Предиктивная и прогностическая значимость явления потери гетерозиготности в генах ABC-транспортеров в опухоли молочной железы

ABC-transporter family genes have been well studied and their involvement in the development of drug resistance has been assessed. The presence of aberrant conditions in these genes can affect the treatment and prognosis of the disease. Loss of heterozygosity (LOH) is one of these conditions; it is a common event in cancer development. Therefore, the aim of this study was to investigate the relationship between LOH in ABC transporter genes in breast cancer and response to chemotherapy and disease prognosis. Material and Methods. A total of 130 breast cancer patients were included in the study. Microarray analysis was performed on Affymetrix CytoScan™ HD Array high-density DNA chips to assess LOH status. Chromosome Analysis Suite 4.1 software (Affymetrix, USA) was used to process microarray results. Results. Forty-nine ABC transporter genes were evaluated for LOH. The frequency of LOH ranged from 6.9 % to 90 %. An association analysis identified two genes: ABCG5 and ABCG8, in which the presence of LOH was associated with a lack of objective response to neoadjuvant chemotherapy. The presence of LOH in the ABCA5, ABCA6, ABCA8, ABCA9, ABCA10 and ABCC3 genes was associated with high rates of metastasis-free survival (log-rank test, p<0.04). conclusion. The presence of loss of heterozygosity in the ABC transporter genes was found to have no significant effect on the response to chemotherapy. However, a high prognostic potential of ABCA family genes was found

Training Specialists in the Field of Innovative Financial Technologies in Russia

Formation of educational programs for new types of activity is a complex task that should be solved on the basis of interaction between educational institutions and the professional community, assessment of the current market demand for specialists with certain competencies. But the task becomes much more complicated if the need for specialists is growing rapidly, and the community of professionals is just being formed and cannot have the proper impact on the educational services market. In this case, the educational infrastructure, under certain conditions, can become a controlling component of market development, but it can also become a factor in false goal-setting and inhibition of development.The popularity of financial technologies among the population and applicants prompts higher educational institutions to form educational programs, which are often criticized, and graduates do not always gain employment in accordance with their diploma qualifications. There is a contradiction between the expectations of the labor market, which have not yet been formalized, and the supply from Russian educational institutions.Purpose. The article aims to formulate proposals for the standardization of requirements for specialists in innovative financial technologies (FinTech) based on the consolidation and analysis of the opinions of companies professionally involved in FinTech. Research methods. The authors applied generalization and empirical research methods such as selective market research, statistical observation. Results. The results of an empirical study on the existing educational programs in the sphere of financial technology (Fintech) are presented. Scientific novelty. It is shown that in the conditions of an underdeveloped market and the initial stage of a professional community development, educational infrastructure can become a tool for market development based on a common understanding and standardization of educational competencies and programming of its further development. Practical significance. Taking into account the results obtained, conclusions were formulated that make it possible to substantiate the need to introduce an independent assessment of the formed qualifications into the educational process

THE CONTRIBUTION OF SELF-REGULATION, SCHOOL ENGAGEMENT AND MOTIVATION OF EIGHTH GRADERS TO COGNITIVE ACTIVITY IN THE 9TH GRADE

Regulatory and motivational predictors of cognitive activity in pre-examination grades 8 and 9 are analyzed on the basis of longitudinal research. Indicators of conscious self-regulation, school engagement and disengagement, academic motivation are studied as predictors. The assumption was verified that students with different attitudes towards learning in grade 8 differ in the resources (regulatory and motivational) of cognitive activity in grade 9.Анализируются регуляторные и мотивационные предикторы познавательной активности в предэкзаменационных 8–9 классах на материале лонгитюдного исследования. В качестве предикторов изучаются показатели осознанной саморегуляции, школьной вовлеченности и безучастности, академической мотивации. Проверку получило предположение о том, что учащиеся с различным отношением к учению в 8-м классе различаются ресурсами (регуляторными и мотивационными) познавательной активности в 9-м классе.Исследование выполнено при финансовой поддержке Российского научного фонда (РНФ) в рамках научного проекта № 20-18-00470 «Саморегуляция и школьная вовлеченность как психологические ресурсы академической успешности: лонгитюдное исследование»

Review of the some specific features of the detecting of heavy recoils

In this paper, we present the results of the first beam tests of the detection system at the focal plane of the Dubna Gas-Filled Recoil Separator-2 (DGFRS-2), which receives beams from the DC-280 FLNR cyclotron. The high beam intensity of $^{48}$Ca$^{+10}$ heavy ions from the cyclotron enables us to obtain a number of superheavy recoils sufficient to compare both the measured and calculated spectra of superheavy recoils implanted into a silicon detector. A real-time algorithm to search for an Evaporation Residue (ER) -- $\alpha$ correlated sequences is described in brief. It should be noted that the DGFRS-2 spectrometer operates in conjunction with the 48x128 strip DSSD (Double-sided Silicon Strip Detector; 48x226 mm2) detector and a low-pressure pentane-filled gaseous detector (1.2 Torr; 80x230 mm$^2$). A block-diagram of the spectrometer and the event format are also presented. Special attention is paid to the response of a low-pressure pentane-filled DeltaE multiwire proportional chamber for recoils of Fl, synthesized in the $^{242}$Pu+$^{48}$Ca $\to$ $^{287}$Fl +3n complete fusion nuclear reaction. Some actual parameters of the detection system have also been extracted from $^{\rm nat}$Yb + $^{48}$Ca, $^{232}$Th + $^{48}$Ca, $^{243}$Am + $^{48}$Ca, $^{238}$U + $^{48}$Ca reactions. The effect of neighbor strip charge sharing for the ohmic side of the DSSD detector is also under consideration.Comment: 18 page