Modelling of FG-TPMS plates

Functionally graded porous plates have been validated as remarkable lightweight structures with excellent mechanical characteristics and numerous applications. With inspiration from the high strength-to-volume ratio of triply periodic minimal surface (TPMS) structures, a new model of porous plates, which is called a functionally graded TPMS (FG-TPMS) plate, is investigated in this paper. Three TPMS architectures including Primitive (P), Gyroid (G), and wrapped package-graph (IWP) with different graded functions are presented. To predict the mechanical responses, a new fitting technique based on a two-phase piece-wise function is employed to evaluate the effective moduli of TPMS structures, including elastic modulus, shear modulus, and bulk modulus. In addition, this function corresponds to the cellular structure formulation in the context of relative density. The separated phases of the function are divided by the different deformation behaviors. Furthermore, another crucial mechanical property of porous structure, i.e, Poisson's ratio, is also achieved by a similar fitting technique. To verify the mechanical characteristics of the FG-TPMS plate, the generalized displacement field is modeled by a seventh-order shear deformation theory (SeSDT) and isogeometric analysis (IGA). Numerical examples regarding static, buckling, and free vibration analyses of FG-TPMS plates are illustrated to confirm the reliability and accuracy of the proposed approach. Consequently, these FG-TPMS structures can provide much higher stiffness than the same-weight isotropic plate. The greater stiffness-to-weight ratio of these porous plates compared to the full-weight isotropic ones should be considered the most remarkable feature. Thus, these complex porous structures have numerous practical applications because of these high ratios and their fabrication ability through additive manufacturing (AM) technology.Comment: 27 pages (including references), 15 figures, 12 table

Predictive Collision Management for Time and Risk Dependent Path Planning

Autonomous agents such as self-driving cars or parcel robots need to recognize and avoid possible collisions with obstacles in order to move successfully in their environment. Humans, however, have learned to predict movements intuitively and to avoid obstacles in a forward-looking way. The task of collision avoidance can be divided into a global and a local level. Regarding the global level, we propose an approach called "Predictive Collision Management Path Planning" (PCMP). At the local level, solutions for collision avoidance are used that prevent an inevitable collision. Therefore, the aim of PCMP is to avoid unnecessary local collision scenarios using predictive collision management. PCMP is a graph-based algorithm with a focus on the time dimension consisting of three parts: (1) movement prediction, (2) integration of movement prediction into a time-dependent graph, and (3) time and risk-dependent path planning. The algorithm combines the search for a shortest path with the question: is the detour worth avoiding a possible collision scenario? We evaluate the evasion behavior in different simulation scenarios and the results show that a risk-sensitive agent can avoid 47.3% of the collision scenarios while making a detour of 1.3%. A risk-averse agent avoids up to 97.3% of the collision scenarios with a detour of 39.1%. Thus, an agent's evasive behavior can be controlled actively and risk-dependent using PCMP.Comment: Extended version of the SIGSPATIAL '20 pape

Review of the Surgical Approaches for Peyronie's Disease: Corporeal Plication and Plaque Incision with Grafting

The understanding and management of Peyronie's disease (PD) has improved but elucidating the exact etiology of the disease has yet to be achieved. In this paper, we review the historical and clinical aspects of PD. We focus on the evolution of surgical management for PD and review recent published articles that compare popular surgical techniques such as plication and plaque incision with vein graft. These two techniques have been reported to be equivalent with respect to patient satisfaction; however, each technique has its own advantages and disadvantages

Penile Corporeal Reconstruction during Difficult Placement of a Penile Prosthesis

For some patients with impotence and concomitant severe tunical/corporeal tissue fibrosis, insertion of a penile prosthesis is the only option to restore erectile function. Closing the tunica over an inflatable penile prosthesis in these patients can be challenging. We review our previous study which included 15 patients with severe corporeal or tunical fibrosis who underwent corporeal reconstruction with autologous rectus fascia to allow placement of an inflatable penile prosthesis. At a mean follow-up of 18 months (range 12 to 64), all patients had a prosthesis that was functioning properly without evidence of separation, herniation, or erosion of the graft. Sexual activity resumed at a mean time of 9 weeks (range 8 to 10). There were no adverse events related to the graft or its harvest. Use of rectus fascia graft for coverage of a tunical defect during a difficult penile prosthesis placement is surgically feasible, safe, and efficacious

A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia

Ceftazidime/avibactam comprises the broad-spectrum cephalosporin ceftazidime and the non-β-lactam β-lactamase inhibitor avibactam. This phase 3, randomised, double-blind study (NCT01726023) assessed the efficacy and safety of ceftazidime/avibactam plus metronidazole compared with meropenem in patients with complicated intra-abdominal infection (cIAI) in Asian countries. Subjects aged 18–90 years and hospitalised with cIAI requiring surgical intervention were randomised 1:1 to receive every 8 h either: ceftazidime/avibactam (2000/500 mg, 2-h infusion) followed by metronidazole (500 mg, 60-min infusion); or meropenem (1000 mg, 30-min infusion). Non-inferiority of ceftazidime/avibactam plus metronidazole to meropenem was concluded if the lower limit of the 95% confidence interval (CI) for the between-group difference in clinical cure rate was greater than −12.5% at the test-of-cure (TOC) visit (28–35 days after randomisation) in the clinically evaluable (CE) population. Safety was also evaluated. Of 441 subjects randomised, 432 received at least one dose of study medication (ceftazidime/avibactam plus metronidazole, n = 215; meropenem, n = 217). In the CE population at the TOC visit, non-inferiority of ceftazidime/avibactam plus metronidazole to meropenem was demonstrated, with clinical cure reported for 93.8% (166/177) and 94.0% (173/184) of subjects, respectively (between-group difference, −0.2, 95% CI −5.53 to 4.97). The clinical cure rate with ceftazidime/avibactam plus metronidazole was comparable in subjects with ceftazidime-non-susceptible and ceftazidime-susceptible isolates (95.7% vs. 92.1%, respectively). Adverse events were similar between the study groups. Ceftazidime/avibactam plus metronidazole was non-inferior to meropenem in the treatment of cIAIs in Asian populations and was effective against ceftazidime-non-susceptible pathogens. No new safety concerns were identified

Carbon nanotube four-terminal devices for pressure sensing applications

Carbon nanotubes (CNTs) are of high interest for sensing applications,owing to their superior mechanical strength, high Young’s modulus and low density. In this work, we report on a facile approach for the fabrication of carbon nanotube devices using a four terminal configuration. Oriented carbon nanotube films were pulled out from a CNT forest wafer and then twisted into a yarn. Both the CNT film and yarn were arranged on elastomer membranes/diaphragms which were arranged on a laser cut acrylic frame to form pressure sensors. The sensors were calibrated using a precisely controlled pressure system, showing a large change of the output voltage of approximately 50 mV at a constant supply current of 100 μA and under a low applied pressure of 15 mbar. The results indicate the high potential of using CNT films and yarns for pressure sensing applications

Cultivating cultural capitals in introductory algebra-based physics through reflective journaling

At a large, diverse, hispanic-serving, master’s-granting university, the Alma Project was created to support the rich connections of life experiences of science, technology, engineering, and mathematics (STEM) students that come from racially diverse backgrounds through reflective journaling. Utilizing frameworks in ethnic studies and social psychology, the Alma Project aims to make learning STEM inclusive by affirming the intersectional identities and cultural wealth that students bring into STEM classrooms. Approximately once per month students who participate in the Alma Project spend 5–10 min at the beginning of class responding to questions designed to affirm their values and purpose for studying STEM in college. Students then spend time in class sharing their responses with their peers, to the extent that they feel comfortable, including common struggles and successes in navigating through college and STEM spaces. For this study, we analyze 180 reflective journaling essays of students enrolled in General Physics I, an algebra-based introductory physics course primarily for life science majors. Students were enrolled in a required lab, a self-selected community-based learning program (Supplemental Instruction), or in a small number of instances, both. Using the community cultural wealth framework to anchor our analysis, we identified 11 cultural capitals that students often expressed within these physics spaces. Students in both populations frequently expressed aspirational, attainment, and navigational capital, while expressions of other cultural capitals, such as social capital, differ in the two populations. Our findings suggest that students bring rich and diverse perspectives into physics classrooms when asked to reflect about their lived experiences. Moreover, our study provides evidence that reflective journaling can be used as an asset-based teaching tool. By using reflective journaling in physics spaces, recognizing students’ assets has the potential for physics educators to leverage students’ lived experiences, goals, and values to make physics learning more meaningful and engaging