The Relationship between the Efficacy of Tonsillectomy and Renal Pathology in the Patients with IgA Nephropathy

Objective. The aim of this study was to evaluate the effects of tonsillectomy as a treatment for IgA nephropathy in relation to renal pathological findings. Methods. This is a retrospective analysis of 13 patients having IgA nephropathy treated by tonsillectomy. Results. UP/UCre levels decreased from 820.8 to 585.4 one month postsurgery and then showed slight worsening to 637.3 at the most recent follow-up. There was no significant difference in the improvement rate between pathological grades I–III and IV. There was positive correlation between Pre-UP/UCre level and the reduction rate of UP/UCre, which was statistically significant (R = 0.667, R2 = 0.445, and P=0.01). Conclusions. Reduction of UP/UCre at one month postsurgery is considered to be an overall prognostic factor, and tonsillectomy is considered to be an effective therapy for IgA patients regardless of the grade of renal pathology

Tubo-ovarian abscess in a patient with cri du chat syndrome: A case report

A tubo-ovarian abscess is an infection that occurs as a sequela of pelvic inflammatory disease. There is no reported association between a tubo-ovarian abscess and cri du chat syndrome in the medical literature. Herein, we report the case of a 44-year-old woman with cri du chat syndrome who was subsequently diagnosed with a tubo-ovarian abscess. After emergent laparotomy, simple total hysterectomy, and bilateral adnexectomy, the patient was discharged 13 days postoperatively without complications

A Gauge-Mediation Model with a Light Gravitino of Mass O(10) eV and the Messenger Dark Matter

In the light of recent experimental data on gaugino searches, we revisit the direct-transmission model of dynamical supersymmery breaking with the gravitino mass m_{\tilde{G}}\leq 16 eV, which does not have any cosmological or astrophysical problems. We find that in the consistent regions of parameter space, the model predicts not only upper bounds on superparticle masses (1.1 TeV, 320 GeV, 160 GeV, 5 TeV, 1.5 TeV and 700 GeV for gluino, Wino, Bino, squarks, left-handed sleptons and right-handed sleptons, respectively), but also a mass of the lightest messenger particle in the range of 10-50 TeV. The lightest messenger particle can naturally be a messenger sneutrino. Therefore, this may suggest that the messenger sneutrino could be the dark matter, as proposed recently by Hooper and March-Russel to account for the gamma-ray spectrum from the galactic center observed by HESS experiment.Comment: 11 pages, 3 figure

Nambu-Goldstone Dark Matter and Cosmic Ray Electron and Positron Excess

We propose a model of dark matter identified with a pseudo-Nambu-Goldstone boson in the dynamical supersymmetry breaking sector in a gauge mediation scenario. The dark matter particles annihilate via a below-threshold narrow resonance into a pair of R-axions each of which subsequently decays into a pair of light leptons. The Breit-Wigner enhancement explains the excess electron and positron fluxes reported in the recent cosmic ray experiments PAMELA, ATIC and PPB-BETS without postulating an overdensity in halo, and the limit on anti-proton flux from PAMELA is naturally evaded.Comment: 3 figure

Comparison of Postoperative Complications after Endoscopic Submucosal Dissection: Differences of Insufflations and Anesthesias

Endoscopic submucosal dissection (ESD) has enabled the collective resection and increased the accuracy of pathological diagnosis. However, ESD requires a long operation time, which results in increased doses of analgesics/sedatives, and causes worsening of respiratory and hemodynamic statuses. To reduce postoperative complications, we have applied ESD with CO2 insufflation and general anesthesia. This study included 50 patients who underwent ESD for early gastric cancer, 25 with air insufflation and intravenous anesthesia (Air/IV group), and the remaining 25 with CO2 insufflation and general anesthesia (CO2/GA group). Postoperative enlarged feeling of the abdomen was observed only in 1 of 25 patients in the CO2/GA group (P = 0.0416). Postoperative severe unrest was observed in none of the patients in the CO2/GA group and in 4 of 25 (16%) patients in the Air/IV group (P = 0.0371). CO2 insufflation and general anesthesia are useful in stabilizing intraoperative conditions and reducing postoperative complications

External Pancreatic Juice Drainage Through a Percutaneous Endoscopic Drainage Tube for the Patient With a Postoperative Pancreatic Juice Leakage

Percutaneous endoscopic gastrostomy (PEG) has been widely accepted for patients who have no swallowing ability but have an intact gut. Its clinical application is mainly for nutritional support and decompression of the intestine in patients with bowel obstruction. In this paper, we report external pancreatic juice drainage through a percutaneous endoscopic drainage tube in a patient with postoperative pancreatic juice leakage. Soon after this procedure, pancreatic juice leakage subsided. This procedure was minimally invasive for the patient and may be a new application of PEG to maintain the good quality of life (QOL) in a patient with pancreatic juice leakage

Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice

金沢大学医学部附属病院薬剤部We examined whether the oral bioavailability of cyclosporin A is controlled primarily by P-glycoprotein (P-gp) or CYP3A in the small intestine. In situ loop method was used to evaluate the uptake of cyclosporin A (40 nmol) at the upper and lower intestine of wild-type and mdr1a/1b knockout mice treated or not treated with dexamethasone (75 mg/kg/day, 7 days, i.p.). Expression of CYP3A mRNA in the control group was higher in the upper than the lower intestine, while that of the multidrug resistance-1a (mdr1a) mRNA was in the opposite order. Dexamethasone administration potently induced CYP3A and mdr1a mRNAs in the lower and upper intestine, respectively. At 45 min after cyclosporin A administration into an upper intestinal loop of the control group of wild-type mice, the ratio of residual cyclosporin A to dose did not differ significantly from that of mdr1a/1b knockout mice, whereas in dexamethasone-treated wild-type mice, the residual ratio was increased significantly. The ratio of the cyclosporin A metabolite M17 to cyclosporin A in portal venous blood at an upper intestinal loop of mdr1a/1b knockout mice was much higher than that a lower intestinal loop. The M17/cyclosporin A ratio of portal venous blood at a lower intestinal loop in mdr1a/1b knockout mice was increased significantly by dexamethasone treatment. These results suggest that, under physiological conditions, the oral bioavailability of cyclosporin A is mainly controlled by CYP3A in the upper intestine, rather than liver, but when P-gp is induced by steroid, the intestinal absorption of cyclosporin A may be inhibited. © 2006 Elsevier Inc. All rights reserved

R&D Progress of HTS Magnet Project for Ultrahigh-field MRI

Proceedings of the 28th International Symposium on Superconductivity (ISS 2015) November 16-18, 2015, Tokyo, JapanAn R&D project on high-temperature superconducting (HTS) magnets using rare-earth Ba2Cu3O7 (REBCO) wires was started in 2013. The project objective is to investigate the feasibility of adapting REBCO magnets to ultrahigh field (UHF) magnetic resonance imaging (MRI) systems. REBCO wires are promising components for UHF-MRI magnets because of their superior superconducting and mechanical properties, which make them smaller and lighter than conventional ones. Moreover, REBCO magnets can be cooled by the conduction-cooling method, making liquid helium unnecessary. In the past two years, some test coils and model magnets have been fabricated and tested. This year is the final year of the project. The goals of the project are: (1) to generate a 9.4 T magnetic field with a small test coil, (2) to generate a homogeneous magnetic field in a 200 mm diameter spherical volume with a 1.5 T model magnet, and (3) to perform imaging with the 1.5 T model magnet. In this paper, the progress of this R&D is described. The knowledge gained through these R&D results will be reflected in the design of 9.4 T MRI magnets for brain and whole body imaging