4,608 research outputs found
Molecular Dynamics Computer Simulation of the Dynamics of Supercooled Silica
We present the results of a large scale computer simulation of supercooled
silica. We find that at high temperatures the diffusion constants show a
non-Arrhenius temperature dependence whereas at low temperature this dependence
is also compatible with an Arrhenius law. We demonstrate that at low
temperatures the intermediate scattering function shows a two-step relaxation
behavior and that it obeys the time temperature superposition principle. We
also discuss the wave-vector dependence of the nonergodicity parameter and the
time and temperature dependence of the non-Gaussian parameter.Comment: 5 pages, Latex, 6 postscript figure
How Many Muscles? Optimal Muscles Set Search for Optimizing Myocontrol Performance
In myo-control, for computational and setup constraints, the measurement of a high number of muscles is not always possible: the choice of the muscle set to use in a myo-control strategy depends on the desired application scope and a search for a reduced muscle set, tailored to the application, has never been performed. The identification of such set would involve finding the minimum set of muscles whose difference in terms of intention detection performance is not statistically significant when compared to the original set. Also, given the intrinsic sensitivity of muscle synergies to variations of EMG signals matrix, the reduced set should not alter synergies that come from the initial input, since they provide physiological information on motor coordination. The advantages of such reduced set, in a rehabilitation context, would be the reduction of the inputs processing time, the reduction of the setup bulk and a higher sensitivity to synergy changes after training, which can eventually lead to modifications of the ongoing therapy. In this work, the existence of a minimum muscle set, called optimal set, for an upper-limb myoelectric application, that preserves performance of motor activity prediction and the physiological meaning of synergies, has been investigated. Analyzing isometric contractions during planar reaching tasks, two types of optimal muscle sets were examined: a subject-specific one and a global one. The former relies on the subject-specific movement strategy, the latter is composed by the most recurrent muscles among subjects specific optimal sets and shared by all the subjects. Results confirmed that the muscle set can be reduced to achieve comparable hand force estimation performances. Moreover, two types of muscle synergies namely “Pose-Shared” (extracted from a single multi-arm-poses dataset) and “Pose-Related” (clustering pose-specific synergies), extracted from the global optimal muscle set, have shown a significant similarity with full-set related ones meaning a high consistency of the motor primitives. Pearson correlation coefficients assessed the similarity of each synergy. The discovering of dominant muscles by means of the optimization of both muscle set size and force estimation error may reveal a clue on the link between synergistic patterns and the force task
Path integral Monte Carlo simulations of silicates
We investigate the thermal expansion of crystalline SiO in the --
cristobalite and the -quartz structure with path integral Monte Carlo
(PIMC) techniques. This simulation method allows to treat low-temperature
quantum effects properly. At temperatures below the Debye temperature, thermal
properties obtained with PIMC agree better with experimental results than those
obtained with classical Monte Carlo methods.Comment: 27 pages, 10 figures, Phys. Rev. B (in press
Antibody-based immunotherapy for ovarian cancer: where are we at?
Cytoreductive surgery and chemotherapy continue to be the mainstay of ovarian cancer treatment. However, as mortality from advanced ovarian cancer remains very high, novel therapies are required to be integrated into existing treatment regimens. Immunotherapy represents an alternative and rational therapeutic approach for ovarian cancer based on a body of evidence supporting a protective role of the immune system against these cancers, and on the clinical success of immunotherapy in other malignancies. Whether or not immunotherapy will have a role in the future management of ovarian cancer is too early to tell, but research in this field is active. This review will discuss recent clinical developments of selected immunotherapies for ovarian cancer which fulfil the following criteria: (i) they are antibody-based, (ii) target a distinct immunological pathway, and (iii) have reached the clinical trial stage. Specifically, the focus is on Catumaxomab (anti-EpCAM × anti-CD3), Abagovomab, Oregovomab (anti-CA125), Daclizumab (anti-CD25), Ipilimumab (anti-CTLA-4), and MXD-1105 (anti-PD-L1). Catumaxomab has reached phase III clinical trials and exhibits promise with reports, showing that it can cause a significant and sustained reduction in ascites. Phase I-III clinical trials continue to be conducted on the other antibodies, some of which have had encouraging reports. We will also provide our perspective on the future of immunotherapy for ovarian cancer, and how it may be best employed in treatment regimen
Frequency-Dependent Squeezing for Advanced LIGO
The first detection of gravitational waves by the Laser Interferometer
Gravitational-wave Observatory (LIGO) in 2015 launched the era of gravitational
wave astronomy. The quest for gravitational wave signals from objects that are
fainter or farther away impels technological advances to realize ever more
sensitive detectors. Since 2019, one advanced technique, the injection of
squeezed states of light is being used to improve the shot noise limit to the
sensitivity of the Advanced LIGO detectors, at frequencies above Hz.
Below this frequency, quantum back action, in the form of radiation pressure
induced motion of the mirrors, degrades the sensitivity. To simultaneously
reduce shot noise at high frequencies and quantum radiation pressure noise at
low frequencies requires a quantum noise filter cavity with low optical losses
to rotate the squeezed quadrature as a function of frequency. We report on the
observation of frequency-dependent squeezed quadrature rotation with rotation
frequency of 30Hz, using a 16m long filter cavity. A novel control scheme is
developed for this frequency-dependent squeezed vacuum source, and the results
presented here demonstrate that a low-loss filter cavity can achieve the
squeezed quadrature rotation necessary for the next planned upgrade to Advanced
LIGO, known as "A+."Comment: 6 pages, 2 figures, to be published in Phys. Rev. Let
Crystal-like high frequency phonons in the amorphous phases of solid water
The high frequency dynamics of low- (LDA) and high-density amorphous-ice
(HDA) and of cubic ice (I_c) has been measured by inelastic X-ray Scattering
(IXS) in the 1-15 nm^{-1} momentum transfer (Q) range. Sharp phonon-like
excitations are observed, and the longitudinal acoustic branch is identified up
to Q = 8nm^{-1} in LDA and I_c and up to 5nm^{-1} in HDA. The narrow width of
these excitations is in sharp contrast with the broad features observed in all
amorphous systems studied so far. The "crystal-like" behavior of amorphous
ices, therefore, implies a considerable reduction in the number of decay
channels available to sound-like excitations which is assimilated to low local
disorder.Comment: 4 pages, 3 figure
Veni Vidi Dixi: Reliable Wireless Communication with Depth Images
The upcoming industrial revolution requires deployment of critical wireless
sensor networks for automation and monitoring purposes. However, the
reliability of the wireless communication is rendered unpredictable by mobile
elements in the communication environment such as humans or mobile robots which
lead to dynamically changing radio environments. Changes in the wireless
channel can be monitored with frequent pilot transmission. However, that would
stress the battery life of sensors. In this work a new wireless channel
estimation technique, Veni Vidi Dixi, VVD, is proposed. VVD leverages the
redundant information in depth images obtained from the surveillance cameras in
the communication environment and utilizes Convolutional Neural Networks CNNs
to map the depth images of the communication environment to complex wireless
channel estimations. VVD increases the wireless communication reliability
without the need for frequent pilot transmission and with no additional
complexity on the receiver. The proposed method is tested by conducting
measurements in an indoor environment with a single mobile human. Up to authors
best knowledge our work is the first to obtain complex wireless channel
estimation from only depth images without any pilot transmission. The collected
wireless trace, depth images and codes are publicly available.Comment: Accepted for publication in CoNext 2019 with reproducibility badges.
The measurements and the processing codes are available at
https://gitlab.lrz.de/lkn_measurements/vvd_measurements for your evaluatio
Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review)
Sick sinus syndrome (SSS) encompasses a group of disorders whereby the heart is unable to perform its pacemaker function, due to genetic and acquired causes. Tachycardia‑bradycardia syndrome (TBS) is a complication of SSS characterized by alternating tachycardia and bradycardia. Techniques such as genetic screening and molecular diagnostics together with the use of pre-clinical models have elucidated the electrophysiological mechanisms of this condition. Dysfunction of ion channels responsible for initiation or conduction of cardiac action potentials may underlie both bradycardia and tachycardia; bradycardia can also increase the risk of tachycardia, and vice versa. The mainstay treatment option for SSS is pacemaker implantation, an effective approach, but has disadvantages such as infection, limited battery life, dislodgement of leads and catheters to be permanently implanted in situ. Alternatives to electronic pacemakers are gene‑based bio‑artificial sinoatrial node and cell‑based bio‑artificial pacemakers, which are promising techniques whose long-term safety and efficacy need to be established. The aim of this article is to review the different ion channels involved in TBS, examine the three‑way relationship between ion channel dysfunction, tachycardia and bradycardia in TBS and to consider its current and future therapies.GT was supported by the BBSRC and YC is supported by the ESRC for their PhD studies. GT is grateful to the Croucher Foundation of Hong Kong for supporting his clinical assistant professorship
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