Coleridge's Phantom and Fact: Two Natures, Trinitarian Resolution, and the Formation of the Pentad to 1825

This thesis discusses how Coleridge develops his trinitarianism, 'God' 'man', and 'nature', in response to modern philosophies since Descartes, especially to Kant's phenomenology, and how he finally forms the 'Pentad' in 1825. It will have seven chapters. The first chapter discusses his two unexecuted plans, 'the hymns to the elements' (1796) and 'Soother of Absence' (1802-10). It investigates how he comes to think that the hymn, or, the praise of the divine presence in nature, is the original and ideal form of poetry, and how he falls behind his ideal and replaces the first plan with the second. The purpose of the chapter is to show how his experience as a poet prepares the ground of his later philosophy and theology. The second chapter interprets 'The Ancient Mariner' (1798) as a poem about the departure from created nature to uncreated ocean, as an autobiographical poem about Coleridge's own yearning for 'something one & indivisible' which leads him to recognize that nature has turned 'ideot', that he has fallen from divine nature. The third chapter shows how in 'Dejection Ode' (1802) he contrasts his 'dejection' with 'Joy' and acknowledges his failure as a poet of nature. It also discusses his attempted recovery from 'Reality's dark dream' by the 'Phantom' creativity of the active human mind illustrated in 'Apologia pro Vita sua' (1800). The fourth chapter concentrates on his days in Malta 1804-5. The first half shows how he experiences difficulty in distinguishing the product of 'the Phantom creativity' from 'Reality's dark dream', and how he shifts the problem to an ethical ground, and finds Kant's ethics insufficient for his problem. The second half shows how he begins to form his 'trinitarianism' under such circumstances and to use the term 'symbol' in relating God and man. The first half of the fifth chapter deals with his ontological speculation on 'space' and shows that it leads him to adopt Leibnizian 'Hypopoeesis', contrasted with Newtonian 'Hypothesis', as an advanced form of 'the Phantom creativity' of the human mind. The second half interprets his 'Confessio Fidei' (1810) as his attempt to accept and to rewrite Kant's ethics in theological terms in order to deal with 'an original corruption in our nature'. The sixth chapter argues that his theory of imagination in Biographia Literaria (1817) is his response to Kant's phenomenology which draws on his own long-standing speculation on the passivity and activity of the human mind, and that he leads his argument towards 'art' and hints at the 'artistic' recovery of human nature. The final chapter deals with the metaphysical and theological recapitulations of his theory of imagination in the Logic (1823-9), and in Aids to Reflection (1825), and shows, as a conclusion, that by forming the Pentad he anchors the whole of his philosophical and theological argument on the mediatory function of 'the spirit, or, 'Mesothesis' of the Pentad

Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions

A "foldamer" is an artificial oligomeric molecule with a regular secondary or tertiary structure consisting of various building blocks. A "stapled peptide" is a peptide with stabilized secondary structures, in particular, helical structures by intramolecular covalent side-chain cross-linking. Helical foldamers and stapled peptides are potential drug candidates that can target protein-protein interactions because they enable multipoint molecular recognition, which is difficult to achieve with low-molecular-weight compounds. This mini-review describes a variety of peptide-based foldamers and stapled peptides with a view to their applications in drug discovery, including our recent progress

Comparisons of Brightness Temperatures of Landsat-7/ETM+ and Terra/MODIS around Hotien Oasis in the Taklimakan Desert

The brightness temperature (BT) of Taklimakan Desert retrieved from the data of Landsat-7/ETM+ band 6 and Terra/MODIS band 31 and 32 indicates the following features: (1) good linear relationship between the BT of ETM+ and that of MODIS, (2) the observation time adjusted BT of ETM+ is almost equal to that of MODIS, (3) the BT of Terra/MODIS band 31 is slightly higher than that of band 32 over a reservoir while opposite feature is recognized over desert area, (4) the statistical analysis of 225 sample data of ETM+ in one pixel of MODIS for different landcovers indicates that the standard deviation and range of BT of ETM+ corresponding to one pixel of MODIS are 0.45∘C, 2.25∘C for a flat area of desert, while respective values of the oasis farmland and shading side of rocky hill amount to 2.88∘C, 14.04∘C, and 2.80∘C, 16.04∘C

Evaluation of atherosclerotic lesions using dextran- and mannan–dextran-coated USPIO: MRI analysis and pathological findings

Magnetic resonance imaging (MRI) can detect atherosclerotic lesions containing accumulations of ultrasmall superparamagnetic iron oxides (USPIO). Positing that improved USPIO with a higher affinity for atherosclerotic plaques would yield better plaque images, we performed MRI and histologic studies to compare the uptake of dextran- and mannan–dextran-coated USPIO (D-USPIO and DM-USPIO, respectively) by the atherosclerotic walls of rabbits. We intravenously injected atherosclerotic rabbits with DM-USPIO (n = 5) or D-USPIO (n = 5). Two rabbits were the controls. The doses delivered were 0.08 (dose 1) (n = 1), 0.4 (dose 2) (n = 1), or 0.8 (dose 3) (n = 3) mmol iron/Kg. The dose 3 rabbits underwent in vivo contrast-enhanced magnetic resonance angiography (MRA) before and 5 days after USPIO administration. Afterwards, all animals were euthanized, the aortae were removed and subjected to in vitro MRI study. The signal-to-noise ratio (SNR) of the aortic wall in the same region of interest (ROI) was calculated in both in vivo and in vitro studies. Histological assessment through measurement of iron-positive regions in Prussian blue-stained specimens showed that iron-positive regions were significantly larger in rabbits injected with DM- rather than D-USPIO (P < 0.05) for all doses. In vivo MRA showed that the SNR-reducing effect of DM- was greater than that of D-USPIO (P < 0.05). With in vitro MRI scans, SNR was significantly lower in rabbits treated with dose 2 of DM-USPIO compared with D-USPIO treatment (P < 0.05), and it tended to be lower at dose 3 (P < 0.1). In conclusion, we suggest that DM-USPIO is superior to D-USPIO for the study of atherosclerotic lesions in rabbits

Detection of Stress Hormone in the Milk for Animal Welfare Using QCM Method

We developed a rapid and sequential analysis system to determine stress marker in the milk. One of the famous stress markers, cortisol, was detected using our method. Quartz crystal microbalance (QCM) method with a twin sensor was used in this study. One channel detected stress marker corresponding to antigen-antibody interaction and the other channel was used as a reference to remove environmental influences. Although nonspecific adsorption was monitored on each channel, frequency difference between them was within a few Hz on the injection of sample solution. One determination cycle including regeneration step could be performed within 10 minutes. The system could detect the cortisol level from 0.1 pg/mL to 100 pg/mL. These results show that our system has a potential to check the daily feeding condition for cows in terms of animal welfare

HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype

ObjectiveAutoimmune hepatitis (AIH) is a chronic progressive liver disease. AIH is composed predominantly of type 1 in Japanese populations. The genetic and environmental factors are associated with the pathogenesis of AIH. HLA-DRB1*03:01 and *04:01 are associated with type 1 AIH in European and *04:05 in Japanese populations. Here, we conducted an HLA association study in order to find HLA alleles or haplotypes predisposing or protective for Japanese AIH.MethodsHLA-DRB1 and DQB1 genotyping of 360 type 1 AIH patients and 1026 healthy controls was performed.ResultsThe predisposing association of DRB1*04:01 (P = 0.0006, corrected P [Pc] = 0.0193, odds ratio [OR] 2.97, 95% confidence interval [CI] 1.62–5.43), DRB1*04:05 (P = 1.89×10−21, Pc = 5.86×10−20, OR 3.41, 95% CI 2.65–4.38), and DQB1*04:01 (P = 4.66×10−18, Pc = 6.99×10−17, OR 3.89, 95% CI 2.84–5.33) and the protective association of DRB1*13:02 (P = 0.0003, Pc = 0.0080, OR 0.48, 95% CI 0.32–0.72) with Japanese type 1 AIH were observed. An association of the DR4/DR8 heterozygous genotype with Japanese AIH was identified for the first time (P = 3.12×10−9, OR 3.52, 95% CI 2.34–5.29). Susceptible diplotypes were DRB1*04:05-DQB1*04:01/DRB1*08:02-DQB1*03:02 (P = 0.0004, OR 24.77, 95% CI 1.45–424.31) and DRB1*04:05-DQB1*04:01/DRB1*08:03-DQB1*06:01 (P = 1.18×10−6, OR 10.64, 95% CI 3.19–35.46). Serum levels of Immunoglobulin G and Immunoglobulin M, International Autoimmune Hepatitis Group score, positive rate of anti-smooth muscle antibodies, and the rate of definite AIH were higher in AIH patients with DRB1*04:05 than without.ConclusionsThe important roles of specific combinations of DRB1 and DQB1 alleles or haplotypes in the pathogenesis of type 1 AIH were suggested. The association of DR4/DR8 heterozygous genotype suggested the pathologic importance of trans-complementing DQα-β heterodimer molecules encoded by DQA1 allele of one haplotype and the DQB1 allele of the other haplotype, as it was proposed in the HLA association studies of Type 1 diabetes

Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

BackgroundHLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical features of adult onset Still’s disease (AOSD) in a Japanese population by determining the DRB1 allele distributions.MethodsDRB1 genotyping of 96 patients with AOSD and 1,026 healthy controls was performed. Genomic DNA samples from the AOSD patients were also genotyped for MEFV exons 1, 2, 3, and 10 by direct sequencing.ResultsIn Japanese patients with AOSD, we observed a predisposing association of DRB1*15:01 (p = 8.60 × 10−6, corrected p (Pc) = 0.0002, odds ratio (OR) = 3.04, 95% confidence interval (95% CI) = 1.91–4.84) and DR5 serological group (p = 0.0006, OR = 2.39, 95% CI = 1.49–3.83) and a protective association of DRB1*09:01 (p = 0.0004, Pc = 0.0110, OR = 0.34, 95% CI = 0.18–0.66) with AOSD, and amino acid residues 86 and 98 of the DRβ chain were protectively associated with AOSD. MEFV variants were identified in 49 patients with AOSD (56.3%). The predisposing effect of DR5 was confirmed only in patients with AOSD who had MEFV variants and not in those without MEFV variants. Additionally, DR5 in patients with AOSD are associated with macrophage activation syndrome (MAS) and steroid pulse therapy.ConclusionThe DRB1*15:01 and DR5 are both associated with AOSD susceptibility in Japanese subjects. A protective association between the DRB1*09:01 allele and AOSD was also observed in these patients. Our data also highlight the effects of DRB1 alleles in susceptibility to AOSD

Conductor and joint test results of JT-60SA CS and EF coils using the NIFS test facility

In 2007, JAEA and NIFS launched the test project to evaluate the performance of cable-in-conduit (CIC) conductors and conductor joints for the JT-60SA CS and EF coils. In this project, conductor tests for four types of coil conductor and joint tests for seven types of conductor joint have been conducted for the past eight years using the NIFS test facility. As a result, the test project indicated that the CIC conductors and conductor joints fulfill the design requirement for the CS and EF coils. In addition, the NIFS test facility is expected to be utilized as the test facility for the development of a conductor and conductor joint for the purpose of the DEMO nuclear fusion power plant, provided that the required magnetic field strength is within 9 T