Érotique du dépôt légal

Situé par-delà le bien et le mal, s\u27il est un lieu où le jugement moral n\u27intervient pas, c\u27est bien le dépôt légal. Agissant pour ces publications comme une réserve naturelle, en retour il trouve en elles sa pleine justification

Age-appropriate and acceptable paediatric dosage forms: Insights into end-user perceptions, preferences and practices from the Children's Acceptability of Oral Formulations (CALF) Study

A lack of evidence to guide the design of age-appropriate and acceptable dosage forms has been a longstanding knowledge gap in paediatric formulation development. The Children’s Acceptability of Oral Formulations (CALF) study captured end-user perceptions and practices with a focus on solid oral dosage forms, namely tablets, capsules, chewables, orodispersibles, multiparticulates (administered with food) and mini-tablets (administered directly into the mouth). A rigorous development and testing phase produced age-adapted questionnaires as measurement tools with strong evidence of validity and reliability. Overall, 590 school children and adolescents, and 428 adult caregivers were surveyed across hospitals and various community settings. Attitudes towards dosage forms primarily differed based on age and prior use. Positive attitudes to tablets and capsules increased with age until around 14 years. Preference was seen for chewable and orodispersible preparations across ages, while multiparticulates were seemingly less favourable. Overall, 59.6% of school children reported willingness to take 10mm diameter tablets, although only 32.1% of caregivers perceived this size to be suitable. While not to be taken as prescriptive guidance, the results of this study provide some evidence towards rational dosage form design, as well as methodological approaches to help design tools for further evaluation of acceptability within paediatric studies

CONSEQUENCES OF CRM CAPABILITIES DIMENSIONS ON CUSTOMER SATISFACTION AND MARKET EFFECTIVENESS

In today’s business environment the main challenge for companies is gaining and maintaining a competitive advantage. A potential source of competitive advantage is customer relationship management (CRM) capabilities. The main contribution of this paper is that we proposed and tested a research model that includes one antecedent and two consequences of CRM capabilities dimensions - customer interaction management (CIM) capability, customer relationship upgrading (CRU) capability and customer win-back (CWB) capability. In this study, we use data from a sample of 102 firms acting in B2B and B2C settings in Romania to investigate how customer relationship orientation (CRO) influences the three dimensions of CRM capabilities, and furthermore, how these dimensions determine customer satisfaction and market effectiveness - two performance outcomes. Our results reveal that CRO has a direct effect on these CRM capabilities. Critically, we found that only CIM capability and CWB capability drives customer satisfaction, while market effectiveness is driven by CRU capability. This paper also discusses the implication of this study, presents managerial implications and the limitations of this research, and provides avenues for further research