2011-2015年の昭和基地レイリー/ラマンライダーを用いた大気温度鉛直構造の観測

第6回極域科学シンポジウム分野横断型セッション：[IM] 横断　中層大気・熱圏11月17日（火）　国立極地研究所１階交流アトリウ

A Case of Wilsonism with Torsion Spasm-like Symptoms

In view of the scarcity in number of the reports on clinical cases of torsion spasm, the authors believe that the case presented here will be of some interest. This patient was a 15-year old boy who had had, since early part of his twelfth year, the episodes of the torsion on the anterior backbone accompanied by that peculiar twisting and turning along with cramping of muscles, which alternately increased or decreased, facial expression blank and entire movement simple and sluggish, without any apparent causative factors. He had been clinically diagnosed as having torsion spasm reactions, but he soon died of somatic weakening. The autopsy findings of this case were the destruction of the lense nucleus, the caudate nucleus, the thalamus, the dentate nucleus, and a marked proliferation of neuroglia, especially, the appearance of giant glia as well as liver cirrhosis; and it was diagnosed as Wilson-pseudosclerosis. Thereupon, the authors have attempted to present their opinions on this particular case here

Lifestyle-related disease in Crohn’s disease: Relapse prevention by a semi-vegetarian diet

AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission, who are a high-risk group for relapse

Lansoprazole-associated collagenous colitis: Diffuse mucosal cloudiness mimicking ulcerative colitis

There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient’s diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infiltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has antineoplastic effects for hepatocellular carcinoma.

Anticancer agents and operating procedures have been developed for hepatocellular carcinoma (HCC) patients, but their prognosis remains poor. It is necessary to develop novel diagnostic and therapeutic strategies for HCC to improve its prognosis. Lactosome is a core-shell-type polymeric micelle, and enclosing labeling or anticancer agents into this micelle enables drug delivery. In this study, we investigated the diagnostic and therapeutic efficacies of indocyanine green (ICG)-loaded lactosome for near-infrared fluorescence (NIF) imaging and photodynamic therapy (PDT) for HCC.The human HCC cell line HuH-7 was treated with ICG or ICG-lactosome, followed by PDT, and the cell viabilities were measured (in vitro PDT efficiency). For NIF imaging, HuH-7 cells were subcutaneously transplanted into BALB/c nude mice, followed by intravenous administration of ICG or ICG-lactosome. The transplanted animals were treated with PDT, and the antineoplastic effects were analyzed (in vivo PDT efficiency).PDT had toxic effects on HuH-7 cells treated with ICG-lactosome, but not ICG alone. NIF imaging revealed that the fluorescence of tumor areas in ICG-lactosome-treated animals was higher than that of contralateral regions at 24 h after injection and thereafter. PDT exerted immediate and continuous phototoxic effects in the transplanted mice treated with ICG-lactosome.Our results demonstrate that ICG-lactosome accumulated in xenograft tumors, and that PDT had antineoplastic effects on these malignant implants. NIF imaging and PDT with ICG-lactosome could be useful diagnostic and/or therapeutic strategies for HCC

Effect of laser irradiation on tumor temperature in the ICG-treated and ICG-lactosome-treated mice with subcutaneous tumors.

<p>At 48 h after ICG (yellow) or ICG-lactosome (brown) injection or no injection (control, dark) in the tumor implanted-mice, the laser irradiation (500 mW/cm² and 200 s, 100 J/cm²) treatment was initiated, and the temperatures were measured at the indicated times. P<0.001 between the ICG and ICG-lactosome groups; n = 6/group.</p

Effect of laser irradiation on temperature in ICG-lactosome-treated HuH-7 cells.

<p>The culture medium temperature was measured using a thermo-camera in the laser and PDT groups with low or high laser irradiation. (A) 18 J/cm²: low laser (190 mW/cm² and 95 s), high laser (340 mW/cm² and 55 s), low laser PDT, and high laser PDT (n = 4 dishes/group). (B) 100 J/cm²: low laser (190 mW/cm² and 525 s), high laser (340 mW/cm² and 300 s), low laser PDT. and high laser PDT (n = 4 dishes/group).</p

Effect of PDT on cells of subcutaneous tumors in the ICG-treated and ICG-lactosome-treated mice.

<p>Tumors were obtained for examination of apoptosis at 24 h after irradiation (500 mW/cm² and 200 s, 100 J/cm²) in the ICG (A) and ICG-lactosome (B) groups. TUNEL staining was performed on the specimens. (C) Apoptotic indexes in the ICG-treated and ICG-lactosome-treated mice with subcutaneous tumors. P = 0.001 between the ICG and ICG-lactosome groups; n = 5/group.</p