Monsters in the uterus:a parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

Many diseases whose frequency increases with advancing age are caused by aging (senescence), but the mechanisms of senescence remain poorly understood. According to G.C. Williams and M.V. Blagosklonny, a major etiological determinant of senescence is late-life, wild-type gene action and non-adaptive execution of biological programs (or quasi-programs). These generate a wide range of senescent pathologies causing illness and death. Here we investigate the etiology of a prominent senescent pathology in the nematode C. elegans, uterine tumors, in the light of the Williams Blagosklonny theory. Uterine tumors develop from unfertilized, immature oocytes which execute incomplete embryogenetic programs. This includes extensive endomitosis, leading to formation of chromatin masses and cellular hypertrophy. The starting point of pathogenesis is exhaustion of sperm stocks. The timing of this transition between program and quasi-program can be altered by blocking sperm production (causing earlier tumors) or supplying additional sperm by mating (delaying tumor onset). Other pathophysiological determinants are yolk consumption by tumors, and bacterial proliferation within tumors. Uterine tumors resemble mammalian ovarian teratomas (tera, Greek: monster) in that both develop from oocytes that fail to mature after meiosis I, and both are the result of quasi-programs. Moreover, older but not younger uterine tumors show expression of markers of later embryogenesis, i.e. are teratoma-like. These results show how uterine tumors in C. elegans form as the result of run-on of embryogenetic quasi-programs. They also suggest fundamental etiological equivalence between teratoma and some forms of senescent pathology, insofar as both are caused by quasi-programs

Regions through time and space: Problem of regionalization

The thesis is rooted in the new regional geography paradigm that gained strength in geographical thought since the 1980s. This approach is characterized by emphasizing the socially constructed nature of regions; thus, regions are scrutinized as a historically contingent process. A region is formed, reproduced and eventually disappears in time. The thesis works with the assumption that a plurality of regions, that exists in changing time- space contexts of different mechanisms and meanings, can be experienced de facto in any particular area. In simpler terms, it can be understood as a plurality of regional images produced on the one side by regional actors to fulfil their particular goals and on the other regional images produced by inhabitants in and outside the region in order to understand the outside world and position themselves within it. Motivation for the production of images can vary, from a simple manifestation of one position in the regional system, through the attempt to attract attention towards the region to exploitation of the regional potential in order to fulfil particular power-oriented aims. The general idea of a region can be sought throughout the synthesis of the many regional images that can be understood as somewhat layers of a region. The thesis contributes to the discussion..

Additional file 5: of Mitochondrial and oxidative stress genes are differentially expressed in neutrophils of sJIA patients treated with tocilizumab: a pilot microarray study

File contains the enriched genes for KEGG_Oxidative Phosphorylation pathway obtained from GSEA. (XLS 13 kb