157 research outputs found
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MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis.
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 01/06/2015
- Field of study
Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data. We provide an open-source software pipeline, which we call MS-DIAL, for DIA-based identification and quantification of small molecules by mass spectral deconvolution. For a reversed-phase LC-MS/MS analysis of nine algal strains, MS-DIAL using an enriched LipidBlast library identified 1,023 lipid compounds, highlighting the chemotaxonomic relationships between the algal strains
Observations of quiet-time moderate midlatitude L-band scintillation in association with plasma bubbles
- Author
- BA Carter
- BM Ledvina
- BM Ledvina
- BW Reinisch
- BW Reinisch
- C Haldoupis
- CA Miller
- CS Huang
- FS Rodrigues
- FW Perkins
- G Ma
- G Wautelet
- G Wautelet
- GG Bowmen
- GS Bust
- GW Prölss
- H. Haralambous
- KJW Lynn
- KJW Lynn
- L Alfonsi
- L Ciraolo
- L Kersley
- LA Hajkowicz
- LA Hajkowicz
- LC Gentile
- M Aquino
- M Fujita
- M Mendillo
- M. Aquino
- PM Kintner
- S Basu
- S Basu
- S Ji
- S. Vadakke Veettil
- SY Su
- T Maruyama
- T Ogawa
- T Tsugawa
- VV Paznukhov
- X Pi
- Y Otsuka
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Observations of moderate night time amplitude scintillation on the GPS L1C/A signal were recorded at the midlatitude station of Nicosia, corresponding geographic latitude and longitude of 35.18˚N and 33.38˚E respectively, on a geomagnetically quiet day. The variations of slant total electron content (STEC) and amplitude scintillation index (S4) on the night of June 12, 2014, indicate the presence of electron density depletions accompanying scintillation occurrence. The estimated apparent horizontal drift velocity and propagation direction of the plasma depletions are consistent with those observed for the equatorial plasma bubbles, thus suggesting that the moderate amplitude L-band scintillation observed over Nicosia may be associated with the extension of such plasma bubbles. The L-band scintillation occurrence was concurrent with the observations of range spread F on the ionograms recorded by the digisonde at Nicosia. The height–time–intensity plot generated using the ionogram data also showed features which can be attributed to off-angle reflections from electron density depletions, thus corroborating the STEC observations. This observation suggests that the midlatitude ionosphere is more active even during geomagnetically quiet days than previously thought and that further studies are necessary. This is particularly relevant for the GNSS user community and related applications
The Evolution of Compact Binary Star Systems
- Author
- A Ahmad
- A Blaauw
- A Bragaglia
- A Burrows
- A Burrows
- A Burrows
- A Büning
- A Cooray
- A Corongiu
- A Duquennoy
- A Gianninas
- A Heger
- A Kashi
- A Kusenko
- A Massevitch
- A Menon
- A Nebot Gómez-Morán
- A Noriega-Crespo
- A Noutsos
- A Palacios
- A Skumanich
- A Stroeer
- A Stroeer
- A Tornambé
- A Ulla
- A Wongwathanarat
- AA Zdziarski
- AC Fabian
- AE Rosenbush
- AG Kuranov
- AG Kuranov
- AG Lyne
- AG Lyne
- AG Lyne
- AG Massevich
- AG Massevitch
- AG Riess
- AH Prestwich
- AI Bogomazov
- AI Karakas
- AJ Farmer
- AJ Faulkner
- AJ Faulkner
- AJ Loveridge
- AJ Ruiter
- AJ Ruiter
- AJ Ruiter
- AJT Poelarends
- AL Kraus
- AL Piro
- AL Piro
- AL Piro
- AM Cherepashchuk
- AM Cherepashchuk
- AM Cherepashchuk
- AR King
- AR King
- AS Endal
- AS Oliveira
- AV Fedorova
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AW Hotan
- B Külebi
- B Külebi
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paxton
- B Paxton
- B Voss
- B Wang
- B Warner
- B Warner
- B Willems
- B Willems
- B Willems
- B Willems
- B-Q For
- BC Barish
- BD Mason
- BD Mason
- BD Metzger
- BE Schaefer
- BJ Shappee
- BJ Shappee
- BMS Hansen
- BP Flannery
- BS Sathyaprakash
- BT Gänsicke
- BT Hayden
- BW Ritchie
- C Badenes
- C Cutler
- C Foellmi
- C Georgy
- C Georgy
- C Georgy
- C Holcomb
- C Karl
- C Kim
- C Knigge
- C Knigge
- C Motch
- C Palenzuela
- C Raskin
- C Raskin
- C Ritossa
- C Weidner
- C-A Faucher-Giguère
- C-A Faucher-Giguère
- CA Whyte
- CD Bailyn
- CD Bailyn
- CJ Deloye
- CJ Philp
- CL Fryer
- CL Fryer
- CL Fryer
- CL Fryer
- CL Fryer
- CL Rodriguez
- CO Heinke
- CR Evans
- D Bhattacharya
- D Branch
- D Foss
- D Gerosa
- D Grossman
- D Hils
- D Hils
- D Ibeling
- D Kasen
- D Koester
- D Koester
- D Kushnir
- D Lai
- D Lai
- D Levitan
- D Lommen
- D Maoz
- D Prialnik
- D Prialnik
- D Prialnik
- D Raghavan
- D Schiminovich
- D Vanbeveren
- DA Dale
- DA Howell
- DJ Champion
- DJ Nice
- DJ Nice
- DL Kaplan
- DM Townsley
- DM Townsley
- DR Lorimer
- DW Schuerman
- E Bear
- E Berger
- E Cappellaro
- E Cappellaro
- E Donder De
- E Donder De
- E Donder De
- E Ergma
- E Ergma
- E García-Berro
- E Kuulkers
- E Livne
- E Livne
- E Nakar
- E Pfahl
- E Pfahl
- E Pfahl
- E Pylyser
- E Schatzman
- E Schatzman
- E-M Pauli
- EE Salpeter
- EF Keane
- EI Popova
- EI Popova
- EJ Lentz
- EL Robinson
- EL Robinson
- EM Green
- EM Sion
- EM Sion
- EM Sion
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- ES Phinney
- F Acernese
- F Camilo
- F D’Antona
- F Espinosa Lara
- F Foucart
- F Herwig
- F Herwig
- F Koliopanos
- F Ozel
- F Ozel
- F Patat
- F Ricci
- F Verbunt
- F Verbunt
- F Yuan
- FB Bianco
- FR Boffi
- FR Stephenson
- FS Kitaura
- FX Timmes
- FX Timmes
- G Duchêne
- G Giampieri
- G Hobbs
- G Lü
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Pandey
- G Ramsay
- G Ramsay
- G Stasińska
- G Tovmassian
- GE Brown
- GE Brown
- GE Soberman
- GH Tovmassian
- GHA Roelofs
- GHA Roelofs
- GJ Savonije
- GL Israel
- GP Kuiper
- GS Bisnovatyi-Kogan
- GS Bisnovatyi-Kogan
- GS Bisnovatyi-Kogan
- GS Bisnovatyi-Kogan
- H Belkus
- H Bondi
- H Ge
- H Ge
- H Ritter
- H Saio
- H Saio
- H Sana
- H Sana
- H Susa
- H-T Janka
- H-T Janka
- HA Abt
- HA Bethe
- HA Kobulnicky
- HB Perets
- HC Harris
- HC Spruit
- HC Spruit
- HHB Lau
- HS Zapolsky
- I Brott
- I Dominguez
- I Domínguez
- I Domínguez
- I Hachisu
- I Hachisu
- I Hachisu
- I Hachisu
- I Hachisu
- I Hachisu
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Idan
- I Kotko
- I Kowalska
- I Mandel
- IF Mirabel
- IF Mirabel
- IH Stairs
- IH Stairs
- IR Seitenzahl
- IS Shklovskii
- J Abadie
- J Abadie
- J Boersma
- J Casares
- J Crowder
- J Faulkner
- J Faulkner
- J Fuller
- J Fuller
- J Girven
- J Guillochon
- J Isern
- J Isern
- J Liebert
- J Nordhaus
- J Papaloizou
- J Schwab
- J Smak
- J Whelan
- J-C Passy
- J-C Passy
- J-E Solheim
- J-E Solheim
- J-E Solheim
- J-P Lasota
- J-U Ness
- JA Edlund
- JA Freitas Pacheco de
- JA Frieman
- JA Orosz
- JA Orosz
- JA Orosz
- JA Orosz
- JB Lamb
- JC Lombardi Jr
- JCA Miller-Jones
- JDM Dewi
- JDM Dewi
- JE Faller
- JE Gunn
- JE McClintock
- JE McClintock
- JE Pringle
- JG Mengel
- JH Shiode
- JH Taylor
- JJ Drake
- JJ Hermes
- JJM Zand in’t
- JM Lattimer
- JM Lattimer
- JM Silverman
- JM Silverman
- JM Silverman
- JM Weisberg
- JM Weisberg
- JP Cox
- JP Greve De
- JPA Clark
- JPA Clark
- JR Hurley
- JR Hurley
- JR Maund
- JS Bloom
- JSW Claeys
- JW Truran
- JW Truran
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Hotokezaka
- K Lepo
- K Moore
- K Nomoto
- K Nomoto
- K Nomoto
- K Nomoto
- K Riles
- K Siellez
- K Somiya
- K Takahashi
- K Yagi
- K-C Pan
- KA Postnov
- KA Postnov
- KA Postnov
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KK Ghosh
- KM Blundell
- KS Thorne
- KS Thorne
- L Bildsten
- L Bildsten
- L Bildsten
- L Chomiuk
- L Chomiuk
- L Dessart
- L Guillemot
- L Kreidberg
- L Mahy
- L Mestel
- L Mestel
- L Piersanti
- L Piersanti
- L Piersanti
- L Piersanti
- L Siess
- L Siess
- L Siess
- L Trepl
- L-X Li
- LA Nelson
- LD Landau
- LD Landau
- LG Althaus
- LM Close
- LM Haaften van
- LM Haaften van
- LM Haaften van
- LP Grishchuk
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LZ Kelley
- M Bailes
- M Burgay
- M Burgay
- M Dan
- M Dan
- M Dan
- M Dominik
- M Dominik
- M Fink
- M Fukugita
- M Gilfanov
- M Gilfanov
- M Hamuy
- M Henze
- M Hicken
- M Ilkov
- M Kato
- M Kato
- M Kato
- M Kato
- M Kilic
- M Kilic
- M Kilic
- M Kool de
- M Kromer
- M Kromer
- M Livio
- M Livio
- M Nauenberg
- M Plavec
- M Politano
- M Reggiani
- M Rieutord
- M Rigault
- M Rigault
- M Tavani
- M Tsugawa
- M Val-Borro de
- M Yamanaka
- M Zorotovic
- M Zorotovic
- MA Ruderman
- MBN Kouwenhoven
- MBN Kouwenhoven
- MBN Kouwenhoven
- MCP Bours
- MCP Bours
- MCR D’Souza
- ME Alexander
- ME Beer
- ME Prokhorov
- MM Kasliwal
- MM Kasliwal
- MM Phillips
- MM Shara
- MM Shara
- MP Muno
- MR Bate
- MR Drout
- MS Hjellming
- MT Botticella
- MTB Nielsen
- MTB Nielsen
- MV Barkov
- MV Sluys van der
- N Andersson
- N Brandt
- N Chamel
- N Epelstain
- N Gehrels
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Langer
- N Langer
- N Panagia
- N Smith
- N Soker
- N Soker
- N Tominaga
- N Vranesevic
- N Wex
- N Yusof
- NI Shakura
- NJ Cornish
- NM Ashok
- NM Gosnell
- NN Chugai
- NN Chugai
- NN Chugai
- NR Tanvir
- NV Raguzova
- O Birnholtz
- O Graur
- O Graur
- O Marco De
- O Marco De
- O Schnurr
- O Yaron
- OF Dorofeev
- OR Pols
- P Amaro-Seoane
- P Amaro-Seoane
- P André
- P Astier
- P Bagot
- P Eggleton
- P Esposito
- P Gil-Pons
- P Hoeflich
- P Höflich
- P Kahabka
- P Kahabka
- P Lorén-Aguilar
- P Madau
- P Munar-Adrover
- P Podsiadlowski
- P Podsiadlowski
- P Podsiadlowski
- P Podsiadlowski
- P Rodríguez-Gil
- P Ruiz-Lapuente
- P Szypryt
- PA Crowther
- PA Crowther
- PA Crowther
- PA Denissenkov
- PA Woudt
- PA Woudt
- PC Peters
- PD Kiel
- PD Kiel
- PD Sackett
- PE Nugent
- PFL Maxted
- PG Jonker
- PG Pérez-González
- PJ Carter
- PJ Carter
- PJ Carter
- PJ Carter
- PL Bender
- PM Motl
- PM Ricker
- PM Ricker
- PP Eggleton
- R Canal
- R Canal
- R Canal
- R Chini
- R Fender
- R Giacconi
- R Mochkovitch
- R Moll
- R Morrison
- R Napiwotzki
- R Napiwotzki
- R Napiwotzki
- R Narayan
- R Narayan
- R O’Shaughnessy
- R Pakmor
- R Scalzo
- R Scalzo
- R Stefano Di
- R Stefano Di
- R Stefano Di
- R Takahashi
- R Tylenda
- R Voss
- R Waldman
- R Wesson
- RA Chevalier
- RA Chevalier
- RA Chevalier
- RA Chevalier
- RA Hulse
- RA Remillard
- RA Saffer
- RA Saffer
- RA Wade
- RC Kennicutt
- RD Ferdman
- RE Falcon
- RE Taam
- RE Taam
- RE Williams
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RH Durisen
- RJ Dewey
- RJ Foley
- RJ Parker
- RK Kopparapu
- RL Barone-Nugent
- RLM Corradi
- RN Manchester
- RP Kraft
- RS Benson
- RW Romani
- RW Romani
- RW Sayer
- S Babak
- S Cassisi
- S Ekström
- S Fabrika
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Horiuchi
- S Ji
- S Johnston
- S Jones
- S Jones
- S Justham
- S Miyaji
- S Mohamed
- S Neo
- S Nissanke
- S Nissanke
- S Oslowski
- S Perlmutter
- S Rappaport
- S Rappaport
- S Rappaport
- S Refsdal
- S Repetto
- S Rosswog
- S Shah
- S Shah
- S Starrfield
- S Starrfield
- S Starrfield
- S Starrfield
- S Taubenberger
- S Toonen
- S Toonen
- S Vennes
- S Vereshchagin
- S Yu
- S Yu
- S-B Qian
- S-C Yoon
- S-C Yoon
- S-C Yoon
- S-C Yoon
- SA Colgate
- SA Sim
- SB Anderson
- SB Popov
- SC Vila
- SE Thorsett
- SE Timpano
- SE Woosley
- SE Woosley
- SE Woosley
- SF Portegies Zwart
- SF Portegies Zwart
- SF Portegies Zwart
- SH Lubow
- SL Larson
- SL Shapiro
- SN Shore
- SP Littlefair
- SS Kumar
- T Abel
- T Bulik
- T Dermine
- T Fragos
- T Kupfer
- T Linden
- T Linden
- T Nugis
- T Pan
- T Shahbaz
- T Wettig
- T-W Wong
- TA Prince
- TB Littenberg
- TE Woods
- TE Woods
- TE Woods
- TF Cartwright
- TJ Maccarone
- TM Tauris
- TM Tauris
- TM Tauris
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- U Heber
- V Gokhale
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- VA Brumberg
- VG Kornilov
- VG Kornilov
- VM Kaspi
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VN Mironovskii
- VS Petrov
- VV Davydov
- W Benz
- W Fong
- W Li
- W Li
- W-R Hamann
- WE Kerzendorf
- WE Kerzendorf
- WK Rose
- WM Farr
- WM Sparks
- WM Wolf
- WR Brown
- WR Brown
- X Meng
- X Wang
- X Zhang
- X-J Xu
- X-J Xu
- Y Osaki
- YA Fadeyev
- YA Fadeyev
- YB Zel’dovich
- YV Baryshev
- Z Barkat
- Z Han
- Z Han
- Z Han
- Z Han
- Z Han
- Z Kopal
- Z Li
- Z-W Liu
- ZW Liu
- ÉÉ Flanagan
- Publication venue
- 'Living Reviews'
- Publication date
- 03/01/2007
- Field of study
We review the formation and evolution of compact binary stars consisting of
white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and
BHs are thought to be the primary astrophysical sources of gravitational waves
(GWs) within the frequency band of ground-based detectors, while compact
binaries of WDs are important sources of GWs at lower frequencies to be covered
by space interferometers (LISA). Major uncertainties in the current
understanding of properties of NSs and BHs most relevant to the GW studies are
discussed, including the treatment of the natal kicks which compact stellar
remnants acquire during the core collapse of massive stars and the common
envelope phase of binary evolution. We discuss the coalescence rates of binary
NSs and BHs and prospects for their detections, the formation and evolution of
binary WDs and their observational manifestations. Special attention is given
to AM CVn-stars -- compact binaries in which the Roche lobe is filled by
another WD or a low-mass partially degenerate helium-star, as these stars are
thought to be the best LISA verification binary GW sources.Comment: 105 pages, 18 figure
Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
- Author
- A Bardelli
- A Bremm
- A Gamboa-Dominguez
- A Gamboa-Dominguez
- A Walch
- A Walch
- A Walch
- AR Mateus
- Axel Walch
- Birgit Luber
- C Moutinho
- C Pinto
- C Pinto
- Christian Peschel
- Esther Endlicher
- Ewald Wöll
- F Di Nicolantonio
- F Lordick
- Falko Fend
- Florian Lordick
- G Keller
- Gisela Keller
- Gunnar Folprecht
- Heinz Höfler
- IJ Kim
- J Ferlay
- JC Machado
- JC Machado
- JJ Ascano
- Joëlle Deplazes
- K Tsugawa
- KF Becker
- KY Chung
- M Moehler
- M Moroni
- MA Shah
- Martin Eichmann
- MB Loughrey
- N Personeni
- PC Black
- RI Nicholson
- Rupert Langer
- S Benavente
- S Li
- S Rauser
- Sandra Rauser
- SE Witta
- SH Lee
- SR Demeester
- Susanna Hegewisch-Becker
- SW Han
- Sylvie Lorenzen
- Thomas Decker
- TJ Lynch
- X Qian
- Y Uchikado
- YJ Bang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>The activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab combined with oxaliplatin/leucovorin/5-fluorouracil (FUFOX) was assessed in first-line metastatic gastric and oesophago-gastric junction (OGJ) cancer in a prospective phase II study showing a promising objective tumour response rate of 65% and a low mutation frequency of <it>KRAS </it>(3%). The aim of the correlative tumour tissue studies was to investigate the relationship between <it>EGFR </it>gene copy numbers, activation of the EGFR pathway, expression and mutation of E-cadherin, V600E BRAF mutation and clinical outcome of patients with gastric and OGJ cancer treated with cetuximab combined with FUFOX.</p> <p>Methods</p> <p>Patients included in this correlative study (<it>n </it>= 39) were a subset of patients from the clinical phase II study. The association between <it>EGFR </it>gene copy number, activation of the EGFR pathway, abundance and mutation of E-cadherin which plays an important role in these disorders, BRAF mutation and clinical outcome of patients was studied. <it>EGFR </it>gene copy number was assessed by FISH. Expression of the phosphorylated forms of EGFR and its downstream effectors Akt and MAPK, in addition to E-cadherin was analysed by immunohistochemistry. The frequency of mutant V600E BRAF was evaluated by allele-specific PCR and the mutation profile of the E-cadherin gene <it>CDH1 </it>was examined by DHPLC followed by direct sequence analysis. Correlations with overall survival (OS), time to progression (TTP) and overall response rate (ORR) were assessed.</p> <p>Results</p> <p>Our study showed a significant association between increased <it>EGFR </it>gene copy number (≥ 4.0) and OS in gastric and OGJ cancer, indicating the possibility that patients may be selected for treatment on a genetic basis. Furthermore, a significant correlation was shown between activated EGFR and shorter TTP and ORR, but not between activated EGFR and OS. No V600E BRAF mutations were identified. On the other hand, an interesting trend between high E-cadherin expression levels and better OS was observed and two <it>CDH1 </it>exon 9 missense mutations (A408V and D402H) were detected.</p> <p>Conclusion</p> <p>Our finding that increased <it>EGFR </it>gene copy numbers, activated EGFR and the E-cadherin status are potentially interesting biomarkers needs to be confirmed in larger randomized clinical trials.</p> <p>Trial registration</p> <p>Multicentre clinical study with the European Clinical Trials Database number 2004-004024-12.</p
Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor
- Author
- A Iwobi
- A Mey
- AB Russell
- AG Torres
- AH Li
- AM Simoons-Smit
- Ana S Almeida
- Anna Tomas
- AS Shon
- B Hochhut
- B Wu
- BW Wortham
- C Fevre
- CP Fung
- CP Ponting
- CR Hsu
- D Balestrino
- D Decre
- D Moranta
- DL Baldi
- DR Flower
- E Llobet
- EG Bligh
- F Boyer
- FF Buettner
- H Tsugawa
- HA Choy
- HF Lavender
- HJ Newton
- HL Tang
- I Shibuya
- J Hinnebusch
- J Hytonen
- J Putze
- JH Yoon
- JM Warszawska
- José A Bengoechea
- K Agladze
- K Beiter
- K Kuhle
- K Mizuta
- K Suzuki
- KM Wu
- KM Yeh
- L Frangeul
- L Izquierdo
- Letícia MS Lery
- Lionel Frangeul
- LK Siu
- M Regue
- M Schlame
- M Teplitski
- MA Bachman
- MA Campos
- MA Khan
- MC Wu
- MM Castiblanco-Valencia
- MS Lawlor
- N Nagarajan
- NB Ray
- O Gal-Mor
- P Di Martino
- P Shah
- P Ye
- PF Sarris
- Philippe Sansonetti
- PJ McNamara
- R Conde-Alvarez
- R Mercado-Lubo
- R Podschun
- R Wacharotayankun
- RC Moellering Jr
- RK Aziz
- Régis Tournebize
- S Bialek-Davenet
- S Brisse
- S Brisse
- S Shrivastava
- SA Shelburne 3rd
- SC Lopes
- SC McKean
- SC McKean
- SC Su
- SF Altschul
- SL Murdoch
- ST Miyata
- Suzanne Bialek-Davenet
- Sylvain Brisse
- T Whitworth
- TL Lin
- V Mohan Das
- Valérie Barbe
- Virginie Passet
- X Nassif
- X Nassif
- X Nassif
- Y Keynan
- YL Chen
- Z Ge
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Contraindications of sentinel lymph node biopsy: Áre there any really?
- Author
- A Fernandez
- A Haid
- A Lichter
- A Luini
- A Shoher
- A Smeets
- AE Giuliano
- AM Derossis
- AM Derossis
- AM Naik
- AR Miller
- B Fisher
- B Fisher
- B Fisher
- BJ O'Hea
- C Carter
- C Chao
- C Tsopelas
- CP Raut
- D Amr
- D Eshima
- D Krag
- DI Weaver
- DJ Winchester
- DL Berry
- DL Weaver
- E Ohtake
- E Tousimis
- EE Deurloo
- EM Heuts
- EP Mamounas
- ER Port
- ET Morita
- F Amersi
- FE Gump
- G Bonadonna
- G Mariani
- G Swhartz
- G Viale
- G Vlastos
- GC Balch
- George M Filippakis
- George Zografos
- GF Schwartz
- GF Schwartz
- GH Lyman
- H Charfare
- H Krontiras
- H Takei
- HS Cody 3rd
- HS Cody 3rd
- I Bedrosian
- I Brenot-Rossi
- I Langer
- J Zujewski
- JA Van Dongen
- JJ Albertini
- JP Julien
- JW Jakob
- JW Jakub
- K Fernandez
- K Scherer
- K Tsugawa
- KM McMasters
- KS Nason
- L Tafra
- L Tafra
- M Cremonesi
- M Intra
- M Knauer
- M Morrow
- MA Chung
- MC van Rijk
- MH Chung
- MJ Silverstein
- MK Leidenius
- ML Smidt
- N Klauber-DeMore
- N Pandit-Taskar
- O Gentilini
- O Gentilini
- P Schrenk
- P Schrenk
- P Treseler
- P Veronesi
- PC Ng
- Pi Haigh
- PJ Borgstein
- PJ Borgstein
- PJ Puckridge
- PJ Tanis
- R Kumar
- R Layeeque
- RN Grant
- RN Kaleya
- S Pendas
- SL Wong
- SL Wong
- SM Feldman
- TB Julian
- TJ Miner
- TM Breslin
- TM Tuttle
- U Veronesi
- V Stearns
- VS Klimberg
- WK Hung
- Y Krausz
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
BACKGROUND: One of the most exciting and talked about new surgical techniques in breast cancer surgery is the sentinel lymph node biopsy. It is an alternative procedure to standard axillary lymph node dissection, which makes possible less invasive surgery and side effects for patients with early breast cancer that wouldn't benefit further from axillary lymph node clearance. Sentinel lymph node biopsy helps to accurately evaluate the status of the axilla and the extent of disease, but also determines appropriate adjuvant treatment and long-term follow-up. However, like all surgical procedures, the sentinel lymph node biopsy is not appropriate for each and every patient. METHODS: In this article we review the absolute and relative contraindications of the procedure in respect to clinically positive axilla, neoadjuvant therapy, tumor size, multicentric and multifocal disease, in situ carcinoma, pregnancy, age, body-mass index, allergies to dye and/or radio colloid and prior breast and/or axillary surgery. RESULTS: Certain conditions involving host factors and tumor biologic characteristics may have a negative impact on the success rate and accuracy of the procedure. The overall fraction of patients unsuitable or with multiple risk factors that may compromise the success of the sentinel lymph node biopsy, is very small. Nevertheless, these patients need to be successfully identified, appropriately advised and cautioned, and so do the surgeons that perform the procedure. CONCLUSION: When performed by an experienced multi-disciplinary team, the SLNB is a highly effective and accurate alternative to standard level I and II axillary clearance in the vast majority of patients with early breast cancer
Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases
- Author
- A Alyass
- A Jedinak
- A Kumar
- A Ordureau
- A Sreekumar
- A Zhang
- A Zhang
- AB Iliuk
- AH Emwas
- AM Kamat
- AP Noon
- B Stransky
- B Zhou
- BJ Trock
- BM Coleman
- BM Wittmann
- BW Carey
- C Li
- C Rolfo
- C Sorio
- C von Mering
- C Zheng
- CE Thomas
- CL Chen
- CM Colangelo
- D Duijvesz
- D Grapov
- D Hessels
- D Theodorescu
- DI Benjamin
- DY Choi
- E Gonzalez
- EM Weissinger
- ES Boja
- EW Deutsch
- F Di Girolamo
- F Dieterle
- F Jentzmik
- GL Hortin
- GS Omenn
- H Kalra
- H Ogata
- H Tsugawa
- HC Kuo
- HH Lai
- J Gopal
- J Kim
- J Krumsiek
- J Muntel
- J Pedroza-Diaz
- J Yang
- Jayoung Kim
- JH Hayes
- JH Jung
- JL Welton
- JM Bauca
- JP Garay
- JQ Clemens
- JR Landis
- KL Schey
- L Anderson
- L Zou
- LC Gillet
- LC Whelan
- M Court
- M Hellstrom
- M Linden
- M Pitto
- M Schostak
- M Stastna
- M Stovsky
- M Yanez-Mo
- MA Ovrehus
- MA Rubin
- MJ Roobol
- MM Matzke
- MP Canter
- N Bansal
- N Goossens
- N Roper
- O Fiehn
- O Mendez
- P Shannon
- PD Robbins
- PN Robinson
- QN Van
- R Fischer
- R Harlan
- RJ Bryant
- RR Drake
- S Bouatra
- S Dijkstra
- S Filip
- S Kuromitsu
- S Naz
- S Roychowdhury
- S Stabler
- SJ Yun
- SK Bechis
- SK Keay
- SL Wood
- T Antunes-Lopes
- T Farrah
- T Shi
- T Yamamoto
- T Yamamoto
- TF Hiemstra
- TS Collier
- V Astro
- V Lygirou
- V Nanjappa
- V Schwammle
- VR Robledo
- W Weckwerth
- W Yang
- W Yang
- WQ Wei
- X Jin
- Y Fukui
- Y Hathout
- Y Zhao
- YA Goo
- YT Cho
- Zhaohui Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
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- Abudu YP
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- Akoumianaki T
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- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
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- Altieri DC
- Alves da Costa C
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- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
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- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Complex Adaptive Systems Modeling: A multidisciplinary Roadmap
- Author
- A Hussain
- A López‐Paredes
- B Iantovics
- B Junker
- C Chen
- C Macal
- C Sueur
- D Hanisch
- E Bonabeau
- E Dijkstra
- E Sklar
- F Aiello
- F Luna
- G Cowan
- G Fortino
- G Gilbert
- H Dia
- H Gimblett
- H Jiang
- H Kitano
- H Qu
- J Banks
- J Berg
- J Epstein
- J Galaskiewicz
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- J Holland
- J Miller
- J Reuter
- J Scott
- J Tian
- J Vidal
- J Vidal
- JM McGloin
- K Calvert
- K Lewis
- L Tesfatsion
- L Tesfatsion
- M Bastian
- M Baur
- M Cline
- M Girvan
- M Holcombe
- M Macy
- M Mitchell
- M Niazi
- M North
- M North
- M Read
- MA Niazi
- MA Niazi
- MA Niazi
- MA Niazi
- MJ North
- N Minar
- N Team
- Niazi MA Hussain, A
- P Shannon
- P Windrum
- R Axelrod
- R Hoffmann
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- S Yang
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- T Høye
- T Kohler
- Tesfatsion L
- U Wilensky
- V Batagelj
- V Grimm
- V Grimm
- W De Nooy
- Y Kim
- Y Mansury
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
- …