Empirical Calculation Method of Bypass Leakage in Scroll Compressors

This study presents an empirical method to calculate the bypass leakage mass flow rate along the tip seal in a scroll compressor. The leakage flows through small axial and radial clearances between the orbiting and fixed scrolls of scroll compressor were previously studied by Ishii et al. In these earlier studies, the pressure decay in the pressurized vessel due to leakage through the axial and radial clearances was measured using a maximum pressure of 3 MPa for CO2 and 0.6 MPa for R22. The Darcy-Weisbach equation for incompressible, viscous fluid flow through the thin rectangular cross-section was applied to calculate the leakage mass flow rate that matched the pressure decay characteristics. The empirical friction factors were determined and plotted on a Moody diagram. As a result, the empirical friction factors for both axial and radial clearance leakage flows have been determined and shown to take on essentially the same value for both CO2 and R22, despite the significantly different working pressures. In contrast, the flow patterns in bypass leakage along the tip seal are so complicated that not even the leakage characteristics are known definitively. No method exists for calculating the bypass leakage mass flow rate. In the present study, a bypass leakage model was constructed, compatible with a production-type scroll compressor with a large cooling capacity. A similar test of the pressure decay in the pressurized vessel due to bypass leakages were conducted with the refrigerant gas R410A. The measured pressure decay characteristics were then simulated by the Darcy-Weisbach equation with the empirical friction factors from our previous study for the leakage flow through the axial clearance. In the present simulations of the measured pressure decay, the complicated flow patterns through bypass clearances were classified into two representative rectangular thin cross-section leakage passes, one with an equivalent width and the other with an equivalent length. Empirical friction factor values for the equivalent pass width and length were determined to match the measured pressure decays. As a result, the calculation of the bypass leakage flow rate along the tip seal in scroll compressors can be accomplished using a simple scheme in terms of the equivalent pass width and equivalent pass length for two representative leakage passes forming a thin rectangular cross-section and applying empirically determined friction factors,

Hydrodynamic-Pressure-Induced Elastic Deformation of Thrust Slide-Bearings in Scroll Compressors and Oil Film Pressure Increase Due to Oil Envelopment

This paper presents the concept of the Elasto-Hydrodynamic Lubrication?EHL?of thrust slide-bearings in scroll compressors, resulting in the superior lubrication characteristics of these bearings. The thrust plate undergoes elastic deformation due to axial loading, resulting in the formation of a uniform fluid wedge between the orbiting and fixed thrust plates. This wedge region has very high induced oil film pressure, which explains the remarkably good lubrication characteristics of the thrust slide-bearing. Furthermore, the high oil film pressure induces further local elastic deformation of the thrust plate, forming an EHL oil pocket with the thrust plate and a further increase in the oil film pressure between the sliding surfaces due to this oil envelopment. The formation of the EHL pocket was confirmed using FEM analysis and lubrication tests on the elastic deformation of the thrust plate. Subsequently, the additional increase in oil film pressure, due to the EHL pocket effect, was examined in computer simulations applying the average Reynolds equation for the boundary of elastic deformation of the thrust plate. In these studies, a 6.7% increase in oil film pressure was ascertained for a small cooling capacity scroll compressor driven at 3600 rpm with 0.1 kW motor. The oil envelopment contributes to the superior lubrication performance of the thrust slide bearings scroll compressors

Optimization of EHL Lubrication Performance in Thrust Slide-Bearings of Scroll Compressors

Previous studies [Refs. 1, 2] revealed the formation of a uniform oil wedge at the periphery of the thrust plate, caused by the elastic deformation of the orbiting thrust plate due to the pressure difference across the orbiting thrust plate, is a significant factor in the high lubrication performance in thrust slide-bearings. In addition to the uniform wedge formation, the high oil film pressure also induces a local elastic deformation of the fixed thrust plate normal to its surface. The normal thrust plate deformation and the oil wedge effectively form an elasto-hydrodynamic-lubrication (EHL) pocket, even more effectively increasing the oil film pressure between the sliding surfaces, due to the envelopment of the oil, as confirmed in our companion paper [3], and an earlier, less-detailed contribution [4]. The present study focuses on aspects of EHL that have both positive and negative effects on the lubrication performance of the thrust slide-bearings in scroll compressors. Theoretical calculations using the average Reynolds equation and Patier-Chen solid contact theory, for the boundary of the local elastic deformation of the thrust slide-bearing, were conducted for a small cooling capacity scroll compressor driven at 3600 rpm with 0.1 kW. An approximate method was developed using characteristic curves to determine the oil film axial force, the average oil film thickness, the frictional force and the frictional coefficient. The calculations considered a variety of pressure differences due to the operation pressure and the thickness of thrust plate. Also cases with a fixed uniform wedge angle at the periphery were calculated. The calculated results suggest a possible maximum reduction in frictional coefficient of about 55% compared to that with a fixed uniform wedge angle. The reduction rate increases with decreasing thrust plate thickness, which, however, restricts the operation pressures to a lower pressure range. Design guidelines for optimizing EHL will be suggested. References: [1] Oku, T., Ishii, N., Anami, K., Knisely, C.W., Sawai, K., Morimoto, T., Hiwata, A. : Theoretical Model of Lubrication Mechanism in the Thrust Slide-Bearing of Scroll Compressors, HVAC&R Research Journal ASHRAE Vol.14, No.2, pp.239-358, 2008-3. [2] Ishii, N., Oku, T., Anami, K., Knisely, C.W., Sawai, K., Morimoto, T., Iida, N. : Experimental Study of the Lubrication Mechanism for Thrust Slide Bearings in Scroll Compressors, HVAC&R Research Journal ASHRAE Vol.14, No.2, 2008-4. [3] Ishii, N., Tsuji, T., Anami, K., Nokiyama, K., Morimoto, T., Sakuda, A., Oku, T., Sawai, K., Knisely, C.W., : “Hydrodynamic-Pressure-Induced Elastic Deformation of Thrust Slide-Bearings in Scroll Compressors and Oil Film Pressure Increase Due to Oil Envelopment,” abstract submitted to 2014 Purdue Herrick Conferences. [4] Ishii, N., Tsuji, T., Oku, T., Anami, K., Knisely, C.W., Nokiyama, K., Morimoto, T., Sakuda, A., Sawai, K. 2012 “Elasto-Hydrodynamic Lubrication Effect in Thrust-Slide Bearings of Scroll Compressors,” 2012 Purdue Conference Paper on (Paper 1438)

Combined use of CSF NfL and CSF TDP-43 improves diagnostic performance in ALS:A comprehensive analysis on diagnostic and prognostic significance of plasma and CSF NfL, TDP-43, and tau

Objective To determine the diagnostic and prognostic significance of neurofilament light chain (NfL), TAR DNA-binding protein 43 (TDP-43), and total tau (t-tau) in cerebrospinal fluid (CSF) and plasma of patients with amyotrophic lateral sclerosis (ALS) and to investigate whether the combined use of those biomarker candidates can improve their diagnostic performance. Methods This was a single-center, prospective, longitudinal study. CSF and plasma samples were collected at the time of enrollment from a discovery cohort of 29 patients with ALS and 29 age-matched controls without neurodegenerative disease. In a validation cohort, there were 46 patients with ALS, and 46 control (not age-matched) patients with motor weakness resulting from neuromuscular diseases. NfL, TDP-43, and t-tau levels in CSF and plasma were measured using ultrasensitive single molecule assay (Simoa) technology. Results The following findings were reproducibly observed among the discovery and validation cohorts: increased levels of CSF NfL, plasma NfL, and CSF TDP-43 in ALS compared with control groups; shorter survival associated with higher levels of CSF and plasma NfL. When the CSF NfL and CSF TDP-43 levels were combined, the areas under the ROC curves (AUC) were slightly improved relative to AUCs for each biomarker alone. Interpretation CSF and plasma NfL may not only serve as diagnostic biomarkers but also provide a measure of disease progression. CSF TDP-43 is also useful as a diagnostic biomarker of ALS, but has no prognostic value. The combined use of CSF NfL and CSF TDP-43 may be a useful biomarker for the diagnosis of ALS

Five-year quality of life assessment after carbon ion radiotherapy for prostate cancer

The aim of this study was to prospectively assess 5-year health-related quality of life (HRQOL) of patients treated with carbon ion radiotherapy (C-ion RT) for clinically localized prostate cancer. A total of 417 patients received carbon ion radiotherapy at a total dose of 63–66 Gray-equivalents (GyE) in 20 fractions over 5 weeks, and neoadjuvant and adjuvant androgen deprivation therapy (ADT) were administered for intermediate and high-risk patients. A HRQOL assessment was performed at five time points (immediately before the initiation of C-ion RT, immediately after, and at 12, 36 and 60 months after completion of C-ion RT) using Functional Assessment of Cancer Therapy (FACT) questionnaires. FACT-G and FACT-P scores were significantly decreased; however, the absolute change after 60 months was minimal. The transient decreases in the Trial Outcome Index (TOI) score returned to their baseline levels. Use of ADT, presence of adverse events, and biochemical failure were related to lower scores. Scores of subdomains of FACT instruments indicated characteristic changes. The pattern of HRQOL change after C-ion RT was similar to that of other modalities. Further controlled studies focusing on a HRQOL in patients with prostate cancer are warranted

Significant impact of biochemical recurrence on overall mortality in patients with high-risk prostate cancer after carbon-ion radiotherapy combined with androgen deprivation therapy

BACKGROUNDWhether biochemical recurrence (BR) is a significant predictive factor of mortality after definitive radiation therapy for prostate cancer remains unknown. The aim of the current study was to investigate the relation between BR and overall mortality (OAM) in high-risk prostate cancer patients who were treated with carbon-ion radiotherapy (CIRT) and had long-term follow-up in 2 prospective trials.METHODSIn the 2 phase 2 clinical trials, which involved 466 prostate cancer patients who received 63.0 to 66.0 Gy of CIRT (relative biological effect) in 20 fractions between 2000 and 2007, 324 patients who were deemed to be at high risk on the basis of the modified D\u27Amico classification criteria and received CIRT along with androgen-deprivation therapy (ADT) were examined. The OAM rate was adjusted for the ADT duration, and multivariate analyses using a Cox proportional hazards model were performed for OAM with BR as a time-dependent covariate.RESULTSThe median follow-up period was 107.4 months, and the 5- and 10-year OAM rates after adjustments for the ADT duration were 7.0% (95% confidence interval [CI], 4.0%-9.4%) and 23.9% (95% CI, 16.4%-26.2%), respectively. A multivariate analysis revealed that the presence of BR (hazard ratio, 2.82; 95% Cl, 1.57-5.08; P = .001) was one of the predictive factors for OAM. On the other hand, the duration of ADT had no impact on OAM.CONCLUSIONSBR after CIRT combined with ADT is an independent predictive factor for OAM in high-risk prostate cancer patients. The results of this study could be applied to other high-dose radiation therapies

High-Resolution Spectroscopy of Extremely Metal-Poor Stars from SDSS/SEGUE: I. Atmospheric Parameters and Chemical Compositions

Chemical compositions are determined based on high-resolution spectroscopy for 137 candidate extremely metal-poor (EMP) stars selected from the Sloan Digital Sky Survey (SDSS) and its first stellar extension, the Sloan Extension for Galactic Understanding and Exploration (SEGUE). High-resolution spectra with moderate signal-to-noise (S/N) ratios were obtained with the High Dispersion Spectrograph of the Subaru Telescope. Most of the sample (approximately 80%) are main-sequence turnoff stars, including dwarfs and subgiants. Four cool main-sequence stars, the most metal-deficient such stars known, are included in the remaining sample. Good agreement is found between effective temperatures estimated by the SEGUE stellar parameter pipeline, based on the SDSS/SEGUE medium-resolution spectra, and those estimated from the broadband (V – K)[subscript 0] and (g – r)[subscript 0] colors. Our abundance measurements reveal that 70 stars in our sample have [Fe/H] +0.7) among the 25 giants in our sample is as high as 36%, while only a lower limit on the fraction (9%) is estimated for turnoff stars. This paper is the first of a series of papers based on these observational results. The following papers in this series will discuss the higher-resolution and higher-S/N observations of a subset of this sample, the metallicity distribution function, binarity, and correlations between the chemical composition and kinematics of extremely metal-poor stars