GENÇLERİN VE YAŞLILARIN YAŞLILIK SÜRECİNE İLİŞKİN GÖRÜŞLERİ: KARŞILAŞTIRMALI BİR ÇALIŞMA

The youth period, expressed as the process of transition from childhood to adulthood, is aprocess that has its own unique lifestyle, values, social life expectancy, views and problems, as well asphysical and mental change. The old age process, which is the last phase of life, similarly has its owncharacteristics. In addition to contributing to the socialization of the new generations by conveyingtheir experiences and knowledge they have gained over the years, the elderly, who have a reputationin the society, can cope with many problems in the aging process with their physical and mentalchanges. Therefore, the expectations, value judgments and views of the elderly and young , which arein different age groups, can be different from each other. This study is based on interviews with a totalof 15 young and 15 elderly individuals residing in Burdur Center to evaluate and compare thesituation of young people who are considered to be at the beginning of life and the elderly in the laststage of life. The obtained data were evaluated by categorical content analysis method and tried to beanalyzed by comparing the opinions of young and the elderly living in Burdur about the old ageprocess.Çocukluktan yetişkinliğe geçiş süreci olarak ifade edilen gençlik dönemi, fiziksel ve zihinseldeğişimin yanı sıra kendine özgü hayat tarzı, değerleri, toplumsal hayattan beklentileri, yaşama dairgörüşleri ve sorunları olan bir süreçtir. Buna karşılık yaşamın son evresi olan yaşlılık sürecinin dekendine özgü özellikleri bulunmaktadır. Toplumda bir saygınlığı olan yaşlıların yıllar itibariylekazandıkları deneyimlerini ve bilgilerini aktararak yeni nesillerin sosyalleşmesine katkısağlamalarının yanı sıra bu süreçte geçirdikleri bedensel ve zihinsel değişimlerle birlikte pek çoksorun yaşlılık sürecinde karşılarına çıkabilmektedir. Dolayısıyla farklı yaş gruplarında yer alangençlerin ve yaşlıların yaşlılık sürecine ilişkin beklentileri, değer yargıları ve görüşleri birbirindenfarklı olabilmektedir. Bu çalışma yaşamın başlangıcında sayılan gençlerin ve yaşamın son evresindeyer alan yaşlıların yaşlılık sürecine ilişkin görüşleri ile ilgili durumu değerlendirmek ve karşılaştırmakamacıyla Burdur Merkez’de ikamet eden toplam 15 genç ve 15 yaşlı bireyle yapılan görüşmeleredayanmaktadır. Elde edilen veriler kategorik içerik analizi yöntemi ile değerlendirilerek, Burdur’dayaşayan geçlerin ve yaşlıların yaşlılık sürecine ilişkin görüşleri karşılaştırılarak analiz edilmeyeçalışılmıştır

A dual role of proton pump inhibition on cancer: a critical review

Proton pump inhibitors (PPIs) are widely used to suppress gastric acid secretion. Proton pumps belong to the family of ATPase and among them P-ATPase and V-ATPase types regulate intracellular as well as extracellular acid equilibrium. The main aim of the current survey is to present the existing literature putting forth the relation between cancer with both the use of PPIs and proton pumps from positive and negative aspects. To perform an objective study, various types of proton pumps and their relation to cancer have been taken into account. Up to date, the studies have been considered in the time range from 2011 to 2021 via various databases (PubMed, Scopus, and Google Scholar). H+/K+ ATPase, located within the gastric parietal cells, is one of the most important examples of P-ATPases. The findings of the literature review along with criticism were presented as decreased P-ATPase expression can be used as a marker for gastric cancer diagnosis whereas the association of the proton pump with cancer may be mainly due to V-ATPase. In conclusion, molecular, epidemiological, and bioinformatic studies are required to enlighten the subject

Distribution of GABPB1 gene rs7181866 polymorphism in rugby players

929-932Nuclear respiration factor 2 is an important respiratory factor for cellular metabolism formed by polypeptides produced by the GA binding protein transcription factor subunit alpha (GABPA) and GA binding protein transcription factor subunit beta 1 (GAPPB1) genes. A functional polymorphism on the GABPB1 gene (rs7181866, G/A) alters the cellular respiration metabolism by affecting the protein dynamics. In this context, here, we examined the distribution of GABPB1 rs718186 polymorphism in professional rugby players to see its relationship with their stamina. Twelve rugby players participated in the study. Genotyping was performed by Real-Time PCR after DNAs were isolated from blood cells using commercially available isolation kits. In our cohort, the AA genotype and the A allele were superior to the AG and GG genotypes and the G allele. There was no statistically significant difference in terms of Genotypes (p=0.9027) and allelic groups (p=0.6948) in the athlete and control groups. Studies have revealed the relationship between endurance characteristics of athletes and rs7181866 AA genotype and A allele. These studies will be an important data source for future studies in sports genetics and GAPPB1 analysis

Management of Paragangliomas in Otolaryngology Practice: Review of a 7-Year Experience

Background and Aims: Paragangliomas of the head and neck are highly vascular lesions originating from paraganglionic tissue located at the carotid bifurcation (carotid body tumors), along the vagus nerve (vagal paragangliomas), and in the jugular fossa and tympanic cavity (jugulotympanic paragangliomas) and should be considered in the evaluation of all lateral neck masses. The aim of this study is to review an institutional experience in the management of these tumors

Evaluation of 25-hydroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic: A cross-sectional study and trend analysis involving 86,772 samples

Background The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic. Methods In this retrospective, cross-sectional and methodological study included 86,772 patients (18-75 years) samples who were admitted to the Izmir Dokuz Eylul University Hospital (latitude and longitude (Turkey): 27 E 09; 38 N 25, respectively) for various reasons and whose 25(OH)D levels were measured in the biochemistry unit between 2019-2020 and 2020- 2021 (before and during the COVID-19 outbreak). A time series analysis of monthly averages for 25(OH)D was performed. For the purpose of seasonal study, the mean levels of 25 (OH)D are grouped by years. Data were modeled in terms of 25(OH)D levels using the MATLAB Curve Fitting Toolbox. Results There was no significant difference between the sexes according to 25(OH)D levels (p>0.05). 25(OH)D levels were significantly higher in the summer months and lower in the winter months (p<0.001). When comparing the spring months, 25(OH)D levels in 2020 (18 ± 10) were found to be significantly lower than in 2019 (22 ± 12) (p<0.001); on the contrary, when examined based on the summer, autumn, and winter months, it was determined that 25(OH)D levels increased in 2020 (summer: 25 ± 13, autumn: 25 ± 14, and winter: 19 ± 10) compared to 2019 (summer: 23 ± 11, autumn: 22 ± 10, and winter: 19 ± 11) (p<0.001). In the estimates curve obtained with an error margin of 11% in the time series analysis, it was estimated that the 25(OH)D averages after the pandemic would be similar to those before the pandemic. Conclusions Restrictions, partial or complete closures, and curfews can significantly affect individuals' 25 (OH)D levels during the COVID-19 outbreak. There is a need for multicenter studies with larger populations covering different regions to strengthen and support our results

Prognostic Factors of Sudden Sensorineural Hearing Loss in Children

Objective: To evaluate the prognostic factors of sudden sensorineural hearing loss (SSNHL) in children

Resisting urban renewal in Istanbul

In this article I examine grassroots responses to state-directed urban renewal in two poor neighborhoods in Istanbul. Through detailed analysis of resident perspectives and urban association tactics, I explore various factors that shape the trajectories of resistance to urban renewal, including solidarity networks, levels of participation and trust in local neighborhood associations, strength of neighborhood identity, extra-local support, and the traditions and channels of negotiation with state actors. I argue that these factors are articulated by a distinct “politics of compensation”—a term that I borrow from Ananya Roy—that is particular to the contemporary neoliberal condition. I find that grassroots mobilizations in Istanbul do not necessarily operate in opposition to neoliberalism; in fact, many struggles remain within the conceptual space of neoliberalism and its cost-benefit calculations. These findings contribute to the emerging literature on struggles against urban renewal in the global south