The validity of police reported accident data

Information theory and signal detection theory techniques were used to assess the validity of police reported traffic accident data. The validity criteria were the data and conclusions of multi-disciplinary accident investigation teams who investigated the same traffic accidents. The results indicated that the accident level variables reported by the police with least reliability were vertical road character, accident severity, and road surface composition. The most reliably reported data were those concerned with the accident location, date, and number of drivers, passengers, and vehicles. The informativeness of the police reports with respect to driver/vehicle characteristics was practically nil, with the exception of driver age, sex and vehicle model for which the police were correct most of the time (but not errorless). It was also found that police reports provided very little information regarding the presence of different human conditions and states, vehicle defects and environmental/road deficiencies. The sensitivity of police investigators to all accident causes was low. When causes were categorized into human direct, human indirect (conditions and states) vehicle, and environmental, police were the most reliable with respect to human direct causes and the least reliable with respect to environmental and human indirect causes. Implications for improvement and use of police data are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25202/1/0000641.pd

1951: Abilene Christian College Bible Lectures - Full Text

Delivered in the Auditorium of Abilene Christian College Abilene, Texas February 18-22, 1951 Price, $3.00 FIRM FOUNDATION PUBLISHING HOUSE Austin, Texa

1957: Abilene Christian College Bible Lectures - Full Text

Featuring the Theme CHRIST IN YOU -THE HOPE OF GLORY PRICE: $3.00 FIRM FOUNDATION PUBLISHING HOUSE BOX 77 AUSTIN, TEXA

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

BACKGROUND: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. METHODS AND FINDINGS: We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene (GRSCRP), and the second consisted of 18 SNPs that were significantly associated with CRP levels in the largest genome-wide association study (GWAS) to date (GRSGWAS). To optimize power, we used summary statistics from GWAS consortia and tested the association of these two GRSs with 32 complex somatic and psychiatric outcomes, with up to 123,865 participants per outcome from populations of European ancestry. We performed heterogeneity tests to disentangle the pleiotropic effect of IVs. A Bonferroni-corrected significance level of less than 0.0016 was considered statistically significant. An observed p-value equal to or less than 0.05 was considered nominally significant evidence for a potential causal association, yet to be confirmed. The strengths (F-statistics) of the IVs were 31.92-3,761.29 and 82.32-9,403.21 for GRSCRP and GRSGWAS, respectively. CRP GRSGWAS showed a statistically significant protective relationship of a 10% genetically elevated CRP level with the risk of schizophrenia (odds ratio [OR] 0.86 [95% CI 0.79-0.94]; p < 0.001). We validated this finding with individual-level genotype data from the schizophrenia GWAS (OR 0.96 [95% CI 0.94-0.98]; p < 1.72 × 10-6). Further, we found that a standardized CRP polygenic risk score (CRPPRS) at p-value thresholds of 1 × 10-4, 0.001, 0.01, 0.05, and 0.1 using individual-level data also showed a protective effect (OR < 1.00) against schizophrenia; the first CRPPRS (built of SNPs with p < 1 × 10-4) showed a statistically significant (p < 2.45 × 10-4) protective effect with an OR of 0.97 (95% CI 0.95-0.99). The CRP GRSGWAS showed that a 10% increase in genetically determined CRP level was significantly associated with coronary artery disease (OR 0.88 [95% CI 0.84-0.94]; p < 2.4 × 10-5) and was nominally associated with the risk of inflammatory bowel disease (OR 0.85 [95% CI 0.74-0.98]; p < 0.03), Crohn disease (OR 0.81 [95% CI 0.70-0.94]; p < 0.005), psoriatic arthritis (OR 1.36 [95% CI 1.00-1.84]; p < 0.049), knee osteoarthritis (OR 1.17 [95% CI 1.01-1.36]; p < 0.04), and bipolar disorder (OR 1.21 [95% CI 1.05-1.40]; p < 0.007) and with an increase of 0.72 (95% CI 0.11-1.34; p < 0.02) mm Hg in systolic blood pressure, 0.45 (95% CI 0.06-0.84; p < 0.02) mm Hg in diastolic blood pressure, 0.01 ml/min/1.73 m2 (95% CI 0.003-0.02; p < 0.005) in estimated glomerular filtration rate from serum creatinine, 0.01 g/dl (95% CI 0.0004-0.02; p < 0.04) in serum albumin level, and 0.03 g/dl (95% CI 0.008-0.05; p < 0.009) in serum protein level. However, after adjustment for heterogeneity, neither GRS showed a significant effect of CRP level (at p < 0.0016) on any of these outcomes, including coronary artery disease, nor on the other 20 complex outcomes studied. Our study has two potential limitations: the limited variance explained by our genetic instruments modeling CRP levels in blood and the unobserved bias introduced by the use of summary statistics in our MR analyses. CONCLUSIONS: Genetically elevated CRP levels showed a significant potentially protective causal relationship with risk of schizophrenia. We observed nominal evidence at an observed p < 0.05 using either GRSCRP or GRSGWAS-with persistence after correction for heterogeneity-for a causal relationship of elevated CRP levels with psoriatic osteoarthritis, rheumatoid arthritis, knee osteoarthritis, systolic blood pressure, diastolic blood pressure, serum albumin, and bipolar disorder. These associations remain yet to be confirmed. We cannot verify any causal effect of CRP level on any of the other common somatic and neuropsychiatric outcomes investigated in the present study. This implies that interventions that lower CRP level are unlikely to result in decreased risk for the majority of common complex outcomes

Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation. We have identified 16 patients from 10 families spanning three continents with a profound phenotype of early-life onset allergic immune dysregulation, widespread treatment-resistant atopic dermatitis, hypereosinophilia with esosinophilic gastrointestinal disease, asthma, elevated serum IgE, IgE-mediated food allergies, and anaphylaxis. The cases were either sporadic (seven kindreds) or followed an autosomal dominant inheritance pattern (three kindreds). All patients carried monoallelic rare variants in STAT6 and functional studies established their gain-of-function (GOF) phenotype with sustained STAT6 phosphorylation, increased STAT6 target gene expression, and TH2 skewing. Precision treatment with the anti-IL-4Rα antibody, dupilumab, was highly effective improving both clinical manifestations and immunological biomarkers. This study identifies heterozygous GOF variants in STAT6 as a novel autosomal dominant allergic disorder. We anticipate that our discovery of multiple kindreds with germline STAT6 GOF variants will facilitate the recognition of more affected individuals and the full definition of this new primary atopic disorder

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A study to determine the causes of accidents: an in-depth case report case no. TAC-SP-75-6, school bus/garbage truck - acute oblique. Final report.

National Highway Traffic Safety Administration, Washington, D.C.Mode of access: Internet.COP: 2Author corporate affiliation: Indiana University, Bloomington, Institute for Research in Public SafetySubject code: DEDSSubject code: DEHSubject code: DGESSubject code: JLKSubject code: MAFSubject code: NVWSubject code: YC

Supervisory guidelines for motor vehicle inspection programs. Final report.

National Highway Traffic Safety Administration, Washington, D.C.Mode of access: Internet.Author corporate affiliation: Indiana University, Bloomington, Institute for Research in Public SafetyReport covers the period 29 Sept 1976-31 Dec 1977. Printed May 1980. Contract amount $40,767Subject code: IFISubject code: RCGB*DESubject code: WWSubject code: YE

Tri-level study of the causes of traffic accidents: final report. Executive summary.

Report covers the period Aug 1972-June 1977. Released Oct 1979. Contract amount - $1,531,466Technical Volume I reports causal factor tabulations from Phases II through V (1972-75). Volume II reports analysis tasks dealing with driver vision, knowledge, psychological make-up, etc. Additional analysis tasks conducted under a contract modification are reported in six separate volumes. Data were collected on three levels. Police reports and other baseline data on the Monroe County, Indiana study area were collected on Level A. On Level B, teams of technicians responded to accidents at the time of their occurrence to conduct on-scene investigations; a total of 2,258 investigations were conducted during Phases II through V. Concurrently, 420 of these accidents were independently examined by a multidisciplinary team on Level C. General population surveys were also conducted. Human factors were cited by the in-depth team as probable causes in 92.6% of accidents investigated in Phases II through V. Environmental factors were cited as probable cause in 33.8% of these accidents, while vehicular factors were identified as probably causes in 12.6%. The major human direct causes were improper lookout, excessive speed, in attention, improper evasive action, and internal distraction. Leading environmental causes were view obstructions and slick roads. The major vehicular causes were brake failure, inadequate tread depth, side-to-side brake imbalance, under-inflation, and vehicle-related vision obstructions. Vision (especially poor dynamic visual acuity) and personality (especially poor personal and social adjustment) were found related to accident-involvement. However, as measured in this study, knowledge of the driving task was not shown to be related.U.S. Department of Transportation, Washington, D.C.http://deepblue.lib.umich.edu/bitstream/2027.42/64993/1/43120.pd