The Effects Of Four Different Strategies Of Information Presentation I

The purpose of this study was to investigate whether learners\u27 computer self-efficacy and prior computer knowledge influence their performance and satisfaction when presented with various instructional strategies of information presentation in computer-based software training. Seventy-eight undergraduate students were randomly assigned into four groups (a) deductive-inquisitory, which present general information first and then require learner to generates examples, (b) deductive-expository, which present general information first then present examples, (c) inductive-inquisitory, which present examples first and then require learners to discover relationship, (d) inductive-expository, which present examples first then present general information. The instructional materials were computer-based Netscape Composer 7.1 tutorials. For the comparison of inductive-inquisitory and inductive-expository groups, results indicated that learners with higher computer self-efficacy not only performed better but also were more satisfied towards inductive-inquisitory strategy for information presentation. Learners with low computer self-efficacy benefited more from the inductive-expository approach of information presentation. Furthermore, for the comparison of deductive-expository and inductive-expository groups, learners with high computer self-efficacy performed better in deductive-expository strategy, while learners with low computer self-efficacy benefited more in inductive-expository strategy. Some of the research recommendations for further research included using a larger sample size for the generality of the finding, measuring how different instructional strategies influence the learners\u27 long term memory, and exploring other possible moderating factors and other strategies for information presentation that has positive impact on learners\u27 performance in and satisfaction towards computer based software training

iPDA: integrated protein disorder analyzer

This article presents a web server iPDA, which aims at identifying the disordered regions of a query protein. Automatic prediction of disordered regions from protein sequences is an important problem in the study of structural biology. The proposed classifier DisPSSMP2 is different from several existing disorder predictors by its employment of position-specific scoring matrices with respect to physicochemical properties (PSSMP), where the physicochemical properties adopted here especially take the disorder propensity of amino acids into account. The web server iPDA integrates DisPSSMP2 with several other sequence predictors in order to investigate the functional role of the detected disordered region. The predicted information includes sequence conservation, secondary structure, sequence complexity and hydrophobic clusters. According to the proportion of the secondary structure elements predicted, iPDA dynamically adjusts the cutting threshold of determining protein disorder. Furthermore, a pattern mining package for detecting sequence conservation is embedded in iPDA for discovering potential binding regions of the query protein, which is really helpful to uncovering the relationship between protein function and its primary sequence. The web service is available at http://biominer.bime.ntu.edu.tw/ipda and mirrored at http://biominer.cse.yzu.edu.tw/ipda

Impacts of Light Rail Transit Tram on the Voltage and Unbalance of the Distribution System

This paper presents the three-phase voltage and unbalance analysis for the distribution system with the loading of a light rail transit (LRT) tram. To investigate the dynamic responses of the system voltage and current, this paper adopts the Alternative Transients Program (ATP) software to model and simulate a multigrounded four-wire distribution system with an LRT loading. Two different definitions about unbalance are used to evaluate the problem. In this paper, the traction supply substation (TSS) with a single-phase transformer configuration is designed first for providing the electric power to the trams of LRT. However, it may result in the significant neutral line current and unbalance phenomenon to deteriorate the power quality of the distribution system. A Le-Blanc connection transformer in the TSS is therefore proposed to solve the problems

Human parvovirus B19 nonstructural protein NS1 enhanced the expression of cleavage of 70 kDa U1-snRNP autoantigen

<p>Abstract</p> <p>Background</p> <p>Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders. Although we have previously reported that B19 non-structural protein (NS1) induces mitochondrial-dependent apoptosis in COS-7 cells, the precise mechanism of B19-NS1 in developing autoimmunity is still obscure.</p> <p>Methods</p> <p>To further examine the effect of B19-NS1 in presence of autoantigens, COS-7 cells were transfected with pEGFP, pEGFP-B19-NS1 and pEGFP-NS1K334E, a mutant form of B19-NS1, and detected the expressions of autoantigens by various autoantibodies against Sm, U1 small nuclear ribonucleoprotein (U1-snRNP), SSA/Ro, SSB/La, Scl-70, Jo-1, Ku, and centromere protein (CENP) A/B by using Immunoblotting.</p> <p>Results</p> <p>Significantly increased apoptosis was detected in COS-7 cells transfected with pEGFP-B19-NS1 compared to those transfected with pEGFP. Meanwhile, the apoptotic 70 kDa U1-snRNP protein in COS-7 cells transfected with pEGFP-B19-NS1 is cleaved by caspase-3 and converted into a specific 40 kDa product, which were recognized by anti-U1-snRNP autoantibody. In contrast, significantly decreased apoptosis and cleaved 40 kDa product were observed in COS-7 cells transfected with pEGFP-NS1K334E compared to those transfected with pEGFP-B19-NS1.</p> <p>Conclusions</p> <p>These findings suggested crucial association of B19-NS1 in development of autoimmunity by inducing apoptosis and specific cleavage of 70 kDa U1-snRNP.</p

Common-mode noise reduction schemes for weakly coupled differential serpentine delay microstrip lines

This paper proposes design schemes to reduce the common mode noise from weakly coupled differential serpentine delay microstrip lines (DSDMLs). The proposed approach is twofold: we leverage strongly coupled vertical-turn-coupled traces (VTCTs) instead of weakly coupled VTCTs (conventional pattern) and add guard traces. Time- and frequency-domain analyses of the proposed schemes for reducing the common-mode noise are performed by studying the transmission waveform and the differential-to-common mode conversion using the circuit solver HSPICE and the 3-D full-wave simulator HFSS, respectively. Compared to the conventional design of the weakly coupled DSDMLs, the proposed solutions yield a reduction of about 54% of the peak-to-peak amplitude of the common-mode noise, while the differential impedance remains matched along the complete length of the DSDML. Moreover, the range of frequencies, over which the magnitude of the differential-to-common mode conversion is now significantly reduced, is very wide, i.e. about 0.3-10 GHz. Furthermore, the differential insertion and reflection loss introduced by the newly proposed designs are almost the same as the ones achieved by using the conventional design. Finally, a favorable comparison between simulated and measured results confirms the excellent common-mode noise reduction performance of the proposed schemes