Test–retest reliability of the magnitude and direction of asymmetry in the countermovement jump, drop jump, and countermovement rebound jump

This study aimed to investigate the test–retest reliability of three bilateral jump tests to assess asymmetry and determine the consistency of both the magnitude and direction of asymmetry between two testing sessions. Thirty-three participants performed the countermovement jump (CMJ), drop jump (DJ), and countermovement rebound jump (CMRJ—jump 1: CMRJ1; jump 2: CMRJ2) over two sessions. Inter-limb asymmetry was calculated for kinetic metrics, including the mean propulsive force, net braking impulse, and net propulsive impulse. Test reliability was computed using intraclass correlation coefficients (ICC), coefficients of variation (CV), and standard error of measurement. Furthermore, analysis of variance was used to determine the systematic bias between jump types and sessions. Kappa coefficients were utilised to assess the consistency of asymmetry favouring the same limb. Results showed poor to excellent reliability for all jump tests between sessions (ICC range = 0.19–0.99, CV range = 2.80–11.09%). A significantly higher magnitude of asymmetry was revealed for the net braking impulse during the DJ compared to the CMRJ2 (p ≥ 0.014, g ≤ 0.53). When computing the direction of asymmetry between test sessions, Kappa coefficients revealed that levels of agreement were substantial (Kappa = 0.63–0.70) for the CMJ, moderate to almost perfect (Kappa = 0.59–0.94) for the CMRJ1, moderate to almost perfect (Kappa = 0.58–0.81) for the DJ, and slight to moderate for the CMRJ2 (Kappa = 0.19–0.57). These results underscore the variable nature of both the magnitude and direction of asymmetry during jump testing. Thus, practitioners should carefully choose evaluation methods and metrics characterised by low variability to ensure robust asymmetry assessments

Treatment of estrogen-induced dermatitis with omalizumab

In 1945, Drs Bernhard Zondek and Yehuda Bromberg demonstrated intradermal treatment with estrone and estradiol benzoate induced urticarial lesions in some patients.1 Fifty years later, Shelley et al,2 who introduced the concept of progesterone dermatitis several decades prior, defined estrogen dermatitis based on studies of 7 women with premenstrual flares of skin eruptions including papulovesicular, urticarial, or eczematous lesions or generalized pruritus. Previously described therapies for estrogen dermatitis include estrogen desensitization, tamoxifen, leuprolide, and oophorectomy.3 Here we report a case of estrogen-induced dermatitis successfully treated with omalizumab

Assessing Options for Remediation of Contaminated Mine Site Drainage Entering the River Teign, Southwest England

The river Teign in Devon has come under scrutiny for failing to meet environmental quality standards for ecotoxic metals due to past mining operations. A disused mine known as Bridford Barytes mine, has been found to contribute a significant source of Zn, Cd and Pb to the river. Recently, studies have been focused on the remediation of such mine sites using low-cost treatment methods to help reduce metal loads to the river downstream. This paper explores the metal removal efficiency of red mud, a waste product from the aluminium industry, which has proven to be an attractive low-cost treatment method for adsorbing toxic metals. Adsorption kinetics and capacity experiments reveal metal removal efficiencies of up to 70% within the first 2 h when red mud is applied in pelletized form. Further, it highlights the potential of biochar, another effective adsorbent observed to remove &gt;90% Zn using agricultural feedstock. Compliance of the Teign has been investigated by analysing dissolved metal concentrations and bioavailable fractions of Zn to assess if levels are of environmental concern. By applying a real-world application model, this study reveals that compressed pellets and agricultural biochar offer an effective, low-cost option to reducing metal concentrations and thus improving the quality of the river Teign.</jats:p

A framework to guide practitioners when selecting metrics during the countermovement and drop jump tests

Researchers and practitioners have highlighted the necessity to monitor jump strategy metrics as well as the commonly reported outcome measures during the countermovement (CMJ) and drop jump (DJ) tests. However, there is a risk of confusion for practitioners, given the vast range of metrics that now seem to be on offer via analysis software when collecting data from force platforms. As such, practitioners may benefit from a framework that can help guide metric selection for commonly used jump tests, which is the primary purpose of this article. To contextualise the proposed framework, we have provided two examples for how this could work: one for the CMJ and one for the DJ, noting that these tests are commonly utilized by practitioners during routine testing across a range of sport performance and clinical settings

An assessment of the hopping strategy and inter-limb asymmetry during the triple hop test: a test–retest pilot study

The aims of the present study are to: (1) determine within- and between-session reliability of multiple metrics obtained during the triple hop test; and (2) determine any systematic bias in both the test and inter-limb asymmetry scores for these metrics. Thirteen male young American football athletes performed three trials of a triple hop test on each leg on two separate occasions. In addition to the total distance hopped, manual detection of touch down and toe-off were calculated via video analysis, enabling flight time (for each hop), ground contact time (GCT), reactive strength index (RSI), and leg stiffness (between hops) to be calculated. Results showed all coefficient of variation (CV) values were ≤ 10.67% and intraclass correlation coefficients (ICC) ranged from moderate to excellent (0.53–0.95) in both test sessions. Intrarater reliability showed excellent reliability for all metrics (CV ≤ 3.60%, ICC ≥ 0.97). No systematic bias was evident between test sessions for raw test scores (g = −0.34 to 0.32) or the magnitude of asymmetry (g = −0.19 to 0.43). However, ‘real’ changes in asymmetry (i.e., greater than the CV in session 1) were evident on an individual level for all metrics. For the direction of asymmetry, kappa coefficients revealed poor-to-fair levels of agreement between test sessions for all metrics (K = −0.10 to 0.39), with the exception of the first hop (K = 0.69). These data show that, given the inherent limitations of distance jumped in the triple hop test, practitioners can confidently gather a range of reliable data when computed manually, provided sufficient test familiarization is conducted. In addition, although the magnitude of asymmetry appears to show only small changes between test sessions, limb dominance does appear to fluctuate between test sessions, highlighting the value of also monitoring the direction of the imbalance

Development of a novel tool for assessing coverage of implementation factors in health promotion program resources

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.Katharine B. Richardson Research Award at Children's Mercy Kansas CityNational Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number F32DK115146Institute of Education Sciences and U.S. Department of Education by grant R305A15027

A T-type channel-calmodulin complex triggers αCaMKII activation

Abstract Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium channels of the Cav3 family have the important role of mediating low threshold calcium influx, but were not believed to interact with CaM. We find a constitutive association between CaM and the Cav3.1 channel at rest that is lost through an activity-dependent and Cav3.1 calcium-dependent CaM dissociation. Moreover, Cav3 calcium influx is sufficient to activate αCaMKII in the cytoplasm in a manner that depends on an intact Cav3.1 C-terminus needed to support the CaM interaction. Our findings thus establish that T-type channel calcium influx invokes a novel dynamic interaction between CaM and Cav3.1 channels to trigger a signaling cascade that leads to αCaMKII activation

Constraints from Inflation on Scalar-Tensor Gravity Theories

We show how observations of the perturbation spectra produced during inflation may be used to constrain the parameters of general scalar-tensor theories of gravity, which include both an inflaton and dilaton field. An interesting feature of these models is the possibility that the curvature perturbations on super-horizon scales may not be constant due to non-adiabatic perturbations of the two fields. Within a given model, the tilt and relative amplitude of the scalar and tensor perturbation spectra gives constraints on the parameters of the gravity theory, which may be comparable with those from primordial nucleosynthesis and post-Newtonian experiments.Comment: LaTeX (with RevTex) 19 pages, 8 uuencoded figures appended, also available on WWW via http://star.maps.susx.ac.uk/index.htm