96 research outputs found
Wideband digital phase comparator for high current shunts
A wideband phase comparator for precise measurements of phase difference of
high current shunts has been developed at INRIM. The two-input digital phase
detector is realized with a precision wideband digitizer connected through a
pair of symmetric active guarded transformers to the outputs of the shunts
under comparison. Data are first acquired asynchronously, and then transferred
from on-board memory to host memory. Because of the large amount of data
collected the filtering process and the analysis algorithms are performed
outside the acquisition routine. Most of the systematic errors can be
compensated by a proper inversion procedure.
The system is suitable for comparing shunts in a wide range of currents, from
several hundred of milliampere up to 100 A, and frequencies ranging between 500
Hz and 100 kHz. Expanded uncertainty (k=2) less than 0.05 mrad, for frequency
up to 100 kHz, is obtained in the measurement of the phase difference of a
group of 10 A shunts, provided by some European NMIs, using a digitizer with
sampling frequency up to 1 MHz. An enhanced version of the phase comparator
employs a new digital phase detector with higher sampling frequency and
vertical resolution. This permits to decrease the contribution to the
uncertainty budget of the phase detector of a factor two from 20 kHz to 100
kHz. Theories and experiments show that the phase difference between two high
precision wideband digitizers, coupled as phase detector, depends on multiple
factors derived from both analog and digital imprint of each sampling system.Comment: 20 pages, 9 figure
MOTOR DYSFUNCTION OF THE "NON AFFECTED" LOWER LIMB: A KINEMATIC COMPARATIVE STUDY BETWEEN HEMIPARETIC STROKE AND TOTAL KNEE PROSTHESIZED PATIENTS
In patients with hemispheric stroke, abnormal motor performances are described also in the ipsilateral limbs. They may be due to a cortical reorganization in the unaffected hemisphere; moreover, also peripheral mechanisms may play a role. To explore this hypothesis, we studied motor performances in 15 patients with hemispheric stroke and in 14 patients with total knee arthroplasty, which have a reduced motility in the prosthesized leg. Using the unaffected leg, they performed five superimposed circular trajectories in a prefixed pathway on a computerized footboard, while looking at a marker on the computer screen. The average trace error was significantly different between the groups of patients and healthy subjects [F ((2,25)) = 7.9; p = 0.003]; on the contrary, the test time execution did not vary significantly. In conclusion, both groups of patients showed abnormal motor performances of the unaffected leg; this result suggests a likely contribution of peripheral mechanisms
Anthropic pressures on Nature 2000 Sites: recommendations and monitoring criteria for the pollution emergency response activities within the Orbetello lagoon
L’elevato valore naturalistico e socioeconomico
di un Sito Natura 2000 richiede che tutte le
attività antropiche che si svolgono al suo interno
(es. pesca, turismo, trasporti, attività industriali,
etc.) siano gestite in maniera tale da non pregiudicare
le specie e gli habitat per i quali l’area è
stata designata. Molti di questi Siti sono ambienti
di transizione, ovvero zone che costituiscono il
passaggio naturale tra terra e mare. La loro
posizione di interfaccia tra questi due ambienti li
rende ecosistemi unici e biologicamente molto
produttivi, sede di meccanismi di regolazione dei processi interattivi della biosfera nelle due
fasi, terrestre e marina. In alcuni Siti la presenza
di attività antropiche diffuse e prolungate nel
tempo ha portato al riscontro di stati di
contaminazione elevata, fino all’inclusione di
queste zone, o parti di esse, tra i Siti di bonifica
di Interesse Nazionale (SIN). Il presente lavoro
descrive le linee di indirizzo e le attività di
monitoraggio da attuare per la salvaguardia della
salute pubblica e dell’ambiente nel corso degli
interventi di messa in sicurezza di emergenza
predisposti nell’area lagunare antistante l’area
industriale Ex Sitoco, all’interno della perimetrazione
del SIN di Orbetello, incluso in un Sito di
Importanza Comunitaria. Le matrici ambientali
potenzialmente a rischio a causa dell’esecuzione
di tali interventi sono: acqua, sedimento,
biocenosi acquatiche, avifauna, uomo.
È altresì importante valutare gli effetti che le
ipotetiche modifiche su microscala, apportate a
livello di ogni matrice, potrebbero causare nel
lungo periodo su macroscala.The high naturalistic and socio-economic value
of Natura 2000 sites requires that all human
activities performed within their borders (e.g.
fishing, tourism, transports, industrial activities)
are regulated. Indeed, the site management
should assure the effective safeguard of all
species and habitats of European interest
included in the protected area. A lot of such
sites are located in transitional environments,
that are areas characterised by a natural
progression from the terrestrial to the water
environments. Such environments include
unique and very productive habitats, and they
represent the regulation mechanisms of the
interactive processes of the terrestrial and
marine biosphere. In some sites, the presence
of human activities that are distributed both in
space and time has led to high levels of contamination,
that in some cases even required their
inclusion in Reclamation Sites of National
Interest (SIN). The present study describes the
planning and monitoring activities to be
performed in order to safeguard human and
environment health during the actions of MISE in the lagoonal area in front of the industrial area
Ex Sitoco, within the borders of the Orbetello
SIN, included in a SCI. The environmental
parameters that are potentially at risk due to
such activities are: water, sediment, water
biocenosis, birds, humans. Furthermore, it is
important to evaluate the effects that potential
variations at the microscale level may cause at
the macroscale level
Realization of the farad from the dc quantum Hall effect with digitally-assisted impedance bridges
A new traceability chain for the derivation of the farad from dc quantum Hall
effect has been implemented at INRIM. Main components of the chain are two new
coaxial transformer bridges: a resistance ratio bridge, and a quadrature
bridge, both operating at 1541 Hz. The bridges are energized and controlled
with a polyphase direct-digital-synthesizer, which permits to achieve both main
and auxiliary equilibria in an automated way; the bridges and do not include
any variable inductive divider or variable impedance box. The relative
uncertainty in the realization of the farad, at the level of 1000 pF, is
estimated to be 64E-9. A first verification of the realization is given by a
comparison with the maintained national capacitance standard, where an
agreement between measurements within their relative combined uncertainty of
420E-9 is obtained.Comment: 15 pages, 11 figures, 3 table
Un laboratorio di taratura e verifica dei contatori elettrici anche in condizioni di scarsa Power Quality
La misura accurata dell’energia elettrica `e determinante, oltre che per un’equa tariffazione, anche per
garantire l’osservabilit`a della rete elettrica. Nella transizione verso il concetto di smart grid, la diffusione
della microgenerazione e di carichi non lineari ha peggiorato i parametri di power quality della rete.
La misura delle corrispondenti forme d’onda di tensione e corrente, non pi`u sinusoidali, pu`o non avere
una riferibilit`a adeguata
Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile
A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A) as a key regulator of fucosylation. We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered fucosylation of N-linked glycans on plasma proteins and that glycan biomarkers could improve the efficiency of a diagnosis of HNF1A-MODY. In a pilot comparison of 33 subjects with HNF1A-MODY and 41 subjects with type 2 diabetes, 15 of 29 glycan measurements differed between the two groups. The DG9-glycan index, which is the ratio of fucosylated to nonfucosylated triantennary glycans, provided optimum discrimination in the pilot study and was examined further among additional subjects with HNF1A-MODY (n = 188), glucokinase (GCK)-MODY (n = 118), hepatocyte nuclear factor 4-α (HNF4A)-MODY (n = 40), type 1 diabetes (n = 98), type 2 diabetes (n = 167), and nondiabetic controls (n = 98). The DG9-glycan index was markedly lower in HNF1A-MODY than in controls or other diabetes subtypes, offered good discrimination between HNF1A-MODY and both type 1 and type 2 diabetes (C statistic ≥ 0.90), and enabled us to detect three previously undetected HNF1A mutations in patients with diabetes. In conclusion, glycan profiles are altered substantially in HNF1A-MODY, and the DG9-glycan index has potential clinical value as a diagnostic biomarker of HNF1A dysfunction
Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes
Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening
FERTILISATION STRATEGIES ACROSS EUROPE: CURRENT SITUATION, POTENTIAL AND LIMITS FOR A HARMONISED APPROACH
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