Exile Vol. XVIII

POETRY The Man And His Table by Al Werder 3 Ours by Debra Tucker 6 Running through rows and pile of leaves by Molly O\u27neill 12 Looking Glass by Alice Colthart 13 16 Years Old by Peter Porteous 14-15 a feather by Judy Meloy 28 I kicked summer\u27s shed garments by Bruce P. Andre 29 Tuesday Afternoon by Juliet Lockwood 30 snuggled deep inside by Judi Hasel 31 Star Spangled Pterdactyl by Peter Porteous 44 Billy\u27s by Suzi Harriss 45 Hong Kong by Peter Porteous 46 Ennui by Debra Tucker 47 pathetic collapse by Bruce P. Andre 48 In place of alphabet by Suzi Harriss 51 Encore by Richard Glaser 58 reflections disrupt by Judi Hasel 60 FICTION Eyes by Clark Blaise 7-11 Characters From New Mexico Life by Ardyth Hilts 16-27 Hospital Scene by Dennis Trudell 34-35 A Late Morning by Peter Porteous 36-42 Accident by Richard Glaser 52-57 ART Cover by Gail Lutsch by Jane Demos 5 by Tom Coulter 10 by Maria Ramoki 13 by Vicki Haskell 11, 15 by Alex Hutton 20 by Pat Menster 31, 59 by Scott Kenan 43 by Ann Merrill 46 by James Lautz PHOTOGRAPHY by Kathy Kerschner 1, 2, 62, 36, 64 by Bruce P. Andre 7, 28, 49 by Bruce Marshall 32, 36, 42, 61 to Paul Bennett, founder of Exile, teacher, 25 years. 2 The following previous graduates of Denison University contributed pieces of fiction to this issue of Exile: Clark Blaise \u2761 (Eyes 7-11) and Dennis Trudell \u2760 (Hospital Scene 34-35

VIDEO: Opening Session: Welcome and Introductions, Opening Reflections, Evening Tributes, and Closing Tribute

VIDEO: 5:30 p.m. - 6:45 p.m. OPENING SESSION Welcome and Introductions: Sarah Krakoff, Professor of Law, University of Colorado Law School; Phil Weiser, Dean, University of Colorado Law School Opening Reflections: Michael Connor, Deputy Secretary, United States Department of the Interior Evening Tributes: Moderator: Phil Weiser, Dean, University of Colorado Law School Speakers: Richard Trudell, Executive Director, American Indian Resources Institute Monte Mills, Assistant Professor & Co-Director, Margery Hunter Brown Indian Law Clinic, Alexander Blewett III School of Law, University of Montana John Leshy, Professor of Law, University of California at Hastings John Echohawk, Executive Director, Native American Rights Fund Michael Connor, Deputy Secretary, United States Department of the Interior Closing Tribute: Ann Marks Getches, GWC Advisory Counci

VIDEO: Opening Session: Welcome and Introductions, Opening Reflections, Evening Tributes, and Closing Tribute

VIDEO: 5:30 p.m. - 6:45 p.m. OPENING SESSION Welcome and Introductions: Sarah Krakoff, Professor of Law, University of Colorado Law School; Phil Weiser, Dean, University of Colorado Law School Opening Reflections: Michael Connor, Deputy Secretary, United States Department of the Interior Evening Tributes: Moderator: Phil Weiser, Dean, University of Colorado Law School Speakers: Richard Trudell, Executive Director, American Indian Resources Institute Monte Mills, Assistant Professor & Co-Director, Margery Hunter Brown Indian Law Clinic, Alexander Blewett III School of Law, University of Montana John Leshy, Professor of Law, University of California at Hastings John Echohawk, Executive Director, Native American Rights Fund Michael Connor, Deputy Secretary, United States Department of the Interior Closing Tribute: Ann Marks Getches, GWC Advisory Counci

Synthesis, Dopamine Transporter Affinity, Dopamine Uptake Inhibition, and Locomotor Stimulant Activity of 2-Substituted 3β-Phenyltropane Derivatives

A series of 2β-substituted 3β-phenyltropanes were synthesized as analogs of cocaine and tested in vitro for their ability to displace bound [3H]WIN 35,428 (2b) and inhibit dopamine uptake in rat caudate-putamen tissue. The analogs bound with high affinity (K i = 11−22 nM) to the dopamine transporter. Increased lipophilicity at the β-C(2)-position was found to lead to increased binding affinity and increased dopamine uptake potency. However, a direct correlation between clogP values and binding affinity and potency of uptake inhibition was not observed. The unsaturated ester 7 was found to possess weak dopamine uptake inhibition relative to the high binding affinity (IC50/K i = 10.2). In vivo measurement of stimulated locomotor activity and drug discrimination against cocaine (10 mg/kg, ip) with selected analogs (4, 6, and 7) demonstrated that the behavioral effects of these drugs were approximately equipotent with those of cocaine. The structure−activity relationships of this series of cocaine analogs supports a pharmacophore model in which lipophilic interactions between the β-C(2)-position of 3β-phenyltropanes and the cocaine binding site on the dopamine transporter lead to enhanced potency while electrostatic interactions have a nonspecific effect

Comparison of root-associated communities of native and non-native ectomycorrhizal hosts in an urban landscape

Non-native tree species are often used as ornamentals in urban landscapes. However, their root-associated fungal communities remain yet to be examined in detail. Here, we compared richness, diversity and community composition of ectomycorrhizosphere fungi in general and ectomycorrhizal (EcM) fungi in particular between a non-native Pinus nigra and a native Quercus macrocarpa across a growing season in urban parks using 454-pyrosequencing. Our data show that, while the ectomycorrhizosphere community richness and diversity did not differ between the two hosts, the EcM communities associated with the native host were often more species rich and included more exclusive members than those of the non-native hosts. In contrast, the ectomycorrhizosphere communities of the two hosts were compositionally clearly distinct in nonmetric multidimensional ordination analyses, whereas the EcM communities were only marginally so. Taken together, our data suggest EcM communities with broad host compatibilities and with a limited numbers of taxa with preference to the non-native host. Furthermore, many common fungi in the non-native Pinus were not EcM taxa, suggesting that the non-native host communities may be enriched in non-mycorrhizal fungi at the cost of the EcM taxa. Finally, while our colonization estimates did not suggest a shortage in EcM inoculum for either host in urban parks, the differences in the fungi associated with the two hosts emphasize the importance of using native hosts in urban environments as a tool to conserve endemic fungal diversity and richness in man-made systems