An intelligent system for trading signal of cryptocurrency based on market tweets sentiments

The purpose of this study is to examine the efficacy of an online stock trading platform in enhancing the financial literacy of those with limited financial knowledge. To this end, an intelligent system is proposed which utilizes social media sentiment analysis, price tracker systems, and machine learning techniques to generate cryptocurrency trading signals. The system includes a live price visu�alization component for displaying cryptocurrency price data and a prediction function that provides both short-term and long-term trading signals based on the sentiment score of the previous day’s cryptocurrency tweets. Additionally, a method for refining the sentiment model result is outlined. The results illustrate that it is feasible to incorporate the Tweets sentiment of cryptocurrencies into the system for generating reliable trading signals

Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function.

We sought to quantify plasma high sensitivity cardiac troponin (hs-cTnT) levels, their determinants, and their associations with left ventricular (LV) myocardial deformation in adult survivors of childhood acute leukaemias.One hundred adult survivors (57 males) of childhood acute leukaemias, aged 24.1 ± 4.2 years, and 42 age-matched controls (26 males) were studied. Plasma cTnT was determined using a highly sensitive assay. Genotyping of NAD(P)H oxidase and multidrug resistance protein polymorphisms was performed. Left ventricular function was assessed by conventional, three-dimensional, and speckle tracking echocardiography. The medians (interquartile range) of hs-cTnT in male and female survivors were 4.9 (4.2 to 7.2) ng/L and 1.0 (1.0 to 3.5) ng/L, respectively. Nineteen survivors (13 males, 6 females) (19%) had elevated hs-cTnT (>95(th) centile of controls). Compared to those without elevated hs-TnT levels, these subjects had received larger cumulative anthracycline dose and were more likely to have leukaemic relapse, stem cell transplant, and cardiac irradiation. Their LV systolic and early diastolic myocardial velocities, isovolumic acceleration, and systolic longitudinal strain rate were significantly lower. Survivors having CT/TT at CYBA rs4673 had higher hs-cTnT levels than those with CC genotype. Functionally, increased hs-cTnT levels were associated with worse LV longitudinal systolic strain and systolic and diastolic strain rates.Increased hs-cTnT levels occur in a significant proportion of adult survivors of childhood acute leukaemias and are associated with larger cumulative anthracycline dose received, history of leukaemic relapse, stem cell transplant, and cardiac irradiation, genetic variants in free radical metabolism, and worse LV myocardial deformation

Comparisons of echocardiographic findings between survivors with (group I) and without (group II) elevated hs-cTnT levels.

<p>Abbreviations: A, peak mitral inflow velocity at late diastole; a, mitral annular late diastolic myocardial tissue velocity; E, peak mitral inflow velocity at early diastole; e, mitral annual early diastolic myocardial tissue velocity; EF, ejection fraction; FS, fractional shortening; IVA, isovolumic acceleration; LV, left ventricular; LVEDd, left ventricular end diastolic dimension; LVESd, left ventricular end systolic dimension; SR_d, early diastolic strain rate; SR_s, systolic strain rate.</p>*<p>statistically significant.</p

Relationships between high sensitivity cardiac troponin T (hs-cTnT) and indices of left ventricular (LV) deformation.

<p>Correlations between hs-cTnT and LV (a) global longitudinal systolic strain, (b) systolic strain rate, and (c) diastolic strain rate are shown. Solid lines represent the best-fit linear regression and dashed lines represent the 95% confidence interval for each parameter of the regression line.</p

Comparisons of demographic and echocardiographic findings between survivors and control subjects.

<p>Abbreviations: A, peak mitral inflow velocity at late diastole; a, mitral annular late diastolic myocardial tissue velocity; E, peak mitral inflow velocity at early diastole; e, mitral annual early diastolic myocardial tissue velocity; EF, ejection fraction; FS, fractional shortening; IVA, isovolumic acceleration; LV, left ventricular; LVEDd, left ventricular end diastolic dimension; LVESd, left ventricular end systolic dimension; SR_d, early diastolic strain rate; SR_s, systolic strain rate.</p>*<p>statistically significant.</p

Levels of high sensitivity cardiac troponin T (hs-cTnT) in survivors and controls by genders.

<p>Distributions of hs-cTnT in (a) male and (b) female survivors and controls are shown using scatter plots. Dashed lines represent 95^th percentile in controls.</p

Genotypic and allelic frequencies of NAD(P)H oxidase and multidrug resistance protein genes in survivors and control subjects, and genotypic frequencies reported in Chinese population from National Center for Biotechnology Information (NCBI) database.

*<p>statistically significant.</p>**<p>4 controls who were siblings of patients were excluded.</p>a<p>CC vs CT/TT.</p>b<p>TT vs AT/AA.</p>c<p>GG/AG vs AA.</p

Levels of high sensitivity cardiac troponin T (hs-cTnT) in survivors by NAD(P)H oxidase and multidrug resistance protein polymorphisms.

<p>Scatter plots showing distributions of hs-cTnT levels in relation to (a) <i>CYBA</i>, (b) <i>RAC2</i>, and (c) <i>NCF4</i> polymorphisms. Solid lines represent median hs-cTnT levels.</p

Comparisons of demographic factors, clinical variables, and genotypic frequencies between survivors with (group I) and without (group II) elevated hs-cTnT levels.

<p>Abbreviations: AML, acute myeloid leukaemia; ALL, acute lymphoblastic leukaemia.</p>*<p>statistically significant.</p