Zdravstveni nadzor nad osobama profesionalno izloženima niskim koncentracijama benzena

The paper presents the results of an investigation of haematotoxicity in workers exposed to low benzene concentrations. Forty-seven female workers in the shoemaking industry, exposed to solvent mixture and twenty-seven non-exposed controls were examined. Benzene concentrations in the working atmosphere ranged from 1.9 to 14.8 ppm. Significant differences in the levels of benzene in blood and phenols in pre- and post-shift urine between the exposed and control groups confirmed benzene exposure. Haemoglobin level and mean corpuscular haemoglobin concentration were significantly lower, and mean corpuscular volume was higher in the shoemaking workers than in controls. In the subgroup of shoemaking workers exposed to benzene concentrations of 5 ppm or lower, no differences in haematological parameters were found. In conclusion, exposure to a benzene concentration lower than 5 ppm does not appear to produce an increased level of abnormal haematological outcomes detectable in routine medical surveillance. The results of the study corroborate the present maximum permissible concentrations (5 ppm) as a protective limit preventing the onset of haematotoxic non-leukemogenic effects of chronic benzene exposure.U zaštiti zdravlja osoba profesionalno izloženih benzenu nuždan je zdravstveni nadzor kojim je moguće otkriti rane pokazatelje oštećenja krvotvornog sustava. U članku su prikazani rezultati ispitivanja krvotvornog sustava u radnica izloženih niskim koncentracijama benzena. U istraživanje je bilo uključeno 47 radnica obućarske industrije i 27 zdravih ženskih osoba. Benzen u zraku radnih prostora iznosio je 1,9-14,8 ppm. Izloženost benzenu potvrđena je značajno višim koncentracijama benzena u krvi i fenola u mokraći prije i poslije radne smjene u radnica obućarske industrije. U njih je nađen niži hemoglobin i srednja koncentracija hemoglobina u eritrocitu te viši srednji volumen eritrocita u usporedbi s osobama poredbene skupine. Međutim, ova odstupanja nisu potvrđena i u skupini radnica obućarske industrije izloženih benzenu ispod 5 ppm. Prema ovim rezultatima, izloženost benzenu koncentracije 5 ppm i niže ne uzrokuje odstupanja koja je moguće utvrditi rutinskim krvnim testovima. To potvrđuje maksimalno dopustivu koncentraciju od 5 ppm benzena kao zaštitnu granicu za sprječavanje hematotoksičnih neleukemogenih učiinaka benzena

The influence of preparation conditions on oleogel-based emulsion properties

V okviru magistrske naloge smo pripravili oleogel emulzije. Svežim oleogel emulzijam in oleogel emulzijam po 4 tednih shranjevanja smo določili trdoto, kohezivnost, konsistenco, jih umestili v barvni spekter CIE (L*,a*,b*) ter si s svetlobnim mikroskopom podrobneje ogledali njihovo strukturo. Oleogel emulzije smo pripravili iz sončničnega olja in vode v različnih razmerjih ter z dodatkom različnih kombinacij in vsebnosti čebeljega voska, zmesi mono- in digliceridov (Glicemul), kappa-karagenana (κ-karagenan) in kalijev klorid (KCl). Postopek, ki smo ga uporabili za pripravo oleogel emulzij, je zajemal tri stopnje: priprava oljne in vodne faze, združevanje obeh faz in homogenizacijo v ledeni kopeli. Ugotovili smo, da ima oleogelator (vosek, Glicemul) največji vpliv na teksturne lastnosti in barvo oleogel emulzij. Pri enaki koncentraciji oleogelatorja so oleogel emulzije z voskom manj trde, bolj lepljive, barva vzorcev pa je bolj izrazita v primerjavi z oleogel emulzijami z Glicemulom. 3 % čebeljega voska ali Glicemula v oljni fazi je najnižja koncentracija, ki omogoča nastanek čvrste oleogel emulzije. Z večanjem količine oleogelatorja se veča trdota, kohezivnost in konsistenca oleogel emulzij. κ karagenan v oleogel emulzijah z voskom deluje optimalno, kadar razmerje sestavin κ karagenan:vosek znaša 1:3 ali več. V oleogel emulzijah z Glicemulom je pri odmerjanju κ karagenana pomembno razmerje vode in Glicemula. Oleogel emulzija, ki vsebuje več voska in κ karagenana, je po shranjevanju mehkejša v primerjavi z oleogel emulzijami, ki ne vsebujejo hidrokoloida. Struktura oleogel emulzije z mono- in digliceridi je po 4 tednih shranjevanja stabilna oz. se lahko v določenih primerih še bolj učvrsti. Učinek KCl na teksturne lastnosti oleogel emulzij se razlikuje glede na razmerje med oljem in vodo ter glede na vsebnost voska.In this master’s thesis the oleogel-based emulsions were made of different combinations and ratios of sunflower oil, beewax, mixture of mono- and diglycerides (Glicemul), water, kappa-carrageenan (κ-carrageenan) and potassium chloride (KCl). Oleogel-based emulsions were analysed on firmness, cohezivness, consistency and CIE (L*,a*,b*) color values. Structure of oleogel emulsions were investigated on optical microscope. Oleogel-based emulsions were prepared in three stages: preparation of oil phase and water phase, combining them and homogenization in icy bath. We discovered that both oleogelators have the biggest effect on textural traits and color of oleogel-based emulsions. When the concentrations of oleogel-based emulsions were the same, those with wax were less hard, stickier and the color of samples was more distinct comparing to oleogel based emulsions with Glicemul. 3 % of beewax or Glicemul in oil phase is the lowest concentration, which enables creation of firm oleogel-based emulsion. When the quantity of oleogelator increases, so does the firmness, cohezivness and consistency of oleogel based emulsions. The κ-carrageenan in oleogel-based emulsions with wax works most optional when components ratios are 1:3 or more, in favor of wax. In oleogel-based emulsions with Glicemul, the proportion of water and Glicemul is important, when dosing κ carrageenan. Oleogel-based emulsion containing more wax and κ-carrageenan is softer after storage compared to oleogel based emulsions that do not contain hydrocolloids. The structure of mono and diglycerides in oleogel-based emulsions is after 4 weeks of storage stable or in some cases it can become even more firm. The effect of KCl on the texture traits of oleogel-based emulsions differs according to the ratio of oil and water to wax content

CD4+T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C viruscoinfected patients

To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was (6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls (G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1 (G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035). Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage.Fil: Laufer, Natalia Lorna. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Ojeda, Diego Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Polo, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Martinez, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Pérez, Héctor. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Cahn, Pedro. Fundación Huésped; ArgentinaFil: Zwirner, Norberto Walter. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

Oporavak pamćenja nakon operacije aneurizme moždanih arterija

The principal study objective was to define whether memory deficits (numerical, working, verbal-mechanical, verbal-logical and visual memory) occurred in patients submitted to surgery for brain artery aneurysm and whether significant recovery of memory took place with time. The study sample included 92 patients, i.e. 35 (38%) male and 57 (62%) female patients aged 27 to 76 years. Neuropsychological testing was conducted at Zagreb University Hospital Centre, Department of Neurosurgery, from 1998 to 2012, in two time intervals: first within 11 months following surgery, and then 12 to 48 months after surgery. The obtained results showed that verbal-mechanical, verballogical, and visual memory deficits were present in the first testing interval. In the second testing, the verbal-logical and visual memory deficits were still present, while the tests of verbal-mechanical memory showed deficits in capacity and learning curve, but the results for short- and long-term memory were within the normal ranges. Neither the first nor the second testing showed deficits of numerical and working memory. Based on our results, we can conclude that long-term verbal-mechanical and visual short- and long-term memory had recovered to a statistically significant level, whereas other types of memory showed no significant recovery.Glavni cilj ovog istraživanja bio je utvrditi postoje li u bolesnika nakon operacije aneurizme moždanih arterija deficiti mnestičkih funkcija (numeričkog, radnog, verbalno-mehaničkog, verbalno-logičkog i vizualnog pamćenja) i dolazi li tijekom vremena proteklog od operacije do oporavka mnestičkih funkcija. U istraživanju je sudjelovalo 92 bolesnika, i to 35 (38%) muškaraca i 57 (62%) žena, u dobi od 27 do 76 godina. Neuropsihologijska procjena provedena je u Klinici za neurokirurgiju Kliničkog bolničkog centra Zagreb u razdoblju od 1998. do 2012. godine u dva vremenska intervala: u prvih 11 mjeseci nakon operacije i ponovno 12 do 48 mjeseci nakon operacije. Dobiveni rezultati su pokazali da u prvom vremenskom intervalu postoje deficiti verbalno-mehaničkog, verbalno-logičkog i vizualnog pamćenja. U drugom vremenskom intervalu i dalje su bili prisutni deficiti verbalno-logičkog i vizualnog pamćenja, dok su na testu verbalno-mehaničkog učenja i pamćenja dobiveni rezultati pokazali da i dalje postoje poteškoće povezane s kapacitetom pamćenja i krivuljom učenja, a rezultati ispitivanja kratkoročnog i dugoročnog verbalno-mehaničkog pamćenja sada su bili u granicama očekivanih rezultata. Niti u prvom niti u drugom testiranju nije utvrđeno postojanje deficita numeričkog i radnog pamćenja. S obzirom na dobivene rezultate ovog istraživanja može se zaključiti da su se kratkoročno i dugoročno verbalno-mehaničko i vizualno pamćenje statistički značajno oporavili tijekom vremena proteklog od operacije, dok na testovima drugih vrsta pamćenja nije utvrđeno postojanje statistički značajnog oporavka

Recovery of Memory After Cerebral Artery Aneurysm Surgery

The principal study objective was to define whether memory deficits (numerical, working, verbal-mechanical, verbal-logical and visual memory) occurred in patients submitted to surgery for brain artery aneurysm and whether significant recovery of memory took place with time. The study sample included 92 patients, i.e. 35 (38%) male and 57 (62%) female patients aged 27 to 76 years. Neuropsychological testing was conducted at Zagreb University Hospital Centre, Department of Neurosurgery, from 1998 to 2012, in two time intervals: first within 11 months following surgery, and then 12 to 48 months after surgery. The obtained results showed that verbal-mechanical, verballogical, and visual memory deficits were present in the first testing interval. In the second testing, the verbal-logical and visual memory deficits were still present, while the tests of verbal-mechanical memory showed deficits in capacity and learning curve, but the results for short- and long-term memory were within the normal ranges. Neither the first nor the second testing showed deficits of numerical and working memory. Based on our results, we can conclude that long-term verbal-mechanical and visual short- and long-term memory had recovered to a statistically significant level, whereas other types of memory showed no significant recovery

Nursing Staffs’ Views on Physical and Psychosocial Care Provision in Slovenian Nursing Homes

The aim of this study was to explore nursing staffs’ perceptions of the physical and psychological care needs of elderly residents, their views on the relative importance of these needs and their perceived ability to meet them. The literature reveals that the quality of elder care in nursing homes should comprise both physical and psychosocial care. Despite this, the nursing staffs’ perceptions of the physical and psychosocial care provision have not often been researched. As a method cross-sectional research design was used, with structured questionnaires and unstructured interviews. Our sample consisted of members of the nursing staff from four nursing homes inSlovenia(survey: n=148; interview: n=16). The resulting data was processed by means of statistical analysis and conventional content analysis. The nursing staff reported more knowledge of, skills with and willingness to meet residents’ physical needs than psychosocial needs. On the other hand, communication, conversation, self-care and a home-like environment were considered by nursing staff as marking quality elder care. Consequently, nursing home administrators should try to strengthen psychosocial care provision to improve the residents’ quality of life. Conversation, as the most often recognised aspect of psychosocial care, should be promoted, since improvements in this area would not be costly, and each nursing staff member may decide individually how best to include more conversation in the daily routines of elder care provision

Oštećenje vida za boje u radnica izvrgnutih niskim razinama toluena

Colour vision was examined by the Lanthony-D-15 desaturated test in 41 women exposed to toluene and in 29 non-exposed referents. Toluene exposure was evaluated by methods ot environmental and biological monitoring. In the exposed group the median value of toluene in air was 35 ppm (range 11.2-49.9 ppm). Quantitative colour vision impairment was expressed as colour confusion index and colour confusion index corrected for alcohol intake. Qualitative impairment was expressed as normal, yellow-blue, red-green range or complex impairment. Statistical analysis showed the index values to be significantly correlated with age in both groups. In the exposed group they were significantly higher than in the non-exposed group. There was no significant difference in the prevalence of impairment in the blue-yellow range between the examined groups, although the prevalence of impairment in the exposed group was higher than in the non-exposed one. Results suggest that exposure to low toluene concentrations may induce colour vision impairment in women.Desaturacijskim testom Lanthony D-15 ispitivan je vid za boje u 41 radnice izvrgnute prosječnoj koncentraciji toluena u zraku od 35 ppm (raspon 11,2-49,9 ppm) i u 29 radnica kontrolne skupine. Kvalitativni vid za boje izražen je kao indeks pogreške i kao indeks pogreške korigiran za utjecaj alkohola, a kvalitativni vid kao normalan, s oštećenjern u plavo-žutom dijelu spektra ili kao složeno oštećenje. Rezultati su statistički analizirani t-testom i Mann-Whitneyevim U-testom. U obje su ispitivane skupine vrijednosti indeksa pogreške i indeksa pogreške korigiranog za utjecaj alkohola bile značajno povezane s dobi ispitanika. U skupini izloženoj toluenu njihove su vrijednosti bile statistički značajno više (P) nego u kontrolnoj skupini. Nije bilo statistički značajno učestalijeg oštećenja vida u žuto-plavom dijelu spektra. Rezultati upućuju na zaključak da u radnica izvrgnutih niskim koncentracijama toluena indeks pogreške značajno odstupa od očekivanoga, ali da kvalitativno oštećenje vida za boje nije učestalije nego u poredbenoj skupini

Histopatološke promjene u sirištima jelena lopatara na Brijunima - kratko priopćenje.

This study was performed to establish histopathological changes in the abomasa of fallow deer (Dama dama) from the Brijuni islands, in order to investigate the possible presence of Helicobacter species in this species, since literature data on abomasal histopathology are scarce, and data on the presence of Helicobacter species in red deer are absent. The study was performed on 23 abomasal samples taken from young adults (c. 1 year of age) shot in legal hunts. In all the samples inflammatory changes were visible. The histopathological findings from the samples examined were similar, indicating the epizootical nature of the disease, and they were similar to findings described in dogs with a gastric infection from Helicobacter-like organisms. However, in the abomasa of fallow deer Helicobacter organisms were not detected after the appropriate stains were applied, therefore the aetiological factor responsible for such histopathological changes has yet to be identified.Istraživanje je provedeno da bi se ustanovile patohistološke promjene u sirištima jelena lopatara (Dama dama) s brijunskog otočja i eventualna prisutnost Helicobacter vrsta u ove vrste, budući da je malo literaturnih podataka koji se tiču patohistoloških promjena u sirištu. Pregledom literature nismo pronašli niti jednu referencu o prisutnosti Helicobacter vrsta u jelena lopatara. Istraživanje je provedeno na 23 uzorka sirišta mladih odraslih jedinki (starosti oko godinu dana), žrtvovanih u redovitom odstrelu. U svim uzorcima ustanovljene su upalne promjene u sirištu. Patohistološki nalazi svih pregledanih uzoraka bili su slični, što ukazuje na epizootsku prirodu bolesti, te sličnost nalazima u želucima pasa inficiranih helikobakteru sličnim organizmima. Međutim, u sirištima jelena lopatara nakon obrade odgovarajućim tehnikama bojenja nismo ustanovili Helicobacter vrste, te zaključujemo da je etiološki čimbenik odgovoran za promjene nepoznat

Development of vaccines for HIV-1: relevance of subtype-specific cellular immunity

Han pasado casi 30 años de la detección de los primeros casos de infección con HIV-1 y aún no se ha conseguido desarrollar una vacuna efectiva y segura. A pesar del impacto positivo sobre la pandemia que se ha conseguido gracias a los avances en la terapia antirretroviral (TARV), el HIV/sida sigue constituyendo un grave problema para la salud pública, especialmente en los países en desarrollo, donde es difícil el acceso al tratamiento. En el mundo, 33 millones de personas viven con el virus del sida, mientras que en la Argentina se calcula que habría unos 120 000 infectados. Uno de los desafíos para lograr una vacuna contra el HIV es la variabilidad viral. El grupo M, responsable de la pandemia, se encuentra dividido en 10 subtipos y varios sub-subtipos, además de las 48 formas recombinantes circulantes y más de cien formas recombinantes únicas. La epidemia de HIV en nuestro país es tan compleja como en el resto del mundo, con la co-circulación principalmente de virus pertenecientes al subtipo B y recombinantes BF (CRF12_BF y derivadas). A pesar de la cantidad de trabajos dedicados a la caracterización de la respuesta inmune y al desarrollo de vacunas, no queda claro cuál es el impacto de la variabilidad en la elección del antígeno. Trabajos realizados en nuestro laboratorio demuestran el papel que juega la inmunidad celular con respecto a las variantes recombinantes BF, tanto en humanos como en modelos animales. Estos resultados son de importancia en el desarrollo de futuras vacunas para nuestra región.It has been almost 30 years since the detection of the first HIV-1 cases and yet an effective and safe vaccine has not been developed. Although, advances in antiretroviral therapy (HAART) have produced a major impact on the pandemic, and even though HIV/aids remains a major concern for developing countries, where access to therapy is limited. The last report from UNAIDS notified 33 million people living with HIV/aids, worldwide, while in Argentina it is estimated that 120 000 persons have been infected. One of the challenges to address and ultimately overcome when developing a vaccine is the high variability of HIV-1. The M group, responsible for the pandemic, is divided into 10 subtypes and several sub-subtypes, in addition to the 48 circulating recombinant forms (CRF) and over one hundred unique recombinant forms (URF). The HIV epidemic in Argentina is as complex as in the rest of the world, characterized by the high prevalence of infections caused by subtype B and BF variants. Despite the wide range of publications focused on the immune response against HIV as well as to vaccine development, how to overcome variability on vaccine antigen selection is still unclear. Studies performed in our laboratory showed the impact of the immunogenicity of BF recombinant variants, both in humans and in animal models. These results are of great concern in vaccine development for our region.Fil: Rodríguez, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia del Sida; ArgentinaFil: Turk, Gabriela Julia Ana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia del Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pascutti, María Fernanda. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia del Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Falivene, Juliana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia del Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gherardi, Maria Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia del Sida; Argentin

Biological evaluation and molecular modelling of didanosine derivatives

Five carbonate derivatives of 50-O-20,30-dideoxyinosine (DDI, 1) have been synthesized by combination with aliphatic alcohols, with their in vitro anti-HIV activity and cytotoxicity being evaluated afterward in human peripheral blood mononuclear cells (PBMCs). One particular compound, namely DDI-Penta, exhibited an outstanding performance because it was found to have both a higher inhibitory potency and a lower cytotoxicity than the lead compound, resulting in a 100 enhancement in its selectivity index. In order to further study this phenomenon, the ability of these derivatives to bind to the cytoplasmatic nucleotidase (ncN-II) was studied by in silico methods. Also, the higher calculated lipophilicity of the synthesized compounds was proposed to improve their permeability through the cell membrane since said lipophilicity would allow a higher concentration of the corresponding prodrug inside the infected cell. Overall, a combination of an optimal lipophilicity and the ability of DDI-Penta to bind to ncN-II is suggested due to the higher potency and lower cytotoxicity observed for this compound. Based on the reported findings, we believe that the combination of certain aliphatic alcohols and DDI through a carbonate linkage could significantly increase the performance of this class of therapeutic compounds; therefore, it merits further evaluations.Fil: Ravetti, Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Candia, Cristian Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Gualdesi, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Pampuro, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Quevedo, Mario Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Briñon, Margarita Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentin