In the absence of these confounders, we take an experimental medicine approach to examine the in vivo utility of remdesivir. Over two independent courses of treatment, we observe a temporally correlated clinical and virological response, leading to clinical resolution and viral clearance, with no evidence of acquired drug resistance. We therefore provide evidence for the antiviral efficacy of remdesivir in vivo, and its potential benefit in selected patients

Researchers' experience with project management in health and medical research: Results from a post-project review

<p>Abstract</p> <p>Background</p> <p>Project management is widely used to deliver projects on time, within budget and of defined quality. However, there is little published information describing its use in managing health and medical research projects. We used project management in the <it>Alcohol and Pregnancy Project </it>(2006-2008) <url>http://www.ichr.uwa.edu.au/alcoholandpregnancy</url> and in this paper report researchers' opinions on project management and whether it made a difference to the project.</p> <p>Methods</p> <p>A national interdisciplinary group of 20 researchers, one of whom was the project manager, formed the Steering Committee for the project. We used project management to ensure project outputs and outcomes were achieved and all aspects of the project were planned, implemented, monitored and controlled. Sixteen of the researchers were asked to complete a self administered questionnaire for a post-project review.</p> <p>Results</p> <p>The project was delivered according to the project protocol within the allocated budget and time frame. Fifteen researchers (93.8%) completed a questionnaire. They reported that project management increased the effectiveness of the project, communication, teamwork, and application of the interdisciplinary group of researchers' expertise. They would recommend this type of project management for future projects.</p> <p>Conclusions</p> <p>Our post-project review showed that researchers comprehensively endorsed project management in the <it>Alcohol and Pregnancy Project </it>and agreed that project management had contributed substantially to the research. In future, we will project manage new projects and conduct post-project reviews. The results will be used to encourage continuous learning and continuous improvement of project management, and provide greater transparency and accountability of health and medical research. The use of project management can benefit both management and scientific outcomes of health and medical research projects.</p

Evidence for link between modelled trends in Antarctic sea ice and underestimated westerly wind changes

Despite global warming, total Antarctic sea ice coverage increased over 1979-2013. However, the majority of Coupled Model Intercomparison Project phase 5 models simulate a decline. Mechanisms causing this discrepancy have so far remained elusive. Here we show that weaker trends in the intensification of the Southern Hemisphere westerly wind jet simulated by the models may contribute to this disparity. During austral summer, a strengthened jet leads to increased upwelling of cooler subsurface water and strengthened equatorward transport, conducive to increased sea ice. As the majority of models underestimate summer jet trends, this cooling process is underestimated compared with observations and is insufficient to offset warming in the models. Through the sea ice-albedo feedback, models produce a high-latitude surface ocean warming and sea ice decline, contrasting the observed net cooling and sea ice increase. A realistic simulation of observed wind changes may be crucial for reproducing the recent observed sea ice increase

A Project Portfolio Management Approach to Tacklingthe Exploration/Exploitation Trade-off

Organizational ambidexterity (OA) is an essen-tial capability for surviving in dynamic business environ-ments that advocates the simultaneous engagement inexploration and exploitation. Over the last decades,knowledge on OA has substantially matured, coveringinsights into antecedents, outcomes, and moderators of OA.However, there is little prescriptive knowledge that offersguidance on how to put OA into practice and to tackle thetrade-off between exploration and exploitation. To addressthis gap, the authors adopt the design science researchparadigm and propose an economic decision model asartifact. The decision model assists organizations inselecting and scheduling exploration and exploitation pro-jects to become ambidextrous in an economically reason-able manner. As for justificatory knowledge, the decisionmodel draws from prescriptive knowledge on projectportfolio management and value-based management, andfrom descriptive knowledge related to OA to structure thefield of action. To evaluate the decision model, its designspecification is discussed against theory-backed designobjectives and with industry experts. The paper alsoinstantiates the decision model as a software prototype andapplies the prototype to a case based on real-world data

A Mouse Model of the Human Fragile X Syndrome I304N Mutation

The mental retardation, autistic features, and behavioral abnormalities characteristic of the Fragile X mental retardation syndrome result from the loss of function of the RNA–binding protein FMRP. The disease is usually caused by a triplet repeat expansion in the 5′UTR of the FMR1 gene. This leads to loss of function through transcriptional gene silencing, pointing to a key function for FMRP, but precluding genetic identification of critical activities within the protein. Moreover, antisense transcripts (FMR4, ASFMR1) in the same locus have been reported to be silenced by the repeat expansion. Missense mutations offer one means of confirming a central role for FMRP in the disease, but to date, only a single such patient has been described. This patient harbors an isoleucine to asparagine mutation (I304N) in the second FMRP KH-type RNA–binding domain, however, this single case report was complicated because the patient harbored a superimposed familial liver disease. To address these issues, we have generated a new Fragile X Syndrome mouse model in which the endogenous Fmr1 gene harbors the I304N mutation. These mice phenocopy the symptoms of Fragile X Syndrome in the existing Fmr1–null mouse, as assessed by testicular size, behavioral phenotyping, and electrophysiological assays of synaptic plasticity. I304N FMRP retains some functions, but has specifically lost RNA binding and polyribosome association; moreover, levels of the mutant protein are markedly reduced in the brain specifically at a time when synapses are forming postnatally. These data suggest that loss of FMRP function, particularly in KH2-mediated RNA binding and in synaptic plasticity, play critical roles in pathogenesis of the Fragile X Syndrome and establish a new model for studying the disorder