Asociación entre el trastorno por déficit de atención e hiperactividad y la rinitis alérgica: una revisión

El trastorno por déficit de atención e hiperactividad (TDAH) y la rinitis alérgica (RA) son diagnósticos frecuentes y con impacto en la calidad de vida de niños y adolescentes. Aunque desde hace varias décadas se ha reportado una posible asociación entre ambos trastornos, los resultados han sido inconsistentes. Se realizó una revisión de la literatura en PubMed y en Google Scholar que incluyó artículos de 1991 al 2014. Se encontró que en los últimos años, nuevos estudios han demostrado asociación entre el TDAH y la RA de manera más consistente que lo reportado con anterioridad. En la presente revisión, se describen también posibles mecanismos fisiopatológicos subyacentes e implicaciones terapéuticas de la asociación. Es importante que se realicen más investigaciones sobre la asociación entre ambos trastornos y se diluciden los mecanismos fisiopatológicos e implicaciones terapéuticas de la misma. ABSTRACT Attention-deficit/hyperactivity disorder (ADHD) and allergic rhinitis (AR) are common diagnoses that impact the quality of life of children and adolescents. Although for several decades a possible association between both disorders has been reported, these results have been inconsistent. We performed a literature search in PubMed and Google Scholar that includes articles from 1991 to 2014. We found that in recent years, new studies have demonstrated a more consistent association between ADHD and AR. Possible underlying pathophysiological mechanisms and therapeutic implications of this association are also described. It is important to continue studying the association between these disorders and dilucidate its physiopathology and therapeutic implications

Association between bullying and major depressive disorder in a psychiatric consultation

Assess if there is a significant association between being bullied and presenting depressive symptoms. Materials and methods: In the March---October period of the present year, 8---16-year-old children and adolescents that attended psychiatric consultation for the first time in Dr. Eleuterio González Hospital were included in this study. Test Bull-S was used to determine the presence of bullying (Victim subtype); to evaluate depression 2 instruments were used according to age: Children’s Depression Rating Scale-Revised (CDRS-R) for 8---12-year olds and the Birleson Depression Self-Rating Scale (DSRS) for 13---16-year olds. A total of 147 clinical patients were studied (73 women and 74 men). Data were captured in excel and the Statistical Package for the Social Sciences (SPSS) program was used for statistical analysis. Results: A very significant association was found between being bullied and presenting depression (X2 = .289, p = .0004). Conclusions: These data are in agreement with national and international studies, therefore, reinforcing the evidence of such association. This is why we suggest inquiring about bullying in children and adolescents whose chief complaint is depressive symptomatolog

Prevalence of sensorineural hearing loss in children and adolescents with diabetes mellitus

To establish the prevalence of sensorineural hearing loss (SNHL), as well as the predisposing risk factors, in children and adolescents with type 1 diabetes mellitus (T1DM) attending the Service of Endocrino-Pediatrics and Otolaryngology Department of the ‘‘Dr. José Eleuterio González’’ University Hospital and the Materno-Infantil Hospital, from January 2011 to December 2012. Material and methods: A total of 84 children with T1DM, with ages between 6 and 18 years old, were studied. Values of glycated hemoglobin (HbA1c) were assessed and Tonal audiometry and Speech audiometry tests were performed. Results: A total of 84 patients with a diagnosis of T1DM were studied, out of which 12 (14.3%) presented SNHL. Fifty percent of patients with hearing loss were in the age range of 10---13 years old. Regarding time of evolution with the disease (T1DM), 33% of patients with more than 5 years with T1DM presented SNHL, and nearly 88.9% of the patients with less than 5 years with T1DM presented normal hearing (p = 0.011). Moreover, 65.47% of the patients presented complications due to poor glycemic control at some point in the evolution of their disease. All (100%) diabetic patients with SNHL and 91% of the patients without SNHL had HbA1c values greater than 6%. In patients with hearing impairments, 83.3% suffered mild and 16.4% suffered moderate hearing loss. Most presented bilateral hearing loss, with the right ear dominating. Acute frequencies, mainly 8000 kHz, were the most affected

Kinematics of the ionized-to-neutral interfaces in Monoceros R2

Context. Monoceros R2 (Mon R2), at a distance of 830 pc, is the only ultra-compact H ii region (UC H ii) where its associated photon-dominated region (PDR) can be resolved with the Herschel Space Observatory. Aims. Our aim is to investigate observationally the kinematical patterns in the interface regions (i.e., the transition from atomic to molecular gas) associated with Mon R2. Methods. We used the HIFI instrument onboard Herschel to observe the line profiles of the reactive ions CH+, OH+ and H2O+ toward different positions in Mon R2. We derive the column density of these molecules and compare them with gas-phase chemistry models. Results. The reactive ion CH+ is detected both in emission (at central and red-shifted velocities) and in absorption (at blue-shifted velocities). OH+ is detected in absorption at both blue- and red-shifted velocities, with similar column densities. H2O+ is not detected at any of the positions, down to a rms of 40 mK toward the molecular peak. At this position, we find that the OH+ absorption originates in a mainly atomic medium, and therefore is associated with the most exposed layers of the PDR. These results are consistent with the predictions from photo-chemical models. The line profiles are consistent with the atomic gas being entrained in the ionized gas flow along the walls of the cavity of the H ii region. Based on this evidence, we are able to propose a new geometrical model for this region. Conclusions. The kinematical patterns of the OH+ and CH+ absorption indicate the existence of a layer of mainly atomic gas for which we have derived, for the first time, some physical parameters and its dynamics.Comment: 6 pages, 5 figures. Accepted for publication in A&

Deuteration around the ultracompact HII region Mon R2

The massive star-forming region Mon R2 hosts the closest ultra-compact HII region that can be spatially resolved with current single-dish telescopes. We used the IRAM-30m telescope to carry out an unbiased spectral survey toward two important positions (namely IF and MP2), in order to studying the chemistry of deuterated molecules toward Mon R2. We found a rich chemistry of deuterated species at both positions, with detections of C2D, DCN, DNC, DCO+, D2CO, HDCO, NH2D, and N2D+ and their corresponding hydrogenated species and isotopologs. Our high spectral resolution observations allowed us to resolve three velocity components: the component at 10 km/s is detected at both positions and seems associated with the layer most exposed to the UV radiation from IRS 1; the component at 12 km/s is found toward the IF position and seems related to the molecular gas; finally, a component at 8.5 km/s is only detected toward the MP2 position, most likely related to a low-UV irradiated PDR. We derived the column density of all the species, and determined the deuterium fractions (Dfrac). The values of Dfrac are around 0.01 for all the observed species, except for HCO+ and N2H+ which have values 10 times lower. The values found in Mon R2 are well explained with pseudo-time-dependent gas-phase model in which deuteration occurs mainly via ion-molecule reactions with H2D+, CH2D+ and C2HD+. Finally, the [H13CN]/[HN13C] ratio is very high (~11) for the 10 km/s component, which also agree with our model predictions for an age of ~0.01-0.1 Myr. The deuterium chemistry is a good tool for studying star-forming regions. The low-mass star-forming regions seem well characterized with Dfrac(N2H+) or Dfrac(HCO+), but it is required a complete chemical modeling to date massive star-forming regions, because the higher gas temperature together with the rapid evolution of massive protostars.Comment: 14 pages of manuscript, 17 pages of apendix, 7 figures in the main text, accepted for publication in A&

Spatial distribution of small hydrocarbons in the neighborhood of the Ultra Compact HII region Monoceros R2

We study the chemistry of small hydrocarbons in the photon-dominated regions (PDRs) associated with the ultra-compact HII region Mon R2. Our goal is to determine the variations of the abundance of small hydrocarbons in a high-UV irradiated PDR and investigate their chemistry. We present an observational study of CH, CCH and c-C$_3$H$_2$ in Mon R2 combining data obtained with the IRAM 30m telescope and Herschel. We determine the column densities of these species, and compare their spatial distributions with that of polycyclic aromatic hydrocarbon (PAH). We compare the observational results with different chemical models to explore the relative importance of gas-phase, grain-surface and time-dependent chemistry in these environments. The emission of the small hydrocarbons show different patterns. The CCH emission is extended while CH and c-C$_3$H$_2$ are concentrated towards the more illuminated layers of the PDR. The ratio of the column densities of c-C$_3$H$_2$ and CCH shows spatial variations up to a factor of a few, increasing from $N(c-C$_3$H$_2$)/N(CCH)\approx0.004$ in the envelope to a maximum of $\sim0.015-0.029$ towards the 8$\mu$m emission peak. Comparing these results with other galactic PDRs, we find that the abundance of CCH is quite constant over a wide range of G$_0$, whereas the abundance of c-C$_3$H$_2$ is higher in low-UV PDRs. In Mon R2, the gas-phase steady-state chemistry can account relatively well for the abundances of CH and CCH in the most exposed layers of the PDR, but falls short by a factor of 10 to reproduce c-C$_3$H$_2$. In the molecular envelope, time-dependent effects and grain surface chemistry play a dominant role in determining the hydrocarbons abundances. Our study shows that CCH and c-C$_3$H$_2$ present a complex chemistry in which UV photons, grain-surface chemistry and time dependent effects contribute to determine their abundances.Comment: 18 pages, 11 figures, 7 tables. Proposed for acceptance in A&A. Abstract abridge

Prevalence of anti-sperm antibodies, risk factors associated and their impact on spermatobioscopy in infertile men

Background: The first immunological correlation with male infertility was reported in 1954 by Wilson and Rumke with the identification of anti-sperm antibodies. The prevalence of anti-sperm antibodies in infertile men varies from 9%-36%, the main cause being the loss of the blood-testicular barrier and otherwise the association with chronic inflammation. It has been shown that immune infertility is found in 15% of patients with varicocele.Methods: A transversal comparative study was carried out with 360 infertile men who were tested for anti-sperm antibodies between January 2011 and July 2018. Two groups were integrated; Group 1, infertile men with positive anti-sperm antibodies >50%, group 2, infertile men with negative anti-sperm <50%. Seminogram parameters were evaluated according to the WHO 5th edition and associated risk factors with anti-sperm antibodies.Results: 360 infertile men were evaluated during the study, 42 were excluded because they did not meet the inclusion criteria, the prevalence of anti-sperm antibodies was 14.5%. Group 1; n=46 (14.5%) and group 2, n=272 (85.5%), the clinical characteristics and the hormonal profile were compared at study admission without significant difference. There was a significant decrease in progressive motility in group 1 (38.7±23.8) vs group 2 (50.1±18.9) p=0.03. Analyzing the risk factors, varicocele was found to be significant 23.7%, OR 2.14 (1.27-3.61) p=0.004 as well as retractable testicle 26.4%, OR 2.13 (1.23-3.70) p= 0.008.Conclusions: The affectation of motility was confirmed, which leads to the suspect varicocele and retractable testicle as risk factors

TRPM8, a Versatile Channel in Human Sperm

BACKGROUND:The transient receptor potential channel (TRP) family includes more than 30 proteins; they participate in various Ca(2+) dependent processes. TRPs are functionally diverse involving thermal, chemical and mechanical transducers which modulate the concentration of intracellular Ca(2+) ([Ca(2+)]i). Ca(2+) triggers and/or regulates principal sperm functions during fertilization such as motility, capacitation and the acrosome reaction. Nevertheless, the presence of the TRPM subfamily in sperm has not been explored. PRINCIPAL FINDINGS:Here we document with RT-PCR, western blot and immunocitochemistry analysis the presence of TRPM8 in human sperm. We also examined the participation of this channel in sperm function using specific agonists (menthol and temperature) and antagonists (BCTC and capsazepine). Computer-aided sperm analysis revealed that menthol did not significantly alter human sperm motility. In contrast, menthol induced the acrosome reaction in human sperm. This induction was inhibited about 70% by capsazepine (20 microM) and 80% by BCTC (1.6 microM). Activation of TRPM8 either by temperature or menthol induced [Ca(2+)]i increases in human sperm measured by fluorescence in populations or individual sperm cells, effect that was also inhibited by capsazepine (20 microM) and BCTC (1.6 microM). However, the progesterone and ZP3-induced acrosome reaction was not inhibited by capsazepine or BCTC, suggesting that TRPM8 activation triggers this process by a different signaling pathway. CONCLUSIONS:This is the first report dealing with the presence of a thermo sensitive channel (TRPM8) in human sperm. This channel could be involved in cell signaling events such as thermotaxis or chemotaxis

Robust Detection of Hierarchical Communities from Escherichia coli Gene Expression Data

Determining the functional structure of biological networks is a central goal of systems biology. One approach is to analyze gene expression data to infer a network of gene interactions on the basis of their correlated responses to environmental and genetic perturbations. The inferred network can then be analyzed to identify functional communities. However, commonly used algorithms can yield unreliable results due to experimental noise, algorithmic stochasticity, and the influence of arbitrarily chosen parameter values. Furthermore, the results obtained typically provide only a simplistic view of the network partitioned into disjoint communities and provide no information of the relationship between communities. Here, we present methods to robustly detect coregulated and functionally enriched gene communities and demonstrate their application and validity for Escherichia coli gene expression data. Applying a recently developed community detection algorithm to the network of interactions identified with the context likelihood of relatedness (CLR) method, we show that a hierarchy of network communities can be identified. These communities significantly enrich for gene ontology (GO) terms, consistent with them representing biologically meaningful groups. Further, analysis of the most significantly enriched communities identified several candidate new regulatory interactions. The robustness of our methods is demonstrated by showing that a core set of functional communities is reliably found when artificial noise, modeling experimental noise, is added to the data. We find that noise mainly acts conservatively, increasing the relatedness required for a network link to be reliably assigned and decreasing the size of the core communities, rather than causing association of genes into new communities.Comment: Due to appear in PLoS Computational Biology. Supplementary Figure S1 was not uploaded but is available by contacting the author. 27 pages, 5 figures, 15 supplementary file