198 research outputs found

    The Effects of Feedback on Mastery of a New Motor Skill: A Pilot Test

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    https://scholarworks.moreheadstate.edu/student_scholarship_posters/1067/thumbnail.jp

    State v. Henderson: A Model for Admitting Eyewitness Identification Testimony

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    Eyewitness identification testimony is notoriously unreliable and has significantly contributed to wrongful convictions. Most courts use the standard set forth by the Supreme Court in Manson v. Brathwaite to assess whether eyewitness identifications are sufficiently reliable to present to the jury. But in the thirty-five years since Manson, an extensive body of research has amassed that calls into question the continuing validity of that standard. Researchers have identified numerous system variables (procedural elements subject to official control) and estimator variables (factors related to the witness, perpetrator, and event) that affect the accuracy of eyewitness identifications. The Manson standard fails to account for most of these factors. In response, the New Jersey Supreme Court in State v. Henderson retooled its state constitutional due process test for admitting eyewitness identification testimony and mandated more comprehensive jury instructions that warn jurors of the vulnerability of eyewitness identifications to both system and estimator variables. Until the Supreme Court is willing to revise the Manson v. Brathwaite standard, state courts should consider adopting more comprehensive due process requirements, as well as jury instructions that better embody the current state of scientific understanding about the complexities of memory and the fallibility of eyewitnesse

    EC740 Simple Hitches for Farm Use

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    Extension circular 740 discusses simple hitches that can help reduce side draft of farm machinery

    EC740 Simple Hitches for Farm Use

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    Extension circular 740 discusses simple hitches that can help reduce side draft of farm machinery

    OER 101

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    OER 101, Getting Started with Open Educational Resources, includes: What is OER? Where can I find it? License Considerations How can OER work for me? Dr. Wibble\u27s OER journe

    Immigrant Cosmopolitanism: Jewish-American Immigrant Narratives and Modernist Cosmopolitan Aesthetics

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    I propose to show in this study how Jewish-American authors of mass media immigrant works from the first three decades of the 20th century utilize a form of modernist cosmopolitan aesthetics to challenge notions that these works are unworthy of study and appreciation. These authors, not happy with the classifications and aesthetics available to them as immigrant authors, borrow from other ideologies and aesthetic schools to create an aesthetic system meeting the needs of immigrant individuals. In theory, this system, which I have termed \u27immigrant cosmopolitanism,\u27 meets the needs of these individuals and capitalizes on the authors\u27 diverse backgrounds and experiences. Only these authors can decide which aesthetics adequately relate their story, and they believe immigrant cosmopolitanism will give them the freedom to tell their stories in a way previously denied them. However, they find that no pure aesthetic, cosmopolitan, modernist, or otherwise, can fully convey their stories. Pure modernist cosmopolitanism leaves little room for the integration of those ethnic details and personal experiences necessary for these texts to function successfully as immigrant novels. Therefore, these authors intend to find an aesthetic allowing them to tell their individual immigrant stories in a way highlighting their intellectualism and artistry. Immigrant cosmopolitanism allows them to relate their stories in the manner they desire and in a way representing immigrant lives: it is a hybrid of popular and intellectual, artistic and commodified, hopeful and cynical, and it ultimately fails to accomplish its goals (just as these Jewish-American immigrant authors fail in their attempts to be seen as something more than just immigrant authors)

    Application of 13C flux analysis to determine impacts of media alterations on industrial CHO cell metabolism

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    Industrial bioprocesses place extraordinary demands on the metabolism of host cells to meet the biosynthetic requirements for maximal growth and protein production. Identifying host cell metabolic phenotypes that promote high recombinant protein titer is a major goal of the biotech industry. 13C metabolic flux analysis (MFA) provides a rigorous approach to quantify these metabolic phenotypes by applying stable isotope tracers to map the flow of carbon through intracellular metabolic pathways. We have conducted a series of 13C MFA studies to examine the metabolic impacts of altering the composition of a proprietary chemically defined growth medium on CHO cell metabolism. CHO cell cultures characteristically produce excess ammonia and lactate as byproducts, both of which are toxic at high concentrations. Whereas lactate is often consumed during stationary growth phase in CHO cell cultures, ammonia continues to accumulate in the extracellular media throughout the course of cell growth due mainly to glutamine catabolism. For CHO cells that utilize glutamine, rational media design can alleviate ammonia stress from the cell culture. However, manipulating carbon sources in the growth medium can also have negative effects on cellular metabolism such as decreased culture growth, viability, recombinant protein productivity, or longevity. This study highlights a rationally engineered cell culture medium that successfully reduces culture ammonia levels by 40% while maintaining the original metabolic phenotype. First, the basal media developed in-house by Sanofi was chemically altered to cause CHO cells to produce significantly less ammonia byproduct. This low ammonia-producing media variant was experimentally developed by altering the ratio of carbon sources in the media to strategically reduce flux through metabolic pathways that result in ammonia production while supplementing complementary, non-ammonia producing pathways to balance metabolism. This altered media variant successfully decreased the ammonia concentration in industrial CHO while maintaining culture growth, viability, and specific productivity. Parallel 13C MFA studies were performed on IgG-producing CHO cells grown identically in three media variants: the basal control media, the low-ammonia media, and the low-ammonia media supplemented with basal ammonia levels. The latter media was used to control for any direct effects of changing ammonia concentrations on cellular metabolism. 13C labeling studies utilizing [U-13C5]glutamine and [1,213C2]glucose were carried out in parallel for each condition. From the comparison of the 13C flux analysis across the three media types, we have concluded that the media alterations did not have a significant impact on the intracellular metabolism of CHO cultures. This suggests that Sanofi can use their newly developed media formulation to decrease toxic ammonia buildup in IgG-producing CHO cell lines without significantly altering host metabolic phenotype or productivit

    Cognitive, affective and social mechanisms in depression risk: cognition, hostility, and coping style

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    Although some research has assessed cognitive variables in individuals at risk for depression, few studies have specifically assessed the role of automatic thinking, and virtually no studies have assessed anger and coping in this group. The current study compared measures of these variables in a high-risk group that was defined on the basis of a previous episode of depression, and a control group comprised of low-risk/never depressed individuals. Even though neither group evidenced depressive symptoms at the time of assessment, group comparisons and regression analyses indicated that high-risk individuals reported more negative automatic thoughts than did low-risk participants and that social support seeking, self-blame, and avoidance emerged as coping predictors of risk as did higher levels of anger and hostility. These data thus suggest patterns of interpersonal, behavioural, and cognitive variables that may characterise depression risk. A number of factors make depression a significant public-health concern. Depression is not only associated with substantial emotional distress and psychological impairment, but also with impaired interpersonal, marital, and occupational functionin
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