FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation

The environmental impact on health is an inevitable by-product of human activity. Environmental health sciences is a multidisciplinary field addressing complex issues on how people are exposed to hazardous chemicals that can potentially affect adversely the health of present and future generations. Exposure sciences and environmental epidemiology are becoming increasingly data-driven and their efficiency and effectiveness can significantly improve by implementing the FAIR (findable, accessible, interoperable, reusable) principles for scientific data management and stewardship. This will enable data integration, interoperability and (re)use while also facilitating the use of new and powerful analytical tools such as artificial intelligence and machine learning in the benefit of public health policy, and research, development and innovation (RDI). Early research planning is critical to ensuring data is FAIR at the outset. This entails a well-informed and planned strategy concerning the identification of appropriate data and metadata to be gathered, along with established procedures for their collection, documentation, and management. Furthermore, suitable approaches must be implemented to evaluate and ensure the quality of the data. Therefore, the 'Europe Regional Chapter of the International Society of Exposure Science' (ISES Europe) human biomonitoring working group (ISES Europe HBM WG) proposes the development of a FAIR Environment and health registry (FAIREHR) (hereafter FAIREHR). FAIR Environment and health registry offers preregistration of studies on exposure sciences and environmental epidemiology using HBM (as a starting point) across all areas of environmental and occupational health globally. The registry is proposed to receive a dedicated web-based interface, to be electronically searchable and to be available to all relevant data providers, users and stakeholders. Planned Human biomonitoring studies would ideally be registered before formal recruitment of study participants. The resulting FAIREHR would contain public records of metadata such as study design, data management, an audit trail of major changes to planned methods, details of when the study will be completed, and links to resulting publications and data repositories when provided by the authors. The FAIREHR would function as an integrated platform designed to cater to the needs of scientists, companies, publishers, and policymakers by providing user-friendly features. The implementation of FAIREHR is expected to yield significant benefits in terms of enabling more effective utilization of human biomonitoring (HBM) data.Most co-authors were financialy supported with their respective inistitution. Some of the co-authors were financialy supportrd by the Safe and Efficient Chemistry by Design (SafeChem) project (grant no. DIA 2018/11) funded by the Swedish Foundation for Strategic Environmental Research, and by the PARC project (grant no. 101057014) funded under the European Union's Horizon Europe Research and Innovation program

Monitoraggio biologico ed esposizione occupazionale: come i risultati di ricerche bibliografiche su riviste indicizzate con l’uso di keywords sono cambiati nell’arco di cinque anni. 76° Congresso Nazionale SIMLII (Società Italiana di Medicina del Lavoro ed Igiene Industriale). Messina, Giardini Naxos. 9-11 ottobre 2013

The objective of the study is to analyze how the topics of the publications regarding the biomonitoring of workers have changed from 2007 to 2011, in order to understand how research subjects and priorities are evolving in the last years. Two bibliographic databases have been used, Scopus and PubMed. This last provided 1338 documents published from 2007 to 2011, that were analyzed using MEVA (MedLine Evaluator): a new search for the MESH terms found in the 5 most frequent journals in 2007 and in 2012 was made and compared. The differences between Scopus and Pubmed results were also analyzed. Results are presented as Clouds. The 5 journals were Ann Occup Hyg , J Occup Environ Hyg , Int Arch Occup Environ Health, Occup Environ Med, J Environ Monit. In 2007 among the most frequent MESH terms traditional concerns like Air Pollutants, Dust, Metallurgy, Chemical Industry and Coal Mining were found. In 2011 new MESH terms occur with high frequency, like noise, endotoxin, nanoparticles, power plants and skin chemistry. Bibliographic databases and new bibliometric tools can help the research community to understand how the changes in the society are reflected by the changing topics explored in the scientific papers highlighting which are the new risks, new substances, old and emerging concerns for the workers’ safety and public health

Relazione tra la suscettibilità individuale e l’incidenza di patologie da stress in ambienti di lavoro: stato dell’arte

La determinazione del rischio lavorativo legato allo stress non è sempre di facile realizzazione. I fattori di sucsettibilità individuale legati a questo rischio vengono esaminati attraverso un'analisi della letteratura esistente

Aspetti metodologici nel monitoraggio ambientale e biologico dell'esposizione a basse dosi di benzene : criticità e possibili soluzioni

This paper aims to examine some methods to measure human exposure to benzene, both in life and occupational environments, through environmental and biological monitoring, examining the critical issues and optimal conditions of use. The overall performance of environmental monitoring, from the analytical point of view, strongly depend on the choice of an appropriate method of sampling and analysis. Urinary SPMA and t, t-MA are the biomarkers listed by ACGIH to evaluate occupational exposure: most of the recent studies use HPLC with tandem mass spectrometry, but since t, t-MA is present in the urine in larger quantities it is also determinable with UV detectors. The urinary benzene is an index not officially Included in the list of the ACGIH BEIs, but it is useful to assess exposure and benzene at low concentrations, that most frequently are found today in the occupational and life environments

Association of exposure to benzene and smoking with oxidative damage to nucleic acids by means of biological monitoring of general population volunteers

In this study, the validation of liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) isotopic dilution method for the determination of benzene and nicotine metabolites in urine was carried out. Limit of detection are 0.026 μg/L for S-phenylmercapturic acid (SPMA), 0.55 μg/L for t,t-muconic acid (t,t-MA), and 12.41 μg/L for the cotinine, and the relative combined uncertainty was also calculated. The study involves 446 healthy volunteer residents since at least 10 years in an area of central Italy. SPMA resulted to be strongly correlated with cotinine (p = 0.75), its concentration in smokers (93) being about ten times than in non/ex-smokers (197/156), while the t,t-MA of smokers is about twice the non/ex-smokers value. A cutoff value for the definition of smoker is set at 100 μg/g creat. Oxidative stress was studied in smokers and non- and ex-smokers by means of the determination of the biomarkers 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), 8-Oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-Oxo-7,8-dihydroguanine (8-oxoGua): no significant differences were found between smokers and non/ex-smokers, but when subjects are classified according to the cotinine cutoff value, a correlation in smokers’ urinary 8-oxodGuo is found with SPMA and cotinine (p = 0.60 and p = 0.57). Results were confirmed by chemometric analysis that also identified the experimental variables most contributing the discrimination as cotinine and t,t-MA

Studio ed analisi delle potenzialità interpretative del sistema PNEI: stato dell’arte

Viene riportatata una analisi critica sullo stato dell'arte di indicatori PNEI, per lo studio dello Stress Lavoro Correlato, uno dei fattori di rischio per cui risulta difficile la valutazione

Ciclofosfamide iodurata come possibile standard interno per l'analisi dei chemioterapici antiblastici mediante spettrometria di massa

The cyclophosphamide is one of the most used antineoplastic agents in therapy and the evaluation of occupational exposition requires the dosage of the drug in complex matrixes. An internal standard is necessary for quantitative analysis in order to get analytical results independent from any errors of the processing phases. This study shows the synthesis and characterization of mono and di-iodiocyclophosphamide, suggested as optimal internal standards. The results show that both the molecules have the same instrumental behaviour of the analyte. Therefore, monoiodade is particularly suitable for an LC/MS analysis, while diiodide in GC/MS one.La ciclofosfamide è uno dei farmaci antiblastici maggiormente utilizzati; la valutazione dell’esposizione professionale include il dosaggio della molecola stessa in matrici complesse. Per la quantificazione è necessario disporre di uno standard interno che renda i risultati analitici indipendenti da qualsiasi errore di processamento. Si riporta la procedura di sintesi e caratterizzazione di ciclofosfamide mono e diiodurata, proposti quali standard interni ottimali. Dai risultati si evidenzia che le due molecole sintetizzate danno risposte strumentali del tutto analoghe a quelle dell’analita. La monoiodurata risulta più idonea per analisi condotte mediante LC/MS, mentre la diidodurata in quelle GC/MS

Correlation between environmental and biological monitoring in petrochemical industry operators.

Risultati preliminari del Progetto