A plan for the development of superconducting Undulator prototypes for LCLS-II and future FELs

Undulators serve as the primary source of radiation for modern storage rings, and more recently for the advent of Free-Electron Lasers (FELs). The performance of future FELs can be greatly enhanced using the much higher magnetic fields of superconducting undulators (SCU) [1]. For example, the LCLS-II hard x-ray undulator can be shortened by up to 70 m using an SCU in place of a PMU (permanent magnet undulator), or its spectral performance can be critically improved when using a similar length. In addition, SCUs are expected to be orders of magnitude less sensitive to radiation dose; a major issue at LCLS-II with its 1-MHz electron bunch rate. We present a funded R&D collaboration between SLAC, ANL, and LBNL, which aims to demonstrate the viability of superconducting undulators for FELs by building, testing, measuring, and tuning two 1.5-m long planar SCU prototypes using two different technologies: NbTi at ANL and Nb Sn at LBNL. Our goal is to review and reassess the LCLS-II HXR baseline plans (PMU) in July of 2015, after the development and evaluation of both prototypes, possibly in favor of an SCU for LCLS-II.

First Observation of Self-Amplified Spontaneous Emission in a Free-Electron Laser at 109 nm Wavelength

We present the first observation of Self-Amplified Spontaneous Emission (SASE) in a free-electron laser (FEL) in the Vacuum Ultraviolet regime at 109 nm wavelength (11 eV). The observed free-electron laser gain (approx. 3000) and the radiation characteristics, such as dependency on bunch charge, angular distribution, spectral width and intensity fluctuations all corroborate the existing models for SASE FELs.Comment: 6 pages including 6 figures; e-mail: [email protected]

Self-amplified spontaneous emission saturation at the Advanced Photon Source free-electron laser (abstract) (invited)

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AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Enzymatic oligomerization and polymerization of arylamines: state of the art and perspectives

The literature concerning the oxidative oligomerization and polymerization of various arylamines, e.g., aniline, substituted anilines, aminonaphthalene and its derivatives, catalyzed by oxidoreductases, such as laccases and peroxidases, in aqueous, organic, and mixed aqueous organic monophasic or biphasic media, is reviewed. An overview of template-free as well as template-assisted enzymatic syntheses of oligomers and polymers of arylamines is given. Special attention is paid to mechanistic aspects of these biocatalytic processes. Because of the nontoxicity of oxidoreductases and their high catalytic efficiency, as well as high selectivity of enzymatic oligomerizations/polymerizations under mild conditions-using mainly water as a solvent and often resulting in minimal byproduct formation-enzymatic oligomerizations and polymerizations of arylamines are environmentally friendly and significantly contribute to a "green'' chemistry of conducting and redox-active oligomers and polymers. Current and potential future applications of enzymatic polymerization processes and enzymatically synthesized oligo/polyarylamines are discussed

Biochemical mechanisms of free-radical damage to the nuclear genome by cadmium

Cadmium, has been used for many years in industry and agriculture. Its active use is associated with a danger to human health due to a significant toxic effect on the body. The purpose of the review was to analyze the literature data and the results of our own experimental research on the biochemical mechanisms of the toxic effect of cadmium on the nuclear chromatin of cells, primarily the liver. Based on this analysis, the concept that the toxicity of cadmium is associated with damage caused by cadmium-induced free radicals was confirmed. The reactive oxygen species formed in this way are active damaging agents that cause toxic effects, including mutagenic, which ultimately leads to apoptosis and cell death

Design and performance of the vacuum chambers for the undulator of the VUV FEL at the TESLA Test Facility at DESY

Three vacuum chambers for the VUV SASE FEL undulator sections at the TESLA Test Facility (TTF) were designed, built, tested and installed. Each chamber is 4.5 m long and of 11.5 mm thick. The inner diameter of the beam pipe is 9.5 mm. The rectangular chamber profile with a width of 128 mm is used to integrate beam position monitors and steerers. This is needed to provide a good overlap between the electron and the photon beam over the entire undulator length. The chambers are built in an aluminum extrusion technology developed for the insertion device vacuum chambers of the Advanced Photon Source. After manufacturing, special processing was performed to reach low outgassing rates (<1×10 −11 mbar·l/s·cm 2 ) and particle-free chambers. Mounting of the chambers at TTF were performed under clean room conditions better class 100

Design and performance of the vacuum chambers for the undulator of the VUV FEL at the TESLA Test Facility at DESY

Three vacuum chambers for the VUV SASE FEL undulator sections at the TESLA Test Facility (TTF) were designed, built, tested and installed. Each chamber is 4.5 m long and of 11.5 mm thick. The inner diameter of the beam pipe is 9.5 mm. The rectangular chamber profile with a width of 128 mm is used to integrate beam position monitors and steerers. This is needed to provide a good overlap between the electron and the photon beam over the entire undulator length. The chambers are built in an aluminum extrusion technology developed for the insertion device vacuum chambers of the Advanced Photon Source. After manufacturing, special processing was performed to reach low outgassing rates (<1×10 −11 mbar·l/s·cm 2 ) and particle-free chambers. Mounting of the chambers at TTF were performed under clean room conditions better class 100