Outcomes of surgery for high transsphincteric anal fistulas: prospective randomized trial

Background. Reliable data on the efficacy and safety of fistulectomy with primary sphincter repair for the treatment of high transsphincteric anal fistulas are deficient.The aim. To compare the efficacy and safety of fistulectomy with advancement muco-muscular flap (F) and fistulectomy with primary sphincter reconstruction (SR) for the treatment of high anorectal fistulas.Methods. A cohort of 92 consecutive patients with transsphincteric anal fistula involving 1/3 to 2/3 of the sphincteric complex were included in prospective randomized study. The primary endpoint was the recurrence rate. The duration of surgery, blood loss, pain intensity, postoperative complications, the duration of wound healing, incontinence, quality of life were registered.Results. Forty-six patients were randomized in each group. A statistically significant difference was obtained for operative time (Group “F” – 45 (20–160) min, Group “SR” – 33 (10–55) min). The blood loss was 3 (1–20) and 2 (1–10) ml in Groups “F” and “SR”, respectively (p = 0.482). The return to work in Groups “SR” and “F” occurred after 7 (2–14) and 8 (4–20) days, respectively (p = 0.005). The pain syndrome was significantly greater in Group “F” (p < 0.05) on days 1 and 7. Recurrence rate was in 23.9 % (11 cases) in Group “F” and in 6.5 % (3 cases) in Group “SR” (p = 0.042). Incontinence was in 7 (15.2 %) people in Group “F”, in 10 patients (21.7 %) – in Group “SR” (p = 0.591). There was no statistically significant difference in postoperative complications.Conclusion. Findings can expand the indications for the treatment of high transsphincteric anorectal fistulas involving from 1/3 to 2/3 of the sphincter complex without statistically significant risk for functional results

Thermophysical properties of the fe48cr15mo14c15b6y2 alloy in liquid state

In this work, the physical properties of Fe48Cr15Mo14C15B6Y2 alloy in liquid state at high temperature are studied. It was observed that the basic physical characteristics of the alloy, such as viscosity, electrical resistivity, and density, decrease with an increase of the temperature to 1700◦C. An abnormal increasing rate of viscosity for Fe48Cr15Mo14C15B6Y2 alloy in the temperature range from 1360 to 1550◦C was noted. The measurement of the electrical resistivity and density did not reveal any anomalies in the same temperature range. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.This research was funded by of the Ministry of Science and Higher Education of the Russian Federation in the framework of the Increase Competitiveness Program of NUST «MISiS» (grant number K2-2020-046). V.S.T., V.V.K. and V.V.V gratefully acknowledge the financial support made within the framework of state work No. FEUZ-0836-0020. Also, D.S.K. and J.V.I. gratefully acknowledge the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 897815 NanoSurf

General Terminology Induction in OWL

Abstract. Automated acquisition, or learning, of ontologies has attracted re-search attention because it can help ontology engineers build ontologies and give domain experts new insights into their data. However, existing approaches to on-tology learning are considerably limited, e.g. focus on learning descriptions for given classes, require intense supervision and human involvement, make assump-tions about data, do not fully respect background knowledge. We investigate the problem of general terminology induction, i.e. learning sets of general class in-clusions, GCIs, from data and background knowledge. We introduce measures that evaluate logical and statistical quality of a set of GCIs. We present methods to compute these measures and an anytime algorithm that induces sets of GCIs. Our experiments show that we can acquire interesting sets of GCIs and provide insights into the structure of the search space.

ИССЛЕДОВАНИЕ И МОДЕЛИРОВАНИЕ ПРОЦЕССОВ КРИСТАЛЛИЗАЦИИ ОБЪЕМНЫХ МЕТАЛЛИЧЕСКИХ СТЕКОЛ НА ОСНОВЕ ЦИРКОНИЯ

The article describes the investigation and simulation of Zr-based bulk metallic glass crystallization kinetics using DSC and DIC techniques. The investigation of the kinetics of crystallization processes may eventually provide deeper understanding of the bulk metallic glass crystallization mechanism and promote the evidence-based selection of heat treatment to form desired structure and properties of bulk metallic glasses based composites.Работа посвящена исследованию и моделированию кинетики кристаллизации объемных металлических стекол на основе циркония при нагреве с постоянной скоростью, а также при изотермической выдержке при повышенной температуре. Исследование кинетики процессов кристаллизации со временем может обеспечить более глубокое понимание механизма кристаллизации объемных металлических стекол и способствовать научно обоснованному выбору режимов термической обработки для формирования желаемых структуры и свойств композиционных материалов на их основе

Ontology Design Patterns for bio-ontologies: a case study on the Cell Cycle Ontology

<p>Abstract</p> <p>Background</p> <p>Bio-ontologies are key elements of knowledge management in bioinformatics. Rich and rigorous bio-ontologies should represent biological knowledge with high fidelity and robustness. The richness in bio-ontologies is a prior condition for diverse and efficient reasoning, and hence querying and hypothesis validation. Rigour allows a more consistent maintenance. Modelling such bio-ontologies is, however, a difficult task for bio-ontologists, because the necessary richness and rigour is difficult to achieve without extensive training.</p> <p>Results</p> <p>Analogous to design patterns in software engineering, Ontology Design Patterns are solutions to typical modelling problems that bio-ontologists can use when building bio-ontologies. They offer a means of creating rich and rigorous bio-ontologies with reduced effort. The concept of Ontology Design Patterns is described and documentation and application methodologies for Ontology Design Patterns are presented. Some real-world use cases of Ontology Design Patterns are provided and tested in the Cell Cycle Ontology. Ontology Design Patterns, including those tested in the Cell Cycle Ontology, can be explored in the Ontology Design Patterns public catalogue that has been created based on the documentation system presented (<url>http://odps.sourceforge.net/</url>).</p> <p>Conclusions</p> <p>Ontology Design Patterns provide a method for rich and rigorous modelling in bio-ontologies. They also offer advantages at different development levels (such as design, implementation and communication) enabling, if used, a more modular, well-founded and richer representation of the biological knowledge. This representation will produce a more efficient knowledge management in the long term.</p