Reusable Ionogel-based Photo-actuators in a Lab-on-a-disc

This paper describes the design, fabrication and performance of a reusable ionogel-based photo-actuator, in-situ photopolymerised into a lab-on-a-disc microfluidic device, for flow control. The ionogel provides an effective barrier to liquids during storage of reagents and spinning of the disc. A simple LED (white light) triggers actuation of the ionogel for selective and precise channel opening at a desired location and time. The mechanism of actuation is reversible, and regeneration of the actuator is possible with an acid chloride solution. In order to achieve regeneration, the Lab-on-a-Disc device was designed with a microchannel connected perpendicularly to the bottom of the ionogel actuator (regeneration channel). This configuration allows the acid solution to reach the actuator, independently from the main channel, which initiates ionogel swelling and main channel closure, and thereby enables reusability of the whole device.Economía y Competitividad), Spain. This project has receivedfunding from the European Union Seventh Framework Programme(FP7) for Research, Technological Development and Demonstrationunder grant agreement no. 604241. JS and FBL acknowledge fund-ing support from Gobierno de Espa˜na, Ministerio de Economía yCompetitividad, with Grant No. BIO2016-80417-P and personallyacknowledge to Marian M. De Pancorbo for letting them to use herlaboratory facilities at UPV/EHU. A.T., L.F., and D.D. are grateful forfinancial support from the Marie Curie Innovative Training Net-work OrgBIO (Marie Curie ITN, GA607896) and Science FoundationIreland (SFI) under the Insight Centre for Data Analytics initiative,Grant Number SFI/12/RC/2289

Poly(ionic Liquid) Thermo-responsive Hydrogel Microfluidic Actuators

tributylhexyl phosphonium sulfopropylacrylate (PSPA) poly(ionic liquid) (PILc) hydrogels as temperature controlled actuators in microfluidic devices. The hydrogel size is modulated by localised changes in its temperature due to the lower critical solution temperature (LCST) behaviour exhibited by PSPA.A.T., L.F., and D.D. are grateful for financial support from the Marie Curie Initial Training Network OrgBIO funded by the European Community’s FP7 People Programme (Marie Curie ITN, GA607896), J.S., F.B.L. and D.D. also acknowledge funding from the European Union’s Seventh Framework Programme (FP7) for Research, Technological Development and Demonstration under grant agreement no. 604241 (NAPES) and L.F. and D.D. acknowledge funding from Science Foundation Ireland (SFI) under the Insight Centre for Data Analytics initiative, Grant Number SFI/12/RC/2289. F.B.L. acknowledges the Ramón y Cajal Programme (Ministerio de Economía y Competitividad) and to Marian M. De Pancorbo for letting him to use her laboratory facilities at UPV/EHU

ДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ МЕЖДИСЦИПЛИНАРНОГО ПОДХОДА В БОРЬБЕ С ТУБЕРКУЛЕЗОМ КАК ПОЛИОРГАННОЙ И КОМОРБИДНОЙ ПАТОЛОГИЕЙ В РЕСПУБЛИКЕ МОЛДОВА

Despite that the turning point was achieved in tuberculosis control in the world, still there is on-going interest to this social disease.Goal: to evaluate changes of main epidemiological rates, to publish achievements and prospects of the implementation of National tuberculosis control programme for the period after 2015.Materials and methods. Comparative analysis included evolution of tuberculosis in various localizations in 2011-2015.Results. Tuberculosis situation has been gradually improving in the Republic of Moldova for the last 5 years. The data evidence about the number of tuberculosis cases going down but the global burden of the disease remains fairly high. The success in tuberculosis control supported by WHO and other international organizations is also related to certain Moldavian research achievements.Conclusion. Due to diversity of clinical forms of tuberculosis and the growing problem of comorbidity the cross-disciplinary approach to tuberculosis control can assure success of these activities. Несмотря на то что в борьбе с туберкулезом (ТБ) в мире наступил переломный момент, к этому социально значимому заболеванию сохраняется неослабевающий интерес.Цель: оценка динамики основных эпидемиологических показателей, освещение достижений и перспектив реализации Национальной программы по борьбе с ТБ на период после 2015 г.Материалы и методы. Проведен сравнительный анализ эволюции ТБ различных локализаций в 2011-2015 гг. Результаты. Последнее пятилетие характеризуется постепенным улучшением эпидемической ситуации по ТБ в Республике Молдова. Приведенные данные свидетельствуют о том, что число заболевших ТБ продолжает уменьшаться, но глобальное бремя болезни в целом остается еще весомым. Отмечаемые успехи в борьбе с ТБ при поддержке ВОЗ и других международных организаций связаны в том числе и с отечественными научными достижениями.Заключение. В связи с многообразием клинических форм ТБ и нарастающей проблемой коморбидности залогом успеха борьбы с этим заболеванием может быть междисциплинарный подход

ACHIEVEMENTS AND PROSPECTS OF CROSS-DISCIPLINARY APPROACH TO TUBERCULOSIS CONTROL AS A MULTI-ORGAN AND COMORBID PATHOLOGY IN MOLDOVA REPUBLIC

Despite that the turning point was achieved in tuberculosis control in the world, still there is on-going interest to this social disease.Goal: to evaluate changes of main epidemiological rates, to publish achievements and prospects of the implementation of National tuberculosis control programme for the period after 2015.Materials and methods. Comparative analysis included evolution of tuberculosis in various localizations in 2011-2015.Results. Tuberculosis situation has been gradually improving in the Republic of Moldova for the last 5 years. The data evidence about the number of tuberculosis cases going down but the global burden of the disease remains fairly high. The success in tuberculosis control supported by WHO and other international organizations is also related to certain Moldavian research achievements.Conclusion. Due to diversity of clinical forms of tuberculosis and the growing problem of comorbidity the cross-disciplinary approach to tuberculosis control can assure success of these activities