Enhanced surface plasmon polariton propagation induced by active dielectrics

We present numerical simulations for the propagation of surface plasmon polaritons in a dielectric-metal-dielectric waveguide using COMSOL multiphysics software. We show that the use of an active dielectric with gain that compensates metal absorption losses enhances substantially plasmon propagation. Furthermore, the introduction of the active material induces, for a specific gain value, a root in the imaginary part of the propagation constant leading to infinite propagation of the surface plasmon. The computational approaches analyzed in this work can be used to define and tune the optimal conditions for surface plasmon polariton amplification and propagation

Cooperative surmounting of bottlenecks

The physics of activated escape of objects out of a metastable state plays a key role in diverse scientific areas involving chemical kinetics, diffusion and dislocation motion in solids, nucleation, electrical transport, motion of flux lines superconductors, charge density waves, and transport processes of macromolecules, to name but a few. The underlying activated processes present the multidimensional extension of the Kramers problem of a single Brownian particle. In comparison to the latter case, however, the dynamics ensuing from the interactions of many coupled units can lead to intriguing novel phenomena that are not present when only a single degree of freedom is involved. In this review we report on a variety of such phenomena that are exhibited by systems consisting of chains of interacting units in the presence of potential barriers. In the first part we consider recent developments in the case of a deterministic dynamics driving cooperative escape processes of coupled nonlinear units out of metastable states. The ability of chains of coupled units to undergo spontaneous conformational transitions can lead to a self-organised escape. The mechanism at work is that the energies of the units become re-arranged, while keeping the total energy conserved, in forming localised energy modes that in turn trigger the cooperative escape. We present scenarios of significantly enhanced noise-free escape rates if compared to the noise-assisted case. The second part deals with the collective directed transport of systems of interacting particles overcoming energetic barriers in periodic potential landscapes. Escape processes in both time-homogeneous and time-dependent driven systems are considered for the emergence of directed motion. It is shown that ballistic channels immersed in the associated high-dimensional phase space are the source for the directed long-range transport

Strain-induced interface reconstruction in epitaxial heterostructures

We investigate in the framework of Landau theory the distortion of the strain fields at the interface of two dissimilar ferroelastic oxides that undergo a structural cubic-to-tetragonal phase transition. Simple analytical solutions are derived for the dilatational and the order parameter strains that are globally valid over the whole of the heterostructure. The solutions reveal that the dilatational strain exhibits compression close to the interface which may in turn affect the electronic properties in that region.Comment: 7 pages, 5 figures, to be published in Physical Review

A smartwater metering deployment based on the fog computing paradigm

In this paper, we look into smart water metering infrastructures that enable continuous, on-demand and bidirectional data exchange between metering devices, water flow equipment, utilities and end-users. We focus on the design, development and deployment of such infrastructures as part of larger, smart city, infrastructures. Until now, such critical smart city infrastructures have been developed following a cloud-centric paradigm where all the data are collected and processed centrally using cloud services to create real business value. Cloud-centric approaches need to address several performance issues at all levels of the network, as massive metering datasets are transferred to distant machine clouds while respecting issues like security and data privacy. Our solution uses the fog computing paradigm to provide a system where the computational resources already available throughout the network infrastructure are utilized to facilitate greatly the analysis of fine-grained water consumption data collected by the smart meters, thus significantly reducing the overall load to network and cloud resources. Details of the system's design are presented along with a pilot deployment in a real-world environment. The performance of the system is evaluated in terms of network utilization and computational performance. Our findings indicate that the fog computing paradigm can be applied to a smart grid deployment to reduce effectively the data volume exchanged between the different layers of the architecture and provide better overall computational, security and privacy capabilities to the system

Transport properties of one-dimensional Kronig-Penney models with correlated disorder

Transport properties of one-dimensional Kronig-Penney models with binary correlated disorder are analyzed using an approach based on classical Hamiltonian maps. In this method, extended states correspond to bound trajectories in the phase space of a parametrically excited linear oscillator, while the on site-potential of the original model is transformed to an external force. We show that in this representation the two probe conductance takes a simple geometrical form in terms of evolution areas in phase-space. We also analyze the case of a general N-mer model.Comment: 16 pages in Latex, 12 Postscript figures include

Demonstration of Calreticulin Expression in Hamster Pancreatic Adenocarcinoma with the Use of Fluorescent Gold Quantum Dots

BACKGROUND: There is dire need for discovery of novel pancreatic cancer biomarkers and of agents with the potential for simultaneous diagnostic and therapeutic capacity. This study demonstrates calreticulin expression on hamster pancreatic adenocarcinoma via bio-conjugated gold quantum dots (AuQDs). MATERIALS AND METHODS: Hamster pancreatic adenocarcinoma cells were cultured, fixed and incubated with fluorescent AuQDs, bio-conjugated to anti-calreticulin antibodies. Anti-calreticulin and AuQDs were produced in-house. AuQDs were manufactured to emit in the near-infrared. Cells were further characterized under confocal fluorescence. RESULTS: AuQDs were confirmed to emit in the near-infrared. AuQD bio-conjugation to calreticulin was confirmed via dot-blotting. Upon laser excitation and post-incubation with bio-conjugated AuQDs, pancreatic cancer cell lines emitted fluorescence in near-infrared. CONCLUSION: Hamster pancreatic cancer cells express calreticulin, which may be labelled with AuQDs. This study demonstrates the application of nanoparticle-based theranostics in pancreatic cancer. Such biomarker-targeting nanosystems are anticipated to play a significant role in the management of pancreatic cancer

Multistable Solitons in the Cubic-Quintic Discrete Nonlinear Schr\"odinger Equation

We analyze the existence and stability of localized solutions in the one-dimensional discrete nonlinear Schr\"{o}dinger (DNLS) equation with a combination of competing self-focusing cubic and defocusing quintic onsite nonlinearities. We produce a stability diagram for different families of soliton solutions, that suggests the (co)existence of infinitely many branches of stable localized solutions. Bifurcations which occur with the increase of the coupling constant are studied in a numerical form. A variational approximation is developed for accurate prediction of the most fundamental and next-order solitons together with their bifurcations. Salient properties of the model, which distinguish it from the well-known cubic DNLS equation, are the existence of two different types of symmetric solitons and stable asymmetric soliton solutions that are found in narrow regions of the parameter space. The asymmetric solutions appear from and disappear back into the symmetric ones via loops of forward and backward pitchfork bifurcations.Comment: To appear Physica D. 23 pages, 13 figure

Cholecystectomy for complicated gallbladder and common biliary duct stones: current surgical management

Gallstone disease accounts for the vast majority of acute surgical admissions in the UK, with a major treatment being cholecystectomy. Practice varies significantly as to whether surgery is performed during the acute symptomatic phase, or after a period of recovery. Differences in practice relate to operative factors, patient factors, surgeon factors and hospital and trust wide policies. In this review we summarize recent evidence on management of gallstone disease, particularly with respect to whether cholecystectomy should occur during index presentation or following recovery. We highlight morbidity and mortality studies, cost, and patient reported outcomes. We speculate on barriers to change in service delivery. Finally, we propose potential solutions to optimize care