ザイタク キョジャク オヨビ ヨウ カイゴ コウレイシャ ニ オケル カイゴドベツ シンタイ キノウ ノ ケントウ

The purpose of this research is to examine body functions in a regional weak living and the nursing necessary senior citizen and the relations to the nursing necessary level. [Subject]:A regional weak living and needed nursing 167 senior citizens were targeted. [Method]:The object person was analyzed, and the crowd division was done according to the nursing level, and the relation between body functions and the nursing level was analyzed. [Result]: The nursing level decreases the capacity of balance, the lower limbs muscular power, the whole body endurance, and the ambulatory ability and the ability has decreased with advancing. However, the relation to the nursing level was not admitted as for the arm muscular power and flexibility. [Conclusion]: It was suggested that it was necessary to make the best use of this result for the programs aimed at preventing elderly people requiring nursing care from further losing physical and mental strength

Plasmon-Enhanced Photocatalytic Activity of Cadmium Sulfide Nanoparticle Immobilized on Silica-Coated Gold Particles

Nanocomposite photocatalysts of CdS nanoparticles immobilized on Au core–SiO₂ shell particles, in which the SiO₂ layer acts as an insulator layer to prevent direct electron transfer from photoexcited CdS to Au particles, were prepared. The photocatalytic activity of CdS particles for H₂ evolution was greatly dependent on the distance between CdS and Au particles, due to the locally enhanced electric field produced by photoexcitation of the localized surface plasmon resonance (LSPR) peak of Au particles. Increase in Au core size enlarged the optimal distance between Au and CdS for the enhancement of photocatalysis. This behavior was theoretically reproduced by solving a self-consistent equation system, in which the range of energy dissipation became wider for larger diameter of the Au sphere, and then the balance with the enhancement of photoexcitation of CdS particles by the LSPR-induced electric field was changed

Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous matrix metalloproteinase inhibitors. TIMP1 is produced by cancer cells and has pleiotropic activities. However, its role and source in multiple myeloma (MM) are unclear. Here, we evaluated TIMP1 protein and mRNA levels in bone marrow (BM) plasma cells and assessed the effects of TIMP1 expression on fibroblast invasive capacity using three-dimensional spheroid cell invasion assays. TIMP1 mRNA and protein levels were elevated when patients progressed from monoclonal gammopathy of undetermined significance or smouldering myeloma to MM. Furthermore, TIMP1 levels decreased at complete response and TIMP1 protein levels increased with higher international staging. TIMP1 mRNA levels were markedly higher in extramedullary plasmacytoma and MM with t(4;14). Overall survival and post-progression survival were significantly lower in MM patients with high TIMP1 protein. Recombinant TIMP1 did not directly affect MM cells but enhanced the invasive capacity of fibroblasts; this effect was suppressed by treatment with anti-TIMP1 antibodies. Fibroblasts supported myeloma cell invasion and expansion in extracellular matrix. Overall, these results suggested that MM-derived TIMP1 induces the invasive phenotype in fibroblasts and is involved in disease progression. Further studies are required to elucidate the specific roles of TIMP1 in MM and facilitate the development of novel therapies targeting the TIMP1 pathway