Automatic controllers for the Apollo LCG Final report

Automatic controllers for liquid cooling garment of Apollo full pressure sui

Rate of heat extraction controller for environmental control

Automatic control device measures a physiological parameter related to heat production and conditions it to control the heat removal capacity of a watercooled environmental control suit

Cycles in metabolism and heat loss

Using calorimetric techniques, subjects' metabolism, thermoregulation, and body temperatures were monitored continuously for 24-hour days, using three types of experimental routines. A water cooling garment (WCG) was used for direct calorimetry, while partitional calorimetry was used to establish a non-suited comparison for one of the routines. In this replicated routine, called the quiet day, the subjects were sedentary throughout the daytime hours and slept normally at night. Results indicate that the WCG may act to reduce 24-hour total oxygen consumption (VO2) or heat production, possibly due to the lowered energy cost of thermoregulation

Programmed-pressure air supply for positive-pressure breathing system

Motor-driven cam varies height of mercury column connected to loading diaphragm of pressure-regulating valve. Air supplied to open-loop, positive pressure breathing system is controlled so repetitive pressure--time profiles can be obtained during every insufflation--exhaust cycle

High-Resolution Near Infrared Spectroscopy of HD 100546: II. Analysis of variable rovibrational CO emission lines

We present observations of rovibrational CO in HD 100546 from four epochs spanning January 2003 through December 2010. We show that the equivalent widths of the CO lines vary during this time period with the v=1-0 CO lines brightening more than the UV fluoresced lines from the higher vibrational states. While the spectroastrometric signal of the hot band lines remains constant during this period, the spectroastrometric signal of the v=1--0 lines varies substantially. At all epochs, the spectroastrometric signals of the UV fluoresced lines are consistent with the signal one would expect from gas in an axisymmetric disk. In 2003, the spectroastrometric signal of the v=1-0 P26 line was symmetric and consistent with emission from an axisymmetric disk. However, in 2006, there was no spatial offset of the signal detected on the red side of the profile, and in 2010, the spectroastrometric offset was yet more strongly reduced toward zero velocity. A model is presented that can explain the evolution of the equivalent width of the v=1-0 P26 line and its spectroastrometric signal by adding to the system a compact source of CO emission that orbits the star near the inner edge of the disk. We hypothesize that such emission may arise from a circumplanetary disk orbiting a gas giant planet near the inner edge of the circumstellar disk. We discuss how this idea can be tested observationally and be distinguished from an alternative interpretation of random fluctuations in the disk emission.Comment: 18 pages, 10 figure

High-Resolution Near Infrared Spectroscopy of HD 100546: I. Analysis of Asymmetric Ro-Vibrational OH Emission Lines

We present observations of ro-vibrational OH and CO emission from the Herbig Be star HD 100546. The emission from both molecules arises from the inner region of the disk extending from approximately 13 AU from the central star. The velocity profiles of the OH lines are narrower than the velocity profile of the [O I] 6300 Angstrom line indicating that the OH in the disk is not cospatial with the O I. This suggests that the inner optically thin region of the disk is largely devoid of molecular gas. Unlike the ro-vibrational CO emission lines, the OH lines are highly asymmetric. We show that the average CO and average OH line profiles can be fit with a model of a disk comprised of an eccentric inner wall and a circular outer disk. In this model, the vast majority of the OH flux (75%) originates from the inner wall, while the vast majority of the CO flux (65%) originates on the surface of the disk at radii greater than 13 AU. Eccentric inner disks are predicted by hydrodynamic simulations of circumstellar disks containing an embedded giant planet. We discuss the implications of such a disk geometry in light of models of planet disk tidal interactions and propose alternate explanations for the origin of the asymmetry

Moral Commitment to Tax Compliance as Measured by the Development of Moral Reasoning and Attitudes Towards the Fairness of the Tax Laws

Business Administratio

Space robotics: Recent accomplishments and opportunities for future research

The Langley Guidance, Navigation, and Control Technical Committee (GNCTC) was one of six technical committees created in 1991 by the Chief Scientist, Dr. Michael F. Card. During the kickoff meeting Dr. Card charged the chairmen to: (1) establish a cross-Center committee; (2) support at least one workshop in a selected discipline; and (3) prepare a technical paper on recent accomplishments in the discipline and on opportunities for future research. The Guidance, Navigation, and Control Committee was formed and selected for focus on the discipline of Space robotics. This report is a summary of the committee's assessment of recent accomplishments and opportunities for future research. The report is organized as follows. First is an overview of the data sources used by the committee. Next is a description of technical needs identified by the committee followed by recent accomplishments. Opportunities for future research ends the main body of the report. It includes the primary recommendation of the committee that NASA establish a national space facility for the development of space automation and robotics, one element of which is a telerobotic research platform in space. References 1 and 2 are the proceedings of two workshops sponsored by the committee during its June 1991, through May 1992 term. The focus of the committee for the June 1992 - May 1993 term will be to further define to the recommended platform in space and to add an additional discipline which includes aircraft related GN&C issues. To the latter end members performing aircraft related research will be added to the committee. (A preliminary assessment of future opportunities in aircraft-related GN&C research has been included as appendix A.

Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension.

Pulmonary arterial compliance (PAC), invasively assessed by the ratio of stroke volume to pulmonary arterial (PA) pulse pressure, is a sensitive marker of right ventricular (RV)-PA coupling that differs across the spectrum of pulmonary hypertension (PH) and is predictive of outcomes. We assessed whether the echocardiographically derived ratio of RV outflow tract velocity time integral to PA systolic pressure (RVOT-VTI/PASP) (a) correlates with invasive PAC, (b) discriminates heart failure with preserved ejection-associated PH (HFpEF-PH) from pulmonary arterial hypertension (PAH), and (c) is associated with functional capacity. We performed a retrospective cohort study of patients with PAH (n = 70) and HFpEF-PH (n = 86), which was further dichotomized by diastolic pressure gradient (DPG) into isolated post-capillary PH (DPG \u3c 7 mmHg; Ipc-PH, n = 54), and combined post- and pre-capillary PH (DPG ≥ 7 mm Hg; Cpc-PH, n = 32). Of the 156 patients, 146 had measurable RVOT-VTI or PASP and were included in further analysis. RVOT-VTI/PASP correlated with invasive PAC overall (ρ = 0.61, P \u3c 0.001) and for the PAH (ρ = 0.38, P = 0.002) and HFpEF-PH (ρ = 0.63, P \u3c 0.001) groups individually. RVOT-VTI/PASP differed significantly across the PH spectrum (PAH: 0.13 [0.010-0.25] vs. Cpc-PH: 0.20 [0.12-0.25] vs. Ipc-PH: 0.35 [0.22-0.44]; P \u3c 0.001), distinguished HFpEF-PH from PAH (AUC = 0.72, 95% CI = 0.63-0.81) and Cpc-PH from Ipc-PH (AUC = 0.78, 95% CI = 0.68-0.88), and remained independently predictive of 6-min walk distance after multivariate analysis (standardized β-coefficient = 27.7, 95% CI = 9.2-46.3; P = 0.004). Echocardiographic RVOT-VTI/PASP is a novel non-invasive metric of PAC that differs across the spectrum of PH. It distinguishes the degree of pre-capillary disease within HFpEF-PH and is predictive of functional capacity

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.

Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists also cause marked hypertriglyceridemia by inducing the expression of sterol regulatory element-binding protein (SREBP)1c and downstream genes that drive fatty acid biosynthesis. Recent studies demonstrated that desmosterol, an intermediate in the cholesterol biosynthetic pathway that suppresses SREBP processing by binding to SCAP, also binds and activates LXRs and is the most abundant LXR ligand in macrophage foam cells. Here we explore the potential of increasing endogenous desmosterol production or mimicking its activity as a means of inducing LXR activity while simultaneously suppressing SREBP1c-induced hypertriglyceridemia. Unexpectedly, while desmosterol strongly activated LXR target genes and suppressed SREBP pathways in mouse and human macrophages, it had almost no activity in mouse or human hepatocytes in vitro. We further demonstrate that sterol-based selective modulators of LXRs have biochemical and transcriptional properties predicted of desmosterol mimetics and selectively regulate LXR function in macrophages in vitro and in vivo. These studies thereby reveal cell-specific discrimination of endogenous and synthetic regulators of LXRs and SREBPs, providing a molecular basis for dissociation of LXR functions in macrophages from those in the liver that lead to hypertriglyceridemia