2D continuous spectrum of shear Alfven waves in the presence of a magnetic island

The radial structure of the continuous spectrum of shear Alfven modes is calculated in the presence of a magnetic island in tokamak plasmas. Modes with the same helicity of the magnetic island are considered in a slab model approximation. In this framework, with an appropriate rotation of the coordinates the problem reduces to 2 dimensions. Geometrical effects due to the shape of the flux surface's cross section are retained to all orders. On the other hand, we keep only curvature effects responsible of the beta induced gap in the low-frequency part of the continuous spectrum. New continuum accumulation points are found at the O-point of the magnetic island. The beta-induced Alfven Eigenmodes (BAE) continuum accumulation point is found to be positioned at the separatrix flux surface. The most remarkable result is the nonlinear modification of the BAE continuum accumulation point frequency

Partial purification and MALDI-TOF MS analysis of UN1, a tumor antigen membrane glycoprotein.

UN1 is a membrane glycoprotein that is expressed in immature human thymocytes, a subpopulation of peripheral T lymphocytes, the HPB acute lymphoblastic leukemia (ALL) T-cell line and fetal thymus. We previously reported the isolation of a monoclonal antibody (UN1 mAb) recognizing the UN1 protein that was classified as "unclustered" at the 5th and 6th International Workshop and Conference on Human Leukocyte Differentiation Antigens. UN1 was highly expressed in breast cancer tissues and was undetected in non-proliferative lesions and in normal breast tissues, indicating a role for UN1 in the development of a tumorigenic phenotype of breast cancer cells. In this study, we report a partial purification of the UN1 protein from HPB-ALL T cells by anion-exchange chromatography followed by immunoprecipitation with the UN1 mAb and MALDI-TOF MS analysis. This analysis should assist in identifying the amino acid sequence of UN

A multichannel reflectometer for edge density profile measurements at the ICRF antenna in ASDEX upgrade

A multichannel reflectometer will be built for the new three-straps ICRF antenna of ASDEX Upgrade (AUG), to study the density behavior in front of it. Ten different accesses to the plasma are available for the three reflectometer channels that can be interchanged without breaking the machine vacuum. Frequency is scanned from 40 GHz to 68 GHz, in 10 mu s, which corresponds to a cut-off density ranging from 10(18) divided by 10(19)m(-3) in the Right cut-off of the X-mode propagation, for standard toroidal magnetic field values of AUG

Implementation of the new multichannel X-mode edge density profile reflectometer for the ICRF antenna on ASDEX Upgrade

A new multichannel frequency modulated continuous-wave reflectometry diagnostic has been successfully installed and commissioned on ASDEX Upgrade to measure the plasma edge electron density profile evolution in front of the Ion Cyclotron Range of Frequencies (ICRF) antenna. The design of the new three-strap ICRF antenna integrates ten pairs (sending and receiving) of microwave reflectometry antennas. The multichannel reflectometer can use three of these to measure the edge electron density profiles up to 2 x 10(19) m(-3), at different poloidal locations, allowing the direct study of the local plasma layers in front of the ICRF antenna. ICRF power coupling, operational effects, and poloidal variations of the plasma density profile can be consistently studied for the first time. In this work the diagnostic hardware architecture is described and the obtained density profile measurements were used to track outer radial plasma position and plasma shape

Coupling and near-field simulations of ion-cyclotron antennas: Numerical validation of the perfectly matched layer technique for several density profiles

A simplified, flat, plasma-loaded, ion-cyclotron antenna has been simulated using three different modeling approaches and a comparison of simulation outputs is presented in this paper. Several plasma profiles with different density gradients and distances between the antenna and the cutoff density have been used as benchmark for the numerical simulations, which have been run at 30 MHz by means of two tools. The one is the TOrino Polythecnic Ion-Cyclotron Antenna (TOPICA) code that has been repeatedly used and validated for this type of problems. The other tool is the finite-element method (FEM) of a commercial software, where inhomogeneous anisotropic materials can be defined and the perfectly matched layer technique can be adopted. In this tool, two models of antenna load have been implemented: an equivalent dielectric, locally matching the perpendicular propagation constant of the fast wave in the plasma, and a cold plasma model. The simulation results by such models are compared with the results by TOPICA, which relies on a 1-D inhomogeneous, hot plasma

A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules

A 24-amino acid leader peptide of a new human recombinant manganese superoxide dismutase can enter cells and carry molecules. Here, we demonstrated that six of the 24 amino acids penetrate cells through a particular gate represented by a specific amino acid sequence of the oestrogen receptor (ER). We analysed the internalization of the synthetic hexapeptide and the cytotoxic activity of the hexapeptide conjugated to cisplatin on a cell line panel. In most cell lines, the hexapeptide delivered an amount of cisplatin that was 2 to 8 times greater than that released by cisplatin when the drug was used alone. This increased delivery increases the therapeutic index of cisplatin and reduces side effects caused by a high dosage or long-term treatment times. We may consider this hexapeptide a new molecular carrier to deliver molecules with therapeutic activity into ER+ cells for diagnostic purposes and clinical or immune therapy

A Multiwavelength Continuum Characterization of High-Redshift Broad Absorption Line Quasars

We present the results of a multiwavelength study of a sample of high-redshift radio-loud (RL) broad absorption line (BAL) quasars. This way, we extend to higher redshift previous studies on the radio properties and broad-band optical colours of these objects. We have selected a sample of 22 RL BAL quasars with 3.6 ≤ z ≤ 4.8 cross-correlating the FIRST radio survey with the Sloan Digital Sky Survey (SDSS). Flux densities between 1.25 and 9.5 GHz have been collected with the Jansky Very Large Array and Effelsberg-100 m telescopes for 15 BAL and 14 non-BAL quasars used as a comparison sample. We determine the synchrotron peak frequency, constraining their age. A large number of gigahertz peaked spectrum and high-frequency peakers sources have been found in both samples (80 per cent for BAL and 71 per cent for non-BAL quasars), not suggesting a younger age for BAL quasars. The spectral index distribution provides information about the orientation of these sources, and we find statistically similar distributions for the BAL and non-BAL quasars in contrast to work done on lower redshift samples. Our sample may be too small to convincingly find the same effect, or might represent a real evolutionary effect based on the large fraction of young sources. We also study the properties of broad-band colours in both optical (SDSS) and near- and mid-infrared (UK Infrared Telescope Deep Sky Survey and Wide-field Infrared Survey Explorer –WISE) bands, finding that also at high-redshift BAL quasars tend to be optically redder than non-BAL quasars. However, these differences are no more evident at longer wavelength, when comparing colours of the two samples by mean of the WISE survey

Conceptual Design of a Variable Geometry, Axial Flow Turbocharger Turbine

The modern automotive industry is under strict regulations to reduce emissions to comply with the Kyoto Protocol, a universally acknowledged treaty aiming at reducing exhaust gas emissions. In order to achieve the required future emission reduction targets, further developments on gasoline engines are required. One of the main methods to achieve this goal is the application of engine downsizing. Turbocharging is a cost-effective method of downsizing an engine whilst reducing exhaust gas emissions, reducing fuel consumption and maintaining prior performance outputs. For these reasons, the turbocharging is becoming the most widely adopted technology in the automotive markets. In 2012, 32% of passenger and commercial vehicles sold had a turbocharger installed, and is predicted to be 40% of 2017 [1]. Even if the engine turbocharging is a widespread technology, there are still drawbacks present in current turbocharging systems. The main problem is overcoming the issue of turbo-lag, which is the poor initial response of the turbocharger to the driver commands due to its inertia. Indeed, the system turbine plus compressor is characterized by an own rotational inertia, therefore, the turbocharger will take a certain time to accelerate and produce the desired boost when a higher amount of exhaust gas is sent to the system. In this work, an innovative solution to the turbo-lag phenomenon will be analyzed: a vaneless stator-axial flow turbine. The proposed turbine configuration would improve the transient response of the system since the axial turbine has intrinsically a lower inertia than the radial turbine as stated by the research works of Ford first [2] and Honeywell after [3]. The whole design process is presented in this paper and particular relevance has been given to the thermo-fluid-dynamic aspect of the machine. Several CFD investigations have been carried out in order to deeply understand the new turbine behavior and, thanks to a 1D model of the target engine, it has been possible to validate the new design simulating the performance of the system engine + turbocharger

Cost-utility and biological underpinnings of Mindfulness-Based Stress Reduction (MBSR) versus a psychoeducational programme (FibroQoL) for fibromyalgia: a 12-month randomised controlled trial (EUDAIMON study)

Background: The EUDAIMON study focuses on fibromyalgia syndrome (FMS), a prevalent chronic condition characterized by pain, fatigue, cognitive problems and distress. According to recent reviews and meta-analyses, Mindfulness-Based Stress Reduction (MBSR) is a promising therapeutic approach for patients with FMS. The measurement of biomarkers as part of the analysis of MBSR effects would help to identify the neurobiological underpinnings of MBSR and increase our knowledge of FMS pathophysiology. The main objectives of this 12-month RCT are: firstly, to examine the effectiveness and cost-utility for FMS patients of MBSR as an add-on to treatment as usual (TAU) versus TAU + the psychoeducational programme FibroQoL, and versus TAU only; secondly, to examine pre-post differences in brain structure and function, as well as levels of specific inflammatory markers in the three study arms and; thirdly, to analyse the role of some psychological variables as mediators of 12-month clinical outcomes. Methods: Effectiveness, cost-utility, and neurobiological analyses performed alongside a 12-month RCT. The participants will be 180 adult patients with FMS recruited at the Sant Joan de Déu hospital (St. Boi de Llobregat, Spain), randomly allocated to one of the three study arms: TAU + MBSR vs. TAU + FibroQol vs. TAU. A comprehensive assessment to collect functional, quality of life, distress, costs, and psychological variables will be conducted pre-, post-intervention, and at 12-month post-intervention. Fifty per cent of study participants will be evaluated at pre- and post-treatment using Voxel-Based Morphometry, Diffusion Tensor Imaging, pseudo-continuous Arterial Spin Labeling, and resting state fMRI. A cytokine multiplex kit of high-sensitivity will be applied (cytokines IL-6, IL-8, IL-10 + high-sensitivity CRP test). Discussion: The findings obtained from this RCT will indicate whether MBSR is potentially cost-effective for FMS and contribute to knowledge of any brain and inflammatory changes associated with MBSR in FMS patients. Specifically, we will determine whether there are morphometric and functional changes associated with participation in MBSR in brain regions related to meta-awareness, body awareness, memory consolidation-reconsolidation, emotion regulation and in networks postulated to underpin the sensory-discriminative, cognitive-evaluative and affective-motivational aspects of the pain experience. Trial registration: NCT02561416. Registered 23 September 201