Beyond the Innovation: An Exploratory Study of Designing Web-based Self-services

AbstractCustomized web-based self-services play an important role in today's product/service innovation. Compared to traditional tangible services, helpful web-based self-services and off-line services may better facilitate creativity, accelerate value co-creation, and reduce the costs and risks of development and commercialization. Therefore, in order to offer a conceptual framework for a web-based self-service system that enhances the fuzzy-front end (FFE) of new product/service development, this study analyzed the needs and challenges found during the transition of the Dechnology (Design Thinking plus Technology Innovation) project at the Industrial Technology Research Institute (ITRI), the largest R&D organization in Taiwan. Through literature review, in-depth interviews, and participatory action research, we formalized five core system modules, including: 1) user behavior and lifestyle, 2) thematic trend analysis, 3) technology screening and translation, 4) idea visualization, and 5) O2O service connection, with corresponding design principles for supporting user creativity in a web-based self-services environment. Finally, this study proposes a conceptual framework integrated with service design to serve as an important reference for enterprises that undergo similar innovation projects in the future

Projected Increase of the East Asian Summer Monsoon (Meiyu) in Taiwan by Climate Models With Variable Performance

The active phase of the East Asian summer monsoon (EASM) in Taiwan during May and June, known as Meiyu, produces substantial precipitation for water uses in all sectors of society. Following a companion study that analysed the historical increase in the Meiyu precipitation, the present study conducted model evaluation and diagnosis based on the EASM lifecycle over Taiwan. Higher and lower skill groups were identified from 17 Couple Model Intercomparison Project Phase 5 (CMIP5) models, with five models in each group. Despite the difference in model performance, both groups projected a substantial increase in the Meiyu precipitation over Taiwan. In the higher skill group, weak circulation changes and reduced low‐level convergence point to a synoptically unfavourable condition for precipitation. In the lower skill group, intensified low‐level southwesterly winds associated with a deepened upper level trough enhance moisture pooling. Thus, the projected increase in Meiyu precipitation will likely occur through the combined effects of (1) the extension of a strengthened North Pacific anticyclone enhancing southwesterlies; and (2) more systematically, the Clausius–Clapeyron relationship that increases precipitation intensity in a warmer climate. The overall increase in the Meiyu precipitation projected by climate models of variable performance supports the observed tendency toward more intense rainfall in Taiwan and puts its early June 2017 extreme precipitation events into perspective

A low-inclination neutral Trans-Neptunian Object in a extreme orbit

We present photometric observations and numerical simulations of 2016 SD$_{106}$, a low inclination ($i=4.8^{\circ}$) extreme trans-Neptunian Object with a large semi-major axis ($a=350$ au) and perihelion ($q= 42.6$ au). This object possesses a peculiar neutral color of $g-r = 0.45\pm0.05$ and $g-i=0.72\pm0.06$, in comparison with other distant trans-Neptunian objects, all of which have moderate-red to ultra-red colors. A numerical integration based on orbital fitting on astrometric data covering eight years of arc confirms that 2016 SD$_{106}$ is a metastable object without significant scattering evolution. Each of the clones survived at the end of the 1 Gyr simulation. However, very few neutral objects with inclinations $<5^{\circ}$ have been found in the outer solar system, even in the main Kuiper belt. Furthermore, most mechanisms which lift perihelion distances are expected to produce a very low number of extreme objects with inclinations $<5^{\circ}$. We thus explored the possibility that a hypothetical distant planet could increase the production of such objects. Our simulations show that no 2016 SD$_{106}$-like orbits can be produced from three Kuiper belt populations tested (i.e. plutinos, twotinos, and Haumea Family) without the presence of an hypothetical planet, while a few similar orbits can be obtained with it; however, the presence of the additional planet produces a wide range of large semimajor-axis / large perihelion objects, in apparent contradiction with the observed scarcity of objects in those regions of phase space. Future studies may determine if there is a connection between the existence of a perihelion gap and a particular orbital configuration of an hypothetical distant planet.Comment: 10 pages, 4 figures, 1 tables, accepted for publication in the ApJ Letter

Col-OSSOS: Z-Band Photometry Reveals Three Distinct TNO Surface Types

Several different classes of trans-Neptunian objects (TNOs) have been identified based on their optical and near-infrared colors. As part of the Colours of the Outer Solar System Origins Survey, we have obtained $g$, $r$, and $z$ band photometry of 26 TNOs using Subaru and Gemini Observatories. Previous color surveys have not utilized $z$ band reflectance, and the inclusion of this band reveals significant surface reflectance variations between sub-populations. The colors of TNOs in $g-r$ and $r-z$ show obvious structure, and appear consistent with the previously measured bi-modality in $g-r$. The distribution of colors of the two dynamically excited surface types can be modeled using the two-component mixing models from Fraser \& Brown (2012). With the combination of $g-r$ and $r-z$, the dynamically excited classes can be separated cleanly into red and neutral surface classes. In $g - r$ and $r - z$, the two dynamically excited surface groups are also clearly distinct from the cold classical TNO surfaces, which are red, with $g-r\gtrsim$0.85 and $r-z\lesssim$0.6, while all dynamically excited objects with similar $g-r$ colors exhibit redder $r-z$ colors. The $z$ band photometry makes it possible for the first time to differentiate the red excited TNO surfaces from the red cold classical TNO surfaces. The discovery of different $r-z$ colors for these cold classical TNOs makes it possible to search for cold classical surfaces in other regions of the Kuiper belt and to completely separate cold classical TNOs from the dynamically excited population, which overlaps in orbital parameter space.Comment: 11 pages, 2 figures, Accepted to A

Discovery of A New Retrograde Trans-Neptunian Object: Hint of A Common Orbital Plane for Low Semi-Major Axis, High Inclination TNOs and Centaurs

Although the majority of Centaurs are thought to have originated in the scattered disk, with the high-inclination members coming from the Oort cloud, the origin of the high inclination component of trans-Neptunian objects (TNOs) remains uncertain. We report the discovery of a retrograde TNO, which we nickname "Niku", detected by the Pan-STARRS 1 Outer Solar System Survey. Our numerical integrations show that the orbital dynamics of Niku are very similar to that of 2008 KV$_{42}$ (Drac), with a half-life of $\sim 500$ Myr. Comparing similar high inclination TNOs and Centaurs ($q > 10$ AU, $a 60^\circ$), we find that these objects exhibit a surprising clustering of ascending node, and occupy a common orbital plane. This orbital configuration has high statistical significance: 3.8-$\sigma$. An unknown mechanism is required to explain the observed clustering. This discovery may provide a pathway to investigate a possible reservoir of high-inclination objects.Comment: 18 pages, 4 figures, 1 table, accepted for publication in ApJ Letter

Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer

AbstractStatins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) inhibitors decreasing serum cholesterol and have shown promise in cancer prevention. In this study, we demonstrated the oncogenic role of HMGR in colorectal cancer (CRC) by disclosing increased HMGR activity in CRC patients and its enhancement of anti-apoptosis and stemness. Our previous studies showed that statins containing carboxylic acid chains possessed activity against histone deacetylases (HDACs), and strengthened their anti-HDAC activity through designing HMGR-HDAC dual inhibitors, JMF compounds. These compounds exerted anti-cancer effect in CRC cells as well as in AOM-DSS and ApcMin/+ CRC mouse models. JMF mostly regulated the genes related to apoptosis and inflammation through genome-wide ChIP-on-chip analysis, and Ingenuity Pathways Analysis (IPA) predicted their respective regulation by NR3C1 and NF-κB. Furthermore, JMF inhibited metastasis, angiogenesis and cancer stemness, and potentiated the effect of oxaliplatin in CRC mouse models. Dual HMGR-HDAC inhibitor could be a potential treatment for CRC

Col-OSSOS: The Colours of the Outer Solar System Origins Survey

The Colours of the Outer Solar System Origins Survey (Col-OSSOS) is acquiring near-simultaneous $g$, $r$, and $J$ photometry of unprecedented precision with the Gemini North Telescope, targeting nearly a hundred trans-Neptunian objects (TNOs) brighter than $m_r=23.6$ mag discovered in the Outer Solar System Origins Survey. Combining the optical and near-infrared photometry with the well-characterized detection efficiency of the Col-OSSOS target sample will provide the first flux-limited compositional dynamical map of the outer Solar System. In this paper, we describe our observing strategy and detail the data reduction processes we employ, including techniques to mitigate the impact of rotational variability. We present optical and near-infrared colors for 35 TNOs. We find two taxonomic groups for the dynamically excited TNOs, the neutral and red classes, which divide at $g-r \simeq 0.75$. Based on simple albedo and orbital distribution assumptions, we find that the neutral class outnumbers the red class, with a ratio of 4:1 and potentially as high as 11:1. Including in our analysis constraints from the cold classical objects, which are known to exhibit unique albedos and $r-z$ colors, we find that within our measurement uncertainty, our observations are consistent with the primordial Solar System protoplanetesimal disk being neutral-class-dominated, with two major compositional divisions in $grJ$ color space.Comment: Accepted to ApJS; on-line supplemental files will be available with the AJS published version of the pape