2,641 research outputs found

    Confirmative Evaluation of Training Outcomes: Using Self-Report Measures to Track Change at the Individual and Organizational Level

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    This article explores the use of an evaluation model of learning and development utilizing formative, summative, and confirmative steps, along with a framework for developing evaluation tools aligned with organizational change goals. A case study is presented in which formative, summative, and confirmative evaluations were used to assess materials and learners following implementation of a new performance management process, tools, and supporting training. A specific model for developing evaluation tools and techniques is introduced as a way to integrate the evaluation process with the specific content of a learning and development intervention, as well as link to higher-order cultural change goals. Results of the case study suggest that evaluation tools can provide evidence of improvement and target areas for further work. Recommendations are provided for the researcher or practitioner interested in applying the same or similar models to evaluation

    Opioids depress cortical centers responsible for the volitional control of respiration

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    Respiratory depression limits provision of safe opioid analgesia and is the main cause of death in drug addicts. Although opioids are known to inhibit brainstem respiratory activity, their effects on cortical areas that mediate respiration are less well understood. Here, functional magnetic resonance imaging was used to examine how brainstem and cortical activity related to a short breath hold is modulated by the opioid remifentanil. We hypothesized that remifentanil would differentially depress brain areas that mediate sensory-affective components of respiration over those that mediate volitional motor control. Quantitative measures of cerebral blood flow were used to control for hypercapnia-induced changes in blood oxygen level-dependent (BOLD) signal. Awareness of respiration, reflected by an urge-to-breathe score, was profoundly reduced with remifentanil. Urge to breathe was associated with activity in the bilateral insula, frontal operculum, and secondary somatosensory cortex. Localized remifentanil-induced decreases in breath hold-related activity were observed in the left anterior insula and operculum. We also observed remifentanil-induced decreases in the BOLD response to breath holding in the left dorsolateral prefrontal cortex, anterior cingulate, the cerebellum, and periaqueductal gray, brain areas that mediate task performance. Activity in areas mediating motor control (putamen, motor cortex) and sensory-motor integration (supramarginal gyrus) were unaffected by remifentanil. Breath hold-related activity was observed in the medulla. These findings highlight the importance of higher cortical centers in providing contextual awareness of respiration that leads to appropriate modulation of respiratory control. Opioids have profound effects on the cortical centers that control breathing, which potentiates their actions in the brainstem

    Comparison of nursing home residents admitted from home or hospital.

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    A growing elderly population coupled with a reduction in hospital long term care has led to an increase in the independent nursing home sector. This is an expensive resource. Proper placement is therefore essential to ensure its efficient use. Prior to the introduction of care management there was no standard assessment procedure for admission to nursing home care from different sources. A nursing home population (n = 624) in North and West Belfast was studied and mental scores, levels of disability, and the source of admission to the nursing home recorded. Residents admitted from geriatric medical units (n = 132) were compared with those from general medical and surgical wards (n = 168) and those from home (n = 243). Residents who were admitted from a geriatric unit were the most disabled, those admitted from home were the least and those from general wards had intermediate levels of disability (p < 0.005). This is likely to be the result of different assessment procedures for prospective nursing home residents. With the introduction of care management, it is hoped that standardised assessment will follow. The roles of different medical specialists in this process is not yet clear. Further study is needed to assess the appropriateness of placement in nursing homes under care management

    Correction to: Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance.

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    After publication of this article (He et al., 2018), the corresponding authors recognised an error in Scheme 1, in particular to section A. HMGB1/TLR4/MD-2 complex formation . Above Step 2: B box binding to MD-2 , the text incorrectly read: Low affinity / extremely slow off . In addition, some text was omitted below TLR4/MD-2 . The correct version of Scheme 1 is included in this Correction article. The original article (He et al., 2018) has been corrected

    Differences in client and therapist views of the working alliance in drug treatment

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    Background - There is growing evidence that the therapeutic alliance is one of the most consistent predictors of retention and outcomes in drug treatment. Recent psychotherapy research has indicated that there is a lack of agreement between client, therapist and observer ratings of the therapeutic alliance; however, the clinical implications of this lack of consensus have not been explored. Aims - The aims of the study are to (1) explore the extent to which, in drug treatment, clients and counsellors agree in their perceptions of their alliance, and (2) investigate whether the degree of disagreement between clients and counsellors is related to retention in treatment. Methods - The study recruited 187 clients starting residential rehabilitation treatment for drug misuse in three UK services. Client and counsellor ratings of the therapeutic alliance (using the WAI-S) were obtained during weeks 1-12. Retention was in this study defined as remaining in treatment for at least 12 weeks. Results - Client and counsellor ratings of the alliance were only weakly related (correlations ranging from r = 0.07 to 0.42) and tended to become more dissimilar over the first 12 weeks in treatment. However, whether or not clients and counsellors agreed on the quality of their relationship did not influence whether clients were retained in treatment. Conclusions - The low consensus between client and counsellor views of the alliance found in this and other studies highlights the need for drug counsellors to attend closely to their clients' perceptions of the alliance and to seek regular feedback from clients regarding their feelings about their therapeutic relationship

    Mean Antarctic Circumpolar Current Transport Measured in Drake Passage

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    The Antarctic Circumpolar Current is an important component of the global climate system connecting the major ocean basins as it flows eastward around Antarctica, yet due to the paucity of data it remains unclear how much water is transported by the current. Between 2007 and 2011 flow through Drake Passage was continuously monitored with a line of moored instrumentation with unprecedented horizontal and temporal resolution. Annual mean near-bottom currents are remarkably stable from year to year. The mean depth-independent, or barotropic transport, determined from the near-bottom current meter records was 45.6 Sv with an uncertainty of 8.9 Sv. Summing the mean barotropic transport with the mean baroclinic transport relative to zero at the seafloor of 127.7 Sv gives a total transport through Drake Passage of 173.3 Sv. This new measurement is 30% larger than the canonical value often used as the benchmark for global circulation and climate models.Fil: Donohue, K. A.. University Of Rhode Island; Estados UnidosFil: Tracey, K. L.. University Of Rhode Island; Estados UnidosFil: Watts, D. R.. University Of Rhode Island; Estados UnidosFil: Chidichimo, María Paz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval; Argentina. Universidad de Buenos Aires; ArgentinaFil: Chereskin, T. K.. University of California at San Diego. Scripps Institution of Oceanography; Estados Unido

    Kinematics of X-ray Emitting Components in Cassiopeia A

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    We present high-resolution X-ray proper motion measurements of Cassiopeia A using Chandra observations from 2000 and 2002. We separate the emission into four spectrally distinct classes: Si-dominated, Fe-dominated, low-energy-enhanced, and continuum-dominated. These classes also represent distinct spatial and kinematic components. The Si- and Fe-dominated classes are ejecta and have a mean expansion rate of 0.2%/yr. This is the same as for the forward shock filaments but less than the 0.3%/yr characteristic of optical ejecta. The low-energy-enhanced spectral class possibly illuminates a clumpy circumstellar component and has a mean expansion rate of 0.05%/yr. The continuum-dominated emission likely represents the forward shock and consists of diffuse circumstellar material which is seen as a circular ring around the periphery of the remnant as well as projected across the center.Comment: 15 pages, 3 figures, accepted to Ap
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