Steady, oscillatory, and unsteady subsonic Aerodynamics, production version 1.1 (SOUSSA-P1.1). Volume 2: User/programmer manual

A user/programmer manual for the computer program SOUSSA P 1.1 is presented. The program was designed to provide accurate and efficient evaluation of steady and unsteady loads on aircraft having arbitrary shapes and motions, including structural deformations. These design goals were in part achieved through the incorporation of the data handling capabilities of the SPAR finite element Structural Analysis computer program. As a further result, SOUSSA P possesses an extensive checkpoint/ restart facility. The programmer's portion of this manual includes overlay/subroutine hierarchy, logical flow of control, definition of SOUSSA P 1.1 FORTRAN variables, and definition of SOUSSA P 1.1 subroutines. Purpose of the SOUSSA P 1.1 modules, input data to the program, output of the program, hardware/software requirements, error detection and reporting capabilities, job control statements, a summary of the procedure for running the program and two test cases including input and output and listings are described in the user oriented portion of the manual

Neutron spin-echo study of the critical dynamics of spin-5/2 antiferromagnets in two and three dimensions

We report a neutron spin-echo study of the critical dynamics in the $S=5/2$ antiferromagnets MnF$_2$ and Rb$_2$MnF$_4$ with three-dimensional (3D) and two-dimensional (2D) spin systems, respectively, in zero external field. Both compounds are Heisenberg antiferromagnets with a small uniaxial anisotropy resulting from dipolar spin-spin interactions, which leads to a crossover in the critical dynamics close to the N\'eel temperature, $T_N$. By taking advantage of the $\mu\text{eV}$ energy resolution of the spin-echo spectrometer, we have determined the dynamical critical exponents $z$ for both longitudinal and transverse fluctuations. In MnF$_2$, both the characteristic temperature for crossover from 3D Heisenberg to 3D Ising behavior and the exponents $z$ in both regimes are consistent with predictions from the dynamical scaling theory. The amplitude ratio of longitudinal and transverse fluctuations also agrees with predictions. In Rb$_2$MnF$_4$, the critical dynamics crosses over from the expected 2D Heisenberg behavior for $T\gg T_N$ to a scaling regime with exponent $z = 1.387(4)$, which has not been predicted by theory and may indicate the influence of long-range dipolar interactions

Clinical impact of double protease inhibitor boosting with Lopinavir/Ritonavir and Amprenavir as part of salvage antiretroviral therapy

Purpose: Double protease inhibitor (PI) boosting is being explored as a new strategy in salvage antiretroviral (ARV) therapy. However, if a negative drug interaction leads to decreased drug levels of either or both PIs, double PI boosting could lead to decreased virologic response. A negative drug interaction has been described between amprenavir (APV) and lopinavir/ritonavir (LPV/r). This observational cohort study assessed the virologic impact of the addition of APV to a salvage ARV regimen, which also contains LPV/r, compared to a regimen containing LPV/r alone. Method: Patients initiated on a salvage ARV regimen that included LPV/r obtained from the expanded access program in Toronto, Canada, were evaluated. APV (600-1,200 mg bid) was added at the discretion of the treating physician. Results: Using multivariate Cox proportional hazards models, we found that the addition of APV to a LPV/r-containing salvage regimen was not significantly associated with time to virologic suppression (< 50 copies/mL; adjusted hazard ratio [HR] = 0.75, p = .12) or with time to virologic rebound (adjusted HR = 1.46, p = .34). Those patients who received higher doses of APV had an increased chance of virologic suppression (p = .03). In a subset of 27 patients, the median LPV Ctrough was significantly lower in patients receiving APV (p = .04), and the median APV Ctrough was reduced compared to reported controls. Conclusion: Our data do not support an additional benefit in virologic reduction of double boosting with APV and LPV/r relative to LPV/r alone in salvage ARV therapy. Our study's limitations include its retrospective nature and the imbalance between the two groups potentially confounding the results. Although these factors were adjusted for in the multivariate analysis, a prospective randomized controlled trial is warranted to confirm our findings

Precise Particle Tracking Against a Complicated Background: Polynomial Fitting with Gaussian Weight

We present a new particle tracking software algorithm designed to accurately track the motion of low-contrast particles against a background with large variations in light levels. The method is based on a polynomial fit of the intensity around each feature point, weighted by a Gaussian function of the distance from the centre, and is especially suitable for tracking endogeneous particles in the cell, imaged with bright field, phase contrast or fluorescence optical microscopy. Furthermore, the method can simultaneously track particles of all different sizes, and allows significant freedom in their shape. The algorithm is evaluated using the quantitative measures of accuracy and precision of previous authors, using simulated images at variable signal-to-noise ratios. To these we add a new test of the error due to a non-uniform background. Finally the tracking of particles in real cell images is demonstrated. The method is made freely available for non-commencial use as a software package with a graphical user-inferface, which can be run within the Matlab programming environment

Effects of ambient gas density on the structure of pressure-atomizedsprays

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77110/1/AIAA-1991-690-582.pd

NMR Simulation of an Eight-State Quantum System

The propagation of excitation along a one-dimensional chain of atoms is simulated by means of NMR. The physical system used as an analog quantum computer is a nucleus of 133-Cs (spin 7/2) in a liquid crystalline matrix. The Hamiltonian of migration is simulated by using a special 7-frequency pulse, and the dynamics is monitored by following the transfer of population from one of the 8 spin energy levels to the other.Comment: 10 pages, 3 figure

Applications of Transmission Electron Microscopy to Coal

Coal consists of a hydrocarbon matrix in which minerals are embedded. The hydrocarbon matter also contains impurities distributed as individual atoms. Thus, coal has phases similar to those in metallic or ceramic alloy systems; a matrix, included precipitates and atoms distributed individually in solid solution. Consequently, techniques of electron microscopy developed to examine metallic and ceramic alloy systems are directly applicable to coal. We report application of microanalytical techniques of electron microscopy to coal using examples of measurements for several coals. Identification and characterization of clays and sulfides is described. Use of x-ray emission spectroscopy for organic element measurement is emphasized

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In addition, there is no approved anti-DENV agents for treating DENV-infected patients. In the present study, we identified new compounds with anti-DENV replication activity by targeting viral replication enzymes – NS5, RNA-dependent RNA polymerase (RdRp) and NS3 protease, using cell-based reporter assay. Subsequently, we performed an enzyme-based assay to clarify the action of these compounds against DENV RdRp or NS3 protease activity. Moreover, these compounds exhibited anti-DENV activity in vivo in the ICR-suckling DENV-infected mouse model. Combination drug treatment exhibited a synergistic inhibition of DENV replication. These results describe novel prototypical small anti-DENV molecules for further development through compound modification and provide potential antivirals for treating DENV infection and DENV-related diseases