RUOLO DEI MOVIMENTI DI IONI CLORURO NELLA DEGRANULAZIONE DEI LEUCOCITI NEUTROFILI UMANI

2004/2005XVIII Ciclo1975Versione digitalizzata della tesi di dottorato cartacea

NLRP1 and NLRP3 polymorphisms in mesothelioma patients and asbestos exposed individuals a population-based autopsy study from North East Italy

NRLP1 (rs12150220, rs9889625, rs9900356, rs6502867, rs2670660) and NLRP3 (rs35829419, rs10754558) polymorphisms have been analyzed in 69 subjects with documented asbestos exposure and death for malignant pleural mesothelioma and 59 patients with documented asbestos exposure but death for other causes, all from a North East Italy. No association was found between NLRP1 and NLRP3 polymorphisms and susceptibility to develop mesothelioma using the general, dominant or recessive models. Also haplotype analysis did not reveal any significant association with mesothelioma. Our findings, being controversial with respect to another study on Italian patients, do suggest the need of further studies to unravel the contribution of NLRP1 and NLRP3 in susceptibility to mesothelioma

Sixth European seminar in virology on virus\u2013host interaction at single cell and organism level

The 6th European Seminar in Virology (EuSeV) was held in Bertinoro, Italy, 22\u201324 June 2018, and brought together international scientists and young researchers working in the field of Virology. Sessions of the meeting included: virus\u2013host-interactions at organism and cell level; virus evolution and dynamics; regulation; immunity/immune response; and disease and therapy. This report summarizes lectures by the invited speakers and highlights advances in the field

Proceedings of CIEC 16 European Inter-regional Conference on Ceramics - Torino, 9-11 September 2018

This e-book collects the extended abstracts of some of the oral and poster presentations, which have enlived the 16th International Inter-Regional European Conference on Ceramics, CIEC 16, held in Torino, Italy, from 9 to 11 September 2018

Varicella seroepidemiology and immunization in a cohort of future healthcare workers in the pre-vaccination era

Objectives: The goal of this study was to establish the seroprevalence of positive antibodies against varicella and compliance with varicella vaccination in the pre-vaccination era. Methods: A cohort of 10 683 Italian students from Padua University Medical School (from 2004 to 2019) were enrolled and classified as unvaccinated, vaccinated once, or vaccinated twice against varicella, according to their vaccination certificate. The antibody titre was measured and the seroprevalence of positive subjects was determined. Subjects with negative or equivocal antibodies were invited for vaccination, and then the antibody titre was retested. Results: Unvaccinated students were mostly seropositive (95.6%), compared with vaccinated students who were less seropositive (68.0% after one dose and 78.6% after two doses) and had significantly lower antibody titres (p < 0.0001). The post-test vaccination had a positive response rate of 85.4%: 67.4% after one dose and 91.4% after two doses. Conclusions: In the pre-vaccination era, only 3.3% of future healthcare workers were vaccinated against varicella (1.1% once and 2.2% twice). Vaccination or revaccination of negative and equivocal individuals could reduce the number of susceptible people. Implementation of varicella vaccine (two doses) in healthcare workers is of primary importance to reduce the risk of transmission

Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016

We describe the dynamics of Zika virus (ZIKV) infection in a man in his early 40s who developed fever and rash after returning from Haiti to Italy, in January 2016. Follow-up laboratory testing demonstrated detectable ZIKV RNA in plasma up to day 9 after symptom onset and in urine and saliva up to days 15 and 47, respectively. Notably, persistent shedding of ZIKV RNA was demonstrated in semen, still detectable at 181 days after onset. This article is copyright of The Authors, 2016

A contribuição dos processos formativos na compreensão das dores emocionais de docentes universitários

In this text we will reflect on the emotional pain of university professors and their possible connections with the training processes, presupposing that they have the potential to signal the recovery of the idea of human nature and can contribute to the process of reconfiguring these pains. The support of our reflections comes from Antonio Damásio’s neuroscientific investigations to whom the relations between the feelings of pain and pleasure influence the human cultural process. It also collaborates with our thinking Baruch Espinosa whose ideas underpinned those of Damásio's neuroscience when he affirmed that human beings affect each other and through this meeting they can recognize themselves and increase their power to act. In order to carry out the reflections proposed here, we used the hermeneutics of the tragedy “As Bacantes” by Euripides (406 BC) whose metaphorical potential helps us to understand the difficulties imposed by a rationality proclaimed as the only possible one. The reflective analyses, evidenced in this text, lead us to glimpse the need for other teaching knowledge that perceive the experience in a sensitive and humanized way. They contribute to the understanding of aspects that should go beyond the current ones and broaden the vision about professional training. Even in view of the detail and scope of the proposals currents for categorizing the teaching knowledge necessary for professionalization, this shortage regarding the teachers' emotional pain persists.En este texto reflexionaremos acerca del dolor emocional de los profesores universitarios y sus posibles entrelazamientos con los procesos de formación, suponiendo que tienen el potencial de señalar la recuperación de la idea de la naturaleza humana y pueden contribuir en el proceso de reconfiguración de estos dolores. El apoyo de nuestras reflexiones proviene de las investigaciones neurocientíficas de Antonio Damásio, para quien las relaciones entre los sentimientos de dolor y placer influyen en el proceso cultural humano. También colabora con nuestro pensamiento Baruch Espinosa cuyas ideas han respaldado las de la neurociencia de Damásio cuando afirmó que los seres humanos se afectan entre ellos y a través de este encuentro pueden reconocerse y aumentar su “potência de agir”. Para llevar a cabo las reflexiones propuestas aquí, recurrimos a la hermenéutica de la tragedia "As Bacantes" de Eurípides (406 a. C.) cuyo potencial metafórico nos ayuda a comprender las dificultades impuestas por una racionalidad proclamada como la única posible. Los análisis reflexivos, evidenciados en este texto, nos llevan a entrever la necesidad de otros saberes docentes que perciban la experiencia de una manera sensible y humanizada, entendiendo aspectos que deberán ir más allá de los actuales y ampliar la visión acerca de la formación profesional. Aún ante la especificación y el alcance de las propuestas actuales para categorización de los saberes docentes necesarios para la profesionalización, persiste esta carencia en relación a los dolores emocionales de los profesores.Neste texto refletiremos sobre as dores emocionais de docentes universitários e os seus possíveis entrelaçamentos com os processos formativos, pressupondo que eles têm o potencial sinalizador da recuperação da ideia de natureza humana e podem contribuir na reconfiguração dessas dores. O suporte de nossas reflexões procede das investigações neurocientíficas de Antonio Damásio, para quem as relações entre os sentimentos de dor e prazer influenciam o processo cultural humano. Também colabora com o nosso pensamento Baruch Espinosa, cujas ideias alicerçaram as da neurociência de Damásio ao afirmar que os seres humanos afetam uns aos outros e, por meio deste encontro, podem reconhecer-se e aumentar a sua “potência de agir”. Para realizar as reflexões aqui propostas recorremos à hermenêutica da tragédia “As Bacantes” de Eurípedes (406 a.C.), cujo potencial metafórico nos auxilia a entender as dificuldades impostas por uma racionalidade proclamada como única possível. Trata-se de uma reflexão teórica que subsidia e sinaliza a pertinência e necessidade de futuras pesquisas envolvendo coleta e análise de dados empíricos, dando vozes aos professores universitários a respeito da questão. As análises reflexivas, evidenciadas neste texto, nos levam a entrever a necessidade de outros saberes docentes que percebam a experiência de uma forma sensível e humanizada, compreendendo aspectos que deverão ir além dos atuais e ampliar a visão acerca da formação profissional. Mesmo diante do detalhamento e abrangência das propostas atuais de categorização dos saberes docentes necessários para a profissionalização, persiste essa carência relativa às dores emocionais docentes

The Secretory Response of Rat Peritoneal Mast Cells on Exposure to Mineral Fibers

Background: Exposure to mineral fibers is of substantial relevance to human health. A key event in exposure is the interaction with inflammatory cells and the subsequent generation of pro-inflammatory factors. Mast cells (MCs) have been shown to interact with titanium oxide (TiO2) and asbestos fibers. In this study, we compared the response of rat peritoneal MCs challenged with the asbestos crocidolite and nanowires of TiO2 to that induced by wollastonite employed as a control fiber. Methods: Rat peritoneal MCs (RPMCs), isolated from peritoneal lavage, were incubated in the presence of mineral fibers. The quantities of secreted enzymes were evaluated together with the activity of fiber-associated enzymes. The ultrastructural morphology of fiber-interacting RPMCs was analyzed with electron microscopy. Results: Asbestos and TiO2 stimulate MC secretion. Secreted enzymes bind to fibers and exhibit higher activity. TiO2 and wollastonite bind and improve enzyme activity, but to a lesser degree than crocidolite. Conclusions: (1) Mineral fibers are able to stimulate the mast cell secretory process by both active (during membrane interaction) and/or passive (during membrane penetration) interaction; (2) fibers can be found to be associated with secreted enzymes\u2014this process appears to create long-lasting pro-inflammatory environments and may represent the active contribution of MCs in maintaining the inflammatory process; (3) MCs and their enzymes should be considered as a therapeutic target in the pathogenesis of asbestos-induced lung inflammation; and (4) MCs can contribute to the inflammatory effect associated with selected engineered nanomaterials, such as TiO2 nanoparticles

Bevacizumab and temozolomide in secondary gliomatosis from gemistocytic astrocytoma: a case report

Gliomatosis cerebri is a rare diffuse glioma with a growth pattern consisting of exceptionally extensive infiltration of the CNS with involvement of at least three lobes. It may appear de novo (primary gliomatosis) or result from the spreading of a focal glioma (secondary gliomatosis). Bevacizumab is a monoclonal antibody anti-VEGF active against recurrent high grade gliomas after standard therapy. We report the case of a 41-year-old man with a secondary gliomatosis treated with bevacizumab and temozolomide who responded and the response lasted 17 months. Moreover, we focus on the side effects (hypertension, deep vein thrombosis) induced by bevacizumab and their effective treatments