Spikes for the gierer-meinhardt system with many segments of different diffusivities

We rigorously prove results on spiky patterns for the Gierer-Meinhardt system with a large number of jump discontinuities in the diffusion coefficient of the inhibitor. Using numerical computations in combination with a Turing-type instability analysis, this system has been investigated by Benson, Maini and Sherratt

Optimal Haplotype Assembly from High-Throughput Mate-Pair Reads

Humans have $23$ pairs of homologous chromosomes. The homologous pairs are almost identical pairs of chromosomes. For the most part, differences in homologous chromosome occur at certain documented positions called single nucleotide polymorphisms (SNPs). A haplotype of an individual is the pair of sequences of SNPs on the two homologous chromosomes. In this paper, we study the problem of inferring haplotypes of individuals from mate-pair reads of their genome. We give a simple formula for the coverage needed for haplotype assembly, under a generative model. The analysis here leverages connections of this problem with decoding convolutional codes.Comment: 10 pages, 4 figures, Submitted to ISIT 201

Energy Relaxation of Hot Dirac Fermions in Graphene

We develop a theory for the energy relaxation of hot Dirac fermions in graphene. We obtain a generic expression for the energy relaxation rate due to electron-phonon interaction and calculate the power loss due to both optical and acoustic phonon emission as a function of electron temperature $T_{\mathrm{e}}$ and density $n$. We find an intrinsic power loss weakly dependent on carrier density and non-vanishing at the Dirac point $n = 0$, originating from interband electron-optical phonon scattering by the intrinsic electrons in the graphene valence band. We obtain the total power loss per carrier $\sim 10^{-12} - 10^{-7} \mathrm{W}$ within the range of electron temperatures $\sim 20 - 1000 \mathrm{K}$. We find optical (acoustic) phonon emission to dominate the energy loss for $T_{\mathrm{e}} > (<) 200-300 \mathrm{K}$ in the density range $n = 10^{11}-10^{13} \mathrm{cm}^{-2}$.Comment: 5 page

Quantized Casimir Force

We investigate the Casimir effect between two-dimensional electron systems driven to the quantum Hall regime by a strong perpendicular magnetic field. In the large separation (d) limit where retardation effects are essential we find i) that the Casimir force is quantized in units of 3\hbar c \alpha^2/(8\pi^2 d^4), and ii) that the force is repulsive for mirrors with same type of carrier, and attractive for mirrors with opposite types of carrier. The sign of the Casimir force is therefore electrically tunable in ambipolar materials like graphene. The Casimir force is suppressed when one mirror is a charge-neutral graphene system in a filling factor \nu=0 quantum Hall state.Comment: 4.2 page

Functional Genomics Profiling of Bladder Urothelial Carcinoma MicroRNAome as a Potential Biomarker.

Though bladder urothelial carcinoma is the most common form of bladder cancer, advances in its diagnosis and treatment have been modest in the past few decades. To evaluate miRNAs as putative disease markers for bladder urothelial carcinoma, this study develops a process to identify dysregulated miRNAs in cancer patients and potentially stratify patients based on the association of their microRNAome phenotype to genomic alterations. Using RNA sequencing data for 409 patients from the Cancer Genome Atlas, we examined miRNA differential expression between cancer and normal tissues and associated differentially expressed miRNAs with patient survival and clinical variables. We then correlated miRNA expressions with genomic alterations using the Wilcoxon test and REVEALER. We found a panel of six miRNAs dysregulated in bladder cancer and exhibited correlations to patient survival. We also performed differential expression analysis and clinical variable correlations to identify miRNAs associated with tobacco smoking, the most important risk factor for bladder cancer. Two miRNAs, miR-323a and miR-431, were differentially expressed in smoking patients compared to nonsmoking patients and were associated with primary tumor size. Functional studies of these miRNAs and the genomic features we identified for potential stratification may reveal underlying mechanisms of bladder cancer carcinogenesis and further diagnosis and treatment methods for urothelial bladder carcinoma

Intrinsic Spin Hall Effect in the presence of Extrinsic Spin-Orbit Scattering

Intrinsic and extrinsic spin Hall effects are considered together on an equal theoretical footing for the Rashba spin-orbit coupling in two-dimensional (2D) electron and hole systems, using the diagrammatic method for calculating the spin Hall conductivity. Our analytic theory for the 2D holes shows the expected lowest-order additive result for the spin Hall conductivity. But, the 2D electrons manifest a very surprising result, exhibiting a non-analyticity in the Rashba coupling strength $\alpha$ where the strictly extrinsic spin Hall conductivity (for $\alpha = 0$) cannot be recovered from the $\alpha \to 0$ limit of the combined theory. The theoretical results are discussed in the context of existing experimental results.Comment: 5 pages, 2 figure