Stanilov-Tsankov-Videv Theory

We survey some recent results concerning Stanilov-Tsankov-Videv theory, conformal Osserman geometry, and Walker geometry which relate algebraic properties of the curvature operator to the underlying geometry of the manifold.Comment: This is a contribution to the Proceedings of the 2007 Midwest Geometry Conference in honor of Thomas P. Branson, published in SIGMA (Symmetry, Integrability and Geometry: Methods and Applications) at http://www.emis.de/journals/SIGMA

Performance of the PADME calorimeter prototype at the DAΦ\PhiNE BTF

The PADME experiment at the DA$\Phi$NE Beam-Test Facility (BTF) aims at searching for invisible decays of the dark photon by measuring the final state missing mass in the process $e^+e^- \to \gamma+ A'$, with $A'$ undetected. The measurement requires the determination of the 4-momentum of the recoil photon, performed using a homogeneous, highly segmented BGO crystals calorimeter. We report the results of the test of a 5$\times$5 crystals prototype performed with an electron beam at the BTF in July 2016

Genetic diversity and host alternation of the egg parasitoid Oencyrtus pityocampae between the pine processionary moth and caper bug

Research ArticleThe increased use of molecular tools for species identification in recent decades revealed that each of many apparently generalist parasitoids are actually a complex of morphologically similar congeners, most of which have a rather narrow host range. Ooencyrtus pityocampae (OP), an important egg parasitoid of the pine processionary moth (PPM), is considered a generalist parasitoid. OP emerges from PPM eggs after winter hibernation, mainly in spring and early summer, long before the eggs of the next PPM generation occurs. The occurrence of OP in eggs of the variegated caper bug (CB) Stenozygum coloratum in spring and summer suggests that OP populations alternate seasonally between PPM and CB. However, the identity of OP population on CB eggs seemed uncertain; unlike OP-PPM populations, the former displayed apparently high male/female ratios and lack of attraction to the PPM sex pheromone. We studied the molecular identities of the two populations since the morphological identification of the genus Ooencyrtus, and OP in particular, is difficult. Sequencing of COI and ITS2 DNA fragments and AFLP analysis of individuals from both hosts revealed no apparent differences between the OP-PPM and the OP-CB populations for both the Israeli and the Turkish OPs, which therefore supported the possibility of host alternation. Sequencing data extended our knowledge of the genetic structure of OP populations in the Mediterranean area, and revealed clear separation between East and West Mediterranean populations. The overall level of genetic diversity was rather small, with the Israeli population much less diverse than all others; possible explanations for this finding are discussed. The findings support the possibility of utilizing the CB and other hosts for enhancing biological control of the PPMinfo:eu-repo/semantics/publishedVersio

Stanilov-Tsankov-Videv Theory

We survey some recent results concerning Stanilov-Tsankov-Videv theory, conformal Osserman geometry, and Walker geometry which relate algebraic properties of the curvature operator to the underlying geometry of the manifold

Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression

Maintenance of pluripotency and specification towards a new cell fate are both dependent on precise interactions between extrinsic signals and transcriptional and epigenetic regulators. Directed methylation of cytosines by the de novo methyltransferases DNMT3A and DNMT3B plays an important role in facilitating proper differentiation, whereas DNMT1 is essential for maintaining global methylation levels in all cell types. Here, we generated single-cell mRNA expression data from wild-type, DNMT3A, DNMT3A/3B and DNMT1 knockout human embryonic stem cells and observed a widespread increase in cellular and transcriptional variability, even with limited changes in global methylation levels in the de novo knockouts. Furthermore, we found unexpected transcriptional repression upon either loss of the de novo methyltransferase DNMT3A or the double knockout of DNMT3A/3B that is further propagated upon differentiation to mesoderm and ectoderm. Taken together, our single-cell RNA-sequencing data provide a high-resolution view into the consequences of depleting the three catalytically active DNMTs in human pluripotent stem cells

Inhibition of 26S Protease Regulatory Subunit 7 (MSS1) Suppresses Neuroinflammation

Recently, researchers have focused on immunosuppression induced by rifampicin. Our previous investigation found that rifampicin was neuroprotective by inhibiting the production of pro-inflammatory mediators, thereby suppressing microglial activation. In this study, using 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), we discovered that 26S protease regulatory subunit 7 (MSS1) was decreased in rifampicin-treated microglia. Western blot analysis verified the downregulation of MSS1 expression by rifampicin. As it is indicated that the modulation of the ubiquitin-26S proteasome system (UPS) with proteasome inhibitors is efficacious for the treatment of neuro-inflammatory disorders, we next hypothesized that silencing MSS1 gene expression might inhibit microglial inflammation. Using RNA interference (RNAi), we showed significant reduction of IkBα degradation and NF-kB activation. The production of lipopolysaccharides-induced pro-inflammatory mediators such as inducible nitric oxide synthase (iNOS), nitric oxide, cyclooxygenase-2, and prostaglandin E2 were also reduced by MSS1 gene knockdown. Taken together, our findings suggested that rifampicin inhibited microglial inflammation by suppressing MSS1 protein production. Silencing MSS1 gene expression decreased neuroinflammation. We concluded that MSS1 inhibition, in addition to anti-inflammatory rifampicin, might represent a novel mechanism for the treatment of neuroinflammatory disorders

The PADME electromagnetic calorimeter

The PADME experiment, hosted at Laboratori Nazionali di Frascati in Italy, is going to start its data taking in September 2018. It is designed to search for the Dark Photon (indicated by the symbol A′), an hypothetical particle that can explain the Dark Matter elusiveness, possibly produced in the reaction e + e - → A′ γ. Together with the target, the segmented electromagnetic calorimeter is the most important component of the experiment, since it is needed to detect the recoil photon energy and position, in such a way to measure the A′ mass. It will consist of 616 2.1 × 2.1 × 23.0 cm3 BGO crystals arranged in a cylindrical shape and read by HZC photomultipliers with a diameter of 1.9 cm. Here we present the results obtained during the measurements performed on the scintillating units with a radioactive source and test beams, together with an overall description of the entire experiment

Characterisation and performance of the PADME electromagnetic calorimeter

The PADME experiment at the LNF Beam Test Facility searches for dark photons produced in the annihilation of positrons with the electrons of a fixed target. The strategy is to look for the reaction e+ + e− → γ + A0, where A0 is the dark photon, which cannot be observed directly or via its decay products. The electromagnetic calorimeter plays a key role in the experiment by measuring the energy and position of the final-state γ. The missing four-momentum carried away by the A0 can be evaluated from this information and the particle mass inferred. This paper presents the design, construction, and calibration of the PADME’s electromagnetic calorimeter. The results achieved in terms of equalisation, detection efficiency and energy resolution during the first phase of the experiment demonstrate the effectiveness of the various tools used to improve the calorimeter performance with respect to earlier prototypes

Ultraweak excitations of the quantum vacuum as physical models of gravity

It has been argued by several authors that the space-time curvature observed in gravitational fields, and the same idea of forms of physical equivalence different from the Lorentz group, might emerge from the dynamical properties of the physical flat-space vacuum in a suitable hydrodynamic limit. To explore this idea, one could start by representing the physical vacuum as a Bose condensate of elementary quanta and look for vacuum excitations that, on a coarse grained scale, resemble the Newtonian potential. In this way, it is relatively easy to match the weak-field limit of classical General Relativity or of some of its possible variants. The idea that Bose condensates can provide various forms of gravitational dynamics is not new. Here, I want to emphasize some genuine quantum field theoretical aspects that can help to understand i) why infinitesimally weak, 1/r interactions can indeed arise from the same physical vacuum of electroweak and strong interactions and ii) why, on a coarse-grained scale, their dynamical effects can be re-absorbed into an effective curved metric structure.Comment: 30 pages, no figures, accepted by Classical and Quantum Gravit