RESEARCH OF ADSORPTION AFLATOXINS BY TECHNICAL LIGNIN

Aflatoxins represent aggressive group of mycotoxins. They are really toxic, carcinogenic and dangerous for human health. There are mechanical, physical and chemical methods for their detoxification. Aflatoxins could be also neutralized by means of various adsorbents as well. We do some research work in the direction of aflatoxin adsorption by presence of lignin, which is quite affordable and gives an effective result.Aflatoxins represent aggressive group of mycotoxins. They are really toxic, carcinogenic and dangerous for human health. There are mechanical, physical and chemical methods for their detoxification. Aflatoxins could be also neutralized by means of various adsorbents as well. We do some research work in the direction of aflatoxin adsorption by presence of lignin, which is quite affordable and gives an effective result

Inhibition of 26S Protease Regulatory Subunit 7 (MSS1) Suppresses Neuroinflammation

Recently, researchers have focused on immunosuppression induced by rifampicin. Our previous investigation found that rifampicin was neuroprotective by inhibiting the production of pro-inflammatory mediators, thereby suppressing microglial activation. In this study, using 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), we discovered that 26S protease regulatory subunit 7 (MSS1) was decreased in rifampicin-treated microglia. Western blot analysis verified the downregulation of MSS1 expression by rifampicin. As it is indicated that the modulation of the ubiquitin-26S proteasome system (UPS) with proteasome inhibitors is efficacious for the treatment of neuro-inflammatory disorders, we next hypothesized that silencing MSS1 gene expression might inhibit microglial inflammation. Using RNA interference (RNAi), we showed significant reduction of IkBα degradation and NF-kB activation. The production of lipopolysaccharides-induced pro-inflammatory mediators such as inducible nitric oxide synthase (iNOS), nitric oxide, cyclooxygenase-2, and prostaglandin E2 were also reduced by MSS1 gene knockdown. Taken together, our findings suggested that rifampicin inhibited microglial inflammation by suppressing MSS1 protein production. Silencing MSS1 gene expression decreased neuroinflammation. We concluded that MSS1 inhibition, in addition to anti-inflammatory rifampicin, might represent a novel mechanism for the treatment of neuroinflammatory disorders

Research Of Adsorption Aflatoxins By Technical Lignin

Aflatoxins represent aggressive group of mycotoxins. They are really toxic, carcinogenic and dangerous for human health. There are mechanical, physical and chemical methods for their detoxification. Aflatoxins could be also neutralized by means of various adsorbents as well. We do some research work in the direction of aflatoxin adsorption by presence of lignin, which is quite affordable and gives an effective result

Psychometric properties of the Patient Health Questionnaire-4 (PHQ-4) in 9230 adults across seven European countries: findings from the ESTSS ADJUST study

Stress and Psychopatholog

The burden of adverse childhood experiences when coping and adjusting to COVID-19 pandemic.

Adverse Childhood Experiences (ACE) are important stressors, impinging the response to other psychological challenges during life. People exposed to ACE tend to be more vulnerable to develop psychiatric disorders and are more prone to adjustment difficulties when facing the extreme stress, uncertainty, and health-related risk of the COVID-19 pandemic. Objective: To disentangle associations between coping strategies, resilience and protective factors, mental health risk, and number and type of ACE. Method: An online survey launched by the ESTSS in eleven countries permits the assessment of protective and resilience factors, coping behaviour, and maladaptive adjustment amidst the COVID-19 pandemic. Evaluation of mental health risk was performed using standardized instruments including measures of depression, anxiety, symptoms of adjustment disorder (ADNM-8), and posttraumatic disorder (PC-PTSD). The presence of ACE was screened in all participants who described the type and number of traumatic experiences experienced during childhood. The analysis will elucidate the presence of ACE in different individuals grouped by demographic characteristics, to foresee: 1) the most predominant variables; 2) if ACE scores relate to mental health-derived risks or resilience. Results: Preliminary results in ten of the participating countries showed variable frequencies of reported ACE in the different populations. The incidence of at least one ACE varies between countries. Conclusions: Childhood adversity may be considered as a cumulative burden and risk for mental disorders and adjustment difficulties when dealing with pandemic-related multiple challenges or may enhance protective mechanisms sustaining the wellbeing of specific subpopulations