Hodgkin Lymphoma at the Paediatric Oncology Unit of Gabriel Touré Teaching Hospital, Bamako, Mali: 5-Year Experience

Introduction. The aim of this retrospective, unicentric study over 5 years is to describe the epidemiologic, pathologic, clinic and therapeutic aspects of children treated for Hodgkin lymphoma in our paediatric oncology unit. Patients and Methods. From January 2005 to December 2009, all children under 18 years of age, with Hodgkin lymphoma were included in this study. The treatment protocol was the GFAOP (Groupe Franco—Africain d'Oncologie Pédiatrique) Hodgkin lymphoma treatment protocol. Results. During the study period, 217 cancer cases were diagnosed in our centre. Of these cases, 7 were Hodgkin Lymphoma (LH) (0.04%). The mean age was 11.7 years. The sex-ratio was 6/1. 4% (5/7) of patients were stage IIB and 28.6% (2/7) stage IIIB of Ann-Arbor classification. There were 3 cases (42.8%) of sclero-nodular subtype, 2 cases (28.6%) of lymphocyte-rich classical HL subtype, 1 case (14.3%) of mixed cellularity and 1 case (14.3%) of lymphocyte depleted subtype. With a median followup of 37 months, 5 patients (71.4%) are alive, and 2 patients (28.6%) died. Conclusion. Broader multicentric studies are needed for more accurate data on this malignancy

Lymphome de Burkitt pédiatrique à révélation orl : quelle prise en charge en milieu sub sahélien ? réflexion sur trois cas

Le lymphome de Burkitt dans sa forme Africaine peut se manifester sous des signes d’emprunt ORL à type de tuméfaction orbito-maxillo-faciale. Le diagnostic peut être fait par les ORL à travers un faisceau de signes cliniques et une cytoponction. La prise en charge se fait dans des unités d’oncologie médicale ou le bilan d’extension et le lancement de la chimiothérapie sont des impératifs incontournables. Actuellement cette tumeur à potentiel très agressif répond à une poly chimiothérapie bien conduite.Mots-clés : Lymphome de Burkitt, cancer, voies aérodigestives supérieures, oncologie pédiatriqu

Influence de la rotation culturale, de la fertilisation et du labour sur les populations de nématodes phytoparasites du sorgho (Sorghum bicolor (L.) Moench)

Influence of crop rotation, fertilization and tillage on populations of plant parasitic nematodes of sorghum (Sorghum bicolor (L.) Moench). The soil nematodes of three long-term trials (1960, 1980 and 1990) representing the production of sorghum (Sorghum bicolor (L.) Moench) under different agricultural practices (rotation, tillage and fertilization) in the Center West of Burkina Faso, have been explored in the wake of the harvest during the agricultural season 2007/2008. The objective was to identify these nematodes and to study the influence of agricultural practices on this nematofauna. Nematodes were extracted by the method of Seinhorst elutriator. Plant-parasitic nematodes identified are Pratylenchus brachyurus, Tylenchorhynchus martini, Helicotylenchus multicinctus, Scutellonema Caveness, Criconemoides curvatum, Telotylenchus indicus and Xiphinema sp. The first three species represent approximately 98% of individuals surveyed. On the first site, the treatments involving mineral fertilizer and recycling of sorghum straw were favorable for the control of nematodes instead of treatments involving manure. As for rotations, monoculture of sorghum was more infested by nematodes than the rotations sorghum – cowpea and sorghum – cotton. On the second site, the nitrogen has increased of infestation by the two major nematodes in comparison to treatments without nitrogen, with the exception of treatment with anaerobic compost incorporation. On the third site, deep plowing has been unfavorable to the main nematode sorghum compared to shallow tillage. The nematofauna in fallow was more diversified than in cultivated sites and P. brachyurus, the main nematode related to sorghum has fallen sharply in fallow

Les Goitres Bénins En ORL Aspects Epidemiologiques Et Anatomocliniques : Étude De 97 Cas

But : Analyse épidémiologique, clinique et anatomopathologique des goitres bénins. Méthodologie : Etude rétrospective de janvier 2002 à décembre 2006 sur dossier de patients ayant consulté en ORL pour goitre. Les paramètres suivant ont été étudiés : - interrogatoire : âge, sexe, profession, résidence, ancienneté du goitre, motif de consultation ; - examen clinique précisant résultats palpation, classification OMS de 1962 du goitre ; - résultats de l\'échographie ; - résultats du dosage de la TSH ultrasensible. Ont été exclus tous les dossiers comportant une histologie suspecte et/ou maligne et les inflammations de la thyroïde. Ainsi a-t-on retenu 97 dossiers sur 122. Résultats : Notre recrutement a été marqué par une forte proportion d\'adulte jeune (classe d\'âge de 31 à 50 ans : 78 patients) et par une prédominance féminine (sex-ratio, 17/80). Ces patients étaient plus souvent des femmes au foyer et résidaient le plus souvent à Bamako. Ils étaient porteurs à 52% de goitre évoluant depuis plus de vingt ans et à 44% de plus de dix ans d\'évolution. Deux signes principaux ont amenés les patients à consulter : les signes d\'hyperthyroïdie et la tuméfaction cervicale disgracieuse. Le goitre était de type 3 de l\'OMS dans 68% des cas. Un aspect multi nodulaire clinique a été vu chez 81 patients. A l\'imagerie, nous avons noté 10% de goitre isoéchogène. L\'examen anatomopathologie a plus souvent trouvé des goitres de type macro folliculaire sur les pièces d\'exérèse. Ils étaient dans 20% des cas des goitres en activité. Conclusion : Le praticien ORL en pays d\'endémie goitreuse se doit de connaître tous les contours de la pathologie thyroïdienne. Il ne doit jamais oublier non plus que la prise en charge efficiente doit être multidisciplinaire (Endocrinologue, Radiologue, Anatomopathologiste, Anesthésiste Réanimateur). Patients and methods : retrospective study of 97 cases traeted from January 2002 to December 2006. Were excluded malignant and inflammatory thyroid deseases. Results: Our patients were essentially young adults (from 31 to 50 years: 78 patients) . We noted a female prevalence (sex-ratio: 17/80) 52% had more than twenty years evolution goiter and 44% more than ten years evolution. Two principal symptoms led the patients to consult: those of hyperthyroidy and cervical swelling. The goiter was classified as type 3 of WHO in 68% of the cases. A multi nodular aspect was found among 81 patients. We noted 10% of isoechogene goiter. The treatment was surgery The histological examination found macrofollicular goiter in the majority of cases. Keywords: Thyroïd gland, goiter bénign, cervical swelling. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 18 2007: pp. 16-1

Increasing rabies data availability: the example of a One Health research project in Chad, Côte d'Ivoire and Mali

Rabies is a fatal but preventable disease that remains notoriously underreported. Weak data availability hampers advocacy, constitutes a barrier to resource allocation and inhibits effective prevention and control. To gain better insight into the global rabies burden and human vaccine demand several studies were funded through the Vaccine Alliance (GAVI) learning agenda. With the help of this funding, Swiss TPH and local in country partner organizations implemented a One Health research project in Chad, Cote d'Ivoire and Mali to collect data at household, public health facility and veterinary level. This paper describes the implementation of this research project and evaluates its success on amount of information gained, achieved capacity building, impact on knowledge creation and influence on national and international policies. The project was based on the One Health concept and guided by the principles of transboundary research partnerships formulated by the Swiss Academy of Sciences. Data was collected on bite incidents and health seeking from over 24'000 households, on access to treatment of over 8'800 bite cases registered in public health facilities and on the status of over 1'800 rabies suspect animals. Selected country specific datasets have contributed to more than 10 scientific articles so far. On the international level, the multi-level data collection provided a unique set of indicators to inform, along with results from other studies, new WHO rabies immunization recommendations and a vaccine investment case scenario to prevent human rabies. New rabies burden estimates based on the data gathered are published for Mali and will be modelled for the whole West and Central African region. On the national level, the project facilitated communication between animal health and human health workers catalyzing creation of local and national committees and formulation of national action plans for Mali and Cote D'Ivoire. Major challenges arose from lack of data collection and documentation experience of human health and veterinary workers and weak infrastructural capacities of the veterinary and human health systems of the project countries. Through adherence to the principles of transboundary research partnerships, project team members acquired valuable research and networking skills despite language barriers, enabling them to play key roles in the future agenda towards national, regional and global canine rabies elimination. Project external collaborations with local public institutions was facilitated through long-term local partnerships. Both factors enabled success in project implementation and outcomes by identifying and mitigating risks in advance, resolving challenges amiably and enabling mutual knowledge creation as a fructuous ground for sustained commitment. Lack of immediate follow-up funding did not allow to maintain activities beyond the project timeframe. However, the national and international policy changes triggered, as well as the strengthened local disease control and research capacities provides sustainable basis for the elimination of dog transmitted human rabies

Contour bunding technology-evidence and experience in the semiarid region of southern Mali

Land and water management practices have been widely implemented in rural Mali since the 1980s to improve agricultural productivity and erosion control. Under conditions of recurring droughts, these practices are expected to increase farmers’ ability to cope with shocks. One of the most common practices applied in the central and southern parts of Mali is contour bunding (CB). In this study the impact of the CB technology is evaluated with a focus on biophysical and socio-economic benefits. Data were collected in two agro-ecologies of southern Mali and were generated through field experimentation and household survey. Field experimentation involved implementation of contour lines with farm ridges, agronomic trails and runoff and erosion measurements. Agronomic data was collected on sorghum, maize, groundnut and millet for three consecutive years (2015 to 2017). Socio-economic data on the use of CB was obtained from individual farmer surveys. CB involves the layout of contour lines with land leveling devices to identify points of equal elevation and construction of contour lines with draught animals and human labor. The majority of the labor input to construct and maintain the CB comes from adult men who are head of the household (58%) and youth male (33%). Results indicate that with the application of CB yield of crops was higher with the highest increase in grain yield and biomass obtained for maize and millet (P < 0.01). CB application was useful in retaining soil water and reduced erosion rate. In treatment fields, 162mmof rainfall per year was saved as soil moisture and on average 13,090 kg per hectare of soil was lost from farm fields without CB, and CB implementation significantly reduced the soil loss by 163% (P < 0.01). The improvements in crops yield and biomass, and the retention of soil nutrients positively changed farm level productivity conditions. The majority of farmers (78%) perceived higher income from the sale of crops grown on CB plots. These results suggest the landscape wide application of CB

Encouraging impact following 2.5 years of reinforced malaria control interventions in a hyperendemic region of the Republic of Guinea.

Malaria is one of the principal causes of morbidity and mortality in the Republic of Guinea, particularly in the highly endemic regions. To assist in malaria control efforts, a multi-component malaria control intervention was implemented in the hyperendemic region of Guéckédou Prefecture. The coverage of the intervention and its impact on malaria parasite prevalence were assessed. Five cross-sectional surveys using cluster-based sampling and stratified by area were conducted from 2011 to 2013 in three sous-préfectures of Guéckédou Préfecture that received the intervention: Guéckédou City, Tékoulo and Guendembou in addition to one comparison sous-préfecture that did not receive the intervention, Koundou. Surveys were repeated every 6 months, corresponding with the dry and rainy seasons. Rapid diagnostic tests (RDT) were used to diagnose malaria infection. In each selected household, bed net use and ownership were assessed. A total of 35,123 individuals participated in the surveys. Malaria parasite prevalence declined in all intervention sous-préfectures from 2011 to 2013 (56.4-45.9 % in Guéckédou City, 64.9-54.1 % in Tékoulo and 69.4-56.9 % in Guendembou) while increasing in the comparison sous-préfecture (64.5-69 %). It was consistently higher in children 5-14 years of age followed by those 1-59 months and ≥15 years. Indicators of intervention coverage, the proportion of households reporting ownership of at least one bed net and the proportion of survey participants with fever who received treatment from a health facility or community health worker also increased significantly in the intervention areas. Implementation of the multi-component malaria control intervention significantly reduced the prevalence of malaria in the sous-préfectures of intervention while also increasing the coverage of bed nets. However, malaria prevalence remains unacceptably high and disproportionately affects children &lt;15 years of age. In such situations additional vector control interventions and age specific interventions should be considered

Livestock keepers’ attitudes: Keystone of effective community-based breeding programs

Livestock keepers in southwestern Burkina Faso hold the local Lobi taurine breed, local Zebu cattle, and their crosses. Some communities in the region have begun to implement community-based cattle breeding programs (CBBPs), which involve animal tagging and recording and, potentially, also bull sharing. Based on the hypothesis that the participation of livestock keepers in CBBPs depends on their attitudes towards these programs, we used questionnaires to survey the attitudes of 125 farmers towards cattle breeding strategies and tools. Results were analyzed using principal component analysis. Farmers showed a highly positive attitude towards maintaining the features of their preferred cattle breed, but their attitudes varied substantially towards crossbreeding for breed improvement. Farmers generally agreed that performance was more important than animal appearance, and most of them were willing to cooperate with breeders’ associations but were skeptical about sharing their bulls with other farmers. The majority was reluctant to record performance data, which may be due to a capacity deficit and their confidence in being able to select the best animals based purely on phenotype. Our analysis suggests that breeders’ associations, as a key component of CBBPs, should lay down clear rules and obligations for their members from the outset. Timely consideration of farmers’ attitudes towards different breeding tools may improve their uptake and guarantee the sustainability of CBBPs